A Pragmatic Clinical Trial to Compare the Real-World Effectiveness of V-Go versus Standard Delivery of Insulin in Patients with Advanced Type 2 Diabetes by Mark J. Cziraky, Scott Abbott, Matt Nguyen, Kay Larholt, Elizabeth Apgar, Thomas Wasser, Poul Strange, Leon Shi, H. Courtenay Harrison, Beverly Everitt, Lynn Nowak

“…**Background:** Many patients with type 2 diabetes mellitus (T2DM) do not have adequate glycemic control, leading to poor patient outcomes and high healthcare costs. …”
Get full text

The Association between the Epicardial Adipose Tissue Thickness and Oxidative Stress Parameters in Isolated Metabolic Syndrome Patients: A Multimarker Approach by Bulent Demir, Esra Demir, Gonul Acıksarı, Turgut Uygun, Irem Kırac Utku, Asuman Gedikbasi, Ilker Murat Caglar, Osman Pirhan, Hande Oktay Tureli, Ersan Oflar, İsmail Ungan, Serkan Ciftci, Osman Karakaya

“…The risk for cardiovascular diseases and type 2 diabetes mellitus significantly increases in the patient population with metabolic syndrome (MeS). …”
Get full text

Liver Biomarkers and Lipid Profiles in Mexican and Mexican-American 10- to 14-Year-Old Adolescents at Risk for Type 2 Diabetes by Ana Cecilia Fernández-Gaxiola, Roxana Valdés-Ramos, Kimberly Fulda, Ana Laura Guadarrama López, Beatriz E. Martínez-Carrillo, Susan F. Franks, Shane Fernando

“…Liver enzymes alanine aminotransferase (ALT) and gamma glutamyl transferase (GGT) are markers for type 2 diabetes mellitus (T2DM); alkaline phosphatase is a marker of liver disease. …”
Get full text

Longitudinal DNA methylation profiles in saliva of offspring from mothers with gestational diabetes: associations with early childhood growth patterns by Teresa M. Linares-Pineda, Alfonso Lendínez-Jurado, Alberto Piserra-López, María Suárez-Arana, María Pozo, María Molina-Vega, María José Picón-César, Sonsoles Morcillo

“…Abstract Background The prevalence of obesity and type 2 diabetes mellitus (T2DM) is rising globally, particularly among children exposed to adverse intrauterine environments, such as those associated with gestational diabetes mellitus (GDM). …”
Get full text

Plasma Asprosin Levels Are Associated with Glucose Metabolism, Lipid, and Sex Hormone Profiles in Females with Metabolic-Related Diseases by Xing Li, Mingyu Liao, Rufei Shen, Linlin Zhang, Hua Hu, Jun Wu, Xiuli Wang, Hua Qu, Shaodong Guo, Min Long, Hongting Zheng

“…However, the role of asprosin in polycystic ovary syndrome (PCOS), a disease partly characterized by insulin resistance, and its potential connection with type 2 diabetes mellitus (T2DM) and PCOS has not been thoroughly elucidated to date. …”
Get full text

Serum ZAG Levels Were Associated with eGFR Mild Decrease in T2DM Patients with Diabetic Nephropathy by Lingling Xu, Weihong Yu, Meng Niu, Caixia Zheng, Bin Qu, Yan Li, Jing Wang, Ping Huang, O. Wang, Fengying Gong

“…To investigate the changes of serum zinc-α2-glycoprotein (ZAG) in type 2 diabetes mellitus (T2DM) with eGFR mild decrease. Subjects and Methods. …”
Get full text

Pleiotropic Effects of a KCNQ1 Variant on Lipid Profiles and Type 2 Diabetes: A Family-Based Study in China by Xiaowen Wang, Junhui Wu, Yao Wu, Mengying Wang, Zijing Wang, Tao Wu, Dafang Chen, Xun Tang, Xueying Qin, Yiqun Wu, Yonghua Hu

“…The genetic variant rs2237895, located in the Potassium Voltage-Gated Channel Subfamily Q Member 1 (KCNQ1) gene, has been replicated to be associated with type 2 diabetes mellitus (T2DM) susceptibility, but the relationship with lipids is conflicting. …”
Get full text

