To Probe Full and Partial Activation of Human Peroxisome Proliferator-Activated Receptors by Pan-Agonist Chiglitazar Using Molecular Dynamics Simulations by Holli-Joi Sullivan, Xiaoyan Wang, Shaina Nogle, Siyan Liao, Chun Wu

“…Chiglitazar is a promising new-generation insulin sensitizer with low reverse effects for the treatment of type II diabetes mellitus (T2DM) and has shown activity as a nonselective pan-agonist to the human peroxisome proliferator-activated receptors (PPARs) (i.e., full activation of PPARγ and a partial activation of PPARα and PPARβ/δ). …”
Get full text

Density functional theory and molecular dynamics simulation-based bioprospection of Agathosma betulina essential oil metabolites against protein tyrosine phosphatase 1B for interve... by Oluwaseye Adedirin, Rukayat A. Abdulsalam, Khadeejah O. Nasir-Naeem, Ayenitaju A. Oke, Akolade O. Jubril, Saheed Sabiu

“…Type II diabetes mellitus (T2DM) is characterized by elevated blood glucose due to impaired insulin secretion/sensitivity. …”
Get full text

Review: cell mechanisms in the control of inflammatory foundations of obesity and secondary metabolic disorders by Kristin Goldstone, Keelin Irwin, Ava O' Meara-Cushen, Cathy Brougham

“…Obesity-related inflammation can precipitate several diseases, such breast cancer, insulin resistance, type II diabetes and cardiovascular issues. As obesity puts human health at inherent risk, the regulation of obesity-related inflammation is therefore a necessary component to reduce disease onset, and progression, and manage symptoms. …”
Get full text

Impact of clinical pharmacist integration on diabetes management: a prospective cohort by Nur Burcu Kutluay, Muhammed Yunus Bektay, Betul Sumbul-Sekerci, Abdusselam Sekerci, Fikret Vehbi Izzettin

“…Methods A Prospective cohort study designed to evaluate the effects of pharmacist intervention on prediabetes (pDG) and type II diabetes mellitus (DMG) patients. The pharmacist conducted a detailed medication review and structured patient education during the first visit, followed by an evaluation of the interventions at the second visit (after 90 days). …”
Get full text

Utilizing physical educators to monitor muscular strength and neuromuscular control among children with varied recess time by G. Kate Webb, Yan Zhang, Deborah J. Rhea

“…Developing appropriate MusS during childhood decreases the chances of physical injuries and many chronic diseases such as type II diabetes and cancer, which leads to healthier, active future adults. …”
Get full text

Metformin versus insulin in glycemic control in pregnancy (MevIP): a randomized clinical trial protocol by Carolina Freitas Alves Amaral-Moreira, Daiane Sofia Morais Paulino, Belmiro G. Pereira, Patricia Moretti Rehder, Fernanda G. Surita

“…Methods We designed an open randomized controlled trial comparing two treatments for pregnant women with type II diabetes mellitus (DM) and gestational diabetes (DMG): the metformin group (intervention) and the insulin group (as a routine service). …”
Get full text

Traffic-related-air-pollutant PM2.5 Caused Toxicity on Caenorhabditis elegans with Cotreatment of High-dose Glucose and Tempeh by Jian-He Lu, Ming-Hsien Tsai, Sen-Ting Huang, Jia-De Lee, Ta-Chih Hsiao, Wan Nurdiyana Wan Mansor, How-Ran Chao

“…Tempeh is a traditional Indonesian food and may be beneficial for patients with type II diabetes. However, the toxicological effects of co-exposure to traffic-related-air-pollutant (TRAP) PM2.5 with high glucose and the potential therapeutic effect of tempeh remain unclear. …”
Get full text

Influence of Duodenal–Jejunal Implantation on Glucose Dynamics: A Pilot Study Using Different Nonlinear Methods by David Cuesta-Frau, Daniel Novák, Vacláv Burda, Daniel Abasolo, Tricia Adjei, Manuel Varela, Borja Vargas, Milos Mraz, Petra Kavalkova, Marek Benes, Martin Haluzik

“…We hypothesized that DJBL also influences the glucose dynamics in type II diabetes, based on the induced changes already demonstrated in other physiological characteristics and parameters. …”
Get full text

Prevalence of Diabetic Foot Ulcer and Associated Factors among Adult Diabetic Patients Who Attend the Diabetic Follow-Up Clinic at the University of Gondar Referral Hospital, North... by Tesfamichael G. Mariam, Abebaw Alemayehu, Eleni Tesfaye, Worku Mequannt, Kiber Temesgen, Fisseha Yetwale, Miteku Andualem Limenih

“…Rural residence [AOR = 2.57; 95% CI: 1.42, 5.93], type II diabetes mellitus [AOR = 2.58; 95% CI: 1.22, 6.45], overweight [AOR = 2.12; 95% CI: 1.15, 3.10], obesity [AOR = 2.65; 95% CI: 1.25, 5.83], poor foot self-care practice [AOR = 2.52; 95% CI: 1.21, 6.53], and neuropathy [AOR = 21.76; 95% CI: 8.43, 57.47] were factors associated with diabetic foot ulcer. …”
Get full text

The BET inhibitor JQ1 targets fat metabolism and counteracts obesity by Claudia Fornelli, Alessia Sofia Cento, Lorenzo Nevi, Raffaella Mastrocola, Gustavo Ferreira Alves, Giuseppina Caretti, Massimo Collino, Fabio Penna

