Developing a risk score using liquid biopsy biomarkers for selecting Immunotherapy responders and stratifying disease progression risk in metastatic melanoma patients by Amalia Azzariti, Simona De Summa, Tommaso M. Marvulli, Ivana De Risi, Giuseppe De Palma, Roberta Di Fonte, Rossella Fasano, Simona Serratì, Sabino Strippoli, Letizia Porcelli, Michele Guida

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Development of [F]FPy-WL12 as a PD-L1 Specific PET Imaging Peptide by Wojciech G. Lesniak PhD, Ronnie C. Mease PhD, Samit Chatterjee PhD, Dhiraj Kumar PhD, Ala Lisok MA, Bryan Wharram MS, Venkateswara Rao Kalagadda PhD, Leisha A. Emens MD, PhD, Martin G. Pomper MD, PhD, Sridhar Nimmagadda PhD

“…In vivo data demonstrated a PD-L1-specific uptake of [ 18 F]FPy-WL12 in tumors that is reduced in mice receiving a blocking dose. …”
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Choriocarcinoma Syndrome as an Initial Presentation of Testicular Cancer by Carlos Eduardo Salazar-Mejía, María Elena García-Gutiérrez, María Inés Contreras-Salcido, Carlos Javier Rodríguez-Álvarez, Blanca Otilia Wimer-Castillo, Jackeline Grace Lara-Campos, Edio Llerena-Hernández, José Luis González-Vela, David Hernández-Barajas

“…Choriocarcinoma syndrome (CS) is a rare clinical entity within the spectrum of nonseminomatous germ-cell tumors (NSGCT). It is characterized by the abrupt establishment of rapidly progressive and hemorrhagic tumors associated with very high levels of the beta fraction of human chorionic gonadotropin (β-hCG) and with a very poor prognosis, particularly in patients with β-hCG values above 50,000 IU/L. …”
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Prognostic evaluation of non-muscle invasive bladder cancer with P-CRP and its nomogram by Junyun Wu, Zhixuan Deng, Xu Lei, Zhiyao Xu, Chenxi Tan, Yunqiao Tang, Xi Sheng, Ning Yang

“…The Nomogram incorporating P-CRP, number of tumors, tumor size, T stage, and tumor pathological grading can better predict the postoperative recurrence risk of NMIBC patients.…”
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The impact of solute carrier proteins on disrupting substance regulation in metabolic disorders: insights and clinical applications by Jiangxia Du, Minhui Shen, Jiajia Chen, Hao Yan, Zhifei Xu, Xiaochun Yang, Bo Yang, Bo Yang, Peihua Luo, Peihua Luo, Kefeng Ding, Yuhuai Hu, Qiaojun He, Qiaojun He, Qiaojun He, Qiaojun He

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Immune dysfunction revealed by digital spatial profiling of immuno-oncology markers in progressive stages of renal cell carcinoma and in brain metastases by Wei Wei, Michael Hurwitz, Sabina Signoretti, Lucia Jilaveanu, Toni K Choueiri, David L Rimm, Adebowale Adeniran, Sandra Martínez, Harriet M Kluger, David A Schoenfeld, Myrto Moutafi, Dijana Djureinovic, Ross D Merkin, David A Braun, Fabio Parisi

“…Background The tumor microenvironment (TME) contributes to cancer progression and treatment response to therapy, including in renal cell carcinoma (RCC). …”
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Blood Genome-Wide Transcriptional Profiles of HER2 Negative Breast Cancers Patients by Ovidiu Balacescu, Loredana Balacescu, Oana Virtic, Simona Visan, Claudia Gherman, Flaviu Drigla, Laura Pop, Gabriela Bolba-Morar, Carmen Lisencu, Bogdan Fetica, Oana Tudoran, Ioana Berindan-Neagoe

“…Tumors act systemically to sustain cancer progression, affecting the physiological processes in the host and triggering responses in the blood circulating cells. …”
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Single-Cell RNA Sequencing Reveals LEF1-Driven Wnt Pathway Activation as a Shared Oncogenic Program in Hepatoblastoma and Medulloblastoma by Christophe Desterke, Yuanji Fu, Jenny Bonifacio-Mundaca, Claudia Monge, Pascal Pineau, Jorge Mata-Garrido, Raquel Francés

“…(1) Background: Hepatoblastoma and medulloblastoma are two types of pediatric tumors with embryonic origins. Both tumor types can exhibit genetic alterations that affect the β-catenin and Wnt pathways; (2) Materials and Methods: This study used bioinformatics and integrative analysis of multi-omics data at both the tumor and single-cell levels to investigate two distinct pediatric tumors: medulloblastoma and hepatoblastoma; (3) Results: The cross-transcriptome analysis revealed a commonly regulated expression signature between hepatoblastoma and medulloblastoma tumors. …”
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Early Effects of Bronchoscopic Cryotherapy in Metastatic Non-Small Cell Lung Cancer Patients Receiving Immunotherapy: A Single-Center Prospective Study by Gediminas Vasiliauskas, Evelina Žemaitė, Erika Skrodenienė, Lina Poškienė, Gertrūda Maziliauskienė, Aurimas Mačionis, Skaidrius Miliauskas, Donatas Vajauskas, Marius Žemaitis

