REVIEW by Sânziana Ionescu, Laurenţiu Simion, Elena Chitoran, V. Rotaru, Ciprian Cirimbei, Octavia Luciana Madge, Adina Ene, Mădălina Radu, Ariana Neicu, Marian Marincaş

“…Neuroendocrine tumors of the small bowel: a literature review…”
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Giant Parotid Pleomorphic Adenoma with Atypical Histological Presentation and Long-Term Recurrence-Free Follow-Up after Surgery: A Case Report and Review of the Literature by Mohammed AlKindi, Sundar Ramalingam, Lujain Abdulmajeed Hakeem, Manal A. AlSheddi

“…Salivary gland tumors (SGT) comprise 3% of all head and neck tumors, are mostly benign, and arise frequently in the parotid gland. …”
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Establishment and characterization of ovarian clear cell carcinoma patient-derived xenografts by Joseph J. Caumanns, Shang Li, Gert J. Meersma, Evelien W. Duiker, Ate G. J. van der Zee, G. Bea A. Wisman, Steven de Jong

“…Cyclophilin A staining depicted the replacement of human stroma by mouse stroma in PDX.F2, while PAS/PAS-D staining confirmed cellular glycogen accumulation in OCCC tumors and PDXs. SNP array and Infinium MethylationEPIC BeadChip array data analysis demonstrated the copy number alterations and DNA methylation signatures of genome-wide and tumor-driver genes in PDXs generally resembled their patients’ tumors. …”
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Molecular Subtypes of Breast Carcinoma and Their Association with Clinicopathological Features by Ambreen Bari, Sumayyah Shawana

“…A significant association was observed between molecular subtypes and tumor grade, stage, and histological subtypes. However, insignificant association was seen with age, laterality, and tumor site. …”
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Head and Neck Schwannomas: A Surgical Challenge—A Series of 5 Cases by Ishtyaque Ansari, Ashfaque Ansari, Arjun Antony Graison, Anuradha J. Patil, Hitendra Joshi

“…Schwannomas, also known as neurilemmomas, are benign peripheral nerve sheath tumors. They originate from any nerve covered with schwann cell sheath. …”
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Intradermal eccrine poroma. Presentation of a case by Javier Martínez Navarro, Adialys Acosta Rodríguez, Martha Yudey Rodríguez del Pino, Virgen Yazmín Martínez Navarro

“…Eccrine poromas are benign adnexal tumors which originate from the intraepidermal duct portion of the sweat gland. …”
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Endobronchial Carcinoid and Concurrent Carcinoid Syndrome in an Adolescent Female by Jonathan D. Cogen, Jonathan Swanson, Thida Ong

“…Endobronchial carcinoid tumors are the most common intrabronchial tumors in children and adolescents. …”
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Emerging Applications for Optically Enabled Intravital Microscopic Imaging in Radiobiology by Azusa Maeda, Iris Kulbatski, Ralph S. DaCosta

“…Studies have demonstrated that various components of tumors and their microenvironments, including vasculature, immune and stem cells, and stromal cells, can influence the response of solid tumors to radiation. …”
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Durable Clinical Benefit after Dual Checkpoint Inhibition and Single-agent Nivolumab Following Pembrolizumab Failure in Mismatch Repair-deficient Colon Cancer by Yat-Fung Chow, Hou-Hsuan Cheng, Ming-Huang Chen

“…Immunotherapy with immune checkpoint inhibitors (ICIs) is beneficial in treating tumors with high microsatellite instability or DNA mismatch repair deficiency (dMMR) tumors. …”
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Expression and Significance of AQP3 in Cutaneous Lesions by Dongfeng Niu, Yanhua Bai, Qian Yao, Wei Hou, Lixin Zhou, Xiaozheng Huang, Chen Zhao

“…Our findings indicate the function of AQP3 maintained in most skin tumors. AQP3 may be used for differential diagnosis in skin tumors.…”
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Insights from in vivo preclinical cancer studies with histotripsy by Tejaswi Worlikar, Timothy Hall, Man Zhang, Mishal Mendiratta-Lala, Michael Green, Clifford S. Cho, Zhen Xu

