Editorial: Mechanism explorations of enhancing immunotherapeutic sensitivity via mediating immune infiltration and programmed cell death in solid tumor microenvironment by Fang Zheng, Fang Zheng, Fang Zheng, Zhiliang Li, Ruoyu Weng, Baochi Ou, Tao Zhang, Ren Zhao, Ren Zhao, Ren Zhao, Haoran Feng, Haoran Feng, Haoran Feng

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Lobar Hepatocellular Carcinoma with Ipsilateral Portal Vein Tumor Thrombosis Treated with Yttrium-90 Glass Microsphere Radioembolization: Preliminary Results by M. Pracht, J. Edeline, L. Lenoir, M. Latournerie, H. Mesbah, O. Audrain, Y. Rolland, B. Clément, J. L. Raoul, E. Garin, E. Boucher

“…Portal vein tumor thrombosis (PVTT) is a common complication of hepatocellular carcinoma (HCC) and has a negative impact on prognosis. …”
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Antibody-based delivery of interleukin-2 modulates the immunosuppressive tumor microenvironment and achieves cure in pancreatic ductal adenocarcinoma syngeneic mice by Carmine Carbone, Roberto De Luca, Emanuele Puca, Antonio Agostini, Alessia Caggiano, Lorenzo Priori, Annachiara Esposito, Serena Ascrizzi, Geny Piro, Lisa Salvatore, Francesco De Sanctis, Stefano Ugel, Vincenzo Corbo, Dario Neri, Giampaolo Tortora

“…Results The tumor-targeted L19-IL2 fusion protein demonstrated potent, dose-dependent anti-tumor activity in mice with pancreatic tumors resistant to standard chemotherapy. …”
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Constitutive activation of the Src-family kinases Fgr and Hck enhances the tumor burden of acute myeloid leukemia cells in immunocompromised mice by Sherry T. Shu, Li Chen, Giancarlo Gonzalez-Areizaga, Thomas E. Smithgall

“…TF-1 cells expressing either active form of Hck or Fgr engrafted immunocompromised mice faster and developed more extensive tumors compared to mice engrafted with the parent cell line, resulting in shorter survival. …”
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Effect of Tumor Necrosis Factor Family Member LIGHT (TNFSF14) on the Activation of Basophils and Eosinophils Interacting with Bronchial Epithelial Cells by Huai Na Qiu, Chun Kwok Wong, Jie Dong, Christopher Wai-Kei Lam, Zhe Cai

“…Allergic asthma can cause airway structural remodeling, involving the accumulation of extracellular matrix and thickening of smooth muscle. Tumor necrosis factor (TNF) family ligand LIGHT (TNFSF14) is a cytokine that binds herpesvirus entry mediator (HVEM)/TNFRSF14 and lymphotoxin β receptor (LTβR). …”
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Enhanced Brain Tumor MRI Classification Using Stationary Wavelet Transform, ResNet50V2, and LSTM Networks by Oussama Abda, Hilal NAIMI

“… Brain tumors constitute a significant health issue in the world today because of their aggressive behavior and short survival rates. …”
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Tumor thickness and depth of invasion in squamous cell carcinoma of tongue as indicators of the loco-regional spread of the disease: A preliminary study by Rupsa Das, Satya Ranjan Misra, Satya Sundar Gajendra Mohapatra, Pravakar Bahinipati, Smita Rani Priyadarshini, Alkananda Sahoo, Debahuti Mishra, Anamika Rai

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A Baffling Presentation of Metastatic Malignant Melanoma: Sporotrichoid Pattern Mimicking Vascular Tumor with Vitiligo-Like Depigmentation Following Immunotherapy by Pramod D. Kamble, Sunanda A. Mahajan, Pooja M. Golwad, Anuj Gupta

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TGF-β signaling orchestrates cancer-associated fibroblasts in the tumor microenvironment of human hepatocellular carcinoma: unveiling insights and clinical significance by Junwei Ge, Hongwei Jiang, Junjun Chen, Xuemin Chen, Yue Zhang, Liangrong Shi, Xiao Zheng, Jingting Jiang, Lujun Chen

