Review of the Structural and Dynamic Mechanisms of PPARγ Partial Agonism by Alice J. Kroker, John B. Bruning

“…While endogenous ligands of PPARγ include fatty acids and eicosanoids, synthetic full agonists of the receptor, including members of the thiazolidinedione (TZD) class, have been widely prescribed for the treatment of type II diabetes mellitus (T2DM). Unfortunately, the use of full agonists has been hampered by harsh side effects with some removed from the market in many countries. …”
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Along for the Ride: Intrahepatic Cholangiocarcinoma with Concomitant LECT2 Amyloidosis by Phoenix D. Bell, Aaron R. Huber, Tom C. DeRoche

“…We present a case of a 69-year-old Hispanic male with a past medical history of type II diabetes mellitus who presented with a two-month history of abdominal pain. …”
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Regulation of Glial Cell Functions by PPAR-𝜸 Natural and Synthetic Agonists by Antonietta Bernardo, Luisa Minghetti

“…In the recent years, the peroxisome proliferator-activated receptor-𝛾 (PPAR-𝛾), a well known target for type II diabetes treatment, has received an increasing attention for its therapeutic potential in inflammatory and degenerative brain disorders. …”
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The Association of Adiposity Indices and Plasma Vitamin D in Young Females in Saudi Arabia by Lubna Ibrahim Al Asoom

“…Some evidences indicate its association with metabolic syndrome, type II diabetes, and cardiovascular diseases. In the current study we aim to study the association of vitamin D level and indicators of adiposity in young Saudi females. …”
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Catecholamines Mediate Multiple Fetal Adaptations during Placental Insufficiency That Contribute to Intrauterine Growth Restriction: Lessons from Hyperthermic Sheep by D. T. Yates, A. S. Green, S. W. Limesand

“…These adrenergically influenced adaptive responses promote in utero survival but also cause asymmetric intrauterine growth restriction and small-for-gestational-age infants that are at greater risk for serious metabolic disorders throughout postnatal life, including obesity and type II diabetes.…”
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Updating Experimental Models of Diabetic Cardiomyopathy by J. Fuentes-Antrás, B. Picatoste, A. Gómez-Hernández, J. Egido, J. Tuñón, Ó. Lorenzo

“…Inflammation, hypertrophy, fibrosis, steatosis, and apoptosis in the myocardium have been studied in numerous diabetic experimental models in animals, mostly rodents. Type I and type II diabetes were induced by genetic manipulation, pancreatic toxins, and fat and sweet diets, and animals recapitulate the main features of human diabetes and related cardiomyopathy. …”
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An Update on Inflamm-Aging: Mechanisms, Prevention, and Treatment by Shijin Xia, Xinyan Zhang, Songbai Zheng, Ramin Khanabdali, Bill Kalionis, Junzhen Wu, Wenbin Wan, Xiantao Tai

“…Increasing evidence indicates that inflamm-aging is intensively associated with many aging diseases, such as Alzheimer’s disease, atherosclerosis, heart disease, type II diabetes, and cancer. Mounting studies have focused on the role of inflamm-aging in disease progression and many advances have been made in the last decade. …”
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Rare Case of Aspergillus ochraceus Osteomyelitis of Calcaneus Bone in a Patient with Diabetic Foot Ulcers by Farhang Babamahmoodi, Tahereh Shokohi, Fatemeh Ahangarkani, Mojtaba Nabili, Elham Afzalian Ashkezari, Sosan Alinezhad

“…The case was a 68-year-old male with a history of type II diabetes for 2 years. The patient had two ulcers on the right heel bones for the past 6 months with no significant improvement. …”
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The Systematic Analysis of Exercise Mechanism in Human Diseases by Lei Pu, Peng Sun

“…Then, GSEA analysis revealed that glycosaminoglycan biosynthesis chondroitin sulfate, type II diabetes mellitus, and basal cell carcinoma were related with exercise samples. …”
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A scoping review of shoulder kinesthetic function in individuals with diabetes mellitus, with and without frozen shoulder by Neena Varghese, Mamta S. Shetty, Rajani Prashant Mullerpatan

“…Background: Kinesthesia, the ability to perceive movements, is diminished in individuals with type II diabetes mellitus. People with frozen shoulders also experience kinesthetic deficits. …”
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Potential of Peroxisome Proliferator-Activated Receptor Gamma Antagonist Compounds as Therapeutic Agents for a Wide Range of Cancer Types by Jack D. Burton, David M. Goldenberg, Rosalyn D. Blumenthal

