ANGPTL4: A Predictive Marker for Diabetic Nephropathy by Eman Al Shawaf, Mohamed Abu-Farha, Sriraman Devarajan, Zahra Alsairafi, Irina Al-Khairi, Preethi Cherian, Hamad Ali, Aditi Mathur, Fahd Al-Mulla, Abdulnabi Al Attar, Jehad Abubaker

“…The study involved 36 controls, as well as 86 people with type 2 diabetes (T2D) including 37 people with normal kidney function and 49 people with DN. …”
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The Chromosome 9p21 CVD- and T2D-Associated Regions in a Norwegian Population (The HUNT2 Survey) by Øyvind Helgeland, Jens K. Hertel, Anders Molven, Helge Ræder, Carl G. P. Platou, Kristian Midthjell, Kristian Hveem, Ottar Nygård, Pål R. Njølstad, Stefan Johansson

“…Two adjacent regions upstream CDKN2B on chromosome 9p21 have been associated with type 2 diabetes (T2D) and progression of cardiovascular disease (CVD). …”
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The specificity of ten non-digestible carbohydrates to enhance butyrate-producing bacteria and butyrate production in vitro fermentation by Jingjing Xu, Ruyue Wang, Weibao Liu, Zhongwei Yin, Jianrong Wu, Xun Yu, Wen Wang, Hongtao Zhang, Zhitao Li, Minjie Gao, Li Zhu, Xiaobei Zhan

“…Ten non-digestible carbohydrates (NDCs), including inulin, fructooligosaccharide (FOS), oats β-glucans (OGS), oats β-glucan oligosaccharides (OGOS), Astragalus polysaccharides (APS), Astragalus oligosaccharides (AOS), xanthan gum oligosaccharides (XGOS), gellan gum oligosaccharides (GGOS), curdlan oligosaccharides (COS), and pullulan oligosaccharides (POS) were used to investigate NDC specificity in modulating butyrate-producing bacteria and butyrate production in 48-h in vitro fermentation studies in combination with fecal inocula from 7 healthy donors and 11 patients with type 2 diabetes (T2D). We observed that the amount of these ten NDCs utilized depended on NDC structure and inter-individual gut microbial differences. …”
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Glu4: An open-source package for real-time forecasting and alerting post-bariatric hypoglycemia based on continuous glucose monitoring by Luca Cossu, Francesco Prendin, Giacomo Cappon, David Herzig, Lia Bally, Andrea Facchinetti

“…Unlike in Type 1 and Type 2 diabetes (T1D, T2D), where decision support systems (DSS) and continuous glucose monitoring (CGM) tools aid blood glucose management, no dedicated DSS exists for PBH. …”
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The Constellation of Macrovascular Risk Factors in Early Onset T2DM: A Cross-Sectional Study in Xinjiang Province, China by Mingchen Zhang, Jiangfeng Mao, Ablikm Tuerdi, Xiaoyun Zeng, Li Quan, Shan Xiao, Jun Zhu, Hua Yao

“…Despite a rapid popular of early onset type 2 diabetes (defined as diagnosis at <40 years old) recently, there is a lack of studies on this population in economically undeveloped area. …”
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Paradoxical Glucose-Sensitizing yet Proinflammatory Effects of Acute ASP Administration in Mice by Alexandre Fisette, Pegah Poursharifi, Katerina Oikonomopoulou, Mercedes N. Munkonda, Marc Lapointe, Katherine Cianflone

“…Acylation stimulating protein (ASP) is an adipokine derived from the immune complement system, which stimulates fat storage and is typically increased in obesity, type 2 diabetes, and cardiovascular disease. Using a diet-induced obesity (DIO) mouse model, the acute effects of ASP on energy metabolism and inflammatory processes in vivo were evaluated. …”
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Impact of noninsulin-dependent diabetes mellitus (level of control) on sex hormone profile and erectile function by Abdullah A. Khawaji, Hossam S. El-Tholoth, Muath A. Albarakati, Bander A. Binjabaan, Abdulaziz Alzahrani, Abdulmajeed Althobity, Abdulmalik Almardawi, Khaled Bedaiwi, Mussa AlNuami

