A Rare Extraskeletal Osteosarcoma Appearing After 55 Years on a Large Stage 3 Burn Scar by O. Vanhooteghem, I. Theate

“…It is widely accepted that chronic burn wounds may lead to the development of various malignant skin tumors. Deep stage 3 burned areas may facilitate deeper carcinogenesis. …”
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A Patient Presenting with Concurrent Testis Torsion and Epididymal Leiomyoma by E. Arpali, A. Tok

“…Leiomyomas are the second most common tumors of epididymis. Patients with leiomyomas are sometimes misdiagnosed with testicular tumors. …”
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Diffuse Neuroendocrine Cell Hyperplasia: Report of Two Cases by Cevriye Cansız Ersöz, Ayten Kayı Cangır, Serpil Dizbay Sak

“…It is believed that a minority of the patients with DIPNECH can develop carcinoid tumors. Here, we report two new cases of DIPNECH with coexisting carcinoid tumors.…”
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CD36 enrichment in HER2-positive mesenchymal stem cells drives therapy refractoriness in breast cancer by Lorenzo Castagnoli, Alma Franceschini, Valeria Cancila, Matteo Dugo, Martina Bigliardi, Claudia Chiodoni, Paolo Toneguzzo, Viola Regondi, Paola A. Corsetto, Filippo Pietrantonio, Serena Mazzucchelli, Fabio Corsi, Antonio Belfiore, Antonio Vingiani, Giancarlo Pruneri, Francesca Ligorio, Mario P. Colombo, Elda Tagliabue, Claudio Tripodo, Claudio Vernieri, Tiziana Triulzi, Serenella M. Pupa

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STING agonism overcomes STAT3-mediated immunosuppression and adaptive resistance to PARP inhibition in ovarian cancer by Changli Qian, Gordon J Freeman, Tao Jiang, Ursula Matulonis, Ziying Lin, Hye-Jung Kim, Anniina Färkkilä, Hua Yu, Xin Cheng, Panagiotis A Konstantinopoulos, Antons Martincuks, Joyce F Liu, Qiwei Wang, Liya Ding, Michael J Kearns, Shaozhen Xie, Inga-Maria Launonen, Thomas M Roberts, Jean J Zhao

“…STAT3 ablation in tumor cells mitigates polarization of protumor macrophages and increases tumor-infiltrating T cells on PARP inhibition. …”
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Development and characterization of orthotopic patient-derived xenograft models of peritoneal metastatic mucinous appendiceal adenocarcinoma by I. Ito, V.K. Pattalachinti, A.M.G. Yousef, S. Chowdhury, M.M. Fanaeian, E. Haque, B.B. Gunes, M. Yousef, E.R. Salle, M.A. Zeineddine, S. Ji, R. Li, W. Wang, B.A. Helmink, M.W. Taggart, M.G. White, K.F. Fournier, N.W. Fowlkes, J.P. Shen

“…Histological, immunohistochemical, genetic, and transcriptomic comparisons of patient and patient-derived xenograft (PDX) tumors were carried out. Results: Higher tumor grade, peritoneal implantation, and RAS/RAF mutation were associated with successful tumor engraftment. …”
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Thyroid-Specific Genes Expression Uncovered Age-Related Differences in Pediatric Thyroid Carcinomas by Maria Isabel Cunha Vieira Cordioli, Lais Moraes, Maria Teresa de Seixas Alves, Rosana Delcelo, Osmar Monte, Carlos Alberto Longui, Adriano Namo Cury, Janete Maria Cerutti

“…By analyzing the expression of thyroid-specific genes in 38 sporadic pediatric tumors, we show that the expression of NIS, PDS, and TSHR was lower in children than adolescents (P<0.05). …”
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Low albumin-to-creatinine ratios (ACR) are associated with poor outcomes in cancer patients by Hong Zhao, Xiangrui Li, Xiaoyue Liu, Chenan Liu, Xin Zheng, Yue Chen, Jinyu Shi, Qiteng Liu, Zhaoting Bu, Hanping Shi

“…Abstract Background The albumin-to-creatinine ratio (ACR) is known to predict prognosis in liposarcoma patients, but its role in other tumors remains unclear. This study aimed to evaluate the prognostic relationship between ACR and common solid tumors. …”
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In Vivo Optical Molecular Imaging of Matrix Metalloproteinase Activity following Celecoxib Therapy for Colorectal Cancer by Rahul A. Sheth, Alexandra Kunin, Lars Stangenberg, Mark Sinnamon, Kenneth E. Hung, Raju Kucherlapati, Umar Mahmood

