GPX8 as a Novel Prognostic Factor and Potential Therapeutic Target in Primary Glioma by Zhao-shou Yang, Qin Yang, Xiao-xiao Sun, Kui Xiong, Xiao-ting Zhu, Yi-chen Wang, Qian-yao Ren, Guo-hui Wu, Shi-min Wang, Xu-qin Cao, Xiao-rong Yang, Wen-gong Jiang

“…One of the most prevalent malignant primary brain tumors is primary glioma. Although glutathione peroxidase 8 (GPX8) is intimately associated with carcinogenesis, its function in primary gliomas has not yet been thoroughly understood. …”
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New method for cytological evaluation using direct nipple discharge without aspiration by Jiang Zhu, Han Cong, Xiaotong Zhang, Xiaoya Dong, Song Zhao, Chaolu Hu, Jude Ranchu Maimo, Yawen Wang, Kai Zhang, Jianli Wang, Pengyu Li, Rong Ma

“…Abstract Conventional smear cytology (CSC) is a specific method used for breast tumor diagnosis in patients with nipple discharge. …”
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Nanocomplex hyaluronic acid/ganciclovir@ZIF-8 for ganciclovir efficient delivery and targeted anti-KSHV treatment by Fangling Li, Chengjing Liu, Wenyi Gu, Qianhe Xu, Dongmei Li, Dongdong Cao, Zhiyong Liu

“…In vivo anti-tumor results showed that HA/GCV@ZIF-8 accumulated in tumor cells and effectively inhibited tumor growth. …”
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Comparative Approach to Define Increased Regulatory T Cells in Different Cancer Subtypes by Combined Assessment of CD127 and FOXP3 by Marc Beyer, Sabine Classen, Elmar Endl, Matthias Kochanek, Martin R. Weihrauch, Svenja Debey-Pascher, Percy A. Knolle, Joachim L. Schultze

“…In recent years an increase of functional CD4+CD25+ regulatory T cells (Treg cells) has been established for patients with solid tumors, acute leukemias, and lymphomas. We have reported an expanded pool of CD4+CD25high Treg cells in patients with chronic lymphatic leukemia (CLL), multiple myeloma (MM) as well as its premalignant precursor monoclonal gammopathy of undetermined significance (MGUS). …”
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KLF5 silencing restrains proliferation, invasion, migration and angiogenesis of gallbladder carcinoma cells by transcriptional regulation of PDGFA by Xiaowei Lu, Kui Hu, Dandan Zhang, Xuefeng Yin, Jifeng Nie, Kai Zhao

“…Abstract Background Krüppel-like factor 5 (KLF5) is recognized as a tumor mediator in multiple types of tumors. Nevertheless, whether KLF5 plays a role in gallbladder cancer (GBC) remains to be elucidated. …”
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Clinical Evaluation of the Diagnostic Role of MicroRNA-155 in Breast Cancer by Fatemeh Hosseini Mojahed, Amir Hossein Aalami, Vahid Pouresmaeil, Amir Amirabadi, Mahdi Qasemi Rad, Amirhossein Sahebkar

“…There was a significant relationship between serum miR-155 expression and the tumor grade (p<0.001), tumor stage (p<0.001), and tumor size (p<0.001) of the patients. …”
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Imaging Hepatocellular Carcinoma With Ga-Citrate PET: First Clinical Experience by Carina Mari Aparici MD, Spencer C. Behr MD, Youngho Seo PhD, R. Kate Kelley MD, Carlos Corvera MD, Kenneth T. Gao, Rahul Aggarwal MD, Michael J. Evans PhD

“…Nuclear imaging tools that can detect molecular subsets of tumors could greatly improve diagnosis and management of HCC. …”
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The burden of medical contraindications to corneal donation: Time for review. by Oliver Dorado-Cortez, Sylvain Poinard, Magali Epinat, Fanny Collange, Sandrine Ninotta, Paul Goin, Jean Luc Perrot, Philippe Gain, Graeme Pollock, Gilles Thuret

“…The list of medical contraindications (CI) to corneal donation also includes diseases for which no actual, only theoretical, risk has been identified, in particular, neurodegenerative diseases, hematological malignancies, melanomas, tumors of the central nervous system, neoplastic meningitis and lymphangitic carcinomatosis. …”
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Mediterranean diet improves liver health but does not protect against azoxymethane-induced colon tumorigenesis compared to Western diet in A/J mice by Weimin Guo, Nicholas Crossland, Jimmy W. Crott

“…Amongst male mice, those fed MED diet presented with significantly more colonic tumors than those on the WRN diet. Conclusion: In this study male mice displayed elevated sensitivity to AOM-induced hepatotoxicity and mortality than females. …”
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EUS-FNA Diagnosis with Core Biopsy of Pancreatic Metastases from Primary Breast Cancer by Samuel Galante Romanini, Juan Pablo Román Serrano, Juliana Silveira Lima de Castro, Isabela Trindade Torres, Alex Ingold, André Lucchiari Borini, Luiz Augusto Sanches Zulske, Maria Bruna Feitosa Matias, Jéssica Said de Marchi, José Andrés Sanchez Pulla, José Celso Ardengh

“…The pancreas as a site of metastasis of other primary tumors is a rare event. Pancreatic metastases may occur years after the start of treatment of a neoplasm of another organ or may be the initial manifestation of an unidentified primary tumor. …”
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A bibliometric study on the impact of gut microbiota on the efficacy of immune checkpoint inhibitors in cancer patients: analysis of the top 100 cited articles by Ziqi Zhao, Kun Xu, Boqian Hu, Yizhuo Jiang, Xisheng Xu, Yuliang Liu

