PPAR-γ Agonists and Their Effects on IGF-I Receptor Signaling: Implications for Cancer by A. Belfiore, M. Genua, R. Malaguarnera

“…Synthetic PPAR-γ agonists, such as thiazolidinediones (TZDs), are drugs universally used as antidiabetic agents in patients with type 2 diabetes. In addition of acting as insulin sensitizers, PPAR-γ agonists mediate in vitro and in vivo pleiotropic anticancer effects. …”
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A mechanism-informed deep neural network enables prioritization of regulators that drive cell state transitions by Xi Xi, Jiaqi Li, Jinmeng Jia, Qiuchen Meng, Chen Li, Xiaowo Wang, Lei Wei, Xuegong Zhang

“…Applied to single-cell multi-omics data on type 2 diabetes and hair follicle development, regX reliably prioritizes key transcription factors and candidate cis-regulatory elements that drive cell state transitions. …”
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Stress in Obesity and Associated Metabolic and Cardiovascular Disorders by Paul Holvoet

“…Obesity has significant implications for healthcare, since it is a major risk factor for both type 2 diabetes and the metabolic syndrome. This syndrome is a common and complex disorder combining obesity, dyslipidemia, hypertension, and insulin resistance. …”
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Maternally Inherited Diabetes Mellitus Associated with a Novel m.15897G>A Mutation in Mitochondrial tRNAThr Gene by Ke Li, Lijun Wu, Jianjiang Liu, Wei Lin, Qiang Qi, Tianlan Zhao

“…We report here the clinical, genetic, and molecular characteristics of type 2 diabetes in a Chinese family. There are differences in the severity and age of onset in diabetes among these families. …”
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Brown fat thermogenesis and branched-chain amino acids in metabolic disease by Zachary Brown, Takeshi Yoneshiro

“…Since the 1960s, researchers have recognized an association between elevated plasma branched chain amino acids (BCAA) and metabolic disease, including type 2 diabetes mellitus and obesity, but the cause for it remained poorly understood. …”
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GLP-1 Receptor Agonists’ Impact on Fertility - A Review by Joanna Wojda, Katarzyna Lesiczka-Fedoryj, Anna Walczak, Zuzanna Kościuszko, Adam Sobiński, Matylda Czerwonka, Katarzyna Kurza, Julianna Podolec, Silvia Ciraolo, Agnieszka Kulczycka-Rowicka

“…Conclusions: We observe, GLP-1 analogs are often used in regulation of type 2 diabetes. They have proven their ability to impact a variety of hormonal as well as metabolic pathways. …”
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Diabetic Muscle Infarction: A Rare Complication of Long-Standing and Poorly Controlled Diabetes Mellitus by Shridhar N. Iyer, Almond J. Drake, R. Lee West, Robert J. Tanenberg

“…We describe a case of a 45-year-old male with an approximately 8-year history of poorly controlled type 2 diabetes mellitus with multiple microvascular complications who presented with the sudden onset of left thigh pain and swelling. …”
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Recommendations for dispensing magnesium products in pharmacy practice and primary health care by Piotr Merks, Urszula Religioni, Marta Jakubowska, Sainul Abideen Parakkal, Suhaj Abdulsalim, Agnieszka Neumann-Podczaska, Beata Chełstowska, Mazhuvanchery Kesavan Unnikrishnan, Alicja Szatko, Piotr Glinicki, Shabeer Ali Thorakkattil, Zbigniew Doniec, Regis Vaillancourt, Dagmara Hering

“…In this context, guidelines were developed to help identify magnesium deficiency in patients with type 2 diabetes, insulin resistance, migraines, fibromyalgia, depression, anxiety states or hypertension. …”
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Hubungan Berbagai Faktor Risiko Terhadap Kejadian Penyakit Jantung Koroner Pada Penderita Diabetes Melitus Tipe 2 by Fadma Yuliani, Fadil Oenzil, Detty Iryani

“…<br />Kata kunci: DM tipe 2, PJK, faktor risiko</p><p>Abstract<br />The main causes of mortality and morbidity in type 2 diabetes mellitus (DM) patients is coronary heart disease (CHD) which adults who suffer from DM are two to four times have the risk of heart disease than people without DM. …”
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Validation of the Chronic Liver Disease Questionnaire for MASH (CLDQ-MASH) by Zobair M. Younossi, Maria Stepanova, Issah Younossi, Andrei Racila

“…Known-groups validity assessment confirmed that CLDQ-MASH can discriminate patients based on liver disease severity (histology- and NIT-based) and the presence of non-hepatic comorbidities (obesity, type 2 diabetes, depression, clinically overt fatigue, insomnia). …”
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The Effect of Sleep Disruption on Cardiometabolic Health by SeokHyun Hong, Da-Been Lee, Dae-Wui Yoon, Seung-Lim Yoo, Jinkwan Kim

