Spatial tumor immune heterogeneity facilitates subtype co-existence and therapy response in pancreatic cancer by Lukas Klein, Mengyu Tu, Niklas Krebs, Laura Urbach, Daniela Grimm, Muhammad Umair Latif, Frederike Penz, Anna Blandau, Xueyan Wu, Rebecca Diya Samuel, Stefan Küffer, Florian Wegwitz, Nathan Chan, Kazeera Aliar, Foram Vyas, Uday Kishore, Elisabeth Hessmann, Andreas Trumpp, Elisa Espinet, Argyris Papantonis, Rama Khokha, Volker Ellenrieder, Barbara T. Grünwald, Shiv K. Singh

“…ATAC-, ChIP-, and RNA-seq analyses reveal that JUNB/AP1- and HDAC-mediated epigenetic programs repress pro-inflammatory signatures in tumor cells, antagonizing cJUN/AP1 signaling, favoring a therapy-responsive classical neoplastic state. …”
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LAMB1 promotes proliferation and metastasis in nasopharyngeal carcinoma and shapes the immune-suppressive tumor microenvironment by Enzi Feng, Xinyu Yang, Jie Yang, Qianqian Qu, Xiaojiang Li

“…But at low level of fibroblasts, LAMB1 directly suppressed immune response. Tumors with high LAMB1 level had weak responses to immunotherapy. …”
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TCfinder: Robust tumor cell discrimination in scRNA‐seq based on gene pathway activity by Chenxu Wu, Wei Ning, Tao Wu, Jing Chen, Huizi Yao, Ziyu Tao, Xiangyu Zhao, Kaixuan Diao, Jinyu Wang, Weiliang Wang, Xinxing Li, Qianqian Song, Xue‐Song Liu

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Glomus tumor in a patient suffering from Von Recklinghausen disease. A case presentation. by Alfredo Oliver Martín, Wilfredo Díaz de León, Jorge Roca, Ricardo Souza Bello

Subjects: “…tumor glómico…”
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Pilomatrixoma of the parotid region: A benign tumor mimicking metastatic cutaneous squamous cell carcinoma by Nikita Grieder, MD, Marcella Pucci, MD, Claudio De Vito, MD, PhD, Yan Monnier, MD, PhD, Nicolas Dulguerov, MD, Maxime Mermod, MD, PhD

“…Head and neck tumors in adults present a broad differential diagnosis, particularly when considering malignant neoplasms that require prompt diagnosis and intervention. …”
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Effects of RARα ligand binding domain mutations on breast fibroepithelial tumor function and signaling by Xi Xiao Huang, Ley Moy Ng, Po-Hsien Lee, Peiyong Guan, Mun Juinn Chow, Aisyah Binte Mohamed Bashir, Meina Lau, Kenric Yi Shu Tan, Zhimei Li, Jason Yongsheng Chan, Jing Han Hong, Sheng Rong Ng, Tun Kiat Ko, Hong Lee Heng, Hsiang Ling Teo, Daniela Rhodes, Patrick Tan, Puay Hoon Tan, Donald P. McDonnell, Bin Tean Teh

“…Abstract Point mutations in the ligand binding domain of retinoic acid receptor alpha (RARα) are linked to breast fibroepithelial tumor development, but their role in solid tumorigenesis is unclear. …”
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Towards Targeted Delivery Systems: Ligand Conjugation Strategies for mRNA Nanoparticle Tumor Vaccines by Kyle K. L. Phua

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Editorial: Revealing the role of mitochondrial gene defects in tumor progression and developing mitochondrial-targeted drugs by Leilei Liang, Yuzhen Gao

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MUNet: a novel framework for accurate brain tumor segmentation combining UNet and mamba networks by Lijuan Yang, Lijuan Yang, Qiumei Dong, Da Lin, Chunfang Tian, Xinliang Lü

Subjects: “…brain tumor segmentation…”
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False Positive Radioiodinated Metaiodobenzylguanidine (123I-MIBG) Uptake in Undifferentiated Adrenal Malignant Tumor by Hee Soo Jung, Seok Jun Moon, Yun Mi Kim, Hye Rim Kang, Seok Mo Lee, Soo Jin Jung, Seok Jin Choi, Tae Kyoon Kim, Min Jeong Kwon, Jeong Hyun Park, Soon Hee Lee

