Klebsiella pneumoniae induces dose-dependent shock, organ dysfunction, and coagulopathy in a nonhuman primate critical care model by Jeffrey R. Strich, Marcos J. Ramos-Benitez, Seth Warner, Heather Kendall, Sydney Stein, Andrew P. Platt, Sabrina C. Ramelli, Shelly J. Curran, Izabella Lach, Kiana Allen, Ashley Babyak, Luis J. Perez-Valencia, Mahnaz Minai, Junfeng Sun, Kevin M. Vannella, Derron Alves, Richard Herbert, Daniel S. Chertow

“…Neutrophil activation evidenced by increased CD11b expression, decreased CD62L expression, and increased circulating levels of myeloperoxidase, lactoferrin, and neutrophil extracellular traps; monocyte activation evidenced by increased circulating levels of interleukin-6, tumor necrosis factor-alpha, granulocyte-macrophage colony-stimulating factor, and monocyte chemotactic protein-1; and endothelial activation evidenced by increased circulating levels of syndecan-1 and angiopoietin-II were all consistent with human sepsis. …”
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Synthetic CB1 Cannabinoids Promote Tunneling Nanotube Communication, Cellular Migration, and Epithelial–Mesenchymal Transition in Pancreatic PANC-1 and Colorectal SW-620 Cancer Cel... by David A. Bunsick, Leili Baghaie, Yunfan Li, Abdulrahman M. Yaish, Emilyn B. Aucoin, Elizabeth Skapinker, Rashelle Aldbai, Myron R. Szewczuk

“…During this reprogramming process, cancer cells’ metabolism and other cellular activities are integrated and mutually regulated by tunneling nanotube communications to alter their specific metabolic functional drivers of tumor growth and progression. Here, we investigated the in vitro effects of the synthetic CB1 cannabinoids AM-404, arvanil, and olvanil on human pancreatic PANC-1 and colorectal SW-620 cancer cell lines to understand further cellular behaviors and the potential risks of their use in cancer therapy. …”
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Immunotherapy combined with chemotherapy without locoregional radiotherapy in de novo metastatic nasopharyngeal carcinoma: two case reports and a literature review by Yingna Gao, Xiaoqiong Shi, Jianqiao He, Hui Yao, Guoning Yu, Lin Zhao, Yi Ma, Yi Ma, Hongliang Zheng, Minhui Zhu, Caiyun Zhang

“…However, patients with a high tumor burden do not benefit from additional LRRT, which inevitably results in toxicity. …”
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Direct effects of prolonged TNF-α and IL-6 exposure on neural activity in human iPSC-derived neuron-astrocyte co-cultures by Noah Goshi, Doris Lam, Chandrakumar Bogguri, Vivek Kurien George, Aimy Sebastian, Jose Cadena, Nicole F. Leon, Nicholas R. Hum, Dina R. Weilhammer, Nicholas O. Fischer, Heather A. Enright

“…A common factor among these conditions is a sustained immune response and increased levels of inflammatory cytokines. Tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) are two such cytokines that are elevated in patients diagnosed with long-COVID and ME/CFS. …”
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Progressive systemic inflammation precedes decompensation in compensated cirrhosis by Rubén Sánchez-Aldehuelo, Càndid Villanueva, Joan Genescà, Juan Carlos García-Pagán, Elisa Castillo, José Luis Calleja, Carles Aracil, Rafael Bañares, Luis Téllez, Lorena Paule, Rosa María Morillas, María Poca, Beatriz Peñas, Salvador Augustin, Juan G. Abraldes, Edilmar Alvarado-Tapias, Jaume Bosch, Agustín Albillos

“…We assessed markers of inflammation (interleukin-6 [IL-6], tumor necrosis factor-alpha, von Willebrand factor [vWF], C-reactive protein), macrophage activation (CD14, CD163), intestinal barrier integrity (fatty acid-binding protein [FABP], haptoglobin), and bacterial translocation (lipopolysaccharide [LPS]). …”
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Co-isolation of human donor eye cells and development of oncogene-mutated melanocytes to study uveal melanoma by Yunxi Chen, Eva Jin, Mohamed Abdouh, Éric Bonneil, Daniel Alexander Jimenez Cruz, Thupten Tsering, Qianqian Zhou, Aurélie Fuentes-Rodriguez, Alexandra Bartolomucci, Alicia Goyeneche, Solange Landreville, Miguel N. Burnier, Julia V. Burnier

