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7921
The Association Between Neutrophil‐Percentage‐to‐Albumin Ratio (NPAR) and Mortality Among Individuals With Cancer: Insights From National Health and Nutrition Examination Survey...
Published 2025-01-01“…ABSTRACT Background Neutrophils interact with tumor cells, potentially exacerbating cancer progression. …”
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7922
Retinal Protection of New Nutraceutical Formulation
Published 2025-01-01“…Finally, Epicolin treatment on DBA/2J mice protected the RGCs from loss of function, as demonstrated by PERG analysis, and attenuated their death by enhancing brain-derived neurotrophic factor (<i>BDNF</i>) and reducing interleukin-1 beta (<i>IL-1β</i>) and tumor necrosis factor-alpha (<i>TNF-α</i>) expression. …”
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7923
Metabolic Profiling by UPLC–Orbitrap–MS/MS of Liver from C57BL/6 Mice with DSS-Induced Inflammatory Bowel Disease
Published 2020-01-01“…We found that the levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 in the liver tissues of mice were highly increased in the context of DSS treatment but were lowered by cecropin A and antibiotics. …”
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7924
Aspergilosis invasiva con compromiso óseo en lactante de cuatro meses con enfermedad granulomatosa crónica
Published 2024-12-01“…Se trata de un lactante de sexo masculino de cuatro meses de edad, de madre hipotiroidea y con quien convive en la celda de la cárcel. El infante presentó tumores en la región axilar izquierda y la radiografía de tórax sugirió fracturas costales; fue hospitalizado ante la sospecha de maltrato infantil. …”
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7925
Decrease in phase angle after Roux-en-Y gastric bypass is related to increase of anti-inflammatory status
Published 2025-02-01“…Assessments included serum levels of alpha-1-acid glycoprotein (AGP), C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), adiponectin, and resistin, as well as anthropometric data and body composition. …”
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7926
Adipose tissue may not be a major player in the inflammatory pathogenesis of Autism Spectrum Disorder
Published 2025-02-01“…However, markedly elevated levels of IL-6, IL-8, and tumor necrosis factor (TNF-α) were detected in children with ASD, suggesting that the inflammatory state is independent of adipokines. …”
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7927
Guttiferone K Exerts the Anti-inflammatory Effect on Mycobacterium Tuberculosis- (H37Ra-) Infected Macrophages by Targeting the TLR/IRAK-1 Mediated Akt and NF-κB Pathway
Published 2020-01-01“…It was evidenced by the decreased production of inflammatory mediators, including interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2). …”
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7928
Enhanced expression of ten‐eleven translocation 1 reverses gemcitabine resistance in cholangiocarcinoma accompanied by a reduction in P‐glycoprotein expression
Published 2019-03-01“…And then, the possible effect of TET1 on the expression of P‐gp was examined by western blot analysis. Xenograft tumor experiment was conducted to confirm the association between TET1 and P‐gp expression under gemcitabine chemoresistance. …”
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7929
PMAIP1 regulates the progression of follicular thyroid carcinoma through the Wnt3/FOSL1 pathway
Published 2025-01-01“…MethodsThis study examined the expression level of PMAIP1 in FTC through comprehensive analysis of databases, tumor tissues, and cell lines. Following the establishment of a stably transfected plasmid in cell lines, a series of functional assays and subcutaneous xenograft experiment were conducted to investigate the role of PMAIP1 in FTC. …”
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7930
Association of immune-related adverse events with the outcomes of immune checkpoint inhibitors in patients with dMMR/MSI-H metastatic colorectal cancer
Published 2023-01-01“…Despite previous investigations in other tumor types, immune-related adverse events (irAEs) have not been well evaluated in patients with MSI-H cancers treated with ICIs.Methods We conducted an international cohort study at tertiary cancer centers collecting clinic-pathological features from 331 patients with MSI-H mCRC treated with ICIs. …”
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7931
Urinary exosomal miRNA-451a can be used as a potential noninvasive biomarker for diagnosis, reflecting tubulointerstitial damage and therapeutic response in IgA nephropathy
Published 2024-12-01“…The uE miR-451a level was positively correlated with the change in eGFR and negatively correlated with serum creatinine, urinary macrophage migration inhibitory factor (MIF), interleukin-6 (IL-6) and tumor necrosis factor (TNF-α). A dual-luciferase reporter assay confirmed that MIF was a direct target of miR-451a. …”
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7932
A novel USP4 inhibitor that suppresses colorectal cancer stemness by promoting β-catenin and Twist1 degradation
Published 2025-01-01“…Treatment with U4-I05 also inhibited tumor metastasis and extended survival in a genetically engineered CRC mouse model. …”
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7933
Prostate cancer cells elevate glycolysis and G6PD in response to caffeic acid phenethyl ester-induced growth inhibition
Published 2025-01-01“…We previously reported that treatment with caffeic acid phenethyl ester (CAPE) suppressed the cell proliferation, tumor growth, as well as migration and invasion of prostate cancer (PCa) cells via inhibition of signaling pathways of AKT, c-Myc, Wnt and EGFR. …”
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7934
Pharmacological ascorbate combined with rucosopasem selectively radio-chemo-sensitizes NSCLC via generation of H2O2
Published 2025-03-01“…Finally, in H1299T NSCLC xenografts the combination of RUC + P-AscH‾ with CIS + ETOP and 12 × 2 Gy radiation significantly inhibits tumor growth and increased median overall over survival. …”
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7935
C1q/TNF-Related Protein5 (CTRP5) as a Biomarker to Predict Metabolic Syndrome and Each of Its Components
Published 2018-01-01“…C1q/TNF-related protein5 (CTRP5) is a member of the C1q/tumor necrosis factor α- (TNF-α-) related protein family and has been reported to be associated with the regulation of glucose and lipid metabolism. …”
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7936
Nrf2/cyclooxygenase 2 signaling in Cr(VI)-induced carcinogenesis
Published 2025-02-01“…The results indicated that COX-2 functioned as an oncogene to promote the malignant transformation of B2B cells and enhance the proliferation, migration, tumor growth, and angiogenesis of Cr-T cells. Nuclear factor E2-related factor-2 (Nrf2) was identified as a transcription factor for COX-2. …”
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7937
Clinical significance of plasma-free amino acids and tryptophan metabolites in patients with non-small cell lung cancer receiving PD-1 inhibitor: a pilot cohort study for developin...
Published 2022-05-01“…Background Amino acid metabolism is essential for tumor cell proliferation and regulation of immune cell function. …”
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7938
AutoLDP: An accurate and efficient artificial intelligence-based tool for automatic labeling of digital pathology
Published 2025-03-01“…Background: Whole-slide image (WSI) is foundational for artificial intelligence in tumor diagnosis, treatment planning, and prognosis prediction. …”
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7939
Venetoclax plus low-intensity chemotherapy for adults with acute lymphoblastic leukemia
Published 2025-02-01“…There were no deaths within 60 days. There was no tumor lysis syndrome, hepatotoxicity, prolonged cytopenias, or early discontinuation for toxicity. …”
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7940
Precise Detection of Gene Mutations in Fine-Needle Aspiration Specimens of the Papillary Thyroid Microcarcinoma Using Next-Generation Sequencing
Published 2019-01-01“…There were no mutations found in TERT promoter or TP53. The tumor with a maximum diameter (Dmax) larger than 5 mm was shown to be significantly correlated with the BRAF mutation in a multivariate analysis (OR 5.52, 95% CI 1.51-26.42, P=0.033). …”
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