Structural and functional connectivity coupling as an imaging marker for bone metastasis pain in lung cancer patients by Jiahui Zheng, Chengfang Wang, Xiaoyu Zhou, Yu Tang, Lin Tang, Yong Tan, Jing Zhang, Hong Yu, Jiuquan Zhang, Daihong Liu

“…Background: Cancer pain is a common symptom in patients with malignant tumors and associated with poor prognosis and a high risk of death. …”
Get full text

Expression and Function of Synthetic Dimeric Exercise-Induced Cytokine Irisin-Irisin by LIU Fengying, HUANG Yide, LIN Jia, CHEN Xuequn, WANG Qingshui, LIN Yao

“…ObjectiveStudies have shown that the exercise-induced cytokine Irisin functions were as a dimer, so tandem Irisin-Irisin mock dimers were designed to explore the similarities and differences between recombinant Irisin-Irisin expressed by <italic>Escherichia coli </italic>and commercial Irisin in activity and function on tumor cells.Methods<italic>Escherichia coli</italic> strain BL21 (DE3) and pET-30a expression vectors were selected to obtain recombinant Irisin-Irisin by isopropyl β-D-1-thiogalactopyranoside (IPTG) induction. …”
Get full text

Humanized Mouse Models for Immuno-Oncology Research: A Review and Implications in Lung Cancer Research by Cheol-Kyu Park, MD, PhD, Maryam Khalil, BSc, Nhu-An Pham, PhD, Stephanie Wong, BSc, Dalam Ly, PhD, Adrian Sacher, MD, FRCPC, Ming-Sound Tsao, MD, FRCPC

“…Cancer immunotherapy has brought significant clinical benefits to patients with cancer, including those with lung cancer. Patient-derived tumor xenograft mouse models have become the preferred animal model for translational cancer research and preclinical studies. …”
Get full text

Strategies for H-score Normalization of Preanalytical Technical Variables with Potential Utility to Immunohistochemical-Based Biomarker Quantitation in Therapeutic Reponse Diagnost... by William E. Pierceall, Michele Wolfe, Jessica Suschak, Hua Chang, Yan Chen, Kam M. Sprott, Jeffery L. Kutok, Stella Quan, David T. Weaver, Brian E. Ward

“…We find H-score variation between fixation conditions within individual patient's tumors that were stained for XPF, ATM, BRCA1, pMK2 and PARP1. …”
Get full text

Discovery and development of ANV419, an IL-2/anti-IL-2 antibody fusion protein with potent CD8+ T and natural killer cell-stimulating capacity for cancer immunotherapy by Patrizia Murer, Barbara Brannetti, Jean-Michel Rondeau, Laetitia Petersen, Nicole Egli, Simone Popp, Catherine Regnier, Kirsten Richter, Andreas Katopodis, Christoph Huber

“…ANV419 also enhances the NK cell killing capacity and increases tumor growth inhibition when used alongside trastuzumab in a Her-2+ xenograft mouse model. …”
Get full text

Genomic characterization and molecular predictive biomarkers for chemotherapy in patients with metastatic triple-negative breast cancer treated in a real-world setting by Erik Olsson, Henrik Lindman, Evangelos Digkas, Viktoria Thurfjell, Haidar Mir Ali, Ute Krüger, Anna-Karin Wennstig, Marie Sundqvist, Antonios Valachis

“…Results: After exclusion due to insufficient tumor tissue or clinical data, material from 97 patients was analyzed. …”
Get full text

Single-cell sequencing analysis reveals cancer-associated pericyte subgroup in esophageal squamous cell carcinoma to predict prognosis by Kai Xiong, Bing Pan, Hao Fang, Ziyou Tao

“…BackgroundThe role of cancer-associated pericytes (CAPs) in tumor microenvironment (TME) suggests that they are potential targets for cancer treatment. …”
Get full text

Laparoscopic Versus Abdominal Myomectomy Postoperative Outcomes by Nicel Taşdemir, Cem Çelik, Remzi Abalı, Ayşegül Kayalı, Abdulaziz Gül, Özkan Özdamar

“… OBJECTIVE: Myomas are benign uterine tumors affecting 25-70% of reproductive-aged women. …”
Get full text

Classification and functional repair and reconstruction of lip and perilabial defects following oncosurgery by CHEN Weiliang

“…Currently, there is a lack of clear classification and principles for repairing and reconstructing the lip and perilabial defects after lip tumor resection surgery. Lip defects are categorized into three types based on their extent by author: partial lip defects, full-thickness lip defects, and full-thickness lip defects with surrounding lip defects. …”
Get full text

Utility of 3D double-echo steady-state with water excitation (3D-DESS-WE) in diagnosing intraparotid facial nerve schwannoma: A case report by Akito Sano, Akira Baba, Koshi Ikeda, Hisashi Kessoku, Reina Kayama, Satoshi Matsushima, Hideomi Yamauchi, Shota Tasaki, Rihito Nakazato, Hiroya Ojiri

“…Differentiating intraparotid facial nerve schwannoma from other parotid tumors, particularly pleomorphic adenoma, is clinically crucial due to significant differences in treatment approaches. …”
Get full text

Evaluation of the immunological functions of placental alkaline phosphatase in vivo using ALPP transgenic mice by Tse-Ching Chen, Kwai-Fong Ng, Ning Chen, Yi-Ling Pan, Chun-An Cheng, Hsiao-Chun Wu, Yi-Jen Hsueh, Nien-Yi Chiang, Hsi-Hsien Lin, Hsi-Hsien Lin, Hsi-Hsien Lin, Hsi-Hsien Lin

