Two Cases of Sarcoma Arising in Giant Cell Tumor of Bone Treated with Denosumab by Cory Julian Broehm, Erika L. Garbrecht, Jeff Wood, Therese Bocklage

“…Giant cell tumor (GCT) of bone is a generally benign, but often locally aggressive, neoplasm of bone, with a propensity for recurrence. …”
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TREM2 promotes the formation of a tumor-supportive microenvironment in hepatocellular carcinoma by Hanrui Guo, Meiling Wang, Caiya Ni, Chun Yang, Chunxue Fu, Xiaoman Zhang, Xueling Chen, Xiangwei Wu, Jun Hou, Lianghai Wang

“…This study aimed to evaluate the role of TREM2 in the tumor microenvironment in the context of HCC progression. …”
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The Clinical Impact of Tumor Grade Heterogeneity in Nonmuscle- invasive Urothelial Carcinoma of the Bladder by Meftun Culpan, Ferhat Keser, Ayberk İplikci, Gözde Kır, Gökhan Atış, Asif Yıldırım

“…Objective: This study aimed to determine the oncological outcomes of mixed-grade tumors by comparing them with pure low-grade and high-grade tumors. …”
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MRI Findings of Causalgia of the Lower Extremity Following Transsphenoidal Resection of Pituitary Tumor by D. Ryan Ormond, Augustine L. Moscatello, Raj Murali

“…Here we report a case of lower extremity causalgia following elective transsphenoidal resection of a pituitary tumor in a young man. Clinical Presentation. A 33-year-old man with acromegaly underwent elective sublabial transsphenoidal resection of his pituitary tumor. …”
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Conservation Law Analysis in Numerical Schema for a Tumor Angiogenesis PDE System by Pasquale De Luca, Livia Marcellino

Subjects: “…tumor angiogenesis…”
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Four-Rod Stabilization of Severely Destabilized Lumbar Spine Caused by Metastatic Tumor by Isao Shibuya, Koichi Sairyo, Yasuo Kanamori, Akira Dezawa

“…We report a case of a 67-year-old female with severely destabilized lumbar spine caused by metastatic malignant tumor. The primary lesion was a thyroid follicular adenocarcinoma. …”
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USP4-mediated CENPF deubiquitylation regulated tumor metastasis in colorectal cancer by Zhongdong Xie, Hanbin Lin, Yuecheng Wu, Yanan Yu, Xintong Liu, Yating Zheng, Xiaojie Wang, Jiashu Wu, Meifang Xu, Yuting Han, Qiongying Zhang, Yu Deng, Lin Lin, Yan Linzhu, Li Qingyun, Xinjian Lin, Ying Huang, Pan Chi

“…We found that CENPF expression was preferentially elevated in CRC tissues compared to adjacent normal tissues, with significantly higher levels in CRC patients with tumor recurrence. Furthermore, a multicenter cohort study demonstrated that upregulated CENPF expression was strongly associated with poorer disease-free survival in CRC. …”
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Myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment and their targeting in cancer therapy by Shuyan He, Lu Zheng, Chunjian Qi

“…This review describes the origins and phenotypes of MDSCs, their biological roles in tumor progression, and regulatory mechanisms, with a focus on current therapeutic approaches targeting tumor-associated MDSCs. …”
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Mucinous Carcinomatosis: A Rare Association between an Ovarian Tumor and an E-GIST by Hugo Palma Rios, André Goulart, Pedro Leão

“…Pseudomyxoma peritonei (PMP) and extragastrointestinal stromal tumors (E-GISTs) are both rare entities. Most of the time, PMP is associated with an appendiceal tumor. …”
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Surgical Management of Endolymphatic Sac Tumor: A Systematic Review and Meta-Analysis by Federico Maria Gioacchini, Giuseppe Chiarella, Shaniko Kaleci, Giannicola Iannella, Pasquale Viola, Davide Pisani, Alfonso Scarpa, Michele Tulli, Massimo Re

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Tumor mutation burden for predicting immune checkpoint blockade response: the more, the better by Ming Zheng

