CCL5 Induces a Sarcopenic-like Phenotype via the CCR5 Receptor by Francisco Aguirre, Franco Tacchi, Mayalen Valero-Breton, Josué Orozco-Aguilar, Sabrina Conejeros-Lillo, Josefa Bonicioli, Renata Iturriaga-Jofré, Daniel Cabrera, Jorge A. Soto, Mauricio Castro-Sepúlveda, Marianny Portal-Rodríguez, Álvaro A. Elorza, Andrea Matamoros, Felipe Simon, Claudio Cabello-Verrugio

Subjects: Get full text

A pan-cancer analysis of MARCH8: molecular characteristics, clinical relevance, and immuno-oncology features by Zihan Quan, Songqing Fan, Hongmei Zheng, Yue Ning, Yang Yang

Subjects: Get full text

Identification of MORF4L1 as an endogenous substrate of CRBN and its potential role as a therapeutic target in cancer by Luyao Zhang, Shunfang Liu, Jingliang He, Zhongke Hu, Lan Zhu, Hongyi Huang, Qi Gao, Dan Wang, Lu Chen, Xingyu Zhang, Ruotong Liu, Jiayun Wang, Yizhuo Song, Kaile Zeng, Xiuming Li, Yulu Chen, Xun Zou, Shaojie Ma, Xiujun Wang, Guofeng Xu, Wei Liu, Bin Liu

Subjects: Get full text

High interstitial fluid pressure enhances USP1-dependent KIF11 protein stability to promote hepatocellular carcinoma progression by Zhengyi Wu, Chao Li, Shouhua Zhang, Liang Sun, Junwen Hu, Bingbing Qiu, Shuiqiu Liu, Yiran Hong, Tianxiang Chen, Kai Wang, Xiangbao Yin, Jinlong Yan

Subjects: Get full text

Systematic Analysis of E3 Ligase-Related Genes Identified UBE2L3 as a Prognostic Biomarker Associated With Drug Resistance in Acute Myeloid Leukemia by Ling C, Cao N, Wang H, Wan Y, Liang X, Guo J, Xiao M, Zhang Q, Zhai Z

Subjects: “…e3 ubiquitin ligase…”
Get full text

Drosophila Cul3 contributes to Diap2-mediated innate immune signaling for antimicrobial defense by Fanrui Kong, Zixuan Wang, Chuchu Zhang, Yihua Xiao, Muhammad Abdul Rehman Saeed, Weini Li, Akira Goto, Qingshuang Cai, Shanming Ji

Subjects: “…death-related ced-3/Nedd2-like caspase (Dredd) ubiquitination…”
Get full text

Biomarkers of traumatic brain injury. Literature review by A. Šmigelskytė, M. Remenčiūtė, V. Ragaišis

Subjects: Get full text

Systematic protein–protein interaction mapping for clinically relevant human GPCRs by Kate Sokolina, Saranya Kittanakom, Jamie Snider, Max Kotlyar, Pascal Maurice, Jorge Gandía, Abla Benleulmi‐Chaachoua, Kenjiro Tadagaki, Atsuro Oishi, Victoria Wong, Ramy H Malty, Viktor Deineko, Hiroyuki Aoki, Shahreen Amin, Zhong Yao, Xavier Morató, David Otasek, Hiroyuki Kobayashi, Javier Menendez, Daniel Auerbach, Stephane Angers, Natasa Pržulj, Michel Bouvier, Mohan Babu, Francisco Ciruela, Ralf Jockers, Igor Jurisica, Igor Stagljar

Subjects: Get full text

Knockdown of Gfi1 increases BMSCs exosomal miR-150-3p to inhibit osteoblast ferroptosis in steroid-induced osteonecrosis of the femoral head through BTRC/Nrf2 axis by Liwen Zheng, Changjie Zhang, Lele Liao, Zhijie Hai, Xin Luo, Haoliang Xiao

Subjects: “…beta-transducin repeat containing e3 ubiquitin protein ligase (btrc)…”
Get full text

Forskolin Stimulates Estrogen Receptor (ER) α Transcriptional Activity and Protects ER from Degradation by Distinct Mechanisms by Houng-Wei Tsai, Vicky Y. Lin, Margaret A. Shupnik

“…ERα ubiquitination was diminished by a mutated ubiquitin (K48R) that prevents elongation of polyubiquitin chains for targeting the proteasome. …”
Get full text

AdipoR1 enhances the radiation resistance via ESR1/CCNB1IP1/cyclin B1 pathway in hepatocellular carcinoma cells by Yuhan Gan, Linhui Zhu, Yimo Li, Ruoting Ge, Jiahe Tian, Yuxin Chen, Xiang He, Shumei Ma, Xiaodong Liu

“…KEGG enrichment analysis indicated that the cell cycle and ubiquitination degradation pathways may be involved in the regulation of radiation resistance by AdipoR1.The knockdown of AdipoR1 can attenuate the radiation-induced G2/M phase arrest through cyclin B1.By the ubiquitination IP assay and a rescue experiment, we confirmed that CCNB1IP1 regulated the ubiquitination and degradation of cyclin B1. …”
Get full text

