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7861
Activated Growth Factor From Platelets as Treatment for Diabetic Retinopathy Through Antioxidant-Oxidative Stress Pathway
Published 2025-01-01“…Advanced glycation end products (AGEs), p38 mitogen activated protein kinase (p38 MAPK), nuclear factor-κβ (NF-κβ), reactive oxygen species (ROS), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), superoxide dismutase (SOD) and vascular endothelial growth factor (VEGF) was assessed using enzyme linked immunoassay (ELISA). …”
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7862
Gedunin Mitigates <i>Cutibacterium acnes</i>-Induced Skin Inflammation by Inhibiting the NF-κB Pathway
Published 2025-01-01“…Key inflammatory mediators, including interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and interleukin-6 (IL-6), were evaluated. …”
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7863
Effect of Propolis on PPP2R1A and Apoptosis in Cancer Cells
Published 2025-01-01“…Moreover, we aimed to investigate the impact of propolis on apoptosis by analyzing apoptosis markers such as tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), APAF-1, and caspases-3, -8, and -9. …”
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7864
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7865
Recent trends in research on the role of cholesterol in leukemia: a bibliometric and visualization study
Published 2025-01-01“…BackgroundCholesterol metabolism significantly impacts leukemia pathophysiology, affecting tumor cell survival, proliferation, and treatment resistance. …”
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7866
Hepatic arterial infusion chemotherapy combined with systemic therapy sequentially or simultaneously for advanced hepatocellular carcinoma
Published 2024-11-01“…We used the Kaplan–Meier method and a log-rank test to compare the overall survival (OS) and progression-free survival (PFS) rates between the SI and SE groups. The tumor response and the incidence of adverse events (AEs) were reported. …”
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7867
Pirfenidone regulates seizures through the HMGB1/TLR4 axis to improve cognitive functions and modulate oxidative stress and neurotransmitters in PTZ-induced kindling in mice
Published 2025-01-01“…Pirfenidone significantly reduced pro-inflammatory cytokines including interleukin-6, interleukin-1β, transforming growth factor-β, tumor necrosis factor- α, high-mobility group box-1, and toll-like receptor-4, elevated gamma-aminobutyric acid, decreased glutamate levels, modulated aspartate aminotransferase and alanine aminotransferase levels. …”
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7868
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7869
Treatment of uterine fibroid: focus on endometrial receptivity. A pilot randomized prospective study
Published 2024-12-01“…The impact of a benign tumor on the endometrium state is currently being actively discussed, which may become another potential target in UF therapy. …”
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7870
TransRAUNet: A Deep Neural Network with Reverse Attention Module Using HU Windowing Augmentation for Robust Liver Vessel Segmentation in Full Resolution of CT Images
Published 2025-01-01“…<b>Conclusions:</b> TransRAUnet is expected to serve as a navigation aid for liver resection surgery through accurate liver vessel and tumor segmentation.…”
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7871
Study on postoperative survival prediction model for non-small cell lung cancer: application of radiomics technology workflow based on multi-organ imaging features and various mach...
Published 2025-02-01“…The study extracted radiomic features from the tumor, whole lung, and erector spinae muscles of the patients and applied 11 machine learning algorithms to construct prediction models. …”
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7872
Curdione combined with borneol treats bacterial mixed HPV infection by regulating the crosstalk among immune cells
Published 2025-01-01“…Furthermore, curdione and borneol enhance the expression of tumor necrosis factor α (TNF-α) and caspase 1 (CASP1) in macrophages, as well as the expression of interleukin 12 (IL-12) and interleukin 23 (IL-23) in dendritic cells (DCs). …”
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7873
Clinical features of autonomic dysfunction in children with anti-N-methyl-D aspartic receptor encephalitis
Published 2025-01-01“…Compared to the group without autonomic dysfunction, the group with dysfunction showed significantly higher rates of prodrome infection, tumor complications (all ovarian teratoma), consciousness disturbance, elevated cerebrospinal fluid protein, initiation of second-line and long-term immunotherapy, length of hospital stay, and hospitalization costs (P < 0.05). …”
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7874
Autoimmune Hepatitis in Children: The Current State of the Problem
Published 2018-11-01“…For a small number of patients, who do not respond to standard treatment and those who suffer from frequent disease relapses, it is advisable to offer an alternative immunosuppressive treatment, the effectiveness of which is still ambiguous and poorly understood (including, in order of priority, mycophenolate mofetil, calcineurin inhibitors, rituximab, Inhibitor of tumor necrosis factor-alpha). In cases of refractoriness to therapy and the disease progression to liver cirrhosis and its decompensation, liver transplantation is justified. …”
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7875
Investigating the antioxidant and anti-inflammatory potential of Nypa fruticans: a multifaceted approach to skin protection and aging
Published 2025-01-01“…In this study, we evaluated the potential of Nypa fruticans (NF), which is known for its antioxidant properties, to mitigate tumor necrosis factor-alpha (TNF-α)- and interferon-gamma (IFN-γ)-induced damage in normal human epidermal keratinocytes. …”
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7876
Artificial Intelligence–Powered Training Database for Clinical Thinking: App Development Study
Published 2025-01-01“…For diseases, pneumonia was the most frequently learned, followed by cholecystolithiasis (n=216, 14.1%), benign prostate hyperplasia (n=196, 12.8%), and bladder tumor (n=193, 12.6%). Among 479 students, roughly a third (n=168, 35.1%) scored in the 60 to 80 range, and half of them scored over 80 points (n=238, 49.7%). …”
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7877
Integrated Transcriptomic and Targeted Metabolomic Analysis Reveals the Key Genes Involved in Triterpenoid Biosynthesis of <i>Ganoderma lucidum</i>
Published 2025-01-01“…These compounds have various pharmacological functions, including anti-tumor, antioxidant, anti-inflammatory, liver-protective, and immune-regulating effects. …”
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7878
Fatal toxoplasmic encephalitis triggered by anti-TNF therapy
Published 2025-02-01“…Here we present a 74-year-old woman who developed fatal cerebral toxoplasmosis after anti-tumor necrosis factor-α (TNF-α). After presenting to a local urgent care with confusion, a worsening cognitive status led to an emergency room visit. …”
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7879
Poor Glycemic Control in Carbapenem-Resistant Klebsiella pneumoniae Infections: Impact on Epidemiological Features, Mortality Risks, and Polymyxin Resistance
Published 2025-02-01“…Logistic regression analysis identified age, glycosylated hemoglobin (HbA1c) ≥ 7%, CKD, tumor, mechanical ventilation, and sepsis as independent risk factors for death associated with CRKP infection. …”
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7880
Low-Concentration Oxygen/Ozone Treatment Attenuated Radiculitis and Mechanical Allodynia via PDE2A-cAMP/cGMP-NF-κB/p65 Signaling in Chronic Radiculitis Rats
Published 2018-01-01“…The expression of the tumor necrosis factor- (TNF-) α, interleukin- (IL-) 1β, IL-6, cyclic adenosine monophosphate (cAMP), cyclic guanosine monophosphate (cGMP), phosphodiesterase 2A (PDE2A), and nuclear factor- (NF-) κB/p65 in spinal dorsal horns was measured by enzyme-linked immunosorbent assay, polymerase chain reaction, and western blot on day 7 after surgery. …”
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