“…BackgroundImmune checkpoint inhibitors (ICIs) have transformed oncological treatment by modulating immune responses against tumors. However, their efficacy is subject to inter-patient variability and is associated with immune-related adverse events (irAEs). …”
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Burkitt’s Lymphoma Presented as Advanced Ovarian Cancer without Evidence of Lymphadenopathy: CT and MRI Findings by Lucia Manganaro, Silvia Bernardo, Maria Eleonora Sergi, Paolo Sollazzo, Valeria Vinci, Alessandra De Grazia, Anna Clerico, Maria Giovanna Mollace, Matteo Saldari

“…Burkitt's lymphoma is a rare non-Hodgkin's lymphoma which can occasionally involve the ovary and may cause confusion for the clinician since its presentation might mimic other much more frequent tumors. We present a case of a 23-year-old woman with sporadic Burkitt’s lymphoma presented as advanced ovarian cancer with bilateral ovarian masses, peritoneal carcinomatosis, ascites, and marked elevation of CA-125. …”
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Defective homologous recombination and genomic instability predict increased responsiveness to carbon ion radiotherapy in pancreatic cancer by Brock J. Sishc, Janapriya Saha, Elizabeth M. Alves, Lianghao Ding, Huiming Lu, Shih-Ya Wang, Katy L. Swancutt, James H. Nicholson, Angelica Facoetti, Arnold Pompos, Mario Ciocca, Todd A. Aguilera, Michael D. Story, Anthony J. Davis

“…These findings suggest that PDAC tumors with HR pathway mutations or high replication stress are more likely to benefit from CIRT while minimizing normal tissue toxicity.…”
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The Therapeutic Targets of miRNA in Hepatic Cancer Stem Cells by Sabrina Bimonte, Maddalena Leongito, Antonio Barbieri, Vitale del Vecchio, Michela Falco, Aldo Giudice, Raffaele Palaia, Vittorio Albino, Raimondo Di Giacomo, Antonella Petrillo, Vincenza Granata, Francesco Izzo

“…Several studies demonstrated that hepatic cancer stem cells (HCSCs), also called tumor-initiating cells, are involved in regulation of HCC initiation, tumor progression, metastasis development, and drug resistance. …”
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Evaluating ChatGPT-4's performance on oral and maxillofacial queries: Chain of Thought and standard method by Kaiyuan Ji, Zhihan Wu, Jing Han, Guangtao Zhai, Guangtao Zhai, Jiannan Liu

“…These questions encompass 12 areas of oral and maxillofacial surgery, including Prosthodontics, Pediatric Dentistry, Maxillofacial Tumors and Salivary Gland Diseases, and maxillofacial Infections.ResultsUsing CoT approach, ChatGPT-4 exhibited marked enhancements in accuracy, structure, completeness, professionalism, and overall impression for open-ended questions, revealing statistically significant differences compared to its performance on general oral and maxillofacial inquiries. …”
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ALKBH3-mediated m1A demethylation promotes the malignant progression of acute myeloid leukemia by regulating ferroptosis through the upregulation of ATF4 expression by Xin Liu, Xinghua Pan

“…Studies have shown that ALKBH3 is upregulated in most tumors, but the role of ALKBH3 in AML remains unclear.Methods: In this study, we investigated the function of ALKBH3 in AML cells (KG-1) by immunofluorescence, ELISA, flow cytometry, HE staining, and Western blotting.Results: Our results revealed that ALKBH3 is upregulated in AML and that the downregulation of ALKBH3 inhibited KG-1 cell proliferation and promoted cell apoptosis; at the same time, ALKBH3 upregulated ATF4 expression through m1A demethylation, and the knockdown of ATF4 resulted in increased ferrous iron content; TFR1, ACSL4, and PTGS2 expression; and ROS and MDA levels, whereas SOD and GSH levels and the expression levels of ATF4, SLC7A11, GPX4, and FTH1 decreased in KG-1 cells, thereby promoting ferroptosis. …”
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Activation of FGD5-AS1 Promotes Progression of Cervical Cancer through Regulating BST2 to Inhibit Macrophage M1 Polarization by Guokun Liu, Xuan Du, Li Xiao, Qing Zeng, QianLing Liu

“…Accumulating evidence has elucidated the biological function of lncRNAs in various tumors. FGD5 antisense RNA 1 (FGD5-AS1) is identified as a significant tumor regulator in malignancies. …”
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Multiparametric Ultrasound (mpUS) of a Rare Testicular Capillary Hemangioma by Paul Spiesecke, Thomas Fischer, Carsten Stephan, Andreas Maxeiner, Bernd Hamm, Markus Lerchbaumer

“…Capillary hemangioma is a rare entity among testicular tumors. We demonstrate the case of an 18-year-old patient with palpatoric and sonographic conspicuous left testicle and negative serum tumor markers (α-fetoprotein, β-human chorionic gonadotropin, and lactate dehydrogenase). …”
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The quality of early breast cancer diagnosis in urban women by doctors of adult polyclinics by V. A. Kozlov, B. A. Polyakov, D. L. Mushnikov, E. L. Funtikova, D. A. Nedavniy

“…However, despite the availability of breast for examination in adult clinics, malignant tumors of these locations are often found with considerable delay. …”
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Pegylated NIR Fluorophore-Conjugated OBHSA Prodrug for ERα-Targeted Theranostics with Enhanced Imaging and Long-Term Retention by Xiaohua Wang, Xiaofei Deng, Lilan Xin, Chune Dong, Guoyuan Hu, Hai-Bing Zhou

“…This integration facilitates targeted drug delivery and enhances the retention of the fluorescent group within the tumor, allowing distinct in vivo tumor imaging periods. …”
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