MRI Features with Pathologic Correlation of Primary Ovarian Carcinoid: A Case Report by Bon Jae Koo, Seong Kuk Yoon, Min Gyoung Pak, Kyeong Ah Kim

“…Primary ovarian carcinoid tumors are rare well-differentiated neuroendocrine tumors classified as monodermal teratomas. …”
Get full text

Goblet Cell Carcinoid in a Patient with Neurofibromatosis Type 1: A Rare Combination by Tine Gregersen, Nanna Holt, Henning Gronbaek, Ida Vogel, Lars J. Jørgensen, Klaus Krogh

“…Neuroendocrine tumors are rare tumors primarily located in the gastrointestinal tract. …”
Get full text

MiRNAs as major players in brain health and disease: current knowledge and future perspectives by Sarika V. Kapplingattu, Sujata Bhattacharya, Yogita K. Adlakha

“…Several reports show downregulation of miR-135 in glioblastoma, indicating its tumor suppressor role in the pathogenesis of brain tumors. …”
Get full text

Clinically relevant orthotopic pancreatic cancer models for adoptive T cell transfer therapy by Gregory B. Lesinski, Chrystal M. Paulos, Maggie Phillips, Jacklyn Hammons, Isaac Karpovsky, Zaid Mahdi, Natalie K. Horvat, Megan M. Wyatt, Margaret A. Hall, Cameron J. Herting, Richard A. Moffitt

“…Interestingly, we found that chimeric antigen receptor (CAR) T cells redirected to recognize mesothelin on these tumors that signal via CD3ζ and 41BB (Meso-41BBζ-CAR T cells) infiltrated the tumors of mice bearing stroma-devoid KPC-Luc orthotopic tumors, but not MT-5 tumors.Conclusions Our data establish for the first time a reproducible and realistic clinical system useful for modeling stroma-rich and stroma-devoid PDAC tumors. …”
Get full text

Prognostic and Risk Factors in Patients with Locally Advanced Cutaneous Squamous Cell Carcinoma of the Trunk and Extremities by de Lima Vazquez Vinicius, Cristovam Scapulatempo, Natalia Martins Perpetuo, Faheez Mohamed, Teóclito Sachetto de Carvalho, Antônio Talvane Torres de Oliveira, José Getúlio Martins Segalla, André Lopes Carvalho

“…Patients with T3 tumors had better cancer-specific survival (CSS) than those with T4 tumors; patients with no lymph node involvement had better CSS than patients with N1 tumors. …”
Get full text

Prognostic factors for head and neck cancer of unknown primary including the impact of human papilloma virus infection by Lars Axelsson, Jan Nyman, Hedda Haugen-Cange, Mogens Bove, Leif Johansson, Shahin De Lara, Anikó Kovács, Eva Hammerlid

“…The majority were males, and had N2 tumors. Sixty-nine percent of the tumors were HPV positive using p16 staining. …”
Get full text

Evaluatıon of contrast enhancement intensity, pattern, and kinetics of breast lesions on contrast-enhanced spectral mammography by Ayşe Füsun Bekirçavuşoğlu, Sibel Kul, Süleyman Bekirçavuşoğlu, Dilara Atasoy, Merve Erkan

“…Abstract Background Contrast-enhanced spectral mammography (CESM) is a new and promising imaging modality that improves tumor visibility through tumor contrast enhancement caused by malignant neovascularization. …”
Get full text

Treatment of Basal Cell Carcinomas with Pulsed Dye Laser: A Case Series by Norman Minars, Marianna Blyumin-Karasik

“…Twenty-four patients with thirty-two tumors reached at least three months followup: 24/32 (75%) tumors with complete resolution (mean 3 treatment sessions); 5/32 (16%) tumors recurred; 3/32 (9%) tumors with incomplete responses after four treatments. …”
Get full text

Radiosynthesis and Evaluation of 5-[I]Iodoindol-3-yl-β--Galactopyranoside as a β-Galactosidase Imaging Radioligand by Marcian E. Van Dort, Kuei C. Lee, Christin A. Hamilton, Alnawaz Rehemtulla, Brian D. Ross

“…In contrast, intratumoral injection of the substrate resulted in efficient trapping of radioactivity in D54L tumors but not D54 tumors, resulting in clear SPECT visualization of the former tumor. …”
Get full text

Endometrial Stromal Nodule: A Rarity and a Pathological Challenge by Camilla Skovvang Borg, Peter Humaidan, Hanne Noer, Huda Galib Majeed

“…Endometrial stromal tumors are rare, and endometrial stromal nodule is the least common. …”
Get full text

Rare Case of Multiple Perirenal, Extra-Adrenal Myelolipoma: Case Report, Current Management Options, and Literature Review by Goran Benko, Andrina Kopjar, Marin Plantak, Danijel Cvetko, Vicko Glunčić, Anita Lukić

