Clinical and molecular characteristics and long-term outcomes of pediatric intracranial meningiomas: a comprehensive analysis from a single neurosurgical center by Leihao Ren, Jiaojiao Deng, Hiroaki Wakimoto, Qing Xie, Ye Gong, Lingyang Hua

“…Abstract Background Meningioma represents the most common intracranial tumor in adults. However, it is rare in pediatric patients. …”
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Elocalcitol, a fluorinated vitamin D derivative, prevents high-fat diet-induced obesity via SCAP downregulation and miR-146a-associated mechanisms by Monika Jürgenson, Keerthana Chithanathan, Aivar Orav, Külli Jaako, Janeli Viil, Mithu Guha, Kalev Kask, Alexander Zharkovsky

“…We also demonstrated that elocalcitol prevents an increase in the expression of proinflammatory cytokines such as interleukin-1 beta (Il1b), tumor necrosis factor-alpha (Tnf), and interleukin-18 (Il18), and this effect was associated with upregulation of microRNA-146a (miR-146a). …”
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Long-term neuropsychologic outcome of pre-emptive mTOR inhibitor treatment in children with tuberous sclerosis complex (TSC) under 4 months of age (PROTECT), a two-arm, randomized,... by Jan H. Driedger, Julian Schröter, PROTECT-Study Group, Steffen Syrbe, Afshin Saffari

“…Secondary endpoints include neuropsychologic outcomes at 12 months of age, seizure frequency, cardiac and cerebral tumor load, and safety assessments. Inclusion criteria are a definite TSC diagnosis and an age below four months at enrolment. …”
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Factores de riesgo modificables en pacientes con cáncer de mama by Wilmer Ramírez Carmona, Julio Padrón González, Maikel Valero Carmona, Beatriz Díaz Fabregat

“…<strong>Fundamento:</strong> el cáncer de mama en Cuba constituye la primera localización y segunda causa de muerte por tumores malignos en el sexo femenino. La identificación de factores de riesgo modificables, es todavía un reto dentro del trabajo comunitario. …”
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Therapeutic efficacy and mechanism of artesunate for mouse model of polycystic ovary syndrome by WANG Xueling, WANG Xueling, ZHONG Peiling, ZHONG Peiling, ZHAO Zhipeng

“…After steroidogenic human granulosa-like tumor cell line KGN were exposed to 100 μmol/L DHEA to simulate the hyperandrogen environment of PCOS, and then treated with 5 and 10 μg/mL AS for 24 h, the protein levels of endoplasmic reticulum stress signaling pathway was detected by Western blotting. …”
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Prognostic value of serum inflammatory markers in patients with esophageal squamous cell carcinoma undergoing surgery: a two-center retrospective cohort study by Yaqin Dong, Fan Wang, Jiaying Deng, Tong Tong, Xiangxun Chen, Liming Wu, Yichun Wang, Mei Kang, Yutong Xu, Guangjie Shi, Liyang Zhu

“…Results The Multi-variable Cox regression analysis revealed that tumor, node, metastasis stage, smoking status, neutrophil-platelet score, and prognostic nutritional index were independent postoperative prognostic factors for patients with esophageal cancer (P < 0.05). …”
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Yunvjian decoction attenuates lipopolysaccharide-induced acute lung injury by inhibiting NF-κB/NLRP3 pathway and pyroptosis by Fanxuan Zhang, Fang Wang, Lisha Zhao, Leqian Wang, Wenjing Li, Feihua Huang, Feihua Huang, Nani Wang, Nani Wang

“…YNJ-containing serum also decreased the secretion of tumor necrosis factor-α, IL-6, and IL-1β in LPS-stimulated RAW264.7 macrophages, and promoted macrophage polarization toward an M2 phenotype. …”
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Evaluating the Effectiveness of Cyclin-Dependent Kinase 4/6 Inhibitors in Early- and Very Early-Onset Metastatic Breast Cancer: A Multicenter Study by Akif Doğan, Nurullah İlhan, Goncagül Akdağ, Sedat Yıldırım, Mustafa Seyyar, Zeynep Yüksel Yaşar, Hande Nur Erölmez, Heves Sürmeli, Buğra Öztosun, Özlem Nuray Sever, Hatice Odabaş, Mahmut Emre Yıldırım, Devrim Çabuk, Nedim Turan, Mahmut Gümüş

