Hubungan Keputusasaan dengan Depresi Pada Pasien Diabetes Melitus Di Padang by Rika Sarfika

“…This study aimed to investigate the relationship between hopelessness and depression among patients diabetes mellitus.This research is analytical research with a cross-sectional study approach. 122 people with type 2 diabetes mellitus at Pauh and Andalas Public health center were designated as samples in this study with inclusion criteria not having a history of mood disorders or mental disorders (based on medical diagnosis), aged 25 - 65 years and willing to sign an informed consent form. …”
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Urinary Microvesicle-Bound Uromodulin: A Potential Molecular Biomarker in Diabetic Kidney Disease by Neng-jun Lou, Yi-hong Ni, Hong-ying Jia, Jing-ti Deng, Lu Jiang, Feng-jie Zheng, Ai-li Sun

“…This study was designed to investigate the changes of urinary microvesicle-bound uromodulin and total urinary uromodulin levels in human urine and the correlations with the severity of diabetic kidney disease (DKD). 31 healthy subjects without diabetes and 100 patients with type 2 diabetes mellitus (T2DM) were included in this study. …”
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Inhibition of Ceramide De Novo Synthesis Ameliorates Diet Induced Skeletal Muscles Insulin Resistance by Krzysztof Kurek, Agnieszka Mikłosz, Bartłomiej Łukaszuk, Adrian Chabowski, Jan Górski, Małgorzata Żendzian-Piotrowska

“…In the present research we evaluated the effects of myriocin application on type 2 diabetes mellitus in three different types of skeletal muscles: (1) slow-oxidative (red gastrocnemius), (2) oxidative-glycolytic (soleus), and (3) glycolytic (white gastrocnemius). …”
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Association of Autoimmune Thyroid Disease with Anti-GAD Antibody ELISA Test Positivity and Risk for Insulin Deficiency in Slowly Progressive Type 1 Diabetes by Masahito Katahira, Hidetada Ogata, Takahiro Ito, Tsutomu Miwata, Megumi Goto, Shizuka Nakamura, Hiromi Takashima

“…Sixty patients with SPT1D and 154 patients with type 2 diabetes were examined by both GADA-RIA and GADA-ELISA and for the presence of autoimmune thyroid disease (AITD). …”
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Total and High Molecular Weight Adiponectin Levels and Prediction of Cardiovascular Risk in Diabetic Patients by Dagmar Horáková, Kateřina Azeem, Radka Benešová, Dalibor Pastucha, Vladimír Horák, Lenka Dumbrovská, Arnošt Martínek, Dalibor Novotný, Zdeněk Švagera, Milada Hobzová, Dana Galuszková, Vladimír Janout, Sandra Doněvská, Jana Vrbková, Helena Kollárová

“…The study aimed at assessing the potential use of lower total and HMW adiponectin levels for predicting cardiovascular risk in patients with type 2 diabetes mellitus (T2DM). Concentrations of total adiponectin or high molecular weight (HMW) adiponectin decrease in association with the development of metabolic dysfunction such as obesity, insulin resistance, or T2DM. …”
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A multidimensional study for design of phytochemical profiling, antioxidant potential, and enzyme inhibition effects of ışgın (Rheum telianum) as an edible plant by Ahmet Zafer Tel, Kubra Aslan, Mustafa Abdullah Yılmaz, İlhami Gulcin

“…The inhibition effects of both leaves and the seeds of the R. telianum extracts on acetylcholinesterase and butyrylcholinesterase, α-glycosidase and human carbonic anhydrases II isoenzyme enzymes, which associated with some global diseases including Alzheimer's disease, type-2 diabetes mellitus and glaucoma were determined. …”
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Quantification of Microvascular Density of the Optic Nerve Head in Diabetic Retinopathy Using Optical Coherence Tomographic Angiography by Jianfeng Huang, Bodi Zheng, Yingyi Lu, Xiaoya Gu, Hong Dai, Tong Chen

“…In this cross-sectional study, 211 eyes of 121 participants with type 2 diabetes with different stages of DR or without DR and 73 eyes of 38 healthy age-matched controls were imaged by OCTA. …”
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Extract of Sesbania grandiflora Ameliorates Hyperglycemia in High Fat Diet-Streptozotocin Induced Experimental Diabetes Mellitus by Ghanshyam Panigrahi, Chhayakanta Panda, Arjun Patra

“…The study evaluates the antidiabetic activity of methanolic extract of Sesbania grandiflora (MESG) in type 2 diabetic rats induced by low dose streptozotocine and high fat diet. …”
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Characterization of Metabolically Healthy Obese People and Metabolically Unhealthy Normal-Weight People in a General Population Cohort of the ABCD Study by Silvio Buscemi, Pierfilippo Chiarello, Carola Buscemi, Davide Corleo, Maria Fatima Massenti, Anna Maria Barile, Giuseppe Rosafio, Vincenza Maniaci, Valentina Settipani, Loretta Cosentino, Carla Giordano

“…Participants were classified as normal weight (BMI < 24.9 kg/m2) or overweight-obese (BMI ≥25 kg/m2); they were also classified as MH in the presence of 0-1 among the following conditions: (a) prediabetes/type 2 diabetes, (b) hypertension, (c) hypertriglyceridemia or low HDL cholesterolemia, and (d) hypercholesterolemia. …”
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Aberrant Phenotype in Human Endothelial Cells of Diabetic Origin: Implications for Saphenous Vein Graft Failure? by Anna C. Roberts, Jai Gohil, Laura Hudson, Kyle Connolly, Philip Warburton, Rakesh Suman, Peter O’Toole, David J. O’Regan, Neil A. Turner, Kirsten Riches, Karen E. Porter