“…Extra-adrenal myelolipomas are rare, asymptomatic entities, although large tumors may cause local symptoms or hemorrhage. When these lesions occur outside the adrenals in the retroperitoneum, they are radiographically easily confused with both primary and secondary retroperitoneal tumors, which tend to be aggressive. …”
Get full text

Impact of the Siewert Classification on the Outcome of Patients Treated by Preoperative Chemoradiotherapy for a Nonmetastatic Adenocarcinoma of the Oesophagogastric Junction by Laurence Moureau-Zabotto, Eric Teissier, Didier Cowen, David Azria, Steve Ellis, Michel Resbeut

“…For OGJA treated with preoperative CRT and surgery, ORR and CRMR were lower for patients with Siewert I tumors in comparison with Siewert II/III tumors.…”
Get full text

Application and Evaluation of [Tc]-Labeled Peptide Nucleic Acid Targeting in Breast Cancer Imaging by Yaqun Jiang MD, Yongkang Gai PhD, Yu Long MD, Qingyao Liu PhD, Chunbao Liu MD, PhD, Yongxue Zhang MD, Xiaoli Lan MD, PhD

“…The relative expression of miR-155 in MCF-7 cells and tumors was higher than that in MDA-MB-231 cells and tumors. …”
Get full text

Loss of BRCA1 Spontaneously Induces the Tumorigenesis in Lacrimal Gland by Sun Eui Kim, Hye Jung Baek, Eun Jung Park, Sung Chul Lim, Sang Soo Kim

“…We have previously shown that spontaneous tumors form frequently in mice homozygous for a full-length Brca1 deletion. …”
Get full text

Multi-omic and single-cell profiling of chromothriptic medulloblastoma reveals genomic and transcriptomic consequences of genome instability by Petr Smirnov, Moritz J. Przybilla, Milena Simovic-Lorenz, R. Gonzalo Parra, Hana Susak, Manasi Ratnaparkhe, John KL. Wong, Verena Körber, Jan-Philipp Mallm, George Philippos, Martin Sill, Thorsten Kolb, Rithu Kumar, Nicola Casiraghi, Konstantin Okonechnikov, David R. Ghasemi, Kendra Korinna Maaß, Kristian W. Pajtler, Anna Jauch, Andrey Korshunov, Thomas Höfer, Marc Zapatka, Stefan M. Pfister, Wolfgang Huber, Oliver Stegle, Aurélie Ernst

Get full text

Hepatobiliary Cystadenocarcinoma by Neal Wilkinson

“…Biliary cystadenocarcinomas are rare tumors that are poorly understood. Preoperative imaging is imprecise and treatment is not standardized. …”
Get full text

Exploring the heterogeneity of HER2 gene status and expression in non-positive breast cancer patients: insights from immunohistochemistry and fluorescence in situ hybridization by Jingmin Zhong, Beibei Gao, Qingjie Wang, Jun He, Danjv Luo, Chen Zhang, Jun Fan, Xiu Nie

“…Our analysis revealed that HER2-low tumors exhibited fewer grade III tumors (39.74% and 55.65%, respectively, P = 0.005) and higher positivity for estrogen receptor (ER, 88.89% vs. 61.74%, P < 0.001) and progesterone receptor (PR, 84.62% vs. 57.39%, P < 0.001) compared to HER2-ZERO tumors. …”
Get full text

MammaPrint Feasibility in a Large Tertiary Urban Medical Center: An Initial Experience by C. Francisco Espinel, Shaughn Keating, Hanina Hibshoosh, Bret Taback, Kathie-Ann Joseph, Mahmoud El-Tamer, Sheldon Feldman

“…Out of all eligible patients, 14/50 (28%) had samples whose quantity of tumor was not sufficient for analysis (QNS). Out of eligible patients with tumors <1 cm, 7/8 (88%) had QNS samples. 7/42 with tumors ≥1 cm (17%) had QNS samples. …”
Get full text

Treatment and Outcomes of Pancreatic Cancer in Armenia: A Retrospective Study From Resource-Limited Settings by Elen Baloyan, Davit Zohrabyan, Liana Safaryan, Armen Avagyan, Lilit Harutyunyan, Vardan Bardakhchyan, Jemma Arakelyan, Amalya Sargsyan, Martin Harutyunyan, Mariam Mailyan, Gevorg Tamamyan, Samvel Bardakhchyan

“…The main independent prognostic factor for overall survival (OS) was the TNM stage, whereas grade of the tumor was not significant. The median OS was 11 months (range, 2-169 months): In stages I-III, patients who had surgery (44.4%) lived significantly longer than those who did not (20 v 11 months; P = .008). …”
Get full text

Sebaceous Lymphadenoma of Parotid: Imaging, Cytological, and Histological Findings in Detail by Golsa Shekarkhar, Hossein Soleimanpour, Seyed Hamed Jafari, Fatemeh Zamani

“…Sebaceous lymphadenomas are rare and account for less than 1% of primary salivary gland tumors. These rare tumors are mostly found in men older than 50 years. …”
Get full text