Assessment of Pathological Response of Breast Carcinoma in Modified Radical Mastectomy Specimens after Neoadjuvant Chemotherapy by Dhanya Vasudevan, P. S. Jayalakshmy, Suresh Kumar, Siji Mathew

“…Clinically small sized tumors (2–5 cms) and Bloom Richardson’s grade 1 tumors showed a pCR. …”
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Identification of a pathogenic SDHD mutation in a Chinese family with hereditary head and neck paraganglioma: implications for genetic counseling and management by Pu Wang, Liming Gao, Wenyang Zhang, Rui Guo, Yin Xia

“…A 31-year-old patient (II-4) was diagnosed with a left parotid gland tumor and a right carotid body tumor, while both the father and elder sister had right carotid body tumors, and the third sister had bilateral carotid body tumors. …”
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Cellular Fibroma of the Ovary with Multiloculated Macroscopic Characteristics: Case Report by Sheila Jorge Adad, Valeria Lima Laterza, Carlos David Teixeira dos Santos, Antonio Alexandre Lisboa Ladeia, Joao Carlos Saldanha, Cleber Sergio da Silva, Luis Ronan Marquez Ferreira e Souza, Eddie Fernando Candido Murta

“…Ovarian fibroma is the commonest benign tumor of the ovarian stroma. The cellular subtype accounts for around 10% of ovarian fibromatous tumors. …”
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Identification of p53 and Its Isoforms in Human Breast Carcinoma Cells by Zorka Milićević, Vladan Bajić, Lada Živković, Jelena Kasapović, Uroš Andjelković, Biljana Spremo-Potparević

“…The isoforms expressed also varied between individual tumors, indicating potential roles of these p53 variants in human breast cancer.…”
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Effect of “Time To Surgery” on the Endometrial Cancer Prognosis by Engin Celik, Harika Yumru Celiksoy, Hamdullah Sozen, Hale Goksever Celik, Semen Onder, Mehmet Yavuz Salihoglu, Samet Topuz

“…There was no significant difference between the groups in terms of progression-free survival and disease-specific survival for cases with endometrioid type grade 1-2 tumors. There was also no significant difference between the groups regarding progression-free survival and disease-specific survival in the patients with tumors of endometrioid type grade 3 and non-endometrioid histology. …”
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HPV Infection in Esophageal Squamous Cell Carcinoma and Its Relationship to the Prognosis of Patients in Northern China by Fangli Cao, Hui Han, Fang Zhang, Baozhong Wang, Wei Ma, Yanwen Wang, Guiming Sun, Miao Shi, Yubo Ren, Yufeng Cheng

“…Twenty-five (86.2%) of the 29 HPV-positive tumors were stained positive for p16. HPV infected patients had better 5-year rates of OS (65.9% versus 43.4% among patients with HPV-negative tumors; P = 0.002 by the log-rank test) and had a 63% reduction in the risk of death (adjusted HR = 0.37, 95% CI = 0.16 to 0.82, and P = 0.01). …”
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A Rare Case Report of Thyroglossal Duct Cyst Carcinoma Coexisting with Thyroid Carcinoma in an Adolescent by Kleanthi Mylopotamitaki, Dionisios Klonaris, Georgios Kazamias, Christos Simandirakis, Irene Vourliotaki, Efthimios Karakostas

“…Clinical presentation of TDC carcinomas is usually indistinguishable from benign tumors preoperatively, and differential diagnosis can be challenging. …”
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Biological Characteristics and Medical Treatment of Breast Cancer in Young Women—A Featured Population: Results from the NORA Study by P. Pronzato, G. Mustacchi, A. De Matteis, F. Di Costanzo, E. Rulli, I. Floriani, M. E. Cazzaniga

“…Younger women more frequently had tumors with ER/PgR-negative(𝜒2=7.07; 𝑃=.008), HER2 amplification (𝜒2=5.76; 𝑃=.01), and high (≥10%) Ki67 labelling index (𝜒2=9.53; 𝑃=.002). …”
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A Journey into the Complexity of Temporo-Insular Gliomas: Case Report and Literature Review by Manuel De Jesus Encarnacion Ramirez, Gervith Reyes Soto, Carlos Castillo Rangel

“…Introduction: Temporo-insular gliomas, rare brain tumors originating from glial cells, comprise about 30% of brain tumors and vary in aggressiveness from grade I to IV. …”
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Prevalence of lumbar disc herniation and its associated factors: A cross-sectional study in Gansu. by Zhiwei Chen, Jirong Zhao, Li Wang, Hong Shao, Liangjia Cao, Xueyun He, Zhenghan Yang, Junfei Ma, Qianwen Chen, Peng Jiang, Licun Zhang, Jihong Hu

“…LDH prevalence differed by latitude, city, age, sex, nationality, education, marital status, income, drinking habits, residence duration, physical activity, exercise intensity, health status (including hypertension, diabetes, CHD, chronic infection, and tumors) (all P <0.05). Logistic regression showed higher LDH risk at high (OR = 2.250) and middle latitudes (OR = 2.551), among males (OR = 0.808), ages 35-49 (OR = 1.530) and 50-64 (OR = 1.991), Tibetans (OR = 1.533) and Hui (OR = 0.557), alcohol consumers (OR = 0.696), those with moderate (OR = 0.742) and mild physical activity (OR = 0.840), cadres (OR = 0.46), workers (OR = 1.568), farmers/herdsmen (OR = 1.840), married individuals (OR = 2.239), residents for ≥36 months (OR = 0.618), annual income ≥50,000 yuan (OR = 1.246), central obesity (OR = 1.399), and those with tumors (OR = 3.953), hypertension (unknown, OR = 1.817), diabetes (yes, OR = 0.529, unknown, OR = 0.565), CHD (unknown, OR = 1.404), and osteoporosis (unknown, OR = 1.404).…”
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Statin drugs enhance responses to immune checkpoint blockade in head and neck cancer models by Chrystal Paulos, Gregory B Lesinski, Zachary S Buchwald, Nabil F Saba, Vikash Kansal, Andre J Burnham, Brendan L C Kinney, Nicole C Schmitt

