Ibuprofen reduces inflammation, necroptosis and protects photoreceptors from light-induced retinal degeneration by Ping-Wu Zhang, Zi-He Wan, Weifeng Li, Abhishek Vats, Kunal Mehta, Laura Fan, Lingli Zhou, Sean Li, Gloria Li, Casey J. Keuthan, Cynthia Berlinicke, Cheng Qian, Noriko Esumi, Elia J Duh, Donald J. Zack

“…Twenty-four hour after LD, retinal mRNA expression for the inflammatory-factors tumor necrosis factor (Tnf), interleukin-1 beta (Il1B), and C-C motif chemokine ligand 2 (Ccl2) increased by 10-, 17-, and 533-fold, respectively; in IBU-treated animals, the expression levels of these inflammatory factors were not significantly different from no-LD controls. …”
Get full text

A retrospective study of pembrolizumab combined with XELOX regimen in the treatment of advanced gastric cancer by FENG Huizhi, LIU Jingmei, BU Xiaoqian

“…Conclusion: The combination of pembrolizumab and XELOX regimen can regulate the expression levels of tumor markers in patients with advanced gastric cancer, prevent disease progression, improve patient quality of life, and help maintain intestinal microecology balance.…”
Get full text

Nomogram for predicting early cancer-related death due to recurrence after liver resection in hepatocellular carcinoma patients with Barcelona Clinic Liver Cancer (BCLC) stage B/C:... by Zhan-Cheng Qiu, Hao-Zheng Cai, You-Wei Wu, Jun-Long Dai, Wei-Li Qi, Chu-Wen Chen, Yue-Qing Xu, Chuan Li, Tian-Fu Wen

“…Results In our LASSO-logistic regression model, three variables were independently associated with the ECRD due to recurrence: the alpha-fetoprotein-tumor burden score (ATS score, Odd Ratio [OR]: 1.12, p = 0.001), BCLC stage (OR: 4.39, p < 0.001) and the aspartate transaminase (AST) to alanine transaminase (ALT) ratio (AAR, OR: 1.49, p = 0.027) and we established the nomogram model based on these three variables. …”
Get full text

Effect of Ginkgolide B on Non-Alcoholic Fatty Liver Disease based on Notch Signaling Pathway by Hong YU, Junzi WU, Bo SONG, Jun LI

“…After intervention for four weeks, some indexs such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were compared; the differences of transforming growth factor-β1(TGF-β1) and tumor necrosis factor-α(TNF-α) in liver and plasma were compared; HE staining method was used to observe liver histopathological changes; Real-time fluorescent quantitative PCR method and Western blot method were used to detect the protein and mRNA expression of Notch-3, Hes-1. …”
Get full text

Effect of Electroacupuncture Prestimulation with Mental Tri-Needles on the Inflammatory Response of Hippocampus in Aged Rats with Perioperative Neurocognitive Disorders by WANG Xiangfeng, HUANG Jinyan, LIU Wei, LUO Huiqin, WANG Guanhui, LIN Qin, CHEN Bin

“…Open field experiment and water maze test were used to evaluate the cognitive function; ELISA method was used to detect interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α in the plasma; HE staining was used to observe the cell morphology of hippocampal tissue; TUNEL staining was used to observe the apoptosis of hippocampal tissue; Western blot and real-time fluorescence quantitative PCR were used to detect the protein content and mRNA expression of IL-1β, IL-6 and TNF-α in hippocampal tissue.Results(1) Cognitive function: compared with the control group and the anesthesia group, the time of staying in the central quadrant, the number of crossings of the quadrant, the number of standing ups, the total distance of swimming, the swimming speed and the number of platform crossings in the operation group significantly decreased, and the latency and the time of staying in the target quadrant were significantly prolonged (<italic>P</italic>&lt;0.05); compared with the operation group, the time of staying in the central square, the number of crossings of the quadrant, the number of standing ups, the total distance of swimming, the swimming speed and the number of platform crossings in the acupuncture group significantly increased, and the latency and the time of staying in the target quadrant were significantly shortened (<italic>P</italic>&lt;0.05). (2) Levels of IL-1β, IL-6 and TNF-α in plasma: compared with the control group, the levels of IL-1β, IL-6 and TNF-α significantly increased in the anesthesia group, operation group and acupuncture group (<italic>P</italic>&lt;0.05); compared with the anesthesia group, the levels of IL-1β, IL-6 and TNF-α in the operation group significantly increased (<italic>P</italic>&lt;0.05); compared with the operation group, the levels of IL-1β, IL-6 and TNF-α in the acupuncture group significantly decreased (<italic>P</italic>&lt;0.05). (3) Morphology and apoptosis of hippocampal neurons: the most sever injury of hippocampal neurons occured in the operation group, showing as interstitial edema and a small amount of glial cell proliferation, while the injury of hippocampal neurons was slight and the morphology was relatively normal in the acupuncture group. …”
Get full text