“…A final diagnosis of undifferentiated adrenal malignant tumor was rendered, instead of histologically malignant pheochromocytoma, despite the uptake of 123I-MIBG demonstrated by scintigraphy.…”
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Knockout or inhibition of DHPS suppresses ovarian tumor growth and metastasis by attenuating the TGFβ pathway by Guannan Zhao, Xinxin Zhao, Ziping Liu, Baojin Wang, Peixin Dong, Hidemichi Watari, Lawrence M. Pfeffer, Gabor Tigyi, Wenjing Zhang, Junming Yue

“…DHPS regulates the translation initiation factor EIF5A, and EIF5A2 knockout inhibits OC tumor growth and metastasis by blocking the epithelial-to-mesenchymal transition (EMT) and the TGFβ pathway. …”
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Editorial: The impact of alkalizing the acidic tumor microenvironment to improve efficacy of cancer treatment, volume II by Reo Hamaguchi, Noha Mousaad Elemam, Shinji Uemoto, Hiromi Wada

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Stable periodic oscillations in a two-stage cancer model of tumor and immune system interactions by Dan Liu, Shigui Ruan, Deming Zhu

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Molecule interacting with CasL-2 enhances tumor progression and alters radiosensitivity in cervical cancer by Yun Teng, Hongmei Zhao, Guoqing Xue, Guohui Zhang, Yanbin Huang, Wei Guo, Kun Zou, Lijuan Zou

“…Conclusion MICAL2 plays a critical role in tumor progression and radiotherapy resistance in cervical cancer. …”
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Comparison of Epirubicin-Iodized Oil Suspension and Emulsion for Transcatheter Arterial Chemoembolization in VX2 Tumor by Tatsuo Ueda, Satoru Murata, Takahiko Mine, Shiro Onozawa, Munehiko Onda, Zenya Naito, Yasuo Amano, Shinichiro Kumita

“…Changes in plasma epirubicin concentration were compared over 24 h immediately after treatment, and enhanced ultrasonographic and histopathological analysis subsequently conducted 7 days after treatment to determine the growth ratio and proportion of viable tumor cells. The growth ratio and proportion of viable tumor cells were found to be significantly lower in the suspension group than in the emulsion group while the plasma epirubicin concentration was found to be significantly higher in the suspension group than in the emulsion group. …”
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Tumores de las glándulas salivales mayores. Estudio de una serie de casos by Yordany Boza Mejías, Julio Romero Rodríguez, Enrique Pérez Abreus, Raúl López Fernández, Arelis Duménico Soler, Teresita Barrios

“…<strong>Fundamento:</strong> el estudio de las neoplasias de las glándulas salivales constituye uno de los problemas más complejos de la enfermedad tumoral de la cabeza y el cuello. <strong><br />Objetivo: </strong>determinar el comportamiento de los tumores de las glándulas salivales mayores. …”
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ALKBH5 acts a tumor-suppressive biomarker and is associated with immunotherapy response in hepatocellular carcinoma by Hehua Ma, Yuxin Hong, Zhenzhen Xu, Zuyi Weng, Yuanxun Yang, Dandan Jin, Zhiyou Chen, Xuan Zhou, Zhi Xu, Fei Fei, Wei Song, Juan Li

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Glutathione-dependent system in the blood of gastric cancer patients with various tumor histotypes and prevalence of the disease by I. A. Goroshinskaya, E. I. Surikova, E. M. Frantsiyants, L. A. Nemashkalova, P. S. Kachesova, D. E. Medvedeva, A. A. Maslov

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Biopsy location and tumor-associated macrophages in predicting malignant glioma recurrence using an in-silico model by Pejman Shojaee, Edwin Weinholtz, Nadine S. Schaadt, Friedrich Feuerhake, Haralampos Hatzikirou

“…In conclusion, the results show that localized biopsies provided more information about tumor behavior, especially at the interface of tumor and normal tissue (Edge).…”
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A Rare Case of Histiocytic Sarcoma Secondary to Gastrointestinal Stromal Tumor in the Stomach: Transdifferentiation or Synchronicity? by Jiankun Tong, Jean Luo, Pierre F. Saldinger, William H. Rodgers

“…Here, we report a 68-year-old female who developed histiocytic sarcoma following chemotherapy with imatinib (Gleevec) for gastrointestinal stromal tumor. Possible mechanisms of transdifferentiation from gastrointestinal stromal tumor to histiocytic sarcoma are discussed based on the features of our case and other two similar cases in the literature.…”
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