“…Simvastatin and lovastatin also enhanced T-cell killing of tumor cells. In mice, daily oral simvastatin or lovastatin enhanced tumor control and extended survival when combined with PD-1 blockade, with rejection of MOC1 tumors in 30% of mice treated with lovastatin plus anti-PD-1. …”
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A central role for Foxp3+ regulatory T cells in K-Ras-driven lung tumorigenesis. by Courtney A Granville, Regan M Memmott, Andria Balogh, Jacopo Mariotti, Shigeru Kawabata, Wei Han, Jaclyn Lopiccolo, Jason Foley, David J Liewehr, Seth M Steinberg, Daniel H Fowler, M Christine Hollander, Phillip A Dennis

“…<h4>Results</h4>Exposure of A/J mice to a tobacco carcinogen tripled lung-associated Foxp3+ cells prior to tumor development. At clinically relevant concentrations, rapamycin prevented this induction and reduced lung tumors by 90%. …”
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Pan-Cancer Analysis of the Prognostic and Immunotherapeutic Value of PDGFB by Bai Y, Wang X, Wang B

“…The study also demonstrated that PDGFB was linked to RNA and DNA stemness in 15 and 36 tumor types, respectively, and had a positive association with tumor lymphocyte infiltration. …”
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Pan-cancer analysis shows that TNFSF4 is a potential prognostic and immunotherapeutic biomarker for multiple cancer types including liver cancer by Zhaoda Deng, Lincheng Li, Zihe Meng, Guineng Zeng, Rui Cao, Rong Liu

“…Abstract Background As a member of the tumor necrosis factor (TNF) superfamily, tumor necrosis factor superfamily member 4 (TNFSF4) is expressed on antigen-presenting cells and activated T cells by binding to its receptor TNFRSF4. …”
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Pan-cancer analysis of SOX2: Prognostic implications and potential as a therapeutic target in immune checkpoint modulation by Shoukai Yu, Lingmei Qian, Liling Xu, Jun Ma

“…Although increased immune checkpoint expression is generally linked to poor prognosis, tumors with high SOX2 expression exhibited higher responsiveness to immune checkpoint inhibitors, suggesting that targeting SOX2 may improve immune checkpoint therapy efficacy.The study highlights SOX2 as a key factor in cancer prognosis and immune infiltration across multiple tumor types. …”
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Identification of B Cell Subpopulations with Pro- and Anti-Tumorigenic Properties in an Immunocompetent Mouse Model of Head and Neck Squamous Cell Carcinoma by Michael Sonntag, Sandra Stanojevic, Simon Laban, Patrick J. Schuler, Thomas K. Hoffmann, Cornelia Brunner

“…Following tumor induction, GCs, as well as increasing numbers of GL7⁺CD95⁺ GC B cells in the spleen and tumor tissues, were detected. …”
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Evaluation of [18F]tetrafluoroborate as a Potential PET Imaging Agent in a Sodium Iodide Symporter-Transfected Cell Line A549 and Endogenous NIS-Expressing Cell Lines MKN45 and K1 by Mengda Niu, Jingjing Qin, Liang Wang, Yujia He, Chuanhuizi Tian, Yanyan Chen, Pufeng Huang, Zhiping Peng

“…In vivo PET imaging clearly delineated the three tumors based on the specific accumulation of [18F]TFB in a mouse model. …”
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Long-term results of surgical treatment of a locally advanced rectal cancer using extrafascial principle of dissection by P. V. Tsarkov, I. A. Tulina, D. N. Fedorov, A. Yu. Kravchenko, O. Yu. Samofalova

“…The true tumor progression to resected structures and organs was revealed in 22% of the cases. …”
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Recent updates of centromere proteins in hepatocellular carcinoma: a review by Zhongyuan Yang, Wenjiao Chen, Yunhui Liu, Yuxin Niu

“…Furthermore, chromosomal instability is a common characteristic of the majority of tumors. Chromosomal instability can lead to uncontrolled and sustained division and proliferation of malignant tumors. …”
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Real-world clinical multi-omics analyses reveal bifurcation of ER-independent and ER-dependent drug resistance to CDK4/6 inhibitors by Zhengyan Kan, Ji Wen, Vinicius Bonato, Jennifer Webster, Wenjing Yang, Vladimir Ivanov, Kimberly Hyunjung Kim, Whijae Roh, Chaoting Liu, Xinmeng Jasmine Mu, Jennifer Lapira-Miller, Jon Oyer, Todd VanArsdale, Paul A. Rejto, Jadwiga Bienkowska

“…Machine learning models predict therapeutic dependency on ESR1 and CDK4 among ER-dependent tumors and CDK2 dependency among ER-independent tumors, confirmed by experimental validation.…”
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