Do PPAR-Gamma Agonists Have a Future in Parkinson's Disease Therapy? by Anna R. Carta, Augusta Pisanu, Ezio Carboni

“…Thiazolidinediones (TZDs) are peroxisome proliferator-activated receptor (PPAR)-γ agonists commonly used as insulin-sensitizing drugs for the treatment of type 2 diabetes. In the last decade, PPAR-γ agonists have received increasing attention for their neuroprotective properties displayed in a variety of neurodegenerative diseases, including Parkinson's disease (PD), likely related to the anti-infammatory activity of these compounds. …”
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Visfatin/Nampt: An Adipokine with Cardiovascular Impact by Tania Romacho, Carlos F. Sánchez-Ferrer, Concepción Peiró

“…Enhanced circulating visfatin/Nampt levels have been reported in metabolic diseases, such as obesity and type 2 diabetes. Moreover, visfatin/Nampt circulating levels correlate with markers of systemic inflammation. …”
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Insulin Therapy in Diabetic Hyperglycemic Emergencies by Diana Machado Ramírez, Manuel Licea Puig

“…<br /><strong>Results:</strong> diabetic ketoacidosis occurred in 57.5 % of the type 1 diabetic patients and in the 42.5 % of the type 2 diabetics. None of the type 1 diabetics developed hyperglycemic hyperosmolar nonketotic state and this complication was observed in 23.0 % of the patients with diabetes type 2. …”
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Evaluating the Effect of Ramadan Fasting on Muslim Patients with Diabetes in relation to Use of Medication and Lifestyle Patterns: A Prospective Study by Melanie Yee Lee Siaw, Daniel Ek Kwang Chew, Rinkoo Dalan, Shaikh Abdul Kader Kamaldeen Abdul Shakoor, Noorani Othman, Chor Hui Choo, Nur Hidayah Shamsuri, Siti Nurhana Abdul Karim, Sui Yung Chan, Joyce Yu-Chia Lee

“…This study aimed to examine the effect of Ramadan fasting on HbA1c in Muslim patients with type 2 diabetes. The incidence of hypoglycemia and glycemic changes in relation to the adjustment of doses of antidiabetic agents, diet, and physical activity during Ramadan was also evaluated. …”
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Genome-Wide DNA Methylation in Mixed Ancestry Individuals with Diabetes and Prediabetes from South Africa by Tandi E. Matsha, Carmen Pheiffer, Stephen E. Humphries, Junaid Gamieldien, Rajiv T. Erasmus, Andre P. Kengne

“…To conduct a genome-wide DNA methylation in individuals with type 2 diabetes, individuals with prediabetes, and control mixed ancestry individuals from South Africa. …”
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Metformin Inhibits Mouse Islet Insulin Secretion and Alters Intracellular Calcium in a Concentration-Dependent and Duration-Dependent Manner near the Circulating Range by Lindor Gelin, Jiewen Li, Kathryn L. Corbin, Ishrat Jahan, Craig S. Nunemaker

“…Metformin is considered the first-line treatment for type 2 diabetes. While metformin primarily increases insulin sensitivity, evidence also suggests that metformin affects the activity of insulin-secreting pancreatic islets. …”
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Mechanistic insights toward progress in alogliptin beyond glycemic control: translational perspective by Faraha Ahmed, Syed Sufian Ahmad, M. Mumtaz Alam, M. Shaqiquzzaman, Abul Kalam Najmi, Mohammad Ahmed Khan

“…Main body Alogliptin is approved for treatment of type 2 diabetes mellitus (T2DM) in majority of the countries. …”
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Engaging with patients with diabetes: the role of social media in low-income healthcare organisations by Jose Rodriguez, Shabbir Syed-Abdul, Andrea Cano, Mohy Uddin, Fernanda Caceres

“…Background Type 2 diabetes is the fastest-growing global health concern, and its global prevalence is projected to affect 643 million individuals by 2030. …”
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Diabetes mellitus educational intervention in patients at risk from a medical office. Nuevitas, 2020-2023 by Maigret Calderón Cruz, Julio Michel Arias Manganelly, Olenis Alicia Aldana Ramos, Lieter Ailed Vidal Rodríguez, Pedro Figueredo Guerra, Aned Hernández Clavijo

“…<br /><strong>Objective</strong>: to describe an educational intervention on type 2 diabetes mellitus results in patients with risk factors.…”
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Infant of a diabetic mother: clinical presentation, diagnosis and treatment by Magdalena Suda-Całus, Katarzyna Dąbrowska, Ewa Gulczyńska

“…Rising incidence of type 1 and type 2 diabetes in young women and increasing maternal age at conception account for the higher risk of birth complications and adverse maternal and infant outcomes. …”
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In Vivo and Ex Vivo Evaluation of 1,3-Thiazolidine-2,4-Dione Derivatives as Euglycemic Agents by Diana Alemán-González-Duhart, Samuel Álvarez-Almazán, Miguel Valdes, Feliciano Tamay-Cach, Jessica Elena Mendieta-Wejebe