Multimodal data deep learning method for predicting symptomatic pneumonitis caused by lung cancer radiotherapy combined with immunotherapy by Mingyu Yang, Jianli Ma, Chengcheng Zhang, Liming Zhang, Jianyu Xu, Shilong Liu, Jian Li, Jiabin Han, Songliu Hu

“…The region of interest (ROI) in the lung parenchyma was outlined separately from the tumor volume, and standard radiomic features were obtained through the use of 3D Slicer software. …”
Get full text

Warm and humid environment induces gut microbiota dysbiosis and bacterial translocation leading to inflammatory state and promotes proliferation and biofilm formation of certain ba... by Yinrui Guo, Jianlang He, Shaojie Li, Shiqi Zou, Haiting Zhang, Xin Yang, Jian Wang

“…On the one hand saliva and tongue coating samples were also taken from human subjects with “Dampness Syndrome” for microorganism culturing and to assess biofilm formation, on the other hand the co-culture products of a macrophage cell line RAW264.7 and Candida albicans and the effect of tumor necrosis factor-α (TNF-α) were evaluated for their impact on the proliferation and biofilm-forming abilities of different bacterial strains. …”
Get full text

Baicalin: a potential therapeutic agent for acute kidney injury and renal fibrosis by Xiaoming Li, Xiaoming Li, Rui Xu, Rui Xu, Dan Zhang, Ji Cai, Ji Cai, He Zhou, He Zhou, Tao Song, Tao Song, Xianyao Wang, Xianyao Wang, Qinghong Kong, Liujin Li, Zhaohui Liu, Zhixu He, Zhengzhen Tang, Jun Tan, Jidong Zhang, Jidong Zhang, Jidong Zhang

Get full text

Survey of the Actual Practices Used for Endoscopic Removal of Colon Polyps in Korea: A Comparison with the Current Guidelines by Jeongseok Kim, Tae-Geun Gweon, Min Seob Kwak, Su Young Kim, Seong Jung Kim, Hyun Gun Kim, Sung Noh Hong, Eun Sun Kim, Chang Mo Moon, Dae Seong Myung, Dong-Hoon Baek, Shin Ju Oh, Hyun Jung Lee, Ji Young Lee, Yunho Jung, Jaeyoung Chun, Dong-Hoon Yang, Eun Ran Kim, Intestinal Tumor Research Group of the Korean Association for the Study of Intestinal Diseases (KASID)

Get full text

Effect of Electroacupuncture Preconditioning on Inflammatory Factors of Rabbits after Spinal Cord Ischemia-Reperfusion Injury by Mengli YAO, Xianghua CHEN, Zhaohui CHEN, Hai WANG

“…Objective:To observe the effects of electroacupuncture preconditioning on the pathological changes of spinal cord tissue and the expression of inflammatory cytokines such as interleukin-1β(IL-1β), interleukin-6(IL-6), tumor necrosis factor-α(TNF-α), interleukin-1 receptor antagonist(IL-1Rα)after spinal cord ischemia-reperfusion injury, and to explore the protective mechanism of electroacupuncture on spinal cord ischemia-reperfusion injury in rabbits.Methods:A total of twenty-four New Zealand white rabbits were randomly divided into the sham operation group, the model group and the electroacupuncture group according to the random number table method, with eight cases in each group.The model was made by Zivin method in the model group and the electroacupuncture group, the abdominal cavity was opened after intravenous anesthesia at ear margin, the abdominal aorta was exposed and temporarily clamped, and the rabbit model of spinal cord ischemia-reperfusion injury was established after ischemia for thirty minutes.The model preparation and experimental animal treatment of the sham operation group were the same as those of the model group, however, the dissection was fully exposed without clamping the abdominal aorta.At thirty minutes before the induction of rabbit spinal cord ischemia-reperfusion model, SDZ-II electroacupuncture instrument was used to acupuncture bilateral"Xuanzhong"and"Yanglingquan"acupoints in the electroacupuncture group, intervention for thirty minutes.All rabbits were killed after intervention for twelve hours, and the L2-5 segments of spinal cord tissue were captured.HE staining method was used to observe the pathological changes of spinal cord tissues in the three groups; Immunohistochemical method was used to observe the localization and content changes of IL-1β, IL-6 and TNF-α; Enzyme-linked immunosorbent assay(ELISA)was used to detect the contents of IL-1β, IL-6, TNF-α and IL-1Rα in serum before modeling and 4, 8, 12 hours after ischemia-reperfusion.Results:①HE staining results: compared with the sham operation group, the number of neurons in spinal cord tissue in the model group decreased, the color of nucleus and cytoplasm of cells became lighter, and the boundary of nuclear membrane was not clear.In severe cases, the nucleus dissolved or even nucleolus disappeared, there were transparent areas around cells, and axons showed different degrees of degeneration such as enlargement, swelling and disappearance; compared with the model group, the number of neurons in the electroacupuncture group increased, the structure of most neurons was clear, the atrophy degree of nucleolus and nucleus was light, only a small amount of cells became deformed and necrosis, the damage degree of cells were lighter, and the density of surviving neurons increased.②Immunohistochemistry results: compared with the sham operation group, the expressions of IL-1β, IL-6 and TNF-α of spinal cord tissue in the model group were significantly increased(<italic>P</italic>&lt;0.05);compared with the model group, the contents of IL-1β, IL-6 and TNF-α in the spinal cord of rabbits in the electroacupuncture group were significantly decreased(<italic>P</italic>&lt;0.05).③ELISA results: Before modeling, there was no significant difference in the three groups(<italic>P</italic>&gt;0.05);compared with before modeling, the expressions of IL-1β, IL-6, TNF-α, IL-1Rα in serum of the three groups increased in different degrees at 4, 8 and 12 h after ischemia-reperfusion, with significantly significance(<italic>P</italic>&lt;0.05);compared with the sham operation group at the same time, the expressions of IL-1β, IL-6, TNF-α and IL-1Rα in the model group increased significantly at 4, 8 and 12 h after reperfusion(<italic>P</italic>&lt;0.05);compared with the model group at the same time, the expression of IL-1β and TNF-α in the electroacupuncture group decreased significantly at 4, 8, 12 h after reperfusion(<italic>P</italic>&lt;0.05).Conclusion:Electroacupuncture pretreatment can effectively alleviate the pathological injury of spinal cord and has a good protective effect on spinal cord ischemia-reperfusion injury, which may be related to inhibit the expression of IL-1β, IL-6 and TNF-α and promote the expression of IL-1Rα.…”
Get full text