“…It induces cancer cell necrosis followed by inflammation in the treated tumor microenvironment, and it stimulates systemic adaptive immunity. …”
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Immunohistochemistry‐based molecular subtypes of urothelial carcinoma derive different survival benefit from platinum chemotherapy by Csilla Olah, Oleksandr Shmorhun, Gilbert Georg Klamminger, Josefine Rawitzer, Lara Sichward, Boris Hadaschik, Mulham Al‐Nader, Ulrich Krafft, Christian Niedworok, Melinda Váradi, Peter Nyirady, Andras Kiss, Eszter Szekely, Henning Reis, Tibor Szarvas

“…In addition, we assessed the tumor heterogeneity within the primary tumor and between the primary and lymph node (LN) metastatic sites. …”
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Differences in expression profiles in malingant melanoma patients according to immunotherapy response by E. N. Lukyanova, M. S. Fedorova, E. A. Pudova, T. V. Nasedkina, E. V. Stepanova, K. M. Nyushko, A. Y. Popov, N. V. Koroban, A. A. Dmitriev, M. V. Kiseleva, A. V. Lipatova, A. S. Zasedatelev, A. V. Kudryavtseva

“…This method allows the condition of the tumor to be assessed by analyzing the body’s natural fluids, such as blood, urine or saliva. …”
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Analysis of mutations in CDC27, CTBP2, HYDIN and KMT5A genes in carotid paragangliomas by E. N. Lukyanova, A. V. Snezhkina, D. V. Kalinin, A. V. Pokrovsky, A. L. Golovyuk, O. A. Stepanov, E. A. Pudova, G. S. Razmakhaev, M. V. Orlova, A. P. Polyakov, M. V. Kiseleva, A. D. Kaprin, A. V. Kudryavtseva

“…These tumors are slowly growing, but occasionally they become aggressive and metastatic. …”
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Exploring the mechanism of rosmarinic acid in the treatment of lung adenocarcinoma based on bioinformatics methods and experimental validation by Chaowang Zhou, Ruqian Zhong, Lei Zhang, Renyi Yang, Yuxin Luo, Huijun Lei, Liang Li, Jianzhong Cao, Zhiying Yuan, Xiaoning Tan, Mengzhou Xie, Haoyu Qu, Zuomei He

“…In vivo experimental results showed that RosA could inhibit the growth of transplanted tumors in nude mice bearing tumors of lung cancer cells, reduce the positive expression of Ki67 in lung tumor tissue, and hinder the proliferation of lung tumor cells. …”
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Liposarcoma of tongue: A case report by Amarjot Kaur, Aminder Singh, Vikram Narang, Chandan Kakkar

“…Liposarcoma (LS) is one of the most common malignant tumors. However, oral LS is an extremely rare lesion that is often clinically misdiagnosed as a benign lesion because of its asymptomatic and indolent clinical course. …”
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Neglected Basal Cell Carcinomas in the 21st Century by Erika Varga, Irma Korom, Zoltán Raskó, Erika Kis, János Varga, Judit Oláh, Lajos Kemény

“…Although tumors on the surface of the skin are considered to be easily recognizable, neglected advanced skin neoplasms are encountered even in the 21st century. …”
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Unlocking prognostic potential: A genomic signature of caloric restriction in patients with epithelial ovarian cancer. by Ori Tal, Tamar Zahavi, Liat Anabel Sinberger, Mali Salmon-Divon

“…Dietary interventions have demonstrated influence on cancer progression; for instance, caloric restriction has exhibited tumor growth reduction and enhanced survival in animal cancer models. …”
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Cutaneous Adnexal Cylindroma of Breast: Epithelial Immunoreactivities for GATA-3, Mammaglobin, and E-Cadherin Do Not Equate to a Mammary Ductal Neoplasm by A. Halima, A. M. Pannunzio, E. M. Erstine, J. S. Ko, W. F. Bergfeld, R. M. Malaya, M. B. Frankel, B. C. Calhoun, C. D. Sturgis

“…Cylindromas are benign epithelial neoplasms derived from cutaneous eccrine adnexal structures. These tumors are most commonly encountered on the head, neck, and scalp of older women. …”
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17α-Ethynyl-5α-androstane-3α, 17β-diol Treatment of MNU-Induced Mammary Cancer in Rats by Clarence N. Ahlem, James M. Frincke, Steven K. White, Christopher L. Reading, Richard J. Trauger, Rajkumar Lakshmanaswamy

“…N-methyl-N-nitrosourea (MNU) induces estrogen-dependent mammary tumors in female Lewis rats. We explored the antineoplastic activity of a synthetic androstane derivative, 17α-ethynyl-5α-androstane-3α, 17β-diol (HE3235), as a single agent or in combination with docetaxel compared to tamoxifen, anastrazole, and docetaxel monotherapies against MNU-induced mammary tumors in female Lewis rats. …”
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Clinical Outcomes of Drug-Eluting Bead Transarterial Chemoembolization Loaded with Raltitrexed for the Treatment of Unresectable or Recurrent Hepatocellular Carcinoma by Yonghua Bi, Dechao Jiao, Jianzhuang Ren, Xinwei Han

“…The response evaluation criteria in solid tumors (RECIST) criteria and modified RECIST criteria (mRECIST) were used to assess the tumor response after the DEB-TACE procedure. …”
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Mini review of spatially fractionated radiation therapy for cancer management by Shrikant B. Mali

“…Investigations into the complexity of tumor radiobiology have confirmed the high heterogeneity of tumors as responsible for poor treatment outcomes. …”
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