“…Abstract Background Uveal melanoma (UM) is the most common intraocular tumor in adults, arises either de novo from normal choroidal melanocytes (NCMs) or from pre-existing nevi that stem from NCMs and are thought to harbor UM-initiating mutations, most commonly in GNAQ or GNA11. …”
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Exploratory profiling of metabolites in cerebrospinal fluid using a commercially available targeted LC-MS based metabolomics kit to discriminate leptomeningeal metastasis by Soojin Jang, Ho-Shin Gwak, Kyue-Yim Lee, Jun Hwa Lee, Kyung-Hee Kim, Jong Heon Kim, Jong Bae Park, Sang Hoon Shin, Heon Yoo, Yun-Sik Dho, Kyu-Chang Wang, Byong Chul Yoo

“…Methods We quantitatively measured amino acids, biogenic amines, hexoses, acylcarnitines (AC), cholesteryl esters (CE), glycerides, phosphatidylcholines (PC), lysophosphatidylcholines (LPC), sphingomyelins (SM), and ceramides (Cer) in 117 CSF samples from various groups of healthy controls (HC, n = 10), patients with LM (LM, n = 47), parenchymal brain tumor (PBT, n = 45), and inflammatory disease (ID, n = 13) with internal standards using the Absolute IDQ- p400® targeted mass spectrometry kit. …”
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D-mannose alleviates chronic periodontitis in rats by regulating the functions of neutrophils by Xue Li, Xueting Chen, Qingyu Zhu, Pengye Zhang, Shunxue Nan, Lei Lv, Shengcai Qi

“…Then, immunofluorescence (IF), Western Blot, and RT-PCR were applied to assess the expression levels of pro-inflammatory cytokines (IL-1β, IL-6, and IL-17), anti-inflammatory cytokine (IL-10), tumor necrosis factor-alpha (TNF-α), granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), ten-eleven translocation 2 (TET2), and key glycolytic enzymes (HK1, HK2, PFKFB3), and to examine D-mannose’s impact on the recruitment and activation of neutrophils in the gingiva. …”
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High-fat diet-induced liver injury in Channa argus through lipid metabolism, anti-oxidative status, apoptosis, and inflammation by Jiaxin Tian, Ying Li, Jiwu Wan, Zhinan Yang, Guiqin Wang

“…At 90 days, the L22 group exhibited a significant upregulation of mRNA expression levels for liver inflammatory factors, including interleukin-1β (IL-1β), IL-8, IL-10, and tumor necrosis factor-α (TNF-α). At 90 days, the L22 group exhibited upregulation of pro-inflammatory genes NF-κB, p65, and MyD88, alongside increased expression of apoptosis-related genes Bax, caspase-3 (Cas3), Cas8, and Cas9. …”
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Dietary patterns related to triglyceride glucose index and risk of type 2 diabetes: a large-scale cohort study by Dong Liu, Dong Liu, Ziwei Liu, Yue Wu, Yan Hong, Jinghao Fang, Ying Lu, Guangfei Xu, Peipei Kang, Tong Liu, Li-Hua Chen, Li-Hua Chen

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The Multifaceted Roles of Myrrha in the Treatment of Breast Cancer: Potential Therapeutic Targets and Promises by Anwar Shams MD, MSc, PhD, Abdullah Ahmed Alzahrani, Taghreed A Ayash MSc, PhD, Shadi Tamur MD, FRCPC, FAAP, Majed AL-Mourgi MD, FRCS, FCCP, FACS

“…Moreover, the GOBO analysis shows an elevated expression profile of the PTGS2/ESR2/EGFR/JUN/MMP2 genes’ signature in the most aggressive breast cancer subtype (Basal) in breast tumor samples and breast cancer cell lines. Furthermore, the STRING protein interaction network and the KEGG analyses indicate that myrrh exerts therapeutic effects on breast cancer by regulating several biological processes such as cell proliferation, cell migration, apoptosis, and various signaling pathways, including TNF, PI3K-Akt, NF-κB, and MAPK. …”
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The PD-1 with PD-L1 Axis Is Pertinent with the Immune Modulation of Atrial Fibrillation by Regulating T Cell Excitation and Promoting the Secretion of Inflammatory Factors by Guodong Chang, Yingwei Chen, Zichang Liu, Yong Wang, Wenkun Ge, Yongan Kang, Shuling Guo