Preventing sensory and motor dysfunctions in children receiving neurotoxic chemotherapy: PrepAir study - an update by Céline Hammadou, Bianca Celine Schmidli, Christina Schindera, Nicolas von der Weid, Uta Tacke, Oliver Faude, Sarah Koch, Fiona Streckmann

“…We have so far recruited N=19/131 children and adolescents (Basel: N=6, Freiburg: N=12, Bern: N=1; %f=47.4; mean age= 16.44 years; cancer type 42.1% leukemia ALL, 42.1% lymphoma, 15.8% solid tumor). Discussion/Conclusion We hypothesize that less children in the intervention group will develop symptoms of CIPN and will be able to maintain relevant motor and sensory functions which will enable them to receive their planned medical therapy but also to stay on the age-appropriate motor development level, improve their quality life and enhance social reintegration after therapy. …”
Get full text

Use of real-world data to study health services utilisation and comorbidities in long-term breast cancer survivors (the SURBCAN study): study protocol for a longitudinal population... by Xavier Castells, Beatriz Poblador-Plou, Alexandra Prados-Torres, Maria Sala, Javier Gorricho, Anna Jansana, Isabel Del Cura, Teresa Sanz Cuesta, A Gimeno Miguel, Manuela Lanzuela, Berta Ibañez, Ibai Tamayo, Conchi Moreno-Iribas, María Padilla-Ruiz, Maximino Redondo, Mercè Comas, Laia Domingo, Antonio Díaz-Holgado, Francisco Javier Salamanca, Mercè Abizanda, Talita Duarte, Javier Louro, María del Carmen Martínez, Cristóbal Molina, Guillermo Pérez, Ana María Muñoz, Óscar Toldos, Javier Baquedano, Rossana Burgui

Get full text

Bibliometric analysis of laryngeal cancer treatment literature (2003–2023) by Yan Zhao, Jiancheng Xue

“…Current research hotspots include disease prognosis, models, clinical trials, tumor recurrence, and surveillance. Notably, targeted therapy and immunotherapy are rapidly advancing fields. …”
Get full text

ATP1B3 may promote glioma proliferation and migration through MAPK/NF-KB signaling pathway by Qikang Yan, Quan Sun, Yan Feng, Qingyun Hu, Jinling Zhu

“…ObjectiveTo investigate the function of ATPase Na+/K+ Transporting Subunit Beta 3 (ATP1B3) in gliomas and the molecular mechanisms associated with them in order to identify a novel target and approach for glioma clinical diagnosis and treatment.MethodsThe Cancer Genome Atlas (TCGA), a public tumor database, and the Chinese Glioma Genome Atlas (CGGA) were used to evaluate the differential expression of ATP1B3 in glioma cells of various grades. …”
Get full text

