Case Report: First use of dental bisphenol A-glycidyl methacrylate composite without UV light polymerization for repair of iatrogenic CSF leak following a frontal craniotomy plus tumor resection by Haman Nassourou Oumarou, Haman Nassourou Oumarou, Ndome Toto Orlane

Get full text

Cutaneous Squamous Cell Carcinoma with Signet-Ring Cell Component and CDX2 Expression in a Patient Treated with PD-1 Inhibitor: A Case Report of a Common Tumor with Unusual Differentiation by Sherehan Zada, Jeremiah Tao, Maria Del Valle Estopinal

“…Immunohistochemical studies demonstrated that the tumor cells were positive for P63, CK5/6, CDX2, and P53 while negative for P16, CK7, CK20, and CD68 stains. …”
Get full text

Carbon Monoxide-Releasing Molecule-3 Suppresses Tumor Necrosis Factor-α- and Interleukin-1β-Induced Expression of Junctional Molecules on Human Gingival Fibroblasts via the Heme Oxygenase-1 Pathway by Jia Lv, Yongsheng Liu, Shuhan Jia, Yuna Zhang, Haoyang Tian, Jingyuan Li, Hui Song

“…In this study, we aimed to investigate the effects of CORM-3 on the expression of tight and adherens junction molecules on human gingival fibroblasts (HGFs) stimulated with tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). …”
Get full text

Micro–Positron Emission Tomography/Contrast-Enhanced Computed Tomography Imaging of Orthotopic Pancreatic Tumor–Bearing Mice Using the αβ Integrin Tracer Cu-Labeled Cyclam-RAFT-c(-RGDfK-) by Winn Aung, Zhao-Hui Jin, Takako Furukawa, Michael Claron, Didier Boturyn, Chizuru Sogawa, Atsushi B. Tsuji, Hidekatsu Wakizaka, Toshimitsu Fukumura, Yasuhisa Fujibayashi, Pascal Dumy, Tsuneo Saga

“…Autoradiography, histologic, and immunohistochemical examinations confirmed the accumulation of 64 Cu-RAFT-RGD in tumor versus nontumor tissues. In comparative PET studies, 64 Cu-RAFT-RGD accumulation provided better tumor contrast to background than 18 F-FDG. …”
Get full text

Value of alpha smooth muscle actin (αSMA) and inducible nitric oxide synthase (iNOS) in oral squamous cell carcinoma (OSCC): An immunohistochemical approach to tumor stroma categorization and clinicopathological parameters by Heba E.M. Youssef, Basant Hamdy AbouZaid

“…Objectives: The aggressive behavior of oral squamous cell carcinoma (OSCC) is not only a cancer-cell centered issue, but also affected by tumor stroma. Cancer-associated fibroblasts (CAFs) are the most abundant component of tumor stroma that can direct tumorigenesis. …”
Get full text

Targeted Inhibition of the miR-199a/214 Cluster by CRISPR Interference Augments the Tumor Tropism of Human Induced Pluripotent Stem Cell-Derived Neural Stem Cells under Hypoxic Condition by Yumei Luo, Xuehu Xu, Xiuli An, Xiaofang Sun, Shu Wang, Detu Zhu

“…These findings suggest a novel application of CRISPRi in NSC-based tumor-targeted gene therapy.…”
Get full text

Ginsenosides 20R-Rg3 and Rg5 enriched black ginseng inhibits colorectal cancer tumor growth by activating the Akt/Bax/caspase-3 pathway and modulating gut microbiota in mice by Peng Yu, Weiyin Xu, Yanqi Li, Zhaoyang Xie, Simeng Shao, Jianing Liu, Ying Wang, Long Wang, Hongmei Yang

“…Moreover, Rg3/Rg5-BG retarded tumor growth in the model mice, as evidenced by downregulation of anti-apoptotic Bcl-2 protein and phosphatidyl Akt, and upregulation of the apoptotic proteins Bax, caspase-8, and cleaved caspase-3, enhancing apoptosis of tumor cells. …”
Get full text

Palmitic Acid Induces Production of Proinflammatory Cytokines Interleukin-6, Interleukin-1β, and Tumor Necrosis Factor-α via a NF-κB-Dependent Mechanism in HaCaT Keratinocytes by Bing-rong Zhou, Jia-an Zhang, Qian Zhang, Felicia Permatasari, Yang Xu, Di Wu, Zhi-qiang Yin, Dan Luo