“…Forty-five patients with atrial fibrillation admitted to the cardiology department of our hospital from July 2019 to March 2021 were selected to be included in the atrial fibrillation group, and another 45 healthy volunteers were selected as the control group to compare the changes of T cell CD69 and human leukocyte antigen-DR (HLA-DR) expression in the peripheral blood of the two study groups; compare the changes of programmed death factor-1 on CD4+ and CD8+ lymphocytes in the peripheral blood of the two groups (PD-1) expression changes and PD-L1 and PD-L2 expression changes on peripheral blood myeloid dendritic cells (mDCs) cells; compare the changes of interleukin-2, interleukin-6, interleukin-10, and interleukin-17A (IL-2, IL-6, IL-10, and IL-17), tumor necrosis factor (TNF), and interferon gamma (IFN-γ) concentrations on peripheral blood inflammatory factors in the two groups; and isolate the two groups of peripheral blood mDCs cells; α interferon upregulated PD-L1 expression in the cells and analyzed the effect of PD-L1 expression on the ability of mDCs to stimulate T cells to secrete cytokines.Results. …”
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Differentiating Liver Metastases from Primary Liver Cancer: A Retrospective Study of Imaging and Pathological Features in Patients with Histopathological Confirmation by Laura Andreea Ghenciu, Mirela Loredana Grigoras, Luminioara Maria Rosu, Sorin Lucian Bolintineanu, Laurentiu Sima, Octavian Cretu

“…Pathological features recorded included tumor differentiation, vascular invasion, necrosis, and fibrosis. …”
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Can exercise as a complementary technique manage inflammatory markers in women with breast cancer who are overweight and obese? A systematic review and meta-analysis by Liang Tan, Jinyu Mei, Ruihong Tang, Duo Huang, Kai Qi, Zbigniew Ossowski, Xiaoning Wang

“…Exercise significantly reduced C-reactive protein (CRP) (MD: −0.52, 95 % CI: −0.94 to −0.11; p = 0.01; heterogeneity p < 0.1), interleukin-6 (IL-6) (MD: −0.87, 95 % CI: −1.62 to −0.11; p = 0.02; heterogeneity p < 0.1), and leptin (MD: −0.92, 95 % CI: −1.71 to −0.13; p = 0.02; heterogeneity p < 0.1) levels and exercise significantly increased adiponectin levels (MD: 0.89, 95 % CI: 0.03–1.75, p = 0.04; heterogeneity p < 0.1) but had no effect on tumor necrosis factor-α (TNF-α) (MD: −0.26, 95 % CI: −0.82–0.29; p = 0.35; heterogeneity p < 0.1) and IL-10 (MD: 0.14, 95 % CI: −0.17–0.45; p = 0.37; heterogeneity p = 0.45) were not significant. …”
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Evaluation of treatment for diffuse large B-cell lymphoma using plasma D-dimer levels by Ruonan Shao, Danchen Meng, Beibei Gao, Lu Zhang, Qingqi Meng, Yanqiu Hou, Zhangbiao Long, Jinsong Yan, Xiaofeng Shi

“…Abstract It has been documented that D-dimer levels have potential utility as a measure of tumor activity in diffuse large B-cell lymphoma (DLBCL), however whether it can be used as a predictive marker of treatment outcome has not been established. …”
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Systemic and mammary inflammation and mammary gland development of Holstein dairy cows around dry-off and calving by J. Gao, T.N. Marins, J.O.S. Calix, Z. Qi, C.G. Savegnago, A.M. Roper, M.W. Woldemeskel, J.K. Bernard, S. Tao

“…After dry-off, LTD cows had increased circulating concentrations of tumor necrosis factor (TNF)-α, haptoglobin, and fibrinogen, suggesting upregulated inflammation. …”
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Prognostic prediction for inflammatory breast cancer patients using random survival forest modeling by Yiwei Jia, Chaofan Li, Cong Feng, Shiyu Sun, Yifan Cai, Peizhuo Yao, Xinyu Wei, Zeyao Feng, Yanbin Liu, Wei Lv, Huizi Wu, Fei Wu, Lu Zhang, Shuqun Zhang, Xingcong Ma

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A KSHV RNA-binding protein promotes FOS to inhibit nuclease AEN and transactivate RGS2 for AKT phosphorylation by Vladimir Majerciak, Beatriz Alvarado-Hernandez, Yanping Ma, Shivalee Duduskar, Alexei Lobanov, Maggie Cam, Zhi-Ming Zheng

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Correlation analysis of DLG5 and PD-L1 expression in triple-negative breast cancer by Jingmin Che, Bo Chen, Xusheng Wang, Baoe Liu, Cuixiang Xu, Huxia Wang, Jingying Sun, Qing Feng, Xiangrong Zhao, Zhangjun Song

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USP22 inhibits microglial M1 polarization by regulating the PU.1/NLRP3 inflammasome pathway by Ming-chen Yu, Xiao-lin Li, Ming-liang Ning, Zhen-zhong Yan, Wan-tao Yu

“…Enzyme-linked immunosorbent (ELISA) assay was employed to determine the levels of inflammatory cytokines tumor necrosis factor-alpha (TNF-α), IL-1 β, and IL-10 in the cells. …”
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