Clinical relevance and druggability of sole reciprocal kinase fusions: A large‐scale study by Jiao Feng, Tonghui Ma, Chunyang Wang, Baoming Wang, Qian Liu, Zhengchuang Liu, Houquan Tao, Zaiyuan Ye

Subjects: Get full text

Myxoid Liposarcoma of the Greater Omentum. Case Report and Literature Review by Alexander Marchena Rodríguez, Flavia Linares Tovar, Jorge Carlos González Fariñas

Subjects: Get full text

THE USE OF PHOTOD YNAMIC THERAPY IN THE DOMESTIC ONCOLOGY. (REVIEW OF THE LITERA TURE) by V. V. Kuznetsov

Subjects: Get full text

Paciente embarazada con meduloblastoma. Reporte de un caso by Joel Marchant K., Pablo Villarroel R., Mariana Maltes P., Cristhofer Decap S., Héctor Figueroa R., María Rosa Miccono I.

Subjects: “…tumor cerebral…”
Get full text

Role of aspirin in cancer prevention by Meng Sun, Jun Yu, Jie Wan, Xiaoyun Dou, Xiaoying Chen, Fang Ye

Subjects: Get full text

Robot-assisted surgery for gynecological cancer by Hao Liang, Hang Yu, Jiangtao Fan

Subjects: Get full text

Microbes, macrophages, and melanin: a unifying theory of disease as exemplified by cancer by Stacie Z. Berg, Jonathan Berg

Subjects: Get full text

The role of interleukin-17 in inflammation-related cancers by Xingru Zhang, Xingru Zhang, Bangjie Li, Tian Lan, Tian Lan, Conner Chiari, Xiaoyang Ye, Kepeng Wang, Ju Chen

Subjects: Get full text

Blood-based prognostic scores and early dynamics under immunotherapy to select patients with metastatic solid tumors for continuing immune check-point inhibition: a prospective longitudinal study by Javier García-Corbacho, Alberto Indacochea, Iván Victoria, Débora Moreno, Laura Angelats, Azucena E. González Navarro, Laura Mezquita, Fara Brasó-Maristany, Patricia Galván, Begoña Mellado, Nuria Viñolas, Tamara Sauri, Miquel Nogué, Barbara Adamo, Joan Maurel, Estela Pineda, Lydia Gaba, Oscar Reig, Neus Basté, Esther Sanfeliu, Manel Juan, Aleix Prat, Francesco Schettini

“…Abstract Introduction Immune check-point inhibitors (ICI) were a major breakthrough in cancer care, but optimal patient selection remains elusive in most tumors. Methods Overall 173 adult patients with metastatic solid tumors candidates to ICI in clinical trials at our Institution were prospectively recruited. …”
Get full text

29 m6A-RNA Methylation (Epitranscriptomic) Regulators Are Regulated in 41 Diseases including Atherosclerosis and Tumors Potentially via ROS Regulation – 102 Transcriptomic Dataset Analyses by Ming Liu, Keman Xu, Fatma Saaoud, Ying Shao, Ruijing Zhang, Yifan Lu, Yu Sun, Charles Drummer, Li Li, Sheng Wu, Satya P. Kunapuli, Gerard J. Criner, Jianxin Sun, Huimin Shan, Xiaohua Jiang, Hong Wang, Xiaofeng Yang

Get full text

CD4 T cell depletion increases memory differentiation of endogenous and CAR T cells and enhances the efficacy of Super2 and IL-33-armored CAR T cells against solid tumors by Chrystal Paulos, Mary Jo Turk, Megen C Wittling, Yina H Huang, Asmaa O Mohamed, David Tyler Boone, Shannon L Ferry, Melanie C Peck, Alicia M Santos, Haille E Soderholm

“…We characterized CAR and endogenous tumor-specific memory T cell precursors, establishment of circulating (TCIRC) and resident (TRM) memory T cell subsets, and ability to protect against secondary tumors.Results TRP1-specific or NKG2D CAR T cells had no effect on primary tumor growth in immunocompetent mice unless they were combined with S233 armoring or CD4 depletion. …”
Get full text

TGFβ-specific T cells induced by a TGFβ-derived immune modulatory vaccine both directly and indirectly modulate the phenotype of tumor-associated macrophages and fibroblasts by Mads Hald Andersen, Inés Lecoq, Evelina Martinenaite, Maria Perez-Penco, Lucia Lara de la Torre