Physical activity and motivational readiness for physical activity behavior change in adults with non-communicable diseases in Germany: a trend analysis of two cross-sectional heal... by Benjamin Wenz, Jonathan Graf, Gorden Sudeck, Wolfgang Geidl, Kristin Manz, Susanne Jordan, Andrea Teti, Lars Gabrys

“…Results Reporting any NCD is associated with lower fulfilment of health-enhancing aerobic PA in both surveys for almost all NCD, with lowest levels among adults reporting stroke, type 2 diabetes mellitus, chronic obstructive pulmonary disease, obesity and coronary heart disease. …”
Get full text

Triglyceride-glucose index predicts adverse cardiovascular events in patients with H-type hypertension combined with coronary heart disease: a retrospective cohort study by Changjiang Li, Shun Zhao, Yingkai Li, Songyuan He, Wen Jian, Yanci Liu, Zichao Cheng, Hongyu Peng

“…Abstract Background The triglyceride‒glucose index (TyG index) is a reliable surrogate for insulin resistance (IR) in individuals with type 2 diabetes mellitus and is associated with cardiovascular disease. …”
Get full text

Utilizing Technology-Enabled Intervention to Improve Blood Glucose Self-Management Outcome in Type 2 Diabetic Patients Initiated on Insulin Therapy: A Retrospective Real-World Stud... by Jian Lin, Xia Li, Shan Jiang, Xiao Ma, Yuxin Yang, Zhiguang Zhou

“…The aim of this study was to assess the benefits of a mobile-enabled app through Lilly Connected Care Program (LCCP) in achieving blood glucose control and adhering to self-monitoring of blood glucose in patients with type 2 diabetes mellitus (T2DM). Methods. This retrospective study included T2DM patients who were initiated on insulin therapy (mostly premixed insulin) after failure to respond to oral antidiabetic drugs. …”
Get full text

The Occurrence or Fibrillary Glomerulonephritis in Patients with Diabetes Mellitus May Not Be Coincidental: A Report of Four Cases by Fayna González-Cabrera, Fernando Henríquez-Palop, Ana Ramírez-Puga, Raquel Santana-Estupiñán, Celia Plaza-Toledano, Gloria Antón-Pérez, Silvia Marrero-Robayna, Davinia Ramírez-Medina, Roberto Gallego-Samper, Nicanor Vega-Díaz, Rafael Camacho-Galan, José C. Rodríguez-Pérez

“…We report four cases between 45–50 years old with documented type 2 diabetes mellitus (T2DM) and arterial hypertension. …”
Get full text

Human Umbilical Cord-Derived Mesenchymal Stem Cell Therapy Ameliorates Nonalcoholic Fatty Liver Disease in Obese Type 2 Diabetic Mice by Bing Li, Yu Cheng, Songyan Yu, Li Zang, Yaqi Yin, Jiejie Liu, Lin Zhang, Yiming Mu

“…Nonalcoholic fatty liver disease (NAFLD) is increasingly common among patients with type 2 diabetes mellitus (T2DM). The two conditions can act synergistically to produce adverse outcomes. …”
Get full text

Hyperglycemia Is a Potential Prognostic Factor for Exacerbation in Severe Psoriasis with Diabetes or Prediabetes by Yongpisarn T, Thadanipon K, Suchonwanit P, Rattanakaemakorn P

“…Patients with psoriasis vulgaris and either type 2 diabetes mellitus (T2DM) or impaired fasting glucose (IFG) who had at least 2 HbA1c values were identified. …”
Get full text

Primary Terminal Haemochromatosis in a 50 Year-Old Patient by M. I. Gonik, M. S. Zharkova, O. Yu. Kiseleva, E. V. Berezina, Sh. A. Ondos, Yu. V. Lerner, E. A. Kogan, V. T. Ivashkin

“…The patient had a history of long-term alcohol consumption at toxic doses, putative cirrhosis, paroxysmal atrial fibrillation, type 2 diabetes mellitus. The patient's severity on admission was conditioned by marked hypotension. …”
Get full text

