Activating CD137 Signaling Promotes Sprouting Angiogenesis via Increased VEGFA Secretion and the VEGFR2/Akt/eNOS Pathway by Bo Li, Yue Zhang, Runting Yin, Wei Zhong, Rui Chen, Jinchuan Yan

“…Combination of antiangiogenesis and immunotherapy may be an effective strategy for treatment of solid tumors. Our previous work reported that activation of CD137 signaling promotes intraplaque angiogenesis. …”
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Case report: Personalized management of treatment resistance in advanced NSCLC patients with mutated epidermal growth factor receptor: special examples and literature review by Jun Wang, Jun Wang, Xiaojing Li, Shuang Dong, Sheng Hu, Fengming Ran, Yu Qian

“…The second mechanism, known as bypass resistance, entails tumor clones utilizing alternative signaling pathways for proliferation. …”
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Indoleamine 2,3-Dioxygenase (IDO) Expression Is an Independent Prognostic Marker in Esophageal Adenocarcinoma by Heike Loeser, Max Kraemer, Florian Gebauer, Christiane Bruns, Wolfgang Schröder, Thomas Zander, Hakan Alakus, Arnulf Hoelscher, Reinhard Buettner, Philipp Lohneis, Alexander Quaas

“…IDO expression on TILs was seen in up to 59.6% of tumors, and expression on tumor cells was seen in 9.2%. …”
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De-escalation of surgical and radiation treatment in elderly luminal breast cancer patients, single institution report and review of the evidence by Yasmin Korzets, Marian Khatib, Hadar Goldvaser, Yehiel Hibshoosh, Alla Nikolaevski-Berlin, Ido Wolf, Viacheslav Soyfer

“…All patients had clinically node-negative disease with a median tumor size was 13 mm. Five (5%) women had lymphovascular invasion. …”
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The Identification and Validation of a Robust Immune-Associated Gene Signature in Cutaneous Melanoma by Le-Bin Song, Jiao-Chen Luan, Qi-Jie Zhang, Lin Chen, Hao-Yang Wang, Xue-Chen Cao, Ning-Hong Song, Yan Lu

“…Cutaneous melanoma is defined as one of the most aggressive skin tumors in the world. An increasing body of evidence suggested an indispensable association between immune-associated gene (IAG) signature and melanoma. …”
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Laparoscopic and Endoscopic cooperative surgery as Rescue-treatment for Advanced gastric Cancer in patients Unfit for Surgery (LE-RACUS): protocol for a feasibility study by Henrik Maltzman, Masami Omae, Fredrik Klevebro, Francisco Baldaque-Silva, Ioannis Rouvelas

“…The inclusion criteria will be patients with gastric cancer cT2-T4aN0M0, Borrman type 1–2 < 5 cm, or type 3 < 2 cm that the tumor board assesses as not fit for gastrectomy. …”
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Design of a humanized CD40 agonist antibody with specific properties using AlphaFold2 and development of an anti-PD-L1/CD40 bispecific antibody for cancer immunotherapy by Kun Du, He Huang

“…Furthermore, in humanized transgenic mice challenged with huPD-L1-expressing tumor cells, BA4415 induced superior anti-tumor activity. …”
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Antitumor Effect of Demethylzeylasteral (T-96) on Triple-Negative Breast Cancer via LSD1-Mediate Epigenetic Mechanisms by Zhengjie Shen, Yongjuan Gu, Ruiyang Jiang, Heya Qian, Siyuan Li, Lixian Xu, Wenzhe Gu, Yun Zuo

“…Breast cancer ranks first in the incidence of female tumors. Triple-negative breast cancer (TNBC), one type of breast cancer, is more aggressive and has a worse prognosis. …”
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Receipt of specialized palliative care and health care utilization at the end of life in hematological cancer patients – the Stockholm experience by Lena von Bahr, Peter Strang, Torbjörn Schultz, Per Fürst

“…Background: The treatments of hematological malignancies tend to be intense, and compared with solid tumors, less is known about the health care consumption during end of life (EOL). …”
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Diagnostic performance of artificial intelligence in detection of renal cell carcinoma: a systematic review and meta-analysis by Mahdi Gouravani, Mohammad Shahrabi Farahani, Mohammad Amin Salehi, Shayan Shojaei, Sina Mirakhori, Hamid Harandi, Soheil Mohammadi, Ramy R. Saleh

“…Abstract Objectives The detection of renal cell carcinoma (RCC) tumors in the earlier stages is of great importance for more effective treatment. …”
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Clinical Outcome of Third-Line Pazopanib in a Patient with Metastatic Renal Cell Carcinoma by Michela Roberto, Maria Bassanelli, Elsa Iannicelli, Silvana Giacinti, Chiara D’Antonio, Anna Maria Aschelter, Paolo Marchetti