“…In addition, ALPP has been identified as a reliable biomarker of diverse germ cell tumors. Nevertheless, little is known of its immune modulatory role in vivo. …”
Get full text

Three-dimensional diffractive acoustic tomography by Luca Menozzi, Tri Vu, Aidan J. Canning, Harshal Rawtani, Carlos Taboada, Marie Elise Abi Antoun, Chenshuo Ma, Jesse Delia, Van Tu Nguyen, Soon-Woo Cho, Jianing Chen, Theresa Charity, Yirui Xu, Phuong Tran, Jun Xia, Gregory M. Palmer, Tuan Vo-Dinh, Liping Feng, Junjie Yao

“…Using 3D-DAT on small animal models, we mapped the distribution of the biliverdin-binding serpin complex in glassfrogs, tracked gold nanoparticle accumulation in a mouse tumor model, imaged genetically-encoded photoswitchable tumors, and investigated polyfluoroalkyl substances exposure on developing embryos. …”
Get full text

Advance in identified targets of berberine by Penghai Sun, Ziyuan Wang, Yinchao Ma, Yuan Liu, Yintong Xue, Yan Li, Xiang Gao, Yuedan Wang, Ming Chu, Ming Chu, Ming Chu, Ming Chu

“…Berberine is an isoquinoline alkaloid, which has demonstrated significant therapeutic potential in the treatment of various diseases, including tumors, acute and chronic infections, autoimmune disorders, and diabetes. …”
Get full text

Tailgut Cyst—Gynecologist’s Pitfall: Literature Review and Case Report by Andrei Mihai Malutan, Viorela-Elena Suciu, Florin Laurentiu Ignat, Doru Diculescu, Razvan Ciortea, Emil-Claudiu Boțan, Carmen Elena Bucuri, Maria Patricia Roman, Ionel Nati, Cristina Ormindean, Dan Mihu

“…A computed tomography (CT) scan showed a presacral tumor with a right pararectal development. A surgical resection of the lesion using an anterior approach was performed, with the final pathological diagnosis of a retrorectal cystic hamartoma (“tailgut cyst”). …”
Get full text

Higher Prostate Weight Is Inversely Associated with Gleason Score Upgrading in Radical Prostatectomy Specimens by Leonardo Oliveira Reis, Emerson Luis Zani, Leandro L. L. Freitas, Fernandes Denardi, Athanase Billis

“…Gleason upgrading showed increased clinical stage (P=0.019), higher tumor extent (P=0.009), extraprostatic extension (P=0.04), positive surgical margins (P<0.001), seminal vesicle invasion (P=0.003), less “insignificant” tumors (P<0.001), and also worse DFS, χ2=4.28, df=1, P=0.039. …”
Get full text

Short-term outcome of endovascular stenting for symptomatic vertebrobasilar stenosis by Mohamed Abdel moneim Abdo Tolba, Mohammed Alaswad, Mohamed Mohamed Tawfik, Ahmed Zaki Akl, Mona Ali Eissa, Hala El-khawas, Hani Mahmoud Zaki Eldin, Mohamed Khaled Ahmed Elewa

“…Patients with previous stent at the target lesion, acute stroke, heavily calcified lesion, complete artery occlusion, massive infarction with marked neurological deficit, intracranial hemorrhage, intracranial brain tumors, contraindicated to antithrombotic and/or anticoagulant, pregnant women, and patients susceptible to follow-up loss were excluded. …”
Get full text

Sequential transcriptome profiling: comparative analysis of normal and canine lymphoma preceding detailed T-cell and B-cell subtype comparison by Yeji Kim, Yeji Kim, Jihyun Kim, Jihyun Kim, Yunji Song, Yunji Song, Keunhwan Jang, Se Eun Kim, Se Eun Kim, Se Eun Kim, Ha-Jung Kim, Ha-Jung Kim

“…IntroductionAs the lifespan of companion animals extends, the incidence of tumor also increases. Among these tumors, lymphoma is reported as the most prevalent hematopoietic tumor with a 80-90% prevalence rate. …”
Get full text

The key role of the NUDT3 gene in lung adenocarcinoma progression and its association with the manganese ion metabolism family by Deyong Ge, Xinyu Xu, Liyi Fang, Huihui Tao

“…Abstract Background Lung adenocarcinoma is one of the most common malignant tumors worldwide. Its complex molecular mechanisms and high tumor heterogeneity pose significant challenges for clinical treatment. …”
Get full text

Inguinal Lymph Node Dissection for Advanced Stages of Plantar Melanoma in a Low-Income Country by Ollo Roland Somé, Malick Diallo, Damien Konkobo, Nassirou Yabré, Valentin Konségré, Issouf Konaté, Sidy Ka

“…We found high Breslow index tumor thickness (>3 mm) and an advanced Clark IV stage (n = 20). …”
Get full text

Deletion of cyclin dependent kinase inhibitor 2a gene as a marker of oropharyngeal carcinomas non-associated with human papillomavirus and its prognostic value by I.S. Shponka, Bondarenko O.O. Bondarenko ч, O.V. Kovtunenko, V.V. Rakhmanov

“…Formalin-fixed and paraffin-embedded samples after transoral radical surgery of oropharyngeal tumors from 26 male patients with average age 57.35±10.33 years were studied. …”
Get full text