One size does not fit all: revising traditional paradigms for assessing accuracy of QSAR models used for virtual screening by James Wellnitz, Sankalp Jain, Joshua E. Hochuli, Travis Maxfield, Eugene N. Muratov, Alexander Tropsha, Alexey V. Zakharov

“…This study explores the value of the conventional norms in the context of using QSAR models for virtual screening of modern large and ultra-large chemical libraries. For this increasingly common task, we now recommend the use of models with the highest positive predictive value (PPV) built on imbalanced training sets as preferred virtual screening tools. …”
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Evaluation of Bioactive Compounds and Chemical Elements in Herbs: Effectiveness of Choline Chloride-Based Deep Eutectic Solvents in Ultrasound-Assisted Extraction by Aleksandra Szydłowska-Czerniak, Agnieszka Kowaluk, Michał Strzelec, Tomasz Sawicki, Małgorzata Tańska

“…Profiles of phenolic acids, flavonoid aglycones, and flavonoid glycosides in the green and conventional herb extracts were quantitatively analyzed using ultra-performance liquid chromatography (UPLC). Among the prepared DESs, the highest antioxidant potential and total contents of phenolic acids, flavonoid aglycones, and flavonoid glycosides in herb extracts were achieved using ChCl:MalA (1:1). …”
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Volumetric trans-scale imaging of massive quantity of heterogeneous cell populations in centimeter-wide tissue and embryo by Taro Ichimura, Taishi Kakizuka, Yoshitsugu Taniguchi, Satoshi Ejima, Yuki Sato, Keiko Itano, Kaoru Seiriki, Hitoshi Hashimoto, Ko Sugawara, Hiroya Itoga, Shuichi Onami, Takeharu Nagai

“…We established a volumetric trans-scale imaging system with an ultra-large field-of-view (FOV) that enables simultaneous observation of millions of cellular dynamics in centimeter-wide three-dimensional (3D) tissues and embryos. …”
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Flexible substrate based wideband polarization converter with extremely high polarization conversion ratio by Ismail Hossain, Mohammad Tariqul Islam, Norsuzlin Mohd Sahar, Abdulwadoud A. Maash, Haitham Alsaif, Mohamed S. Soliman, Md Samsuzzaman

“…The PCR ratio of 80 % is achieved by this ultra-wideband linear-to-cross- and circular-to-cross-polarization converter. …”
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Ammonia-induced CuO/13X for H2S removal from simulated blast furnace gas at low temperature by Erping Cao, Yuhua Zheng, Hao Zhang, Jianshan Wang, Yuran Li, Tingyu Zhu, Zhan-guo Zhang, Guangwen Xu, Yanbin Cui

“…The desulfurization of BFG is urgent for integrated steel plants due to the stringent ultra-low emission standards. Compared with other desulfurization materials, zeolite-based adsorbents represent a viable option with low costs and long service life. …”
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Effects of Stewing Modes on Physicochemical Quality and Formation of Flavour Compounds of Chinese Dagu Chicken Soup by Haining Guan, Xiaojun Xu, Chunmei Feng, Yanli Tian, Dengyong Liu, Xiaoqin Diao

“…This study aimed to evaluate the influences of stewing modes, including high fire short time (HFST, 100°C/1 h), medium-high fire mid-length time (MFMT, 98°C/2 h), medium fire long time (MFLT, 90°C/3 h), and low fire ultra-length time (LFUT, 83°C/4 h) processing, on physicochemical parameters and flavour compound profile of Chinese Dagu chicken soup. …”
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Metabolomics insights into doxorubicin and 5-fluorouracil combination therapy in triple-negative breast cancer: a xenograft mouse model study by Mai M. Hassanein, Mai M. Hassanein, Yousra A. Hagyousif, Yousra A. Hagyousif, Ruba A. Zenati, Ruba A. Zenati, Hamza M. Al-Hroub, Farman Matloob Khan, Ahmad Y. Abuhelwa, Ahmad Y. Abuhelwa, Karem H. Alzoubi, Karem H. Alzoubi, Nelson C. Soares, Nelson C. Soares, Waseem El-Huneidi, Waseem El-Huneidi, Eman Abu-Gharbieh, Eman Abu-Gharbieh, Eman Abu-Gharbieh, Hany Omar, Hany Omar, Dana M. Zaher, Yasser Bustanji, Yasser Bustanji, Yasser Bustanji, Mohammad H. Semreen, Mohammad H. Semreen

