Intratumor heterogeneity of HPV integration in HPV-associated head and neck cancer by Noah Sasa, Toshihiro Kishikawa, Masashi Mori, Rie Ito, Yumie Mizoro, Masami Suzuki, Hirotaka Eguchi, Hidenori Tanaka, Takahito Fukusumi, Motoyuki Suzuki, Yukinori Takenaka, Keisuke Nimura, Yukinori Okada, Hidenori Inohara

“…Whole-genome sequencing of 51 tumors revealed intratumor heterogeneity of HPV integration, with 44% of breakpoints subclonal, and a biased distribution of integration breakpoints across the HPV genome. …”
Get full text

Periocular Myxoma in a Child by Dolores Ríos y Valles-Valles, Ana María Vera-Torres, Héctor A. Rodríguez-Martínez, Abelardo A. Rodríguez-Reyes

“…The lesion was resected with a clinical diagnosis of lacrimal sac tumor. Histopathology and immunohistochemistry proved the tumor to be a myxoma. …”
Get full text

Melanosis coli in patients with colon cancer by Dorota Biernacka-Wawrzonek, Michał Stępka, Alicja Tomaszewska, Agnieszka Ehrmann-Jóśko, Natalia Chojnowska, Magdalena Zemlak, Jacek Muszyński

“…We analyzed sections of the cancer and intestinal mucosa from the tumor’s proximal (2–5 cm) and distal (8–10 cm) zone. …”
Get full text

Humoral Bone Morphogenetic Protein 2 Is Sufficient for Inducing Breast Cancer Microcalcification by Fangbing Liu, Nathalie Bloch, Kumar R. Bhushan, Alec M. De Grand, Eiichi Tanaka, Stephanie Solazzo, Pawel M. Mertyna, Nahum Goldberg, John V. Frangioni, Robert E. Lenkinski

“…Importantly, when two tumors were initiated in a single host, the ipsilateral tumor expressing BMP-2 was able to induce microcalcification in the contralateral tumor that was not expressing BMP-2, suggesting that BMP-2 can act humorally. …”
Get full text

Comparison of Syndecan-1 Immunohistochemical Expression in Lobular and Ductal Breast Carcinoma with Nodal Metastases by Ivana Miše, Majda Vučić

“…This study determined and compared Sdc1 expression in the tumor cells and stroma of 30 invasive lobular and 30 invasive ductal breast carcinomas (ILCs/IDCs), also in the axillary node metastases of ductal type, and correlated it with clinical and tumor parameters. …”
Get full text

A rare case of bladder paraganglioma treated successfully with robotic partial cystectomy by Kalyan M Shekhda, Jessal M Palan, Christo B Albor, Simon Wan, Teng-Teng Chung

“…Bladder paragangliomas are rare extra-adrenal urological tumors that account for around 0.05% of bladder cancers. …”
Get full text

Autoimmune Hemolytic Anemia Associated with Mature Ovarian Cystic Teratoma Containing Monoclonal Immunoglobulin G: A Case Report and Review of Literature by Yuma Nato, Keiki Nagaharu, Keika Itoh, Naoki Shinke, Keiko Maeyama, Akihiko Sawaki, Hiroyuki Miyashita

“…Autoimmune hemolytic anemia (AIHA) associated with solid tumors such as mature cystic teratomas is rare and poorly understood. …”
Get full text

Case Reports in Oncological Medicine Myoepithelioma: A New Rearrangement Involving the LPP Locus in a Case of Multiple Bone and Soft Tissue Lesions by Géraldine Pairet, Gaëlle Tilman, Rafaël Sciot, Thomas Schubert, Vasiliki Perlepe, Hélène A. Poirel, Christine Galant

“…We report a case of multiple myoepithelioma with synchronous bone and soft tissue tumors, associated with a new genomic alteration of the LPP locus. …”
Get full text

In Vivo Method to Monitor Changes in HER2 Expression Using Near-Infrared Fluorescence Imaging by Moinuddin Hassan, Victor Chernomordik, Rafal Zielinski, Yasaman Ardeshirpour, Jacek Capala, Amir Gandjbakhche

“…Near-infrared optical imaging studies were carried out using mice with subcutaneous HER2-positive tumors. Animals were divided into groups of five: no treatment and 12 hours and 1 week after treatment of the tumors with the Hsp90 inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG). …”
Get full text

Three Trocars Laparoscopic Resection of Angiomyolipoma of the Liver by J. M. Ramia, R. De la Plaza, J. Quiñones, M. D. Sanchez-Tembleque, A. Caminoa, P. Veguillas, J. García Parreño

“…Laparoscopic resection of liver tumors is becoming a excellent approach for operating on benign liver tumors. …”
Get full text

Metastasis of Uterine Leiomyosarcoma to the Breast: Medical and Histopathological Criteria by Eugenia Colón