“…Introduction: Type 2 diabetes mellitus (T2DM) is a well-established risk factor for erectile dysfunction (ED); the precise impact of glycemic control on male sexual function, including hormonal profiles, remains to be fully elucidated. …”
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Protocol for the systematic review of age and sex in preclinical models of age-correlated diseases [version 2; peer review: 2 approved] by Céline Heinl, Ines Schadock, Maximilian Wurm, Paul Lucas Wildner, Daniel Butzke, Bettina Bert, Alexandra Bannach-Brown, Matthias Steinfath, Kai Diederich

“…We compare the results with the age and sex of patients in clinical trials focusing on Alzheimer's disease, stroke, type 2 diabetes mellitus, ischemic heart disease, and chronic obstructive pulmonary disease. …”
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Intensive Blood Pressure Control and Diabetes Mellitus Incidence for Patients with Impaired Fasting Glucose: A Secondary Analysis of SPRINT by Beiru Lin, Xiaochuan Liu, Sichen Yao, Zhigang Pan

“…Previous studies indicated that intensive blood pressure (BP) control (systolic BP < 120 mm·Hg) compared with standard BP control (<140 mm·Hg) was associated with an increased risk of type 2 diabetes (T2D) and impaired fasting glucose (IFG) among hypertensive patients with normoglycemia. …”
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Abnormal Obesity Phenotype Is Associated with Reduced eGFR among Diabetes Mellitus and Hypertensive Patients in a Peri-Urban Community in Ghana by Richard K. D. Ephraim, Frederick Ahordzor, Kwame Kumi Asare, Evans Duah, Ibrahim W. Naveh-Fio, Grace Essuman, Justice Afrifa

“…Three hundred and ten (310) adult patients diagnosed with type 2 diabetes mellitus, hypertension, or both who attended the Presbyterian Hospital, Dormaa Ahenkro, from October 2016 to March 2017 were recruited for the study. …”
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Phytochemical study and evaluation of the antidiabetic and antihyperglycemic activities of the fruit extracts of Physalis peruviana L. (Solanaceae) by Damien S.T. Tshibangu, Fortune S. Kavugho, Carlos N. Kabengele, Adrien T. Masunda, Gédéon N. Bongo, Giresse N. Kasiama, Domaine T. Mwanangombo, Clément L. Inkoto, Clément M. Mbadiko, Benjamin Z. Gbolo, Désiré M. Musuyu, Dorothée D. Tshilanda, Jean Paul K.N. Ngbolua, Pius T. Mpiana

“…This inhibition was confirmed by molecular docking analyzes by interacting the molecules of the studied plant with two receptors, alpha-glucosidase (PDB id: 3WY1) and the kinase domain of the 5HHW insulin receptor.These experimental results lend credibility to the use of this species in traditional Congolese medicine to treat type 2 diabetes.…”
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Effects of <i>Cordyceps cicadae</i> Polysaccharide on Gut Microbiota, the Intestinal Mucosal Barrier, and Inflammation in Diabetic Mice by Lijia Sun, Huaibo Yuan, Huiqing Ma, Yani Wang

“…<b>Methods:</b> This study investigated its effects on the intestinal microbiota, intestinal mucosal barrier, and inflammation in mice with type 2 diabetes mellitus (T2DM) induced by streptozotocin, and its potential mechanisms. …”
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Advances in the treatment of glioma-related signaling pathways and mechanisms by metformin by Xingyuan Ma, Xingyuan Ma, Chao Sun, Xiao Ding, Yuhang Zhang, Yuhang Zhang, Tingzhen Deng, Tingzhen Deng, Yatao Wang, Yatao Wang, Haijun Yang, Haijun Yang, Ruiwen Ding, Ruiwen Ding, Haotian Li, Haotian Li, Dawen Wang, Dawen Wang, Maohua Zheng, Maohua Zheng

“…Metformin (MET) is a commonly used drug for the treatment of type 2 diabetes in the department of endocrinology. In recent years, due to the few clinically effective treatment options including glioma, some scholars have proposed the possibility of metformin in the treatment of glioma, and studies have shown that metformin has a certain inhibitory effect on this tumor. …”
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Role of the serum levels of the inter-organs messenger fibroblast growth factor 21 (FGF21) in the diagnosis and prognosis of breast cancer patients by Stella Maris Ranuncolo, Eduardo Armanasco, Myriam Nuñez, Laura Yuan, Sujhrob Makhkamov, Mariana S. De Lorenzo