“…Epidemiological studies have consistently demonstrated that insufficient sleep duration (<7 h) and poor sleep quality are associated with increased risks of obesity, type 2 diabetes, and cardiovascular disease. The underlying mechanisms are multifaceted, involving the disruption of circadian clock genes, alterations in glucose and lipid metabolism, the activation of inflammatory pathways, and the modulation of the gut microbiome. …”
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Addressing Stem Cell Therapeutic Approaches in Pathobiology of Diabetes and Its Complications by Bou-Yue Peng, Navneet Kumar Dubey, Viraj Krishna Mishra, Feng-Chou Tsai, Rajni Dubey, Win-Ping Deng, Hong-Jian Wei

“…Type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) are most prevalent forms. …”
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Alpinia oxyphylla Miq. Extract Prevents Diabetes in Mice by Modulating Gut Microbiota by Yiqiang Xie, Man Xiao, Yali Ni, Shangfei Jiang, Guizhu Feng, Shenggang Sang, Guankui Du

“…Recently, the role of gut microbiota in the development of obesity and type 2 diabetes mellitus (T2DM) has been highlighted. …”
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The Role of the Liver in the Pathophysiology of PCOS: A Literature Review by Abrar Alhermi, Heather Perks, Varsha Nigi, Noor Altahoo, Stephen L. Atkin, Alexandra E. Butler

“…Women with PCOS commonly have insulin resistance, increased susceptibility to type 2 diabetes mellitus, dyslipidemia, hyperinsulinemia, increased cardiovascular risk, hepatic steatosis, infertility, and an overall reduction in physical and psychological well-being. …”
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Neuroimmune axis: Linking environmental factors to pancreatic β-cell dysfunction in Diabetes by Luz Andreone

“…Pancreatic β-cells are specialized in secreting insulin in response to circulating nutrients, mainly glucose.Diabetes is one of the most prevalent endocrine-metabolic diseases characterized by an imbalance in glucose homeostasis, which result mainly from lack of insulin production (type 1 diabetes) or insufficient insulin and peripheral insulin resistance (type 2 diabetes), both influenced by genetic and environmental components. …”
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Establishing Differences in Thermographic Patterns between the Various Complications in Diabetic Foot Disease by Alfred Gatt, Owen Falzon, Kevin Cassar, Christian Ellul, Kenneth P. Camilleri, Jean Gauci, Stephen Mizzi, Anabelle Mizzi, Cassandra Sturgeon, Liberato Camilleri, Nachiappan Chockalingam, Cynthia Formosa

“…To evaluate the potential of thermography as an assessment tool for the detection of foot complications by understanding the variations in temperature that occur in type 2 diabetes mellitus (DM). Methods. Participants were categorized according to a medical examination, ankle brachial index, doppler waveform analysis, and 10-gram monofilament testing into five groups: healthy adult, DM with no complications, DM with peripheral neuropathy, DM with neuroischaemia, and DM with peripheral arterial disease (PAD) groups. …”
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Reenvisioning Traditional to Regenerative Therapeutic Advances in Managing Nonalcoholic Fatty Liver Disease in Diabetes Mellitus by Lung-Wen Tsai, Yi-Hsiang Lu, Rajni Dubey, Jeng-Fong Chiou

“…Clinically, it has also been revealed that the existence of nonalcoholic fatty liver disease (NAFLD) enhances the incidence of type 2 diabetes mellitus (T2DM), while T2DM exacerbates NAFLD to extremely severe forms of steatohepatitis, cirrhosis, and hepatocellular carcinoma. …”
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Risk Factors for Microvascular Complications of Diabetes in a High-Risk Middle East Population by Sohaila Cheema, Patrick Maisonneuve, Mahmoud Zirie, Amin Jayyousi, Hekmat Alrouh, Amit Abraham, Sura Al-Samraye, Ziyad Mahfoud, Ibrahim Mohammed Al-Janahi, Buthaina Ibrahim, Albert B. Lowenfels, Ravinder Mamtani

“…We collected information via a structured questionnaire and directly from the patient’s record on 1034 adult type 2 diabetic patients who were attending outpatient clinics in Qatar. …”
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Animal Models of Diabetes-Associated Renal Injury by Zahra Samadi Noshahr, Hossein Salmani, Abolfazl Khajavi Rad, Amirhossein Sahebkar

“…Many rodent models of type 1 and type 2 diabetes have been established to elucidate the pathogenesis of diabetes and examine novel therapies against DN. …”
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Primary Signet-Ring Cell Adenocarcinoma of the Urinary Bladder Treated with Partial Cystectomy: A Case Report and Review of the Literature by Umesh Jayarajah, D. M. Hilary Fernando, Kasun Bandara Herath, M. V. Chandu de Silva, S. A. S. Goonewardena

“…A 71-year-old female with a history of type 2 diabetes, hypertension, and ischaemic heart disease presented with painless haematuria for 2 months’ duration. …”
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