Management of Early Stage, High-Risk Endometrial Carcinoma: Preoperative and Surgical Considerations by Sareena Singh, Shandhini Raidoo, Gaetan Pettigrew, Robert DeBernardo

“…There exists a subgroup of patients with early, high-risk disease, whose management remains controversial, as current data is clouded by inclusion of early stage tumors with different high-risk features for recurrence, unstandardized protocols for surgical staging, and an evolving staging system by which we are grouping these patients. …”
Get full text

Microwave Ablation of T1a and T1b Renal Masses: A Retrospective Study by Assim Saad Eddin, Karan Rao, Bradford Oliva, Ajmain Chowdhury, Shetty Zubin, Chad Tracy, Brian J. Smith, Sandeep T. Laroia

“…The mean renal mass size was 2.8 ± 0.94 cm (range, 1.2–6.5 cm). Most of the renal tumors were T1a. Three of the 53 total renal tumors were larger than 4 cm (T1b) and the remaining 50 were less than 4 cm in size (T1a). …”
Get full text

The expression landscape and clinical significance of methyltransferase-like 17 in human cancer and hepatocellular carcinoma: a pan-cancer analysis using multiple databases by Yezhou Ding, Mingyang Feng, Wanqing Chi, Xiaoyin Wang, Baoyan An, Kehui Liu, Shike Lou, Xiaolin Wang, Hui Wang

“…An array of bioinformatics methods was employed to explore the potential oncogenic roles of METTL17, including analyzing its related prognosis, mutation, landscapes, tumor stemness index, immune cell infiltration, and other factors among different tumors. …”
Get full text

Impact of the Number of Administered Systemic Treatment Lines on Local Response to Radiation Therapy for Multiple Myeloma by Andrea Emanuele Guerini, MD, Eneida Mataj, MD, Paolo Borghetti, MD, Luca Triggiani, Ludovica Pegurri, MD, Stefania Nici, Stefano Riga, Alessandra Tucci, MD, Angelo Belotti, MD, Marco Lorenzo Bonù, MD, Giorgio Facheris, MD, Stefano Maria Magrini, Luigi Spiazzi, Michela Buglione

“…The primary outcome for this analysis was radiologic local response at 6 months after RT, according to RECIST 1.1 (Response Evaluation Criteria in Solid Tumors) or PERCIST 1.0 (Positron Emission Tomography Response Criteria in Solid Tumors) criteria. …”
Get full text

An analysis of extraskeletal osteosarcoma based on the literature by De-Hui Wang, Jun-Liang Zhang, Xiao-Wen Fan, Hui-Qun Du, Zi-Fan Gao, Dong-Dong Ling, Ying Cui, Meng-Han Chang, Xing Zhou

“…RT reduced the incidence of local recurrence in patients ≤ 45years (P = 0.035) and patients with tumors > 5 cm (P = 0.044). So, we recommend that CT should be used for patients aged ≤ 45years, and RT can be used for patients ≤ 45years or those with tumors > 5 cm for the sake of decreasing the incidence of local recurrence, which we believe would indirectly benefit the survival of ESOS patients.…”
Get full text

Chemotherapy in synergy with innate immune agonists enhances T cell priming for checkpoint inhibitor treatment in pancreatic cancer by Nan Niu, Keyu Li, Junke Wang, Vanessa Funes, Birginia Espinoza, Pan Li, Jianxin Wang, Melissa Lyman, Mengni He, Brian Herbst, Michael Wichroski, Ruslan Novosiadly, Sami Shoucair, Yiping Mou, Lei Zheng

“…Adding chemotherapy to innate agonists enhances the infiltration of dendritic cells (DCs) in the tumors and CD86+ mature DCs in tumor draining lymph nodes. …”
Get full text

Radiation dose and fraction in immunotherapy: one-size regimen does not fit all settings, so how does one choose? by Marka Crittenden, Sandra Demaria, C Norman Coleman, Jonathan Schoenfeld, Arta Monjazeb, Samir Khleif, Seema Gupta, Andrew Sikora, Zachary Morris, Chandan Guha, Stephen Shiao, Silvia Chiara Formenti, Bhadrasain Vikram, Mansoor M Ahmed

“…Hypofractionation or other modifications of standard fractionation may improve radiation’s ability to promote immune responses to tumors. Other novel delivery options may also affect immune responses, including T-cell activation and tumor-antigen presentation changes. …”
Get full text

First Clinical Experience of ⁶⁸Ga-FAPI PET/CT in Tertiary Cancer Center: Identifying Pearls and Pitfalls by Akram Al-Ibraheem, Ahmed Saad Abdlkadir, Ula Al-Rasheed, Dhuha Al-Adhami, Feras Istatieh, Farah Anwar, Marwah Abdulrahman, Rula Amarin, Issa Mohamad, Asem Mansour