“…There was an apparent linear relationship ( r = .91) between measured MMP activity and tumor growth rate. Finally, in the GEM model experiment, treated murine tumors remained relatively unchanged in volume and MMP activity; however, untreated tumors grew significantly and showed an increase in MMP activity. …”
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Adrenal Cavernous Hemangioma: A Rarely Perceived Pathology—Case Illustration and Review of Literature by Jad A. Degheili, Nassib F. Abou Heidar, Mouhammad El-Moussawi, Ayman Tawil, Rami W. Nasr

“…Cavernous hemangiomas are endothelial tumors that rarely affect the adrenal glands. Most of these tumors remain silent and are incidentally found on abdominal imaging. …”
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Transformation of Follicular Lymphoma to Double Hit B-Cell Lymphoma Causing Hypercalcemia in a 69-Year-Old Female: A Case Report and Review of the Literature by Sakshi Kapur, Miles B. Levin

“…These tumors mostly occur in adults and carry a very poor prognosis. …”
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Differential Diagnosis of Parotid Lipoma in a Breast Ca Patient by Melda Misirlioglu, Yagmur Yilmaz Akyil, Mehmet Zahit Adisen, Alime Okkesim

“…Lipomas are common benign tumors usually detected on the torso, neck, upper thighs, and upper arms. …”
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Combination of AAV-CCL19 and GPC3 CAR-T Cells in the Treatment of Hepatocellular Carcinoma by Min Meng, Yi-chen Wu

“…Chimeric antigen receptor-modified T cell (CAR-T) therapy has great potential for treating malignant tumors, especially hematological malignancies. However, the therapeutic effect of solid tumors is limited. …”
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Pulmonary Sarcomatoid Carcinoma Associated with Arterial Thromboembolism in a Cat by Aria L. Guarino, Albert B. Jeon, Jeffrey R. Abbott, Richard C. Hill

“…The World Health Organization classification of mixed pulmonary tumors and its application to previously reported mixed pulmonary tumors in companion animals is discussed. …”
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Noninvasive Monitoring of mRFP1- and mCherry-Labeled Oncolytic Adenoviruses in an Orthotopic Breast Cancer Model by Spectral Imaging by Anton V. Borovjagin, Lacey R. McNally, Minghui Wang, David T. Curiel, Mary J. MacDougall, Kurt R. Zinn

“…This allows for noninvasive control of CRAd delivery and distribution in tumors and facilitates quantitative assessment of viral replication. …”
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Massa mediastinal em lactente - relato de caso by Thiago Rezende Silveira, Daniel Pinheiro Ferreira, Elina Tosta Oliveira, Danielle Paula de Oliveira Gonçalves, Eliene Machado de Freitas Félix, Adriana Cartafina Perez Bóscollo

“…INTRODUCTION: Mediastinal Teratoma is a neoplasm originating from germ cells and comprises about 8-16% of tumors in this region. They are uncommon in children and equally incident among sexes. …”
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A new insight into the impact of copy number variations on cell cycle deregulation of luminal-type breast cancer by Amir Mahdi Khamaneh, Davoud Jafari-Gharabaghlou, Khalil Ansarin, Khalil Ansarin, Khalil Ansarin, Pouya Pazooki, Zahra Akbarpour, Behrooz Naghili, Behrooz Naghili, Nosratollah Zarghami, Nosratollah Zarghami

“…ER+ (Luminal subtype), representing over 70% of breast tumors, is a genetically diverse group. Structural and Numerical-Chromosomal instability initiates tumor development and is recognized as the primary driver of genetic alteration in luminal breast tumors. …”
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68Ga-NOTA-RM26 PET/CT in the evaluation of glioma: a pilot prospective study by Yilin Li, Rongxi Wang, Jingci Chen, Zhaohui Zhu, Yu Wang, Wenbin Ma

“…Abstract Background Gliomas are the most common malignant primary tumors of the central nervous system. There is an urgent need for new convenient, targeted and specific imaging agents for gliomas. …”
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Age-related aspects of glioma: current understanding. Literature review by Serhii P. Luhovskyi, Tetiana Y. Kvitnytska-Ryzhova

“… The updated 2021 WHO Classification of Central Nervous System (CNS) Tumors introduces, for the first time, an age-based approach to glioma classification, leveraging advances in molecular biology and epigenetics of CNS tumors. …”
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Molecular characterization of mixed-histology endometrial carcinoma provides prognostic and therapeutic value over morphologic findings by Paulina J. Haight, Ashwini Esnakula, Courtney J. Riedinger, Adrian A. Suarez, Jessica Gillespie, Ashley Patton, Alexis Chassen, David E. Cohn, Casey M. Cosgrove

“…Recurrence risk significantly differed based upon molecular class, but not histology. 44% of MEC cases had a HER2 IHC score of 2–3+, and this was not limited to p53abnl tumors. Transcriptional analysis demonstrated 93 differentially expressed genes between p53abnl and NSMP tumors, including many associated with the innate immune response and DNA damage repair. …”
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