“…Secretion levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), NF-κB nuclear translocation, NF-κB activation, Stat3 phosphorylation, and peroxisome proliferator-activated receptor alpha (PPARα) mRNA and protein levels, as well as the cell proliferation ability were measured at the end of the treatment and after 24 hours of recovery. …”
Get full text

Phase II Study of Personalized Peptide Vaccination with Both a Hepatitis C Virus-Derived Peptide and Peptides from Tumor-Associated Antigens for the Treatment of HCV-Positive Advanced Hepatocellular Carcinoma Patients by Shigeru Yutani, Kazuomi Ueshima, Kazumichi Abe, Atsushi Ishiguro, Junichi Eguchi, Satoko Matsueda, Nobukazu Komatsu, Shigeki Shichijo, Akira Yamada, Kyogo Itoh, Tetsuro Sasada, Masatoshi Kudo, Masanori Noguchi

“…A maximum of four HLA-matched peptides were selected based on the preexisting IgG responses specific to 32 different peptides, which consisted of a single HCV-derived peptide at core protein positions 35–44 (C-35) and 31 peptides derived from 15 different tumor-associated antigens (TAAs), followed by subcutaneous administration once per week for 8 weeks. …”
Get full text

Engineered CAF-cancer cell hybrid membrane biomimetic dual-targeted integrated platform for multi-dimensional treatment of ovarian cancer by Yuwei Yao, Jiarui Zhang, Kexin Huang, Yingying Peng, Shuangshuang Cheng, Shuangge Liu, Ting Zhou, Jinhua Chen, Haojia Li, Yingchao Zhao, Hongbo Wang

Subjects: Get full text

Role of Central Nervous System Circuits in Promotion of Breast Cancer Progression by Depression by Yingchao WU, Yuqi LIANG, Qian ZUO, Qianjun CHEN

Subjects: Get full text

Case report: Detection and treatment of a rare submucosal gland duct adenoma of the esophagus by Yu Zhou, Daoxing He, Zhigang Huang, Zhaoyi Chen, Zheng Zhou, Hui Duan, Jie Xu

Subjects: Get full text

Leveraging explainable AI and large-scale datasets for comprehensive classification of renal histologic types by Seung Wan Moon, Jisup Kim, Young Jae Kim, Sung Hyun Kim, Chi Sung An, Kwang Gi Kim, Chan Kwon Jung

Subjects: “…Renal tumor classification…”
Get full text

Research Progress of Fuzheng Jiedu Huayu Method in Reducing Toxicity and Enhancing Efficacy of Immunotherapy by Yufan CHEN, Sicong LI, Yiyuan CUI, Li FENG

Subjects: “…malignant tumor…”
Get full text

Atypical conjunctival sporotrichosis secondary to Mooren’s ulcer: a case report by Qing Su, He Dong, Lin Cui, Lijun Zhang

Subjects: “…Salmon-pink conjunctival tumor…”
Get full text

TP53 Mutation Predicts Worse Survival and Earlier Local Progression in Patients with Hepatocellular Carcinoma Treated with Transarterial Embolization by Ken Zhao, Anita Karimi, Luke Kelly, Elena Petre, Brett Marinelli, Erica S. Alexander, Vlasios S. Sotirchos, Joseph P. Erinjeri, Anne Covey, Constantinos T. Sofocleous, James J. Harding, William Jarnagin, Carlie Sigel, Efsevia Vakiani, Etay Ziv, Hooman Yarmohammadi

Subjects: Get full text

Macrophages infiltration and oral potentially malignant disorders: A systematic review and meta-analysis by Lara Krusser Feltraco, Julia Rodrigues Fernandes, Leonardo Francisco Diel, Leonardo da Silva Bittencourt, Lisiane Bernardi, Marcelo Lazzaron Lamers

Subjects: Get full text

Alpha-linolenic acid-mediated epigenetic reprogramming of cervical cancer cell lines by Amrita Ulhe, Prerna Raina, Amol Chaudhary, Ruchika Kaul-Ghanekar

Subjects: Get full text

Exploration of the mechanism of 5-Methylcytosine promoting the progression of hepatocellular carcinoma by Qiyao Zhang, Zhen Cao, Yuting He, Ziwen Liu, Wenzhi Guo

Subjects: Get full text

Human papillomavirus (HPV) role in causing oral cancer by Ramar Vanajothi

Subjects: Get full text