“…<b>Results:</b> Notably, pancreaticobiliary tumors exhibited the highest tracer uptake, with mean maximum standardized uptake values (SUVmax) and tumor-to-background ratios (TBR) surpassing 10. …”
Get full text

Human soft tissue sarcomas harbor an intratumoral viral microbiome which is linked with natural killer cell infiltrate and prognosis by William J Murphy, Robert J Canter, Nikhil Joshi, Sean J Judge, Morgan A Darrow, Steve W Thorpe, Alicia A Gingrich, Lauren M Perry, Sylvia M Cruz, Kara T Kleber, Louis B Jones, Ugur N Basmaci, Matthew L Settles, Blythe P Durbin-Johnson, Arta Monir Monjazeb, Janai Carr-Ascher, Jonathan A Eisen

“…Our data suggest that the STS tumor microbiome has prognostic significance with viral relative abundance associated with NK infiltration and oncologic outcome. …”
Get full text

Shikonin Inhibits Non-Small-Cell Lung Cancer H1299 Cell Growth through Survivin Signaling Pathway by Haini Wang, Junli Zuo

“…Overexpressed survivin is associated with worse survival of several types of human tumors. In this study, the antitumor activity of shikonin in non-small-cell lung cancer (NSCLC) by regulating survivin pathway was investigated. …”
Get full text

Surgical Procedures for External Auditory Canal Carcinoma and the Preservation of Postoperative Hearing by Hiroshi Hoshikawa, Takenori Miyashita, Nozomu Mori

“…The pathophysiology of these tumors is different from other skin lesions because of their anatomical and functional characteristics. …”
Get full text

Aquaporins in oral health and disease: A narrative review by Shailja Chatterjee

“…Its expression has been shown to have a significant correlation with the aggressiveness of tumors as well as prognosis. Aim: The current narrative review aimed to highlight the role of AQPs in maintaining homeostasis in cellular functioning and their expressions in diseased states and other conditions. …”
Get full text

Scientific-methodical support of gifted teenagers in creative education by Valentina G. Ryndak, Ekaterina S. Mikhaleva

“…The article actualizes the importance of the development of talented teenager potential for productive relationship with society through the acquisition of a teenager personality tumors ("Actual Self", "Potential Self", "Perspective Self"). …”
Get full text

Multimodality Imaging of a Giant Aortic Valve Papillary Fibroelastoma by Nowell M. Fine, David A. Foley, Jerome F. Breen, Joseph J. Maleszewski

“…Papillary fibroelastomas (PFEs) are benign cardiac tumors arising from endocardium. They are commonly found on valvular surfaces and average 1.0–1.5 cm in size. …”
Get full text

Metastatic Breast Carcinoma to the Prostate Gland by Meghan E. Kapp, Giovanna A. Giannico, Mohamed Mokhtar Desouki

“…This case demonstrates the importance of considering a broad differential diagnosis and comparing histology and IHC to prior known malignancies in the setting of atypical presentation or rare tumors.…”
Get full text

Breast Angiosarcoma Metastatic to the Ovary by Frederico F. Souza, Amol Katkar, Annick D. Van den Abbeele, Pamela J. Dipiro

“…Approximately 5%–10% of ovarian malignancies are diagnosed as metastatic tumors. Primary angiosarcoma can arise anywhere in the body and when it arises in the breast, it usually affects women in their 3rd and 4th decades and accounts for one in 1700–2300 cases of primary breast cancer. …”
Get full text

A Case Report on Juvenile Ossifying Fibroma Unveiling the Pivotal Role of its Prompt Diagnosis by Amakcham Nita, Kavleen K. Sethi, Haider Iqbal, Anuj Mishra, Tanmay Srivastava, Sparsh Srivastava

“…The benign, bone-forming tumor referred to as juvenile ossifying fibroma (JOF) predominantly affects children and teenagers. …”
Get full text

Metastatic Renal Cell Carcinoma with Level IV Thrombus: Contemporary Management with Complete Response to Neoadjuvant Targeted Therapy by Abhishek Bhat, Bruno Nahar, Vivek Venkatramani, Indraneel Banerjee, Oleksandr N. Kryvenko, Dipen J. Parekh

“…It also has a propensity for venotropism with a proportion of tumors developing thrombi up to the right atrium. …”
Get full text

An Unusual Localization of a Pleomorphic Adenoma in the Rhinopharynx by Fabio Pagella, Francesco Chu, Alessandro Pusateri, Elina Matti

“…Pleomorphic adenoma is the most common benign tumor of the parotid glands. Rarely it may arise from minor salivary glands of the upper aerodigestive tract. …”
Get full text

Concurrent Angiomyolipoma and Clear Cell Renal Cell Carcinoma in the Same Kidney: A Rare Finding in a Patient without Tuberous Sclerosis by Amal Fekkar, Kaoutar Znati, Fouad Zouaidia, Hafsa Elouazzani, Zakia Bernoussi, Ahmed Jahid

“…However, the association of these tumors in the same kidney without TS is even more rare. …”
Get full text