The diagnostic value and validation of IL-22 combined with sCD40L in tuberculosis pleural effusion by Yuzhen Xu, Jing Wu, Qiuju Yao, Qianqian Liu, Huaxin Chen, Bingyan Zhang, Yuanyuan Liu, Sen Wang, Lingyun Shao, Wenhong Zhang, Qinfang Ou, Yan Gao

“…The concentrations of interleukin-1β (IL-1β), IL-4, IL-6, IL-10, IL-17 A, IL-17 F, IL-21, IL-22, IL-25, IL-31, IL-33, interferon-γ (IFN-γ), soluble CD40 ligand (sCD40L) and tumor necrosis factor-α (TNF-α) in pleural effusion were measured using a multiplex cytokine assay. …”
Get full text

Early treatment discontinuation in patients with deficient mismatch repair or microsatellite instability high metastatic colorectal cancer receiving immune checkpoint inhibitors by Chiara Cremolini, Sara Lonardi, Filippo Pietrantonio, Julien Taieb, David Tougeron, Margherita Ambrosini, Michael J Overman, Alice Boilève, Lisa Salvatore, Rosine Guimbaud, Priya Jayachandran, Frank A Sinicrope, Thibault Mazard, Javier Ros, Vincenzo Nasca, Simon Pernot, Emily Alouani, Marie Decraecker, Emilie Hafliger, Pauline Parent

“…Outcomes were adjusted for patient/tumor characteristics. Primary endpoint was progression-free survival (PFS) and secondary endpoints were objective response rate (ORR), overall survival (OS) and safety.Results Of 976 patients, 137 and 394 were allocated to the ETD and LTD groups, respectively. …”
Get full text

Genetic characteristics involving the PD-1/PD-L1/L2 and CD73/A2aR axes and the immunosuppressive microenvironment in DLBCL by Tingting Zhang, Zhenzhen Zhang, Xiubao Ren, Jin He, Zhengzi Qian, Bin Meng, Lei Jiao, Hengqi Liu, Lanfang Li, Lihua Qiu, Shiyong Zhou, Wenchen Gong, Huilai Zhang, Xianhuo Wang

“…The immunosuppressive effect of these two pathways on the tumor microenvironment was evaluated via RNA sequencing. …”
Get full text

RETRACTED: Mechanism of action of Asparagus officinalis extract against multiple myeloma using bioinformatics tools, in silico and in vitro study by Yanju Li, Xu Yang, Feiqing Wang, Feiqing Wang, Jianing Zhao, Chike Zhang, Dan Wu, Bo Yang, Rui Gao, Peng Zhao, Yun Zan, Min Su, Zhixu He, Yang Liu, Yang Liu, Yang Liu, Jishi Wang, Dongxin Tang

“…Its main components have tumor-prevention, immune system-enhancement, and anti-inflammation effects. …”
Get full text

Clinical Features at Onset and Genetic Characterization of Pediatric and Adult Patients with TNF-α Receptor—Associated Periodic Syndrome (TRAPS): A Series of 80 Cases from the AIDA... by Carla Gaggiano, Antonio Vitale, Laura Obici, Giampaolo Merlini, Alessandra Soriano, Ombretta Viapiana, Marco Cattalini, Maria Cristina Maggio, Giuseppe Lopalco, Davide Montin, Masen Abdel Jaber, Lorenzo Dagna, Raffaele Manna, Antonella Insalaco, Matteo Piga, Francesco La Torre, Virginia Berlengiero, Viviana Gelardi, Luisa Ciarcia, Giacomo Emmi, Piero Ruscitti, Francesco Caso, Rolando Cimaz, José Hernández-Rodríguez, Paola Parronchi, Ludovico Luca Sicignano, Elena Verrecchia, Florenzo Iannone, Jurgen Sota, Salvatore Grosso, Carlo Salvarani, Bruno Frediani, Roberto Giacomelli, Maria Antonietta Mencarelli, Alessandra Renieri, Donato Rigante, Luca Cantarini

“…This study explores demographic, clinical, and therapeutic features of tumor necrosis factor receptor-associated periodic syndrome (TRAPS) in a cohort of 80 patients recruited from 19 Italian referral Centers. …”
Get full text

Global, regional, and national epidemiology of childhood neuroblastoma (1990–2021): a statistical analysis of incidence, mortality, and DALYsResearch in context by Jusen Nong, Cheng Su, Changhua Li, Congjun Wang, Wei Li, Yong Li, Peng Chen, Yanqiang Li, Zihao Li, Xinjin She, Zuxin Yuan, Sentian Liu, Chao Chen, Qian Liao, Yige Luo, Bo Shi

“…Summary: Background: Neuroblastoma is the most prevalent extracranial solid tumor in pediatric populations worldwide, representing 8–10% of childhood malignancies and contributing to approximately 15% of pediatric cancer-related fatalities. …”
Get full text