“…Background Recently, the US Food and Drug Administration (FDA) has approved immune checkpoint blockade (ICB) for treating cancer patients with tumor mutation burden (TMB) >10 mutations/megabase (mut/Mb). …”
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Initial validation of the clinical significance of the NETest in Japanese gastroenteropancreatic neuroendocrine tumor patients by Hao Zhang, Takahiro Tsuchikawa, Satoshi Takeuchi, Kenji Hirata, Kimitaka Tanaka, Aya Matsui, Yoshitsugu Nakanishi, Toshimichi Asano, Takehiro Noji, Toru Nakamura, Shintaro Takeuchi, Masataka Wada, Satoshi Hirano

Subjects: “…gastroenteropancreatic neuroendocrine tumor…”
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Ezrin Polarization as a Diagnostic Marker for Circulating Tumor Cells in Hepatocellular Carcinoma by Ibrahim Büdeyri, Olaf Guckelberger, Elsie Oppermann, Dhruvajyoti Roy, Svenja Sliwinski, Felix Becker, Benjamin Struecker, Thomas J. Vogl, Andreas Pascher, Wolf O. Bechstein, Anna Lorentzen, Mathias Heikenwalder, Mazen A. Juratli

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Tumor organoids in cancer medicine: from model systems to natural compound screening by Rong Cong, Can Lu, Xinying Li, Zhijie Xu, Yaqin Wang, Shusen Sun

“…Context The advent of tissue engineering and biomedical techniques has significantly advanced the development of three-dimensional (3D) cell culture systems, particularly tumor organoids. These self-assembled 3D cell clusters closely replicate the histopathological, genetic, and phenotypic characteristics of primary tissues, making them invaluable tools in cancer research and drug screening.Objective This review addresses the challenges in developing in vitro models that accurately reflect tumor heterogeneity and explores the application of tumor organoids in cancer research, with a specific focus on the screening of natural products for antitumor therapies.Methods This review synthesizes information from major databases, including Chemical Abstracts, Medicinal and Aromatic Plants Abstracts, ScienceDirect, Google Scholar, Scopus, PubMed and Springer Link. …”
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Comparison of Myeloid Cells in Circulation and in the Tumor Microenvironment of Patients with Colorectal and Breast Cancers by Salman M. Toor, Eyad Elkord

“…We have previously reported levels of myeloid cells in the periphery and in the tumor microenvironment (TME) of patients with primary breast cancer (PBC) and colorectal cancer (CRC). …”
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Caracterización clínica epidemiológica de pacientes con enfermedad inflamatoria pélvica tumoral by Sara Amneris Urgellés Carreras, Martiza Álvarez Fiallo, Vilvia Ramos Zamora, Enrique Reyes Guerrero

Subjects: “…enfermedad inflamatoria pélvica tumoral…”
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Preoperative prediction of pituitary neuroendocrine tumor invasion using multiparametric MRI radiomics by Qiuyuan Yang, Tengfei Ke, Jialei Wu, Yubo Wang, Jiageng Li, Yimin He, Jianxian Yang, Nan Xu, Bin Yang

Subjects: “…pituitary neuroendocrine tumor…”
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Stimulus-activated ribonuclease targeting chimeras for tumor microenvironment activated cancer therapy by Yuqi Zhang, Jinfeng Zhu, Ling Qiu, Zhengzhong Lv, Zhongsheng Zhao, Xingxiang Ren, Yirui Guo, Yan Chen, Miao Li, Yurong Fan, Zhixin Han, Yiming Feng, Haibin Shi

“…Here, a RiboTAC is designed for tumor microenvironment triggered activation. The tumor microenvironment activated RiboTAC (TaRiboTAC) incorporates two pre-miR-21 binders, a near-infrared fluorophore IR780, an RGD targeting peptide and a phenylboronic acid caged ribonuclease recruiter. …”
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The Tumor Necrosis Factor Superfamily of Cytokines in the Inflammatory Myopathies: Potential Targets for Therapy by Boel De Paepe, Kim K. Creus, Jan L. De Bleecker

“…The crucial role played by tumor necrosis factor alpha (TNFα) in the IM has long been recognized. …”
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Robustness of optimal controls for a class of mathematical models for tumor anti-angiogenesis by Heinz Schättler, Urszula Ledzewicz, Benjamin Cardwell

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