“…The tumor microenvironment (TME) of pancreatic cancer is highly immunosuppressive. …”
Get full text

Immunomodulatory Effects of Hemagglutinin- (HA-) Modified A20 B-Cell Lymphoma Expanded as a Brain Tumor on Adoptively Transferred HA-Specific CD4+ T Cells by Valentin P. Shichkin, Roman M. Moriev

“…Previously, the mouse A20 B-cell lymphoma engineered to express hemagglutinin (HA) antigen (A20HA) was used as a systemic tumor model. In this work, we used the A20HA cells as a brain tumor. …”
Get full text

Allelic and Genotypic Analysis of LncRNA ANRIL rs4977574 A/G Mutations in Oral Squamous Cell Carcinoma Patients: Insights into Tumor Characteristics and Genotypic Correlations by Mohammad Amin Amiri, Delara Amiri, Mohammad Javad Mokhtari, Fatemeh Lavaee, Mohammad Javad Fattahi, Abbas Ghaderi, Bijan Khademi

“…Furthermore, the association of the genotypes with the lymph node metastasis and the tumors stage was not found to be significant (p>0.05). …”
Get full text

Chimeric cytokine receptor TGF-β RⅡ/IL-21R improves CAR-NK cell function by reversing the immunosuppressive tumor microenvironment of gastric cancer by Yaojun Ren, Min Xue, Xinhui Hui, Xiuyu Liu, Muhammad Asad Farooq, Yiran Chen, Yuzhou Ji, Yixin Duan, Iqra Ajmal, Jie Yao, Wenzheng Jiang

Subjects: Get full text

Targeting sphingosine 1-phosphate receptor 3 inhibits T-cell exhaustion and regulates recruitment of proinflammatory macrophages to improve antitumor efficacy of CAR-T cells against solid tumor by Weiting Liao, Ge Gao, Xia He, Pei Shu, Qizhi Ma, Benxia Zhang, Diyuan Qin, Yongsheng Wang

“…Backgrounds Chimeric antigen receptor (CAR)-modified T cells (CAR-T) are limited in solid tumors due to the hostile tumor microenvironment (TME). …”
Get full text

c-MET-positive circulating tumor cells and cell-free DNA as independent prognostic factors in hormone receptor-positive/HER2-negative metastatic breast cancer by Jieun Park, Eun Sol Chang, Ji-Yeon Kim, Chaithanya Chelakkot, Minjung Sung, Ji-Young Song, Kyungsoo Jung, Ji Hye Lee, Jun Young Choi, Na Young Kim, Hyegyeong Lee, Mi-Ran Kang, Mi Jeong Kwon, Young Kee Shin, Yeon Hee Park, Yoon-La Choi

Subjects: Get full text

Evaluation of circulating tumor DNA as a prognostic and predictive biomarker in BRAF V600E mutated colorectal cancer—results from the FIRE‐4.5 study by Susanne Klein‐Scory, Alexander Baraniskin, Wolff Schmiegel, Thomas Mika, Roland Schroers, Swantje Held, Kathrin Heinrich, David Tougeron, Dominik P. Modest, Ingo Schwaner, Jan Eucker, Rudolf Pihusch, Martina Stauch, Florian Kaiser, Christoph Kahl, Meinolf Karthaus, Christian Müller, Christof Burkart, Sebastian Stintzing, Volker Heinemann

Subjects: Get full text

CpG Oligodeoxynucleotides Enhance the Efficacy of Adoptive Cell Transfer Using Tumor Infiltrating Lymphocytes by Modifying the Th1 Polarization and Local Infiltration of Th17 Cells by Lin Xu, Chunhong Wang, Zhenke Wen, Ya Zhou, Zhongmin Liu, Yongjie Liang, Zengguang Xu, Tao Ren

“…Adoptive cell transfer immunotherapy using tumor infiltrating lymphocytes (TILs) was an important therapeutic strategy against tumors. …”
Get full text

Relative expression of IL-10 and TNF-α mRNA of kidney and spleen tissues of rat with and without mammary tumor after exposed to alternating current electric field by Nafisa Khoirun Widiasri, Anysah Nur Fauziyah, Firman Alamsyah, Rarastoeti Pratiwi

Subjects: Get full text