“…Introduction: Obesity, one of the most frequent health problems in the adult population, is a condition characterized by excessive white adipose tissue accumulation and accompanied by the increased risk to develop other disorders such as type II diabetes, cardiovascular disorders, physical disability, frailty and sarcopenia. …”
Get full text

Evaluation of Sialic Acid Levels in the Umbilical Cord Blood of Newborns of Diabetic and Non-Diabetic Mothers and the Relation with Poor Neonatal Outcome by Yuksel Kurban, İbrahim Uyar, Koza Murat, Murat Alan

“…The others, in decreasing order, were participants with Type II diabetes (33.00±4.1) and gestational diabetes (20.87±3.7) and the difference was statistically significant (p=0.001). …”
Get full text

Sex differences of molecular mechanisms of insulin sensitivity in young and adult C57BL/6J mice by T. V. Yakovleva, A. Yu. Kazantseva, E. N.  Makarova, N. M. Bazhan

“…Reduced insulin sensitivity plays an important role in the pathogenesis of type II diabetes. There are sex differences in the development of metabolic disorders. …”
Get full text

Real-World Assessment of Weight Change in People with HIV-1 After Initiating Integrase Strand Transfer Inhibitors or Protease Inhibitors by Yen-Wen Chen, Helene Hardy, Christopher D. Pericone, Wing Chow

“…At baseline, 46% were <50 years old, 26% were females, 12% had Type II diabetes and 30% had hypertension (mean baseline weight: INSTI: 83 kg (183 lb), PI: 82 kg (181 lb); P = 0.3). …”
Get full text

Interleukin 6 Function in the Skin and Isolated Keratinocytes Is Modulated by Hyperglycemia by Eric G. Lee, Lerin R. Luckett-Chastain, Kaitlin N. Calhoun, Benjamin Frempah, Anja Bastian, Randle M. Gallucci

“…Interleukin 6 (IL-6) plays an important role in wound healing and is known to be elevated in the serum of both type I and type II diabetes patients. This study assesses the expression and function of IL-6 in the hyperglycemic epidermis and keratinocyte culture. …”
Get full text

Antidiabetic Effect of Fenugreek Seed Powder Solution (Trigonella foenum-graecum L.) on Hyperlipidemia in Diabetic Patients by Genet Alem Geberemeskel, Yared Godefa Debebe, Nigisty Abraha Nguse

“…This study investigated the effect of Trigonella foenum-graecum seed powder solution on the lipid profile of newly diagnosed type II diabetic patients. Methods. A total of N=114 newly diagnosed type II diabetic patients without any significant diabetes complication were selected. …”
Get full text

Impact of metformin on disease control and survival in patients with head and neck cancer: a retrospective cohort study by Daniel J. Lee, Caitlin P. McMullen, Andrew Foreman, Shao Hui Huang, Lin Lu, Wei Xu, John R. de Almeida, Geoffrey Liu, Scott V. Bratman, David P. Goldstein

“…Our aim was to determine the effect of metformin on outcomes within our large cohort of head and neck cancer patients with Type II Diabetes (T2DM). Study design Retrospective cohort study. …”
Get full text

Increased DHEAS and Decreased Total Testosterone Serum Levels in a Subset of Men with Early-Onset Androgenetic Alopecia: Does a Male PCOS-Equivalent Exist? by Rossella Cannarella, Rosita A. Condorelli, Federica Dall’Oglio, Sandro La Vignera, Laura M. Mongioì, Giuseppe Micali, Aldo E. Calogero

“…It has been suggested that a male polycystic ovarian syndrome- (PCOS-) equivalent, defined as an endocrine syndrome with a metabolic background and a PCOS-like hormonal pattern, predisposing to type II diabetes mellitus (DM II), cardiovascular and prostate diseases later in life, may occur in at least a part of these men. …”
Get full text

Enterotype Bacteroides Is Associated with a High Risk in Patients with Diabetes: A Pilot Study by Jiajia Wang, Wenjuan Li, Chuan Wang, Lingshu Wang, Tianyi He, Huiqing Hu, Jia Song, Chen Cui, Jingting Qiao, Li Qing, Lili Li, Nan Zang, Kewei Wang, Chuanlong Wu, Lin Qi, Aixia Ma, Huizhen Zheng, Xinguo Hou, Fuqiang Liu, Li Chen

“…More and more studies focus on the relationship between the gastrointestinal microbiome and type 2 diabetes, but few of them have actually explored the relationship between enterotypes and type 2 diabetes. …”
Get full text

Frequency and Predictors of Self-Reported Hypoglycemia in Insulin-Treated Diabetes by Samir Malkani, Anupam Kotwal

“…Hypoglycemia occurred more frequently in type 1 than in type 2 diabetes; however, 19% of type 2 diabetes patients did experience at least one episode of severe hypoglycemia. …”
Get full text

Evidence for the Gut Microbiota Short-Chain Fatty Acids as Key Pathophysiological Molecules Improving Diabetes by Alessandra Puddu, Roberta Sanguineti, Fabrizio Montecucco, Giorgio Luciano Viviani

“…In type 2 diabetes, hyperglycemia, insulin resistance, increased inflammation, and oxidative stress were shown to be associated with the progressive deterioration of beta-cell function and mass. …”
Get full text