Usp11 maintained the survival of marginal zone B cells under ionizing radiation by deubiquitinating DLL1 and JAG2 by Jiaqi Sheng, Depei Wu, Jingzhe Shang, Xiaodan Fu, He Gao, Jianjie Rong, Jun Wang, Jiancheng Hu, Xiaofei Qi

“…Conducted Co-IP and ubiquitination experiments for mechanism elucidation. …”
Get full text

Protective Effect of Uric Acid on ox-LDL-Induced HUVECs Injury via Keap1-Nrf2-ARE Pathway by Yajuan Lin, Yunpeng Xie, Zhujing Hao, Hailian Bi, Yang Liu, Xiaolei Yang, Yunlong Xia

“…In addition, uric acid reduced Nrf2 ubiquitination and increased nuclear translocation of Nrf2 protein, thus activating the Keap1-Nrf2-ARE pathway and playing a protective role. …”
Get full text

The Human IL-22 Receptor Is Regulated through the Action of the Novel E3 Ligase Subunit FBXW12, Which Functions as an Epithelial Growth Suppressor by Joseph Franz, Jacob Jerome, Travis Lear, Qiaoke Gong, Nathaniel M. Weathington

“…We recently described processing of mouse lung epithelial IL-22 receptor (IL-22R) by ubiquitination on the intracellular C-terminal. To identify cellular factors that regulate human IL-22R, we screened receptor abundance while overexpressing constituents of the ubiquitin system and identify that IL-22R can be shuttled for degradation by multiple previously uncharacterized F-box protein E3 ligase subunits. …”
Get full text

FBXL16 Promotes Endometrial Progesterone Resistance via PP2AB55α/Cyclin D1 Axis in Ishikawa by Haoen Liu, Li Han, Liyan Zhong, Xiaodan Zhuang, Yan Peng

“…F-box proteins are essential components of the E3 ubiquitin ligases which are involved in the regulation of almost all life activities such as cell cycle, proliferation, and apoptosis, which have become an important research and drug target. …”
Get full text

HDAC1-3 inhibition triggers NEDD4-mediated CCR2 downregulation and attenuates immunosuppression in myeloid-derived suppressor cells by Zhiqi Xie, Jinjin Shao, Zeren Shen, Zhichao Ye, Yoshiaki Okada, Daisuke Okuzaki, Naoki Okada, Masashi Tachibana

“…ATAC-seq and RNA-seq analyses revealed 115 genes epigenetically upregulated by HDAC1-3 inhibitors, primarily linked to transcriptional regulation and ubiquitination. We further elucidated that HDAC1-3 inhibitors facilitate CCR2 protein degradation through ubiquitination-mediated by NEDD4 E3 ligase. …”
Get full text

F-box protein Fbx23 acts as a transcriptional coactivator to recognize and activate transcription factor Ace1. by Zhongjiao Liu, Kexuan Ma, Panpan Zhang, Siqi Zhang, Xin Song, Yuqi Qin

“…Protein ubiquitination is usually coupled with proteasomal degradation and is crucial in regulating protein quality. …”
Get full text

USP20 mediates malignant phenotypic changes in bladder cancer through direct interactions with YAP1 by Wensun Chen, Siqi Wu, Yifan Chen, Weijian Li, Yiqing Cao, Yingchun Liang, Xiyu Dai, Xinan Chen, Yilin Chen, Tian Chen, Shenghua Liu, Chen Yang, Haowen Jiang

“…Hippo pathway activity is controlled by the phosphorylation cascade in the MST1/2-LATS1/2-YAP1 axis, in addition to other modifications such as ubiquitination of the Hippo pathway proteins through the co-regulation of E3 ligases and deubiquitinases. …”
Get full text

Activation of lysophagy by a TBK1-SCFFBXO3-TMEM192-TAX1BP1 axis in response to lysosomal damage by Na Yeon Park, Doo Sin Jo, Jae-Yoon Yang, Ji-Eun Bae, Joon Bum Kim, Yong Hwan Kim, Seong Hyun Kim, Pansoo Kim, Dong-Seok Lee, Tamotsu Yoshimori, Eun-Kyeong Jo, Eunbyul Yeom, Dong-Hyung Cho

“…Abstract Lysophagy eliminates damaged lysosomes and is crucial to cellular homeostasis; however, its underlying mechanisms are not entirely understood. We screen a ubiquitination-related compound library and determine that the substrate recognition component of the SCF-type E3 ubiquitin ligase complex, SCFFBXO3(FBXO3), which is a critical lysophagy regulator. …”
Get full text

Nongenomic Mechanisms of PTEN Regulation by Jimmie E. Fata, Shawon Debnath, Edmund C. Jenkins, Marcia V. Fournier

“…Here we discuss PTEN ubiquitination, PTEN complex formation with components of the adherens junction, PTEN nuclear localization, and microRNA regulation of PTEN as essential regulatory mechanisms that determine PTEN function independent of gene mutations and epigenetic events.…”
Get full text