“…Renal cell carcinoma accounts for about 2-3% of all malignant tumors. The prevalence of brain metastases from RCC is less than 20% of cases. …”
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Nomogram for prognosis prediction in metastatic pancreatic cancer patients undergoing intra-arterial infusion chemotherapy: incorporating immune-inflammation scores and coagulation... by Yifan Yang, Shaoqi Zong, Yongqiang Hua

“…Abstract Background Pancreatic cancer is one of the most malignant tumors with an inferior prognosis. This study aims to determine the prognostic significance of immune-inflammatory scores and coagulation indices in patients with metastatic pancreatic cancer(MPC) and develop a predictive nomogram. …”
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Comparison of CT-Guided Microwave Ablation of Liver Malignancies with and Without Intra-Arterial Catheter Placement for Contrast Administration by Anne Bettina Beeskow, Holger Gößmann, Hans-Jonas Meyer, Daniel Seehofer, Thomas Berg, Florian van Bömmel, Aaron Schindler, Manuel Florian Struck, Timm Denecke, Sebastian Ebel

“…Methods: 148 patients (45 female, 65.1 ± 14.9 years) with liver tumors who underwent CT-guided MWA were included. …”
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High-Fat Mouse Model to Explore the Relationship between Abnormal Lipid Metabolism and Enolase in Pancreatic Cancer by Lin Qin, Kai Sun, Li Shi, Yushan Xu, Rongping Zhang

“…Hyperlipidemia can promote tumor growth and increase the expression levels of ENO1, ENO2, and ENO3 in subcutaneous tumor formation of pancreatic cancer in mice. …”
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Digestive cancers: mechanisms, therapeutics and management by Tianzuo Zhan, Johannes Betge, Nadine Schulte, Lena Dreikhausen, Michael Hirth, Moying Li, Philip Weidner, Antonia Leipertz, Andreas Teufel, Matthias P. Ebert

“…Over the last decade, genomic and functional studies have provided unprecedented insights into the biology of digestive cancers, identifying genetic drivers of tumor progression and key interaction points of tumor cells with the immune system. …”
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Direct-Acting Antivirals in Hepatitis C Treatment for Renal Impairment: Liver Safety Concerns and Effectiveness in Peritoneal Dialysis by Hsuan-Yu Hung, Wei-Liang Hung, Ye Gu, Chung-Yu Chen

“…A case–time–control analysis suggested liver instability despite treatment, with comorbid liver tumors (aOR 18.89; 95% CI 5.4–66.12) and hypertension (aOR 4.25; 95% CI 1.49–12.15) linked to higher DILI risk. …”
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Expression and prognosis of cellular senescence genes in head and neck squamous cell carcinoma by Chen Feng, Lijuan Zhu, Wei Mao, Pin Dong, Xinwei Chen

“…Abstract Background Cellular senescence refers to cells entering a relatively stable state of cell cycle arrest, which is a barrier that tumor cells must cross to achieve immortalization and plays an extremely important role in preventing the occurrence and development of tumors. …”
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Progression of an Invasive ACTH Pituitary Macroadenoma with Cushing’s Disease to Pituitary Carcinoma by Clarissa Groberio Borba, Rafael Loch Batista, Nina Rosa de Castro Musolino, Vanielle Carvalho Machado, Ana Elisa Evangelista Alcantara, Gilberto Ochman da Silva, Valter Angelo Sperling Cescato, Malebranche Berardo Carneiro da Cunha Neto

“…Pituitary carcinomas are very rare tumors that in most cases produce prolactin and adrenocorticotropic hormone (ACTH). …”
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IL1RN and KRT13 Expression in Bladder Cancer: Association with Pathologic Characteristics and Smoking Status by Thomas S. Worst, Verena Reiner, Ute Gabriel, Christel Weiß, Philipp Erben, Thomas Martini, Christian Bolenz

“…Expression scores were correlated with pathologic characteristics (tumor stage and grade) and with smoking status. Results. …”
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Influence of In Vitro IL-2 or IL-15 Alone or in Combination with Hsp-70-Derived 14-mer Peptide (TKD) on the Expression of NK Cell Activatory and Inhibitory Receptors by Ilona Hromadnikova, Petra Pirkova, Lucie Sedlackova

“…NK cells represent a potential tool for adoptive immunotherapy against tumors. Membrane-bound Hsp70 acts as a tumor-specific marker enhancing NK cell activity. …”
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