“…High serum FGF21 was found in obesity, metabolic syndrome, type 2 diabetes mellitus, and coronary heart disease. …”
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How Much Do We Know about the Biopsychosocial Predictors of Glycaemic Control? Age and Clinical Factors Predict Glycaemic Control, but Psychological Factors Do Not by Mohammad Farris Iman Leong Bin Abdullah, Hatta Sidi, Arun Ravindran, Paula Junggar Gosse, Emily Samantha Kaunismaa, Roslyn Laurie Mainland, Norlaila Mustafa, Nurul Hazwani Hatta, Puteri Arnawati, Amelia Yasmin Zulkifli, Luke Sy-Cherng Woon

“…Results. 300 patients with diabetes mellitus were recruited, with the majority (90%) having type 2 diabetes. In this population, the prevalence of poor glycaemic control (HbA1C≥7.0%) was 69%, with a median HbA1C of 7.6% (IQR=2.7). …”
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Bariatric Surgery in Moderately Obese Patients: A Prospective Study by M. Cerci, M. I. Bellini, F. Russo, D. Benavoli, M. Capperucci, A. L. Gaspari, P. Gentileschi

“…Between September 2011 and September 2012, 25 patients with grade I obesity and comorbidities underwent bariatric surgery: preoperative mean BMI 33.2 kg/m2, 10 males, mean age 42 years. In presence of type 2 diabetes mellitus (T2DM) (56%), gastric bypass was performed; in cases with hypertension (64%) and obstructive sleep apnea (OSA) (12%), sleeve gastrectomy was performed. …”
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Atherogenic Index of Plasma (AIP) a Tool to Assess Changes in Cardiovascular Disease Risk Post Laparoscopic Sleeve Gastrectomy by Eman Al Shawaf, Ebaa Al-Ozairi, Fahad Al-Asfar, Anwar Mohammad, Shaima Al-Beloushi, Sriraman Devarajan, Fahd Al-Mulla, Jehad Abubaker, Hossein Arefanian

“…Metabolic surgery is the most effective treatment for a rapid improvement of morbid obesity and its comorbidities such as type 2 diabetes (T2D) and CVD. A decreased reoccurrence of CVD after metabolic surgery has been reported by several studies. …”
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Impact of Metabolic States on SARS-CoV-2 Vaccine Responses in Mouse Models of Obesity and Diabetes by Olivia A. Smith, Brent Fujimoto, Teri Ann S. Wong, Albert To, Troy Odo, Aquena Ball, Brien K. Haun, Hiromi Muramatsu, Ying K Tam, Norbert Pardi, Axel T. Lehrer

“…However, it should be noted that mRNA vaccines demonstrated strong neutralizing responses across all metabolic states, while adjuvanted subunit vaccines elicited higher antibody avidity in mice with type 2 diabetes (T2D) and obesity compared to healthy mice. …”
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Effect of potent nucleos(t)ide analog on alpha fetoprotein changes and occurrence of hepatocellular carcinoma in patients with chronic hepatitis B by Qianqian Ma, Junzhao Ye, Ling Luo, Yanhong Sun, Wei Wang, Shiting Feng, Bing Liao, Bihui Zhong

“…The combination of shear wave elastography (SWE), mPage-B score, age and type 2 diabetes mellitus had an area under the curve of 0.838 (P < 0.001) in predicting the occurrence of HCC. …”
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Investigating misclassification of type 1 diabetes in a population-based cohort of British Pakistanis and Bangladeshis using polygenic risk scores by Timing Liu, Alagu Sankareswaran, Gordon Paterson, Genes & Health Research Team, Diane P. Fraser, Sam Hodgson, Qin Qin Huang, Teng Hiang Heng, Meera Ladwa, Nick Thomas, David A. van Heel, Michael N. Weedon, Chittaranjan S. Yajnik, Richard A. Oram, Giriraj R. Chandak, Hilary C. Martin, Sarah Finer

“…Abstract Correct classification of type 1 (T1D) and type 2 diabetes (T2D) is challenging due to overlapping clinical features and the increasingly early onset of T2D, particularly in South Asians. …”
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