The immunohistochemical combination of low SGLT2 expression and high PRDX4 expression independently predicts shortened survival in patients undergoing surgical resection for hepato... by Yao Liu, Jia Han, Akihiro Shioya, Yang-Xian Zhang, Vu Anh Dung, Takeru Oyama, Xin Guo, Qian Yang, Tohru Ito, Sohsuke Yamada

“…Abstract Background Hepatoblastoma (HB) is the most common malignant solid tumor of the liver in children and is a fatal disease with a poor prognosis. …”
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Comparative analysis of the profile of circulating microRNAs in the blood plasma of patients with gliomas by D. Yu. Gvaldin, N. A. Petrusenko, E. E. Rostorguev, S. N. Dimitriadi, S. E. Kavitskiy, N. N. Timoshkina

“…Against the background of modest successes in the development of new diagnostic and therapeutic tools to improve the survival of patients with glial brain tumors, early diagnosis of this pathology remains relevant. …”
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Melanoma Development and Progression Are Associated with Rad6 Upregulation and β-Catenin Relocation to the Cell Membrane by Karli Rosner, Darius R. Mehregan, Evangelia Kirou, Judith Abrams, Seongho Kim, Michelle Campbell, Jillian Frieder, Kelsey Lawrence, Brittany Haynes, Malathy P. V. Shekhar

“…Eighty-eight cutaneous tumors, 30 nevi, 29 primary melanoma, and 29 metastatic melanomas, were immunostained with anti-β-catenin and anti-Rad6 antibodies. …”
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Evaluation of Epstein-Barr Virus Latent Membrane Protein 2 Specific T-Cell Receptors Driven by T-Cell Specific Promoters Using Lentiviral Vector by Dongchang Yang, Qing Shao, Hua Sun, Xiaoxin Mu, Yun Gao, Runqiu Jiang, Jiajie Hou, Kun Yao, Yun Chen, Beicheng Sun

“…In conclusion, LMP2-specific CTLs by lentiviral transduction have the potential use for treatment of EBV-related tumors.…”
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Expression of Intratumoral IGF-II Is Regulated by the Gene Imprinting Status in Triple Negative Breast Cancer from Vietnamese Patients by Vinodh Kumar Radhakrishnan, Lorraine Christine Hernandez, Kendra Anderson, Qianwei Tan, Marino De León, Daisy D. De León

“…We previously demonstrated that tumors from these patients express high IGF-II and exhibit high activation of the IGF signaling pathways. …”
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Akt/p27kip1 Pathway Is Not Involved in Human Insulinoma Tumorigenesis by Adriana Graciela Díaz, Andrea Paes de Lima, Paula Garibaldi, Maria de los Milagros Rubio, Florencia García, Marta Kral, Oscar D. Bruno

“…Insulinomas are pancreatic neuroendocrine tumors (pNET), usually benign. Akt/p27kip1 is an intracellular pathway overexpressed in many pNET. …”
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Clinicopathological and prognostic factor analyses of primary fallopian tube carcinoma and high-grade serous ovarian cancer: a single-institution retrospective study by Mengyan Tu, Xueyan Gao, Tianchen Guo, Weiguo Lu, Junfen Xu

“…OS was significantly related to FIGO stage, residual tumor size, and laterality. However, only residual tumor size was an independent prognostic variable for OS. …”
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Underlying Anticancer Mechanisms and Synergistic Combinations of Phytochemicals with Cancer Chemotherapeutics: Potential Benefits and Risks by Muhammad Ayaz, Asif Nawaz, Sajjad Ahmad, Osama F. Mosa, Alashary Adam Eisa Hamdoon, Modawy Alnour Khalifa, Abdul Sadiq, Farhat Ullah, Abdul Wadood, Atul Kabra, H. C. Ananda Murthy

“…Cancer therapies are associated with various challenges including the emergence of multidrug resistant tumors, toxicological issues, severe side effects, and economic burden. …”
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A Clinicopathological Study of 24 Cases of DFSP by Miyako Kachi, Atsumori Hamahata, Kohei Oashi, Hisato Konoeda, Miho Kirita, Masashi Ishikawa, Hirotaka Koyanagi, Hiroyuki Sakurai

“…The median tumor diameter was 4.35 cm. A total of 18 patients underwent surgical resection before arriving at our hospital, 16 of whom had positive surgical margins. …”
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Advancing precision cancer immunotherapy drug development, administration, and response prediction with AI-enabled Raman spectroscopy by Jay Chadokiya, Kai Chang, Saurabh Sharma, Jack Hu, Jennie R. Lill, Jennifer Dionne, Jennifer Dionne, Jennifer Dionne, Amanda Kirane

“…Molecular characterization of tumors is essential to identify predictive biomarkers that inform treatment decisions and improve precision immunotherapy development and administration. …”
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Preclinical Evaluation of Oncolytic Δγ134.5 Herpes Simplex Virus Expressing Interleukin-12 for Therapy of Breast Cancer Brain Metastases by James J. Cody, Pietro Scaturro, Alan B. Cantor, G. Yancey Gillespie, Jacqueline N. Parker, James M. Markert

