The impact of uric acid on musculoskeletal diseases: clinical associations and underlying mechanisms by Jing Zhang, Na Sun, Wanhao Zhang, Wenjie Yue, Xiaochen Qu, Xiaochen Qu, Zhonghai Li, Zhonghai Li, Gang Xu, Gang Xu

“…Serum urate (SU) levels are significantly elevated in conditions such as gout, type 2 diabetes (T2D), obesity, and other metabolic syndromes. …”
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Phytochemical study and evaluation of the antidiabetic and antihyperglycemic activities of the fruit extracts of Physalis peruviana L. (Solanaceae) by Damien S.T. Tshibangu, Fortune S. Kavugho, Carlos N. Kabengele, Adrien T. Masunda, Gédéon N. Bongo, Giresse N. Kasiama, Domaine T. Mwanangombo, Clément L. Inkoto, Clément M. Mbadiko, Benjamin Z. Gbolo, Désiré M. Musuyu, Dorothée D. Tshilanda, Jean Paul K.N. Ngbolua, Pius T. Mpiana

“…This inhibition was confirmed by molecular docking analyzes by interacting the molecules of the studied plant with two receptors, alpha-glucosidase (PDB id: 3WY1) and the kinase domain of the 5HHW insulin receptor.These experimental results lend credibility to the use of this species in traditional Congolese medicine to treat type 2 diabetes.…”
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The role of insulin signaling with FOXO and FOXK transcription factors by Masaji Sakaguchi

“…In both mice and humans, excessive dietary intake can lead to insulin resistance in various organs, ultimately displaying metabolic syndrome and type 2 diabetes. Insulin signals require thorough regulation to maintain metabolism across diverse environments. …”
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Characterization of Natural Killer Cells and Cytokines in Maternal Placenta and Fetus of Diabetic Mothers by Cristiane de Castro Pernet Hara, Eduardo Luzía França, Danny Laura Gomes Fagundes, Adriele Ataides de Queiroz, Marilza Vieira Cunha Rudge, Adenilda Cristina Honorio-França, Iracema de Mattos Paranhos Calderon

“…In the maternal blood from the hyperglycemic groups, the CD16+CD56− NK cells increased, whereas that of CD16+CD56+ decreased in gestational diabetes mellitus [GDM] group. Cord blood from type 2 diabetes [DM-2] showed a higher proportion of CD16+CD56− and CD16−CD56+. …”
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Exploring the Molecular Modalities in the Pathogenesis of Diabetic Kidney Disease with a Focus on the Potential Therapeutic Implications by Lyubomir Gaydarski, Kristina Petrova, Ivan Angushev, Stancho Stanchev, Alexandar Iliev, Nikola Stamenov, Vidin Kirkov, Boycho Landzhov

“…Diabetic kidney disease (DKD) is a leading cause of chronic kidney disease (CKD) and end-stage renal disease worldwide, affecting approximately 40% of individuals with type 2 diabetes (T2DM) and 30% of those with type 1 diabetes (T1DM). …”
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Barriers and facilitating factors in the prevention of diabetes type 2 and gestational diabetes in vulnerable groups: A scoping review. by Jessica Breuing, Dawid Pieper, Annika Lena Neuhaus, Simone Heß, Lena Lütkemeier, Fabiola Haas, Mark Spiller, Christine Graf

“…<h4>Aims</h4>Type 2 diabetes mellitus (T2DM) and gestational diabetes (GDM) are globally on the rise, accompanied by comorbidities and associated health costs. …”
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Follistatin-Like 1: A Potential Mediator of Inflammation in Obesity by Nengguang Fan, Haiyan Sun, Yufan Wang, Yifei Wang, Lijuan Zhang, Zhenhua Xia, Liang Peng, Yanqiang Hou, Weiqin Shen, Rui Liu, Jiajing Yin, Yongde Peng

“…Obesity is associated with a state of chronic low-grade inflammation, which contributes to insulin resistance and type 2 diabetes. However, the molecular mechanisms that link obesity to inflammation are not fully understood. …”
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Investigation of Pharmacokinetic Parameters of Trelagliptin in Egyptian Volunteers Using Sensitive LC-MS/MS: A Comparative Study with a Japanese Population by Shereen Mowaka, Nermeen Ashoush, Mariam M. Tadros, Bassam M. Ayoub

“…Trelagliptin (TLN) is a novel once-weekly antidiabetic drug that enhanced the patient compliance in type 2 diabetes. TLN analysis and bioanalysis literature review showed many methods for TLN assay either in dosage form or as biological fluids (pharmacokinetic parameters), but all those methods did not consider the full details dealing with biological assay of TLN. …”
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Diabetes and Insulin Therapy, but Not Metformin, Are Related to Hepatocellular Cancer Risk by Luca Miele, Cristina Bosetti, Federica Turati, Gianlodovico Rapaccini, Antonio Gasbarrini, Carlo La Vecchia, Stefania Boccia, Antonio Grieco

“…Metabolic conditions, including type 2 diabetes, have been related to hepatocellular carcinoma (HCC) risk. …”
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Risk Factors for Mortality in Melioidosis: A Single-Centre, 10-Year Retrospective Cohort Study by Raviraj Menon, Poornima Baby, Anil Kumar V., Sandeep Surendran, Manu Pradeep, Aiswarya Rajendran, Gaayathri Suju, Arathy Ashok