“…It is uncommon for extramammary tumors to metastasize to the breast, and very few cases describing metastasis of primary uterine leiomyosarcoma to the breast have been reported. …”
Get full text

Multiple Extrauterine Adenomyomas Presenting in Upper Abdomen and Pelvis: A Case Report and Brief Review of the Literature by Mana Moghadamfalahi, Daniel S. Metzinger

“…Adenomyomas are benign tumors composed of smooth muscle and endometrial tissue. …”
Get full text

Fatal Disruption of a Left Atrial Myxoma Associated with Trauma by Anthony Iacco, Nazneen Billimoria, Greg Howells

“…Cardiac myxomas are benign tumors composed of sparse stellate cells in an extensive mucoid stroma. …”
Get full text

Local and distant response to intratumoral immunotherapy assessed by immunoPET in mice by Aurélien Marabelle, Louis Meyblum, Lambros Tselikas, Thierry de Baere, Sandrine Susini, Fréderic Deschamps, Baptiste Bonnet, Céline Chevaleyre, Benoit Jego, Dimitri Kereselidze, Vincent Lebon, Charles Truillet

“…Background Despite the promising efficacy of immune checkpoint blockers (ICB), tumor resistance and immune-related adverse events hinder their success in cancer treatment. …”
Get full text

Cryoablation combined with dual immune checkpoint blockade enhances antitumor efficacy in hepatocellular carcinoma model mice by Jun Gu, Zepeng Yu, Xiangxiang Tang, Wenying Chen, Xuedong Deng, Xiaoli Zhu

“…Background Cryoablation (Cryo) is a minimally invasive treatment for tumors. Cryo can activate the body’s immune response, although it is typically weak. …”
Get full text

TLR7/8/9 agonists and low-dose cisplatin synergistically promotes tertiary lymphatic structure formation and antitumor immunity by Shuting Wu, Rong Xiang, Yiwei Zhong, Shushu Zhao, Zhiyu Zhang, Zhihua Kou, Shijie Zhang, Yi Zhao, Cheng Zu, Gan Zhao, Yanling Xiao, Sulin Ren, Xiaoming Gao, Bin Wang

“…Moreover, combo-therapy led to full regression of 4T-1 tumors in a large percentage of mice, who became strongly resistant to secondary tumor challenge, a clear indication of antitumor immunological memory. …”
Get full text

Evaluation of the Definitions of “High-Risk” Cutaneous Squamous Cell Carcinoma Using the American Joint Committee on Cancer Staging Criteria and National Comprehensive Cancer Netwo... by Melinda B. Chu, Jordan B. Slutsky, Maulik M. Dhandha, Brandon T. Beal, Eric S. Armbrecht, Ronald J. Walker, Mark A. Varvares, Scott W. Fosko

“…By AJCC criteria, most tumors (n=211,82.1%) were of Stage 1; 46 tumors (13.9%) were of Stage 2. …”
Get full text

Synchronous Occurrence of Splenic Pleomorphic Mantle Cell Lymphoma and Esophageal Adenocarcinoma with Overexpression of BCL1 Protein by Dominik Dabrowski, Roberto F. Silva, Michael Constantinescu, Rodney E. Shackelford, Nestor Dela Cruz, Eric X. Wei

“…We report a case of synchronic MCL and an esophageal tumor in an elderly male patient. Morphologically, the tumors were classified as splenic pleomorphic MCL and adenocarcinoma of the esophagus occurring concurrently. …”
Get full text

Downregulation of S100 Calcium Binding Protein A9 in Esophageal Squamous Cell Carcinoma by Harsh Pawar, Srinivas M. Srikanth, Manoj Kumar Kashyap, Gajanan Sathe, Sandip Chavan, Mukul Singal, H. C. Manju, Kariyanakatte Veeraiah Veerendra Kumar, M. Vijayakumar, Ravi Sirdeshmukh, Akhilesh Pandey, T. S. Keshava Prasad, Harsha Gowda, Rekha V. Kumar

“…In the present study, we carried out immunohistochemical validation of S100A9 in a large cohort of ESCC patients to determine the expression and subcellular localization of S100A9 in tumors and adjacent normal esophageal epithelia. Downregulation of S100A9 was observed in 67% (n=192) of 288 different ESCC tumors, with the most dramatic downregulation observed in the poorly differentiated tumors (99/111). …”
Get full text

Diagnostic Accuracy of Mammography, Ultrasound, and Fine-Needle Aspiration in Detecting Breast Cancer in Patients with Painful Breast Masses:A Medical Record-Base Study by Hassan Vafapour, Sajad Borzoueisileh, Fatemeh Vafapour, Zafar Masoumi Moghaddam, Frough Nikeghbali, Yaghoub Barfar, Amir Hekmatifar

“…Breast cancer is a prevalent malignant tumor, and early detection is critical for successful treatment. …”
Get full text