“…We have previously described an oncolytic herpes simplex virus (HSV), designated M002, which lacks both copies of the γ134.5 neurovirulence gene and carries a murine interleukin 12 (IL-12) expression cassette, and have validated its antitumor efficacy in a variety of preclinical models of primary brain tumors. However, M002 has not been yet evaluated for use against metastatic brain tumors. …”
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Hypoxia-tolerant polymeric photosensitizer prodrug for cancer photo-immunotherapy by Jie Yu, Jiayan Wu, Jingsheng Huang, Cheng Xu, Mengke Xu, Clarence Zhi Han Koh, Kanyi Pu, Yan Zhang

“…Abstract Although photodynamic immunotherapy represents a promising therapeutic approach against malignant tumors, its efficacy is often hampered by the hypoxia and immunosuppressive conditions within the tumor microenvironment (TME) following photodynamic therapy (PDT). …”
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Reliability of Endoscopic Ultrasound Using Miniprobes and Grayscale Histogram Analysis in Diagnosing Upper Gastrointestinal Subepithelial Lesions by Samiullah Khan, Rui Zhang, Weili Fang, Tao Wang, Shu Li, Danna Wang, Yixiang Chang, Lanping Zhu, Bang-mao Wang, Wentian Liu

“…The EUS images of SELs, particularly, leiomyoma and GIST, were further analyzed via a grayscale histogram to differentiate between the two tumors. Results. Of the 709 patients, 47 cases were pathologically undetermined. …”
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Investigating proteogenomic divergence in patient-derived xenograft models of ovarian cancer by Jesenia M. Perez, Jolene M. Duda, Joohyun Ryu, Mihir Shetty, Subina Mehta, Pratik D. Jagtap, Andrew C. Nelson, Boris Winterhoff, Timothy J. Griffin, Timothy K. Starr, Stefani N. Thomas

“…Abstract Within ovarian cancer research, patient-derived xenograft (PDX) models recapitulate histologic features and genomic aberrations found in original tumors. However, conflicting data from published studies have demonstrated significant transcriptional differences between PDXs and original tumors, challenging the fidelity of these models. …”
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NIR-II-excited off-on-off fluorescent nanoprobes for sensitive molecular imaging in vivo by Yufu Tang, Yuanyuan Li, Chunxu He, Zhen Wang, Wei Huang, Quli Fan, Bin Liu

“…Due to its low background, a blind study employing our probes could identify female mice with orthotopic liver tumors with 100% accuracy from mixed subjects of healthy and tumor mice, and implemented sensitive locating of early orthotopic liver tumors with sizes as small as 4 mm. …”
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Deletions of N33, STK11 and TP53 Are Involved in the Development of Lymph Node Metastasis in Larynx and Pharynx Carcinomas by Marta Alonso Guervós, César Álvarez Marcos, Mario Hermsen, Andrés Sampedro Nuño, Carlos Suárez, José Luis Llorente

“…Gain of EMS1 had the same relation with survival but not significant (p=0.08). Lymph node positive tumors presented a specific pattern of genetic alterations, with losses of N33, STK11 (19p13) and TP53 (17p13), the latter especially in larynx tumors. …”
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Comprehensive evaluation of compound Kushen injection combined with zoledronic acid in treating bone metastasis cancer pain based on meta-analysis and decision tree model by Xi Zhao, Tianwei Meng, Kaiqiang Wang, Xi Yan, Yuqiang Liu, Xinghua Li

“…ObjectiveTo evaluate the safety, efficacy, and cost-effectiveness of combining Compound Kushen Injection (CKI) with zoledronic acid in the treatment of bone metastasis-induced cancer pain in malignant tumors.MethodsA comprehensive search of Chinese and English databases identified randomized controlled trials (RCTs) investigating CKI combined with zoledronic acid for bone metastases in malignancies. …”
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Mechanistic insights into epithelial-mesenchymal transition mediated cisplatin resistance in ovarian cancer by Taha Umair Wani, Hyun-Yi Kim, Geum-Hwa Lee, Young Je Lim, Han-Jung Chae, Ji-Ye Kim, Hyonok Yoon

“…Further, we induced xenograft tumors in nude mice. The histopathological analysis confirmed the aggressive nature of resistant tumors and showed the presence of necrotic core which could be implicated to EMT. …”
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Intratesticular Angiolipoma: A Rare Case of Adipose Tissue Presence in the Testis by V. Kalyvas, C. Gkekas, D. Papadopoulos, A. Malioris, S. Milias, M. Papathanasiou, N. Kalinderis, K. Moysidis, K. Hatzimouratidis

“…Solid, fat-containing tumors of the testes are extremely rare with only a few cases having been reported so far, contrary to the more frequent occurrence of paratesticular lipomatosis. …”
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HDAC1-3 inhibition triggers NEDD4-mediated CCR2 downregulation and attenuates immunosuppression in myeloid-derived suppressor cells by Zhiqi Xie, Jinjin Shao, Zeren Shen, Zhichao Ye, Yoshiaki Okada, Daisuke Okuzaki, Naoki Okada, Masashi Tachibana

“…In an orthotropic hepatocellular carcinoma (HCC) murine model, HDAC1-3 inhibitors reduced the infiltration of M-MDSCs, increased the number of natural killer cells in tumors, and suppressed tumor growth. Our results also suggest that HDAC1-3 inhibitors potentiate the antitumor effects of anti-programmed cell death protein 1 antibodies. …”
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