“…Type 2 diabetes (T2DM) confers increased risk of endothelial dysfunction, coronary heart disease, and vulnerability to vein graft failure after bypass grafting, despite glycaemic control. …”
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Inhibition of MEK1 Signaling Pathway in the Liver Ameliorates Insulin Resistance by Atsunori Ueyama, Nobuhiro Ban, Masanori Fukazawa, Tohru Hirayama, Minako Takeda, Tatsuo Yata, Hiroyasu Muramatsu, Masaki Hoshino, Marii Yamamoto, Masao Matsuo, Yuka Kawashima, Tatsuhiko Iwase, Takehisa Kitazawa, Youichi Kushima, Yuichiro Yamada, Yoshiki Kawabe

“…Although mitogen-activated protein kinase kinase (MEK) is a key signaling molecule and a negative regulator of insulin action, it is still uncertain whether MEK can be a therapeutic target for amelioration of insulin resistance (IR) in type 2 diabetes (T2D) in vivo. To clarify whether MEK inhibition improves T2D, we examined the effect of continuous MEK inhibition with two structurally different MEK inhibitors, RO5126766 and RO4987655, in mouse models of T2D. …”
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Wolfram Syndrome: A Case Report and Review of Clinical Manifestations, Genetics Pathophysiology, and Potential Therapies by N. B. Toppings, J. M. McMillan, P. Y. B. Au, O. Suchowersky, L. E. Donovan

“…We describe a woman without risk factors for gestational or type 2 diabetes who presented with gestational diabetes (GDM) at the age of 39 years during her first and only pregnancy. …”
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Antidiabetic Potential of Marine Brown Algae—a Mini Review by Thilina L. Gunathilaka, Kalpa Samarakoon, Pathmasiri Ranasinghe, L. Dinithi C. Peiris

“…Therefore, in lieu with herbal drug development, it is important to find the potential benefits of seaweeds for the management of type 2 diabetes as they are underexplored yet in Sri Lanka. …”
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Potential roles of cigarette smoking on gut microbiota profile among Chinese men by Jiayao Fan, Fangfang Zeng, Haili Zhong, Jun Cai, Wentao Shen, Chunxiao Cheng, Chunfeng He, Yuanjiao Liu, Yuan Zhou, Shujie Chen, Yimin Zhu, Tao Liu, Ju-Sheng Zheng, Lan Wang, Yu-Ming Chen, Wenjun Ma, Dan Zhou

“…Furthermore, we revealed putative mediation roles of the gut microbiome in the associations between smoking and common diseases including cholecystitis and type 2 diabetes. Conclusions We characterized the gut microbiota profile in male smokers and further revealed their potential involvement in mediating the impact of smoking on health outcomes. …”
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VEGF in the Crosstalk between Human Adipocytes and Smooth Muscle Cells: Depot-Specific Release from Visceral and Perivascular Adipose Tissue by Raphaela Schlich, Miriam Willems, Sabrina Greulich, Florian Ruppe, Wolfram Trudo Knoefel, D. Margriet Ouwens, Bujar Maxhera, Artur Lichtenberg, Jürgen Eckel, Henrike Sell

“…Perivascular adipose tissue (PAT) from type 2 diabetic patients releases significantly higher amounts of VEGF and induces stronger proliferation of VSMC as compared to SAT and SAT/PAT of nondiabetics. …”
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Network pharmacology-based screening of the active ingredients and mechanisms of Cymbaria daurica against diabetes mellitus by Ruyu Shi, Dongxue Chen, Mingyue Ji, Baochang Zhou, Ziyan Zhang, Chunhong Zhang, Minhui Li

“…In this study, the potential mechanism of C. daurica against type 2 diabetes mellitus (T2DM) was postulated via pharmacological network analysis. …”
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Glomerulopathy in the KK.Cg-Ay/J Mouse Reflects the Pathology of Diabetic Nephropathy by Stephen P. O'Brien, Mandy Smith, Hong Ling, Lucy Phillips, William Weber, John Lydon, Colleen Maloney, Steven Ledbetter, Cynthia Arbeeny, Stefan Wawersik

“…The KK.Cg-/J (KK-) mouse strain is a previously described model of type 2 diabetes with renal impairment. In the present study, female KK- mice received an elevated fat content diet (24% of calories), and a cohort was uninephrectomized (Unx) to drive renal disease severity. …”
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The Association of TNF-Alpha Inhibitors and Development of IgA Nephropathy in Patients with Rheumatoid Arthritis and Diabetes by Vedran Premužić, Ivan Padjen, Mislav Cerovec, Marijana Ćorić, Bojan Jelaković, Branimir Anić

“…Two of our patients had previously been diagnosed with type 2 diabetes mellitus while the third patient developed diabetes years after the onset of IgAN. …”
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Implication of Cytotoxic Helicobacter pylori Infection in Autoimmune Diabetes by Alessandro P. Delitala, Giovanni M. Pes, Hoda M. Malaty, Gavino Pisanu, Giuseppe Delitala, Maria P. Dore

“…Type 1 diabetes (T1D) and type 2 diabetes (T2D) have been linked to Helicobacter pylori infection, although results are conflicting. …”
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α-Amylase and α-Glucosidase Inhibitory Activities of Chemical Constituents from Wedelia chinensis (Osbeck.) Merr. Leaves by Nguyen Phuong Thao, Pham Thanh Binh, Nguyen Thi Luyen, Ta Manh Hung, Nguyen Hai Dang, Nguyen Tien Dat

“…As part of an ongoing search for new natural products from medicinal plants to treat type 2 diabetes, two new compounds, a megastigmane sesquiterpenoid sulfonic acid (1) and a new cyclohexylethanoid derivative (2), and seven related known compounds (3–9) were isolated from the leaves of Wedelia chinensis (Osbeck.) …”
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