Treatment of Severe Hypercapnic Respiratory Failure Caused by SARS-CoV-2 Lung Injury with ECCO2R Using the Hemolung Respiratory Assist System by Ramiro Saavedra-Romero, Francisco Paz, John M. Litell, Julia Weinkauf, Carina C. Benson, Lisa Tindell, Kari Williams

“…This patient’s multiple comorbid conditions included obesity, hypertension, type 2 diabetes mellitus, and hypercholesterolemia. On her fifth day of admission at the referring hospital, her worsening hypoxemia prompted endotracheal intubation during which she developed pneumothorax. …”
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The Clinical Pharmacokinetics and Pharmacodynamics of Glimepiride—A Systematic Review and Meta-Analysis by Mubara Azhar, Mohammed S. Alasmari, Ammara Zamir, Hamid Saeed, Faleh Alqahtani, Tanveer Ahmad, Muhammad Fawad Rasool

“…<b>Background/Objectives:</b> Glimepiride (GLM), a commonly used sulphonylurea drug for the management of type 2 diabetes mellitus (T2DM), has been the subject of numerous studies exploring its kinetic behaviors. …”
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Cardiovascular Risk and Metabolic Syndrome Characteristics in Patients with Nonfunctional Pituitary Macroadenoma by Guadalupe Vargas-Ortega, Baldomero González-Virla, Lourdes Balcázar-Hernández, Oriana Nieto-Guzmán, Ana Pamela Garrido-Mendoza, Marco Antonio Flores-Maya, Victoria Mendoza-Zubieta

“…An elevated incidence of type 2 diabetes and cardiovascular disease (CVD) has been reported in patients with nonfunctional pituitary macroadenoma (NFPMA). …”
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The Imbalance of B-Lymphocyte Subsets in Subjects with Different Glucose Tolerance: Relationship with Metabolic Parameter and Disease Status by Chao Deng, Yufei Xiang, Tingting Tan, Zhihui Ren, Chuqing Cao, Bingwen Liu, Gan Huang, Xiangbing Wang, Zhiguang Zhou

“…B lymphocytes are involved in inflammation and are related to insulin resistance in obesity and type 2 diabetes (T2D). This study investigated the phenotype and frequency of B-lymphocyte subsets in subjects recently diagnosed with T2D (n=60), impaired glucose regulation (IGR, n=73), and normal glucose tolerance (NGT, n=169) by flow cytometry. …”
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Incidence of diabetic retinopathy and predictors among adult patients with diabetes in central and southern Ethiopia: a multicentre retrospective cohort study by Tagese Yakob, Awoke Abraham, Begidu Yakob, Mesfin Menza Jaldo

“…Positive proteinuria (adjusted HR (AHR)=2.19; 95% CI 1.18 to 4.08), hypertension (HTN) (AHR=2.23; 95% CI 1.39 to 3.55) and type 2 diabetes mellitus (AHR=2.89; 95% CI 1.19 to 7.05) were independently significant predictors of DR.Conclusion The overall incidence rate of DR (type 1 and type 2) was high. …”
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Association of TCF7L2 genetic variants rs12255372 and rs7903146 with the polycystic ovary syndrome risk: systematic review and meta-analysis by Idrees A. Shah, Rabiya Rashid, Haroon Rashid, Abid Bhat, Mohd Ashraf Ganie

“…Abstract Background A significant overlap in the pathophysiological features of polycystic ovary syndrome (PCOS) and type 2 diabetes mellitus (T2DM) has been reported; and insulin resistance is considered a central driver in both. …”
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Natural History of Metabolic Dysfunction-Associated Steatotic Liver Disease: From Metabolic Syndrome to Hepatocellular Carcinoma by Melchor Alpízar Salazar, Samantha Estefanía Olguín Reyes, Andrea Medina Estévez, Julieta Alejandra Saturno Lobos, Jesús Manuel De Aldecoa Castillo, Juan Carlos Carrera Aguas, Samary Alaniz Monreal, José Antonio Navarro Rodríguez, Dulce María Fernanda Alpízar Sánchez