“…Promising preclinical results including local tumor suppression, improved survival outcomes, local and systemic anti-tumor immune responses, and histotripsy-induced abscopal effects have been reported in various animal tumor models. …”
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Chromosomal Changes in relation to Clinical Outcome in Larynx and Pharynx Squamous Cell Carcinoma by Mario Hermsen, Marta Alonso Guervós, Gerrit Meijer, Paul van Diest, Carlos Suárez Nieto, Cesar Alvarez Marcos, Andrés Sampedro

“…The segments most frequently amplified were 3q26-qter, 11q13, 11q22, 3q12–13, 18p11.3, 18q11.2 and 8q24.3. Tumors with stages III and IV, and lymph node positive tumors had a worse clinical outcome. …”
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A Gamut of Astounding Diagnosis as Paraganglioma of Urinary Bladder: A Retrospective Study from North India by Nazia Manzoor Walvir, Aiffa Aiman, Inara Abeer, Mohammad Iqbal Lone, Shadab Maqsood

“…Background and Aim: Urinary bladder paraganglioma (UBPGL) is a rare neuroendocrine neoplasm, accounting for <0.05% of all bladder tumors and 0.7% of all paragangliomas. This study aimed to describe the histopathology of UBPGL, emphasizing the histologic attributes that may help pathologists recognize this rare bladder tumor and aid in differentiation from urothelial malignancies and other tumors that may resemble paragangliomas. …”
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Prognostic Features and Potential for Immune Therapy in Metastatic Mismatch Repair‐Deficient Colorectal Cancer: A Retrospective Analysis of a Large Consecutive Population‐Based Pat... by Erkki‐Ville Wirta, Hanna Elomaa, Jukka‐Pekka Mecklin, Toni T. Seppälä, Marja Hyöty, Jan Böhm, Maarit Ahtiainen, Juha P. Väyrynen

“…Histological tumor parameters were evaluated from hematoxylin‐ and eosin‐stained whole‐slide samples. …”
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Dysbiosis of Gastric Mucosal Fungal Microbiota in the Gastric Cancer Microenvironment by Zhenzhan Zhang, Hao Feng, Yaopeng Qiu, Zhou Xu, Qingfeng Xie, Wenfu Ding, Hao Liu, Guoxin Li

“…Dysbiosis of gastric mucosal fungal microbiome was observed between the tumor and normal groups in GC. The tumor group had a higher abundance of certain taxa than the normal group. …”
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Involvement of p38 MAPK and MAPKAPK2 in promoting cell death and the inflammatory response to ischemic stress associated with necrotic glioblastoma by Soo Yeon Kim, Miaolu Tang, Stephen Y. Chih, Jessica Sallavanti, Yan Gao, Zhiqiang Qiu, Hong-Gang Wang, Wei Li

“…Abstract The association of necrosis in tumors with poor prognosis implies a potential tumor-promoting role. …”
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Biometabolic Distribution of Tc-3PRGD2 and its Potential Value in Monitoring Chemotherapeutic Effects by Jian-Guo Wu, Shao-Li Song, Xiang Zhou, Fan Wang, Yin-Yan Zhu, Lei Xie, Fan Zhang, Gang Huang

“…Previous studies have reported that 99m Tc-3PRGD2 is an excellent tumor imaging agent that showed a good correlation with integrin α v β 3 , a main factor of tumor-induced angiogenesis. …”
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Primary Oral Malignant Melanoma: Two Case Reports and Review of Literature by Neeraj Sharma

“…Primary malignant melanoma of the oral cavity is a rare neoplasm. The tumors tend to metastasize or locally invade tissue more readily than other malignant tumors in the oral region. …”
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Cardiac Angiosarcoma by Monique Esteves Cardoso, Leonardo Secchin Canale, Rosana Grandelle Ramos, Edson da Silva Salvador Junior, Stephan Lachtermacher

“…Despite cardiac metastases are found in about 20% of cancer deaths, the presence of primary cardiac tumors is rare. Most primary tumors are benign, and malignant tumors comprise about 15%. …”
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From the Guest Editors by Alberto d’Onofrio, Paola Cerrai, Alberto Gandolfi

“…There is an increasing awareness that to properly understand how tumorsoriginate and grow, and then how to develop effective cures, it must be taken into accountthe dynamics of tumors and its great complexity. Tumors are characterized not only by thecoexistenceof multiple scales, both temporal and spatial, but also by multiple and quitedifferent kinds of interactions, from chemical to mechanical. …”
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