“…This study aimed to investigate the effects of doxorubicin (DOX) and 5-fluorouracil (5-FU) as monotherapies and in combination using an established MDA-MB-231 xenograft model in female BALB/C nude mice employing advanced metabolomics analysis to identify molecular alterations induced by these treatments.MethodsWe conducted comprehensive plasma and tumor tissue sample profiling using ultra-high-performance liquid chromatography-electrospray ionization quadrupole time-of-flight mass spectrometry (UHPLC-ESI-QTOF-MS).ResultsEach treatment group exhibited unique metabolic profiles in plasma and tumor analysis. …”
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Microbiomics and metabolomics insights into the microbial regulation on the formation of flavor components in the traditional fermentation process of Chinese Hongqu aged vinegar by Shangong Tong, Wenlong Li, Yuandong Rao, Yanqin Xiao, Yingyin Yan, Weiling Guo, Xucong Lü, Jinyuan Sun, Lianzhong Ai, Li Ni

“…Correspondingly, non-volatile metabolites were also detected through ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry. …”
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Pharmacokinetics of Transdermal Flunixin Meglumine Following a Single Dose in Marine Toads (Rhinella marina) by Gregory Scott, Meghan M. Louis, Julie A. Balko, Claire M. Bublitz, Brigid V. Troan, Ronald E. Baynes, Dustin Smith, Larry J. Minter

“…Plasma was analyzed by ultra-performance liquid chromatography-tandem mass spectrometry. …”
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Recovery of Bioactive Constituents from Olive Leaf Pruning Waste of Five Different Cultivars: A Comparison of Green Extraction Techniques to Maximize Health Benefits by Hamid Mushtaq, Simona Piccolella, Jose A. Mendiola, Lidia Montero, Elena Ibáñez, Severina Pacifico

“…Chemical profiling by UHPLC-HR-MS/MS (ultra-high-performance liquid chromatography high-resolution tandem mass spectrometry) and GC-MS (gas chromatography mass spectrometry) showed that UAM-EtOH effectively extracted polyphenols (especially luteolin derivatives) and triterpenes (notably maslinic acid), while PLE yielded the highest amount of secoiridoids (e.g., secologanoside). …”
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Association of immunoglobulin G N-glycosylation with carotid atherosclerotic plaque phenotypes and actual clinical cardiovascular events: a study protocol for a longitudinal prospe... by Gehendra Mahara, Hongxia Zhang, Cuihong Tian, Xuerui Tan

“…In total, 2720 participants routinely examined by carotid ultrasound will be divided into different groups according to plaque phenotype characteristics. Ultra-performance liquid chromatography will be performed to separate and detect IgG N-glycans in serum collected at baseline and at the end of the first, second and third years. …”
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Metagenomic and Transcriptomic Analysis Reveals Crosstalk Between Intratumor Mycobiome and Hosts in Early‐Stage Nonsmoking Lung Adenocarcinoma Patients by Yaohui Sun, Zhiming Gan, Shijiancong Liu, Sheng Zhang, Wei Zhong, Jian Liu, Xiuting Huang, Wei He, Hongcheng Zhong, Qingdong Cao

“…Methods In this study, we conducted ultra‐deep metagenomic and transcriptomic sequencing on 128 samples collected from 46 nonsmoking ES‐LUAD patients and 41 healthy controls (HC), aiming to characterize the tumor‐resident mycobiome and its interactions with the host. …”
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Personalized allele-specific antisense oligonucleotides for GNAO1-neurodevelopmental disorder by Inna Shomer, Nofar Mor, Shaul Raviv, Noga Budick-Harmelin, Tanya Matchevich, Sharon Avkin-Nachum, Yoach Rais, Rebecca Haffner-Krausz, Ariela Haimovich, Aviv Ziv, Reut Fluss, Bruria Ben-Ze’ev, Gali Heimer, Denis N. Silachev, Vladimir L. Katanaev, Dan Dominissini