Impact of Novel Guidelines on Multifactorial Control and Its Association with Mortality in Adult Patients with Hypertension and Newly Diagnosed Type 2 Diabetes: A 4-Year Prospectiv... by Ngoc-Thanh-Van Nguyen, Hoa Ngoc Chau, Nam Hoai Le, Hai Hoang Nguyen, Hoai-An Nguyen

“…This prospective, observational study involved adult hypertensive patients with newly diagnosed type 2 diabetes mellitus at two university hospitals in Vietnam. …”
Get full text

Cross-sectional design and protocol for Artificial Intelligence Ready and Equitable Atlas for Diabetes Insights (AI-READI) by Gerald McGwin, Linda M Zangwill, Nicholas Evans, Shannon McWeeney, Cecilia S Lee, Bhavesh Patel, Jeffrey C Edberg, Cynthia Owsley, Aaron Lee, Cecilia Lee, Sally L Baxter, Michael Snyder, Samantha Hurst, Nicole Ehrhardt, Christopher Chute, Dawn S Matthies, Julia P Owen, Amir Bahmani, Sally Baxter, Edward Boyko, Aaron Cohen, Jorge Contreras, Garrison Cottrell, Virginia de Sa, Jeffrey Edberg, Irl Hirsch, Michelle Hribar, T.Y. Alvin Liu, Bonnie Maldenado, Sara Singer, Bradley Voytek, Joseph Yracheta, Linda Zangwill

“…Introduction Artificial Intelligence Ready and Equitable for Diabetes Insights (AI-READI) is a data collection project on type 2 diabetes mellitus (T2DM) to facilitate the widespread use of artificial intelligence and machine learning (AI/ML) approaches to study salutogenesis (transitioning from T2DM to health resilience). …”
Get full text

High Serum Advanced Glycation End Products Are Associated with Decreased Insulin Secretion in Patients with Type 2 Diabetes: A Brief Report by Tsuyoshi Okura, Etsuko Ueta, Risa Nakamura, Yohei Fujioka, Keisuke Sumi, Kazuhisa Matsumoto, Kyoko Shoji, Kazuhiko Matsuzawa, Shoichiro Izawa, Yuri Nomi, Hitomi Mihara, Yuzuru Otsuka, Masahiko Kato, Shin-ichi Taniguchi, Kazuhiro Yamamoto

“…Advanced glycation end products (AGEs) are important in the pathophysiology of type 2 diabetes mellitus (T2DM). They directly cause insulin secretory defects in animal and cell culture models and may promote insulin resistance in nondiabetic subjects. …”
Get full text

Cardio-renal effect of dapagliflozin and dapagliflozin- saxagliptin combination on CD34 + ve hematopoietic stem cells (HSCs) and podocyte specific markers in type 2 diabetes (T2DM)... by Seshagiri Rao Nandula, Arad Jain, Sabyasachi Sen

“…Both Dapa (a sodium-glucose co-transporter 2 or SGLT2, receptor inhibitor) and Saxagliptin (a Di-peptydl-peptidase-4 or DPP4 enzyme inhibitor) are commonly used type 2 diabetes mellitus or T2DM medications, however the benefit of using the combination has not been evaluated for cardio-renal risk assessment, in a real-life practice setting, compared to a placebo. …”
Get full text

Targeted gut microbiome therapy: Applications and prospects of probiotics, fecal microbiota transplantation and natural products in the management of type 2 diabetes by Luqi Qin, Bei Fan, Yixia Zhou, Jiahuan Zheng, Rao Diao, Fengzhong Wang, Jiameng Liu

“…Type 2 diabetes mellitus (T2DM) is considered as one of the most pressing public health challenges worldwide. …”
Get full text

Anthropometric and metabolic parameters associated with visceral fat in non-obese type 2 diabetes individuals by Ming Jiao, Jiaoli Chen, Xiaoling Wang, Wenyu Tao, Yunhua Feng, Huijun Yang, Haiying Yang, Shanshan Zhao, Ying Yang, Yiping Li

“…Abstract Background and Aim Visceral fat (VF) was proved to be a more precise predictor of atherosclerotic cardiovascular disease (ASCVD) risk in individuals with type 2 diabetes mellitus (T2DM) than body mass index (BMI) itself. …”
Get full text