“…Additional factors associated with poorer outcomes included liver metastasis, progesterone receptor negativity, high tumor grade, and the concurrent use of fulvestrant with CDK4/6 inhibitors. …”
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Dietary protein requirement of Chinese hook snout carp (Opsariichthys bidens) and transcriptomic analysis of the liver in response to different protein diets by Yijiang Bei, Linqiang He, Jin Jing, Xiaoming Chen, Fan Yuan, Gaohua Yao, XueYan Ding, Lei Wang, Fan Zhou

“…., NF-kappa B inhibitor alpha, tumor necrosis factor alpha-induced protein 3, complement C3, and C7) were significantly upregulated in the P47 group. …”
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Potential Mechanisms and Effects of Dai Bai Jie Ethanol Extract in Preventing Acute Alcoholic Liver Injury by Niantong Xia, Hongwei Xue, Yihang Li, Jia Liu, Yang Lou, Shuyang Li, Yutian Wang, Juan Lu, Xi Chen

“…DBJ-3 reduced malondialdehyde (MDA), reactive oxygen species (ROS), and inflammatory factors, such as tumor necrosis factor (TNF-α), interleukin-1β (IL-1β), and interleukin 6 (IL-6), while increasing superoxide dismutase (SOD) and glutathione S-transferase (GST) activities. …”
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The potential benefits of radiotherapy in elderly patients with early-stage triple-negative breast cancer by Zheng Xu, Zheng Xu, Chengdong Qin, Binxiao Cao, Binxiao Cao, Pengcheng Ruan, Pengcheng Ruan, Mianhao Zhang, Mianhao Zhang, Guidong Chen, Guidong Chen

“…Cox regression analysis on the non-RT cohort within the BCS group identified age, tumor grade, and T stage as independent risk factors. …”
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The Efficacy of Moxibustion on the Serum Levels of CXCL1 and β-EP in Patients with Rheumatoid Arthritis by Siyu Tao, Xue Wang, Chenxi Liao, Yan Xiong, Jie Tang, Nannan Jiang, Yuan Li, Xinyue Hu, Rouxian Shuai, Yueyue Wang, Ping Wu

“…Trial endpoints were change (∆) in symptoms, measured by Ritchie’s articular index (RAI), swollen joint count (SJC), and laboratory indicators, measured by the level of CXCL1, β-EP, tumor necrosis factor-a (TNF-α), and interleukin-1β (IL-1β). …”
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Therapeutic Potential of Clove Oil in Mitigating Cadmium-Induced Hepatorenal Toxicity Through Antioxidant, Anti-Inflammatory, and Antiapoptotic Mechanisms by Inas M. Elgharib, Fatma M. Abdelhamid, Gehad E. Elshopakey, Hatem Sembawa, Talat A. Albukhari, Waheed A. Filimban, Rehab M. Bagadood, Mohamed E. El-Boshy, Engy F. Risha

“…Cadmium toxicity caused elevated expression of liver apoptosis markers, such as tumor necrosis factor-alpha (TNF-α) and caspase-3, and inflammation. …”
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Selective expression and significance of ACKR2 in lung aerocytes by Alberto Mantovani, Gianluigi Condorelli, Raffaella Bonecchi, Massimo Locati, Marina Sironi, Roberta Carriero, Francesca Albano, Valeria Mollica Poeta, Lucia Zotti, Alessandra Castagna, Arianna Felicetta, Alessandro Mesaglio, Elisa Zaghen, Arianna Capucetti, Rachele Di Donato, Mattia Laffranchi, Matteo Massara, Silvano Sozzani

“…Previous findings suggest that the genetic absence of ACKR2 leads to heightened tumor growth in inflammation-driven models. Conversely, mice lacking ACKR2 exhibit protection against lung metastasis in melanoma and breast cancer models. …”
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Immunoregulatory programs in anti‐N‐methyl‐D‐aspartate receptor encephalitis identified by single‐cell multi‐omics analysis by Xinhui Li, Yicong Xu, Weixing Zhang, Zihao Chen, Dongjie Peng, Wenxu Ren, Zhongjie Tang, Huilu Li, Jin Xu, Yaqing Shu