“…GNAO1-associated disorders are ultra-rare autosomal dominant conditions, which can manifest, depending on the exact pathogenic variant in GNAO1, as a spectrum of neurological phenotypes, including epileptic encephalopathy, developmental delay with movement disorders, or late-onset dystonia. …”
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Novel source/drain contact structure for a-IGZO devices: Oxygen-scavenger-layer metal-interlayer-semiconductor (OSL MIS) approach by Sungjoo Song, Jong-Hyun Kim, Jongyoun Park, Seung-Hwan Kim, Dongjin Ko, Hyejung Choi, Seiyon Kim, Hyun-Yong Yu

“…Recently, amorphous indium gallium zinc oxide (a-IGZO) has gained prominence for its application to stackable 3-dimensional (3D) dynamic random-access memory (DRAM) due to its ultra-low off-current and low-temperature fabrication. …”
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A novel cost-effective heterostructured Fe-based medium-entropy alloy with high cryogenic strength and ductility by Hongyan Wang, Qiuyu Gao, Zhimin Yang, Chongxun Fang, Yongfu Cai, Juqiang Zhang, Xin Zhao, Ran Wei

“…Particularly, the MEA exhibits the ultra-high specific yield strength (200 MPa cm3/g) at 77 K, compared to previously reported medium/high entropy alloys (M/HEAs). …”
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Mass Platooning: Information Networking Structures for Long Platoons of Connected Vehicles by Mahdi Razzaghpour, Babak Ebrahimi Soorchaei, Rodolfo Valiente, Yaser P. Fallah

“…Given the safety-critical nature of these communications, both reliability and ultra-low latency are essential, particularly in platooning contexts. …”
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Potential of Cover Crop Use and Termination with a Roller-Crimper in a Strip-Till Silage Maize (<i>Zea mays</i> L.) Production System in the Central Valley of California by Robert Willmott, Jennifer Valdez-Herrera, Jeffrey P. Mitchell, Anil Shrestha

“…Five cover crop treatments (rye (<i>Secale cereale</i> L.) alone, ultra-high diversity mix, multiplex cover crop mix, fava bean (<i>Vicia faba</i> L.) + phacelia (<i>Phacelia tanacetifolia</i> Benth.), and rye + field pea (<i>Pisum sativum</i> L.) + purple vetch (<i>Vicia americana</i> Muhl. …”
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Taming of trinitromethyl-oxadiazole to access high density and high oxygen balance via a dual modulation strategy by Jinya Zhang, Teng Fei, Jingwei Meng, Jinxiong Cai, Lei Zhang, Siping Pang, Chunlin He

“…Encouragingly, while maintaining ultra-high oxygen balance (21.73%), 3 achieves impressive densities (1.97–1.98 g/cm3). …”
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A New Four‐Component L*‐Dependent Model for Radial Diffusion Based on Solar Wind and Magnetospheric Drivers of ULF Waves by Kyle R. Murphy, Jasmine Sandhu, I. Jonathan Rae, Thomas Daggitt, Sarah Glauert, Richard B. Horne, Clare E. J. Watt, Sarah Bentley, Adam Kellerman, Louis Ozeke, Alexa J. Halford, Sheng Tian, Aaron Breneman, Leonid Olifer, Ian R. Mann, Vassilis Angelopoulos, John Wygant

“…Abstract Waves which couple to energetic electrons are particularly important in space weather, as they drive rapid changes in the topology and intensity of Earth's outer radiation belt during geomagnetic storms. This includes Ultra Low Frequency (ULF) waves that interact with electrons via radial diffusion which can lead to electron dropouts via outward transport and rapid electron acceleration via inward transport. …”
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Effect of p-InGaN Cap Layer on Low-Resistance Contact to p-GaN: Carrier Transport Mechanism and Barrier Height Characteristics by Mohit Kumar, Laurent Xu, Timothée Labau, Jérôme Biscarrat, Simona Torrengo, Matthew Charles, Christophe Lecouvey, Aurélien Olivier, Joelle Zgheib, René Escoffier, Julien Buckley

“…This research underscores the importance of doping, cap layer thickness, and polarization effects in achieving ultra-low contact resistivity, offering valuable insights for improving the performance of p-GaN-based power devices.…”
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