“…PPARγ is a therapeutic target that has been exploited for treatment of type II diabetes mellitus (T2DM) with agonist drugs. Since PPARγ is expressed by many hematopoietic, mesodermal and epithelial cancers, agonist drugs were tested and shown to have both preclinical and clinical anticancer activities. …”
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Atypical Presentation of Disseminated Zoster in a Patient with Rheumatoid Arthritis by Nirav Patel, Davinder Singh, Krunal Patel, Shadab Ahmed, Prachi Anand

“…Comorbidities include hypertension, type II diabetes, and dyslipidemia. Patient was on methotrexate 12.5 mg and was not receiving any corticosteroids, anti-TNF therapy, or other biological agents. …”
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Plasma Gelsolin Levels Decrease in Diabetic State and Increase upon Treatment with F-Actin Depolymerizing Versions of Gelsolin by Neeraj Khatri, Amin Sagar, Nagesh Peddada, Vikas Choudhary, Bhupinder Singh Chopra, Veena Garg, Renu Garg, Ashish

“…The study aims to map plasma gelsolin (pGSN) levels in diabetic humans and mice models of type II diabetes and to evaluate the efficacy of gelsolin therapy in improvement of diabetes in mice. …”
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Therapeutic molecules for multiple human diseases identified from pigeon pea (Cajanus cajan L. Millsp.) through GCâMS and molecular docking by Deepu Mathew, Lidiya John P., Manila T.M., Divyasree P., Sandhya Rajan V.T.K.

“…Keywords: Breast cancer, Drug discovery, Herbal medicine, In silico, Malaria, Measles, Phyto-compounds, Rheumatoid arthritis, Sickle cell disease, Type II diabetes…”
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Risk Factors of Ureteral Stenosis in Kidney Transplant Recipients: A Retrospective Study in National Referral Hospital in Indonesia by Gampo A. Irdam, Bobby Sutojo, Putu A. R. Raharja

“…There is no association between type II diabetes mellitus and hypertension with ureteral stenosis in this study. …”
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Reducing oxidative stress and hepatoprotective effect of water extracts from Pu-erh tea on rats with high-fat diet by Jingjing Su, Xueqing Wang, Wenjun Song, Xiaoli Bai, Changwen Li

“…Meanwhile, the extracts could increase the production of hepatic glycogen and the activity of PK, and reduce glucose level, protecting the liver from the diseases associated with type II diabetes.…”
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Subgingival Delivery of Statins as an Adjunct in the Non-Surgical Treatment of Periodontitis: A Systematic Review by Magdalena Maria Pietrzko, Maciej Pietrzko, Wojciech Niemczyk, Dariusz Skaba, Rafał Wiench

“…Results: The improvement was more pronounced in patients without systematic diseases compared to those with type II diabetes and in non-smokers compared to smoking patients. …”
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Adenocarcinoma of the Right Colon in a Patient with Bloom Syndrome by Carlos Augusto Real Martinez, Lilian Vital Pinheiro, Debora Helena Rossi, Michel Gardere Camargo, Maria de Lourdes Setsuko Ayrizono, Raquel Franco Leal, Cláudio Saddy Rodrigues Coy

“…Clinical manifestations also include short stature, dolichocephaly, prominent ears, micrognathia, malar hypoplasia and a high-pitched voice, immunodeficiency, type II diabetes, and hypogonadism associated with male infertility and female subfertility. …”
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Controversial Roles of Regenerating Family Proteins in Tissue Repair and Tumor Development by Luting Yu, Qingyun Wu, Shenglong Jiang, Jia Liu, Junli Liu, Guoguang Chen

“…Successively, short peptides derived from Reg3δ and Reg3α have been employed in clinical trials, showing favorable therapeutic effects in patients with type I and type II diabetes. However, continued reports have been limited, presumably attributed to the potential side effects. …”
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Metformin Use and Survival in Patients with Advanced Extrahepatic Cholangiocarcinoma: A Single-Center Cohort Study in Fuyang, China by Jinqing Wu, Yabo Zhou, Guizhou Wang

“…Metformin is an oral antidiabetic agent that has been widely prescribed for the treatment of type II diabetes. In recent years, anticancer properties of metformin have been revealed for numerous human malignancies. …”
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