“…<i>Introduction</i>: Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) stems from disrupted lipid metabolism in the liver, often linked to obesity, type 2 diabetes, and dyslipidemia. In Mexico, where obesity affects 36.9% of adults, MASLD prevalence has risen, especially with metabolic syndrome affecting 56.31% by 2018. …”
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ADAM19: A Novel Target for Metabolic Syndrome in Humans and Mice by Lakshini Weerasekera, Caroline Rudnicka, Qing-Xiang Sang, Joanne E. Curran, Matthew P. Johnson, Eric K. Moses, Harald H. H. Göring, John Blangero, Jana Hricova, Markus Schlaich, Vance B. Matthews

“…Obesity is one of the most prevalent metabolic diseases in the Western world and correlates directly with insulin resistance, which may ultimately culminate in type 2 diabetes (T2D). We sought to ascertain whether the human metalloproteinase A Disintegrin and Metalloproteinase 19 (ADAM19) correlates with parameters of the metabolic syndrome in humans and mice. …”
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Circulating T Cells Exhibit Different TIM3/Galectin-9 Expression in Patients with Obesity and Obesity-Related Diabetes by Lili Sun, Shengyi Zou, Sisi Ding, Xuan Du, Yu Shen, Cuiping Liu, Bimin Shi, Xueguang Zhang

“…Obesity is highly associated with type 2 diabetes mellitus (T2DM). The TIM3/galectin-9 pathway plays an important role in immune tolerance. …”
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Safety Assessment of Glucose-Lowering Drugs and Importance of Structured Education during Ramadan: A Systematic Review and Meta-Analysis by Rashmi Shiju, Ayesha Akhil, Smitha Thankachan, Jaakko Tuomilehto, Monira Al Arouj, Abdullah Bennakhi

“…Ramadan is the sacred month of the Islamic Hijri (lunar) calendar, and during this entire month, healthy adult Muslims abstain from eating and drinking from dawn to sunset. Muslims with Type 2 Diabetes Mellitus (T2DM) who choose to fast during Ramadan encounter major risks such as hypoglycemia, hyperglycemia, diabetic ketoacidosis, dehydration, and thrombosis. …”
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Extracellular volume fraction and native T1 mapping in diabetic cardiomyopathy: a comprehensive meta-analysis by Ahmed Marey, Ali Alabdullah, Hossam Ghorab, Fatima Ali, Jawdat Abdulla, Akhil Narang, Muhammad Umair

“…Abstract Background Type 2 diabetes mellitus (T2DM) is associated with myocardial fibrosis (MF), a major contributor to adverse cardiovascular outcomes. …”
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Association between Chinese visceral adiposity index and risk of new-onset hypertension in middle-aged and older adults with prediabetes: evidence from a large national cohort stud... by Lanlan Li, Lanlan Li, Linqiang Xi, Qianhui Wang

“…PurposeChinese Visceral Adiposity Index (CVAI) has been found significantly associated with hypertension in general and type-2 diabetes adults. However, the predictive value of CVAI for the incidence of hypertension in adults with prediabetes is unclear. …”
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Characterization of Metabolically Healthy Obese People and Metabolically Unhealthy Normal-Weight People in a General Population Cohort of the ABCD Study by Silvio Buscemi, Pierfilippo Chiarello, Carola Buscemi, Davide Corleo, Maria Fatima Massenti, Anna Maria Barile, Giuseppe Rosafio, Vincenza Maniaci, Valentina Settipani, Loretta Cosentino, Carla Giordano

“…Participants were classified as normal weight (BMI < 24.9 kg/m2) or overweight-obese (BMI ≥25 kg/m2); they were also classified as MH in the presence of 0-1 among the following conditions: (a) prediabetes/type 2 diabetes, (b) hypertension, (c) hypertriglyceridemia or low HDL cholesterolemia, and (d) hypercholesterolemia. …”
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Home Medication Review among Patients with Chronic Diseases in Rural Villages of Pahang, Malaysia: A Case Report by Norny Syafinaz Ab Rahman, Nur Alyaa Anisa Mat Harom, Nor Ilyani Mohamed Nazar