“…Seventy-three melioidosis patients’ records were analysed, and the most common comorbidity was type 2 diabetes mellitus (n = 53, 72.6%). The patients showed diverse presentations: pulmonary involvement, 30 (41.1%); splenomegaly, 29 (39.7%); abscesses and cutaneous involvement, 18 (24.7%); lymph node, 10 (13.7%); arthritis and osteomyelitis, 9 (12.3%); and genitourinary infection, 4 (5.4%). …”
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A New Preprocessing Method for Diabetes and Biomedical Data Classification by Sarbast CHALO, İbrahim Berkan AYDİLEK

“… People of all ages and socioeconomic levels, all over the world, are being diagnosed with type 2 diabetes at rates that are higher than they have ever been. …”
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Obesity Related Alterations in Plasma Cytokines and Metabolic Hormones in Chimpanzees by Pramod Nehete, Elizabeth R. Magden, Bharti Nehete, Patrick W. Hanley, Christian R. Abee

“…Obesity is characterized by chronic low-grade inflammation and serves as a major risk factor for hypertension, coronary artery disease, dyslipidemias, and type-2 diabetes. The purpose of this study was to examine changes in metabolic hormones, inflammatory cytokines, and immune function, in lean, overweight, and obese chimpanzees in a controlled environment. …”
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Hypertriglyceridemic Waist Phenotype in Adolescents Aged 15 to 18 Years by Caridad Hernández Gutiérrez, Elodia Rivas Alpízar, Teresita Rodríguez Izaguirre, Alain Francisco Morejón Giraldoni

“…<strong>Background:</strong> presence of the hypertriglyceridemic waist phenotype is a predictor of cardiometabolic deterioration, increased type 2 diabetes mellitus and coronary heart disease.<br /> <strong>Objective:</strong> to determine the hypertriglyceridemic waist phenotype in adolescents aged 15 to 18 years from the Area III of Cienfuegos. …”
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Bariatric Surgery in Moderately Obese Patients: A Prospective Study by M. Cerci, M. I. Bellini, F. Russo, D. Benavoli, M. Capperucci, A. L. Gaspari, P. Gentileschi

“…Between September 2011 and September 2012, 25 patients with grade I obesity and comorbidities underwent bariatric surgery: preoperative mean BMI 33.2 kg/m2, 10 males, mean age 42 years. In presence of type 2 diabetes mellitus (T2DM) (56%), gastric bypass was performed; in cases with hypertension (64%) and obstructive sleep apnea (OSA) (12%), sleeve gastrectomy was performed. …”
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Physical activity at home during the COVID-19 lockdown in India: Need of the hour for optimum physical health and psychological resilience by Suraj CHAWLA, Manisha KOCHER

“…It can reduce high blood pressure, help manage overweight, improve immune regulation, reduce the risk of getting heart disease, type 2 diabetes, stroke, and various cancers- all conditions which increase vulnerability to COVID-19. …”
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Diagnostic Challenge in a Patient with Severe Anion Gap Metabolic Acidosis by Eugene M. Tan, Ejaaz Kalimullah, M. Rizwan Sohail, Kannan Ramar

“…We present a 76-year-old female with type 2 diabetes mellitus, who was found at home in a confused state. …”
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Evaluation of the Obesity Prevention, Blood Glucose, and Blood Lipid Control of Vietnamese Rice Varieties in High-Fat Diet-Induced Obese Mice by Thuy Linh Nguyen, Khanh Son Trinh

“…The results obtained from this study help patients with overweight, obesity, and type 2 diabetes choose the right rice variety for their daily diet to be able to control their diseases.…”
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The Relationship between Cardiovascular Autonomic Dysfunction and Ocular Abnormality in Chinese T2DM by Dandan Wang, Baiyu Shen, Chunrong Wu, Yanyan Xue, Yanjun Liu

“…This study aims to explore the relationship between autonomic nerve dysfunction—assessed by cardiovascular autonomic neuropathy risk score (CAN-RS)—and ocular abnormality in Chinese type 2 diabetes mellitus (T2DM). Method. This is a cross-sectional study. …”
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Preventive interventions for diabetic foot ulcer adopted in different healthcare settings: A scoping review protocol. by Açucena Leal de Araújo, Francisca Diana da Silva Negreiros, Raquel Sampaio Florêncio, Thiago Dos Santos Garces, Virna Ribeiro Feitosa Cestari, Samuel Miranda Mattos, Samara Jesus Sena Marques, Francisca Eridan Fonteles Albuquerque, Wánderson Cássio Oliveira Araújo, Vanessa de Brito Poveda, Thereza Maria Magalhães Moreira

“…Studies with participants diagnosed with type 1 and type 2 diabetes, aged 18 years or older, without an active ulcer at baseline, and studies of preventive interventions for foot ulcers in various healthcare settings will be screened. …”
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Rational design, synthesis, in vitro, and in-silico studies of pyrazole‑phthalazine hybrids as new α‑glucosidase inhibitors by Mehrdad Roshan, Roghieh Mirzazadeh, Azadeh Tajmir-Riahi, Mohammad Sadegh Asgari

“…The primary aim of this study was to explore the potential of novel pyrazole-phthalazine hybrids as selective inhibitors of α-glucosidase, an enzyme involved in carbohydrate metabolism, which plays a key role in the management of type 2 diabetes. The rationale for this study stems from the need for new, more effective inhibitors of α-glucosidase with improved efficacy and safety profiles compared to currently available therapies like Acarbose. …”
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