“…Thiazolidinediones (TZDs), used to treat type 2 diabetes mellitus, act as full agonists of the peroxisome proliferator-activated receptor gamma. …”
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Diabetic Retinopathy Screening Ratio Is Improved When Using a Digital, Nonmydriatic Fundus Camera Onsite in a Diabetes Outpatient Clinic by Pia Roser, Hannes Kalscheuer, Jan B. Groener, Daniel Lehnhoff, Roman Klein, Gerd U. Auffarth, Peter P. Nawroth, Florian Schuett, Gottfried Rudofsky

“…This cross-sectional study included 502 patients, 112 with type 1 and 390 with type 2 diabetes. Patients attended screenings for microvascular complications, including diabetic nephropathy (DN), diabetic polyneuropathy (DP), and DR. …”
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Charge-Based Inhibitors of Amylin Fibrillization and Toxicity by Sharadrao M. Patil, Andrei T. Alexandrescu

“…To test the hypothesis that electrostatic repulsion is an important force opposing amyloid fibril assembly, we designed peptides that substitute strings of positively or negatively charged residues into the sequence of the amyloidogenic hormone amylin, which contributes to type 2 diabetes pathology. Arg-1 and Arg-2 substitute four positively charged arginines for segments that in structural models of amylin fibrils form the end of strand β1 and the beginning of strand β2, respectively. …”
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Review of Finger millet (Eleusine coracana (L.) Gaertn): A power house of health benefiting nutrients by Dinesh Chandra, Satish Chandra, Pallavi, A.K. Sharma

“…It has distinguished health beneficial properties, such as anti-diabetic (type 2 diabetes mellitus), anti-diarrheal, antiulcer, anti-inflammatory, antitumerogenic (K562 chronic myeloid leukemia), atherosclerogenic effects, antimicrobial and antioxidant properties.…”
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Acylcarnitine Profiles in Plasma and Tissues of Hyperglycemic NZO Mice Correlate with Metabolite Changes of Human Diabetes by Anna Weiser, Pieter Giesbertz, Hannelore Daniel, Britta Spanier

“…The New Zealand obese (NZO) mouse is a polygenic model for obesity and diabetes with obese females and obese, diabetes-prone males, used to study traits of the metabolic syndrome like type 2 diabetes mellitus (T2DM), obesity, and dyslipidaemia. …”
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Diabetes Risk Score in a Young Student Population in Jordan: A Cross-Sectional Study by Abdel-Ellah Al-Shudifat, Amjad Al-Shdaifat, Ahmad Ali Al-Abdouh, Mohammad Ibrahim Aburoman, Sara Mohammad Otoum, Amro Ghaleb Sweedan, Ibrahim Khrais, Ibrahim Hisham Abdel-Hafez, Asgeir Johannessen

“…The Middle East is the home to the most obese population in the world, and type 2 diabetes mellitus is endemic in the region. However, little is known about risk factors for diabetes in the younger age groups. …”
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Performance Comparison of Two Gene Set Analysis Methods for Genome-wide Association Study Results: GSA-SNP vs i-GSEA4GWAS by Ji-sun Kwon, Jihye Kim, Dougu Nam, Sangsoo Kim

“…GSA runs were made with two sets of p-values from a Korean type 2 diabetes mellitus GWAS study: 259,188 and 1,152,947 SNPs of the original and imputed genotype datasets, respectively. …”
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What patients with diabetes mellitus type 2 know on their disease by Belkis Mercedes Vicente Sánchez, Gisela Zerquera Trujillo, Elodia M. Rivas Alpizar, José A. Muñoz Cocina, Yaremy Teresita Gutiérrez Cantero, Eduardo Castañedo Álvarez

“…<strong><br />Objective:</strong> to determine how much patients with type 2 diabetes know about the disease. <br /><strong>Methods:</strong> descriptive study of a case series conducted between January and June 2008. …”
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Comparison of Insulin Lispro Protamine Suspension with NPH Insulin in Pregnant Women with Type 2 and Gestational Diabetes Mellitus: Maternal and Perinatal Outcomes by Antonietta Colatrella, Natalia Visalli, Santina Abbruzzese, Sergio Leotta, Marzia Bongiovanni, Angela Napoli

“…Eighty-nine pregnant women (25 with type 2 diabetes and 64 with gestational diabetes mellitus; 53 under insulin lispro protamine suspension and 36 under human NPH insulin) were recruited. …”
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Functional Stability of Plasminogen Activator Inhibitor-1 by Songul Yasar Yildiz, Pinar Kuru, Ebru Toksoy Oner, Mehmet Agirbasli

“…The biological effects of PAI-1 extend far beyond thrombosis including its critical role in fibrotic disorders, atherosclerosis, renal and pulmonary fibrosis, type-2 diabetes, and cancer. The conversion of PAI-1 from the active to the latent conformation appears to be unique among serpins in that it occurs spontaneously at a relatively rapid rate. …”
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