“…The first case describes a 62-year-old single Malay female with multiple chronic conditions, including Type 2 diabetes mellitus (T2DM), hypertension, dyslipidemia, and bronchial asthma, managed with eight prescribed medications. …”
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Hyperglycemia Does Not Affect Iron Mediated Toxicity of Cultured Endothelial and Renal Tubular Epithelial Cells: Influence of L-Carnosine by Shiqi Zhang, Emmanouil Ntasis, Sarah Kabtni, Jaap van den Born, Gerjan Navis, Stephan J. L. Bakker, Bernhard K. Krämer, Benito A. Yard, Sibylle J. Hauske

“…Iron has been suggested to affect the clinical course of type 2 diabetes (T2DM) as accompanying increased intracellular iron accumulation may provide an alternative source for reactive oxygen species (ROS). …”
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Composite cardiovascular risk factor control in US adults with diabetes and relation to social determinants of health: The All of Us research program by Frances Golden, Johnathan Tran, Nathan D. Wong

“…Background: Data are limited on composite cardiovascular risk factor control in patients with type 2 diabetes mellitus (T2DM). This study aims to identify disparities in cardiovascular risk factor control based on most recent recommendations and relationships to social determinants of health in a large-scale real-world cohort of US adults. …”
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Amyloid-β and heart failure in Alzheimer’s disease: the new vistas by Hayder M. Al-Kuraishy, Ghassan M. Sulaiman, Hamdoon A. Mohammed, Sohaib G. Mohammed, Ali I. Al-Gareeb, Ali K. Albuhadily, Retaj A. Dawood, Amer Al Ali, Mohammed H. Abu-Alghayth

“…It has been shown that cardiometabolic conditions such as obesity, type 2 diabetes (T2D), and heart failure (HF) are regarded as possible risk factors for the development of AD and other types of dementia, such as vascular dementia. …”
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Banxia Xiexin Decoction Ameliorates t-BHP-Induced Apoptosis in Pancreatic Beta Cells by Activating the PI3K/AKT/FOXO1 Signaling Pathway by Li-juan Du, Bing Pang, Yu-meng Tan, Ya-nan Yang, Mei-zhen Zhang, Qing Pang, Min Sun, Qing Ni

“…BXXD protected MIN6 cells against t-BHP-induced apoptosis and improved insulin secretory function through modulation of the PI3K/AKT pathway and the downstream FOXO1, thus suggesting a novel therapeutic approach for type 2 diabetes mellitus (T2DM).…”
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Glomerulopathy in the KK.Cg-Ay/J Mouse Reflects the Pathology of Diabetic Nephropathy by Stephen P. O'Brien, Mandy Smith, Hong Ling, Lucy Phillips, William Weber, John Lydon, Colleen Maloney, Steven Ledbetter, Cynthia Arbeeny, Stefan Wawersik

“…The KK.Cg-/J (KK-) mouse strain is a previously described model of type 2 diabetes with renal impairment. In the present study, female KK- mice received an elevated fat content diet (24% of calories), and a cohort was uninephrectomized (Unx) to drive renal disease severity. …”
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Impact of cooling diabetic patients’ fingertips compared to vibrating stimulation on pain from the glucometer needle: A cross-over trial study by Vahid Vejdanihemmat, Hiva Azami, Leili Tapak, Shiva Borzouei, khodayar Oshvandi

“…Methods: Sixty diabetic inpatients from Shahid Beheshti Hospital in Hamadan, Iran, participated in a crossover study, comprising 3 individuals with type 1 diabetes and 57 with type 2 diabetes. The cohort included 40 males and 20 females, with ages ranging from 18 to 70 years and a mean age of 55.7 years. …”
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