“…Additionally, activation of Toll‐like receptor 2 (TLR2) in myeloid cells was noted, which may connect to tumor necrosis factor‐alpha (TNF‐α) secretion. This cytokine may contribute to the activation of B and T cells, thereby perpetuating immune dysregulation. …”
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Uncertainty quantification in multi-parametric MRI-based meningioma radiotherapy target segmentation by Lana Wang, Zhenyu Yang, Zhenyu Yang, Dominic LaBella, Zachary Reitman, John Ginn, Jingtong Zhao, Justus Adamson, Kyle Lafata, Kyle Lafata, Kyle Lafata, Evan Calabrese, John Kirkpatrick, Chunhao Wang

“…PurposeThis work investigates the use of a spherical projection-based U-Net (SPU-Net) segmentation model to improve meningioma segmentation performance and allow for uncertainty quantification.MethodsA total of 76 supratentorial meningioma patients treated with radiotherapy were studied. Gross tumor volumes (GTVs) were contoured by a single experienced radiation oncologist on high-resolution contrast-enhanced T1 MRI scans (T1ce), and both T1 and T1ce images were utilized for segmentation. …”
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Correlation between Hyperalgesia and Upregulation of TNF-α and IL-1β in Aqueous Humor and Blood in Second Eye Phacoemulsification: Clinical and Experimental Investigation by Ruibo Yang, Chang Liu, Di Yu, Lechong Ma, Yan Zhang, Shaozhen Zhao

“…The aim of this study was to explore the correlation between intraoperative hyperalgesia of the second eye and the dynamic changes of tumor necrosis factor (TNF)-α and interleukin (IL)-1β levels in aqueous humor (AH) of the second eye and whole blood after the first eye cataract surgery. …”
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Neuroprotective role of epigallocatechin-3-gallate, albeginin and melanoxetin in alzheimer's disease by Arif Malik, Mehreen Hassan, Sulayman Waquar, Muhammad Wasim, Anam Naz, Faryal M. Awan, Muhammad T. Khan, Ali I. Khawaja, Sumera Zaib, Jamshed Iqbal, Ayesha Zahid, Marvi Marvi, Javeid Iqbal, Heng Wang, Dong-Qing Wei

“…Study design: The study targeted specific AD-related proteins, including acetylcholinesterase (AChE), alpha serine/threonine-protein kinase (AKT-1), β-secretase-1 (BACE-1), cyclooxygenase-2 (COX-2), caspase-3, glycogen synthase kinase-3 (GSK-3), interleukin-6 (IL-6), mitogen-activated protein kinase-2 (MAPK-2), matrix metalloproteins-8 (MMP-8), N-methyl-d-aspartate receptor (NMDAR), Peptidyl arginine deiminase-2 (PAD-2), Presenilin-1 (PSEN-1), mitogen-activated protein kinase-14 (MAPK-14/P38), and tumor necrosis factor-alpha (TNF-α). Methods: Before conducting experimental work, molecular dynamic (MD) simulations were performed to assess the binding affinity of EGCG, albeginin, and melanoxetin against the selected targets. …”
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A generative whole-brain segmentation model for positron emission tomography images by Wenbo Li, Zhenxing Huang, Hongyan Tang, Yaping Wu, Yunlong Gao, Jing Qin, Jianmin Yuan, Yang Yang, Yan Zhang, Na Zhang, Hairong Zheng, Dong Liang, Meiyun Wang, Zhanli Hu

“…Additionally, clinical tolerance rates, which are determined by the tumor background ratio, have confirmed the ability of the method to distinguish highly metabolic regions accurately from normal regions, reinforcing its clinical applicability. …”
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NCAPD3 promotes diffuse large B-cell lymphoma progression through modulating SIRT1 expression in an H3K9 monomethylation-dependent manner by Tiange Lu, Juan Yang, Yiqing Cai, Mengfei Ding, Zhuoya Yu, Xiaosheng Fang, Xiangxiang Zhou, Xin Wang

“…In vivo experiments further indicated targeting NCAPD3 suppressed tumor growth. Noteworthily, NCAPD3 deficiency disturbed the mitosis, triggering the formation of aneuploids. …”
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