Characterisation of clinical response and transcriptional profiling of proliferating CD8 T cells in the blood of cancer patients after PD-1 monotherapy or combination therapy by Peng Li, Haydn Kissick, Rebecca C Obeng, Tahseen H Nasti, Christiane S Eberhardt, Rafi Ahmed, Zhengjia Chen, Warren J Leonard, Suresh S Ramalingam, Andreas Wieland, Annapaola Mariniello, Jeffrey M Switchenko, Kylee Martens, Daniel Y Chang, Donald McGuire, Candace Daugherty, Yuzi Zhang, Rathi Pillai, Alice O Kamphorst

“…Transcriptional analysis of CD8 T cells after the first treatment cycle with effector cells generated following yellow fever virus (YFV-17D) vaccine-induced infection was also compared.Results An early proliferative (Ki-67+) CD8 T-cell response was observed after cycle 1 in 60 patients (58.3%). …”
Get full text

Hubungan Karakteristik dan Tingkat Pengetahuan Petugas Imunisasi terhadap Praktik Penyimpanan dan Transportasi Vaksin Imunisasi di Tingkat Puskesmas Kota Padang Tahun 2014 by Nadia Rahmah, Putri Sri Lasmini, Rahmatini

“…<br />Keywords: characteristics, knowledge, storage, handling of vaccines<br /><br /><br /><br />…”
Get full text

Self-replicating recombinant virus-like particles of lentivirus proliferating in glioblastoma cells and normal human macrophages by Herman D. Moshkoff, Andrey E. Moshkoff, Dmitry A. Moshkoff

“…Both attenuated and inactivated vaccines are used in disease control. Inactivated vaccines are very diverse and include whole cell and acellular vaccines containing protein target antigens or nucleic acids encoding target antigens. …”
Get full text

Comparison of bison and elk susceptibility to experimental challenge with Brucella abortus strain 2308 by S. C. Olsen, P. M. Boggiatto, E. J. Putz

“…Vaccinated bison had lower (p &lt; 0.002) abortion rates and recovery of Brucella from fetal or uterine/mammary tissues when compared to naïve bison. …”
Get full text

Multiplex Evaluation of Influenza Neutralizing Antibodies with Potential Applicability to In-Field Serological Studies by Eleonora Molesti, Edward Wright, Calogero Terregino, Rafat Rahman, Giovanni Cattoli, Nigel J. Temperton

“…Sera obtained from chickens vaccinated with a monovalent H5N2 vaccine, chickens vaccinated with a bivalent H7N1/H5N9 vaccine, or turkeys naturally infected with an H7N3 virus were evaluated in this assay and the results correlated strongly with data obtained by HI assay. …”
Get full text

Cytomegalovirus in the Neonate: Immune Correlates of Infection and Protection by Mark R. Schleiss

“…Fetal and neonatal infections caused by human cytomegalovirus (CMV) are important causes of morbidity and occasional mortality. Development of a vaccine against congenital CMV infection is a major public health priority. …”
Get full text

Brief communication: gaps and opportunities in HIV research in Venezuela by Jesús A. Morgado, María G. Medina, Rafael N. Guevara, Martín Carballo, Jaime R. Torres, Fhabián S. Carrión-Nessi, David A. Forero-Peña

Get full text

Influenza and Bacterial Pathogen Coinfections in the 20th Century by Xuan-Yi Wang, Paul E. Kilgore, Kyung Ah Lim, Song-Mei Wang, Jeongseok Lee, Wei Deng, Mei-Qi Mo, Batmunkh Nyambat, Jing-Chen Ma, Michael O. Favorov, John D. Clemens

Get full text

Nonhuman primate antigenic cartography of SARS-CoV-2 by Annika Rössler, Antonia Netzl, Ninaad Lasrado, Jayeshbhai Chaudhari, Barbara Mühlemann, Samuel H. Wilks, Janine Kimpel, Derek J. Smith, Dan H. Barouch

“…We also found that the monovalent XBB.1.5 mRNA vaccine induced broad immunity against the mapped antigenic space. …”
Get full text

Newly identified c-di-GMP pathway putative EAL domain gene STM0343 regulates stress resistance and virulence in Salmonella enterica serovar Typhimurium by Kaifeng Chen, Lili Li, Nanwei Wang, Zhouping Zhou, Peng Pan, Chenggang Xu, Dage Sun, Jiayi Li, Changzhi Dai, Dai Kuang, Ming Liao, Jianmin Zhang

Get full text

Experience on postmortem minimally invasive tissue sampling to ascertain the cause of death determination in South African children: A case for implementing as standard of care by J du Toit, K Storath, I Dunn, P Makekeng, M Moosa, K Mothibi, N Umuneza, C A Rees, D Blau, S Lala, Y Adam, S Velaphi, M Hale, P Swart, J Wadula, L Mothibi, A Wise, V Baba, P Jaglal, S Mahtab, S Madhi, Z Dangor

Get full text

Characterization of Shigella flexneri serotype 6 strains from geographically diverse low- and middle-income countries by Caitlin E. Gabor, Charlotte E. Chong, Jose M. Lemme-Dumit, Tracy H. Hazen, Kate S. Baker, Karen L. Kotloff, Irene N. Kasumba, Sharon M. Tennant, Henry Badji, M. Jahangir Hossain, Richard Omore, Benjamin Ochieng, Alex O. Awuor, Billy Ogwel, Jane Juma, Eileen M. Barry, David A. Rasko

“…The inclusion of S. flexneri serotype 6 (Sf6) is a necessary component of a multivalent vaccine strategies based on its clinical and epidemiological importance. …”
Get full text

Practices and Perceptions Regarding Pain and Pain Management during Routine Childhood Immunizations: Findings from a Focus-Group Study with Nurses Working at Toronto Public Health,... by Andrew Kikuta, Fauzia Gardezi, Vinita Dubey, Anna Taddio

“…INTRODUCTION: Despite the availability of a variety of evidence-based interventions, it has previously been reported that the majority of infants and children undergo vaccine injections without the benefit of analgesia. …”
Get full text

One step further: improving paediatric TB diagnosis through user-centred research approaches by F.W. Basile, E.M. Bijker, M. Sekadde, S.E. Dorman, J.J. Ellner, N. Engel, M. Ruhwald, R. Song

Get full text

Cognitive authorities of COVID-19 information: educational differences and outcomes of trust in health experts and social media influencers in Finland by Sanna Malinen, Aki Koivula

“…Then, linear probability models were employed to analyse the factors shaping trust and determining vaccine intention. Finally, the analysis examined the indirect effects of trust in the association between education and vaccine uptake. …”
Get full text

Innate Immune Defenses in Human Tuberculosis: An Overview of the Interactions between Mycobacterium tuberculosis and Innate Immune Cells by Jonathan Kevin Sia, Maria Georgieva, Jyothi Rengarajan

“…Insights into the human innate immune response to Mtb infection are necessary for providing a rational basis for the augmentation of immune responses against Mtb infection, especially with respect to the generation of effective anti-TB immunotherapeutics and vaccines.…”
Get full text

RBD-displaying OMV nanovaccine boosts immunity against SARS-CoV-2 by Rang Feng, Ruo-Yi Xue, Chang Liu, Guo-Cheng Li, Yan Deng, Zhe Jin, Jing-Yi Liu, Shan-Shan Zhang, Hao Cheng, Man-Ying Guo, Quan-Ming Zou, Hai-Bo Li

“…Importantly, the induced antibodies effectively inhibited the binding of RBD to human angiotensin-converting enzyme 2 (hACE2) and neutralized SARS-CoV-2 pseudoviruses. Conclusions This vaccine platform offers an alternative strategy for developing recombinant subunit vaccines against SARS-CoV-2, potentially enhancing immune responses and improving vaccine efficacy. …”
Get full text

Global progress, challenges and strategies in eliminating public threat of viral hepatitis by Sihui Zhang, Fuqiang Cui

“…While improving the coverage of vaccine use, drugs for treating hepatitis B are not only becoming more effective, but also decreasing in price. …”
Get full text

Genotype Diversity of Newcastle Disease Virus in Nigeria: Disease Control Challenges and Future Outlook by Muhammad Bashir Bello, Khatijah Mohd Yusoff, Aini Ideris, Mohd Hair-Bejo, Ben P. H. Peeters, Abdurrahman Hassan Jibril, Farouk Muhammad Tambuwal, Abdul Rahman Omar

“…We then discuss the challenges of ND control as a result of the wide genetic distance between the currently circulating NDV isolates and the commonest vaccines used to combat the disease in the country. …”
Get full text

Protective potential of structural proteins of the SARS-CoV-2 virus in protecting against COVID-19 by Inna V. Dolzhikova, Daria M. Grousova, Ilya D. Zorkov, Anna A. Ilyukhina, Anna V. Kovyrshina, Olga V. Zubkova, Olga D. Popova, Tatiana A. Ozharovskaya, Denis I. Zrelkin, Daria M. Savina, Ekaterina G. Samokhvalova, Amir I. Tukhvatulin, Dmitry V. Shcheblyakov, Denis Yu. Logunov, Alexander L. Gintsburg

“…Introduction. Many different vaccines for the prevention of COVID-19 have received emergency use approval in the shortest possible time. …”
Get full text