“…Abstract Liver cancer, specifically hepatocellular carcinoma (HCC), stands out as one of the most formidable solid tumors, characterized by a dauntingly low survival rate. …”
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Prognostic impact of tumor size on cancer-specific survival for postoperative WHO grade II oligodendroglioma: a SEER-based study by Qin Lu, Yongyan Wu, Yonglin Xie, Shuxu Yang, Hongchuan Jin

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Denosumab Chemotherapy for Recurrent Giant-Cell Tumor of Bone: A Case Report of Neoadjuvant Use Enabling Complete Surgical Resection by Amit Agarwal, Brandon T. Larsen, Lawrence D. Buadu, Jack Dunn, Russell Crawford, Jonathan Daniel, Maria C. Bishop

“…Giant-cell tumor of the bone (GCTB) is a rare neoplasm that affects young adults. …”
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Tumor-associated lymphatic vessel density is a postoperative prognostic biomarker of hepatobiliary cancers: a systematic review and meta-analysis by Jin Li, Yu-Bo Liang, Qing-Bo Wang, Yu-Kai Li, Xing-Ming Chen, Wan-Ling Luo, Yawhan Lakang, Zi-Sheng Yang, Yan Wang, Zhi-Wei Li, Yang Ke, Yang Ke, Yang Ke

“…PurposeThis study aimed to investigate whether tumor-associated lymphatic vessel density (LVD) could predict the survival of patients with hepato-biliary-pancreatic (HBP) cancers after radical resection.MethodsA systematic search was conducted using PubMed, Embase, and Cochrane Library from the inception to July 31, 2024 for literature that reported the role of LVD in overall survival (OS) and recurrence-free survival (RFS) of patients with HBP cancers after radical resection.ResultsTen studies with 761 patients were included for the meta-analysis. …”
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The Oxidative Stress Response Gene P66SHC and the Tumor Suppressor Gene P53 Induce Mitochondrial Dna Damages by Mirella Trinei, Marco Giorgio, Sara Barozzi, Pier Giuseppe Pelicci

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A bispecific antibody-drug conjugate targeting pCAD and CDH17 has antitumor activity and improved tumor-specificity by Alyssa Synan, Nila C. Wu, Roberto Velazquez, Thomas Gesner, Claude Logel, Kathrin Mueller, Andrew Green, Patrizia Barzaghi-Rinaudo, Quincey Simmons, Samuele Mercan, Xingyi Shi, Xun Li, Vivek Sagar, Joshua Korn, Margaret McLaughlin, William R. Tschantz, Dominik Hainzl, Anthony Malamas, Thomas Huber, Regis Cebe, Kathleen T. Xie, Joseph A. D’Alessio

“…In in vivo dual flank mouse models, we demonstrated antitumor activity of the bispecific ADC in tumors expressing both antigens but not in tumors expressing only pCAD or only CDH17. …”
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Stachydrine targeting tumor-associated macrophages inhibit colorectal cancer liver metastasis by regulating the JAK2/STAT3 pathway by Yang Gui, Gengchen Xue, Yuyi Yuan, Jingbo Wang, Shuangjiao Deng, Fei Gao, Yushi Tian, Zhiqiang Zhao, Heng Fan

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Simultaneous Anti-Tuberculosis and Anti-Tumor Treatment with Immune Checkpoint Inhibitors for Co-Existent Pulmonary Tuberculosis and Advanced Lung Cancer by Wang H, Gao L, Cai X, Li J, Lang Y, Zheng R, Yang S

Subjects: “…anti-tumor therapy…”
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Successful Intravascular Correction of Intratumoral Pseudoaneurysm by Erosion of the Aorta in a Patient with Thoracic Giant Cell Tumor of Bone Responding to Denosumab by Natalia M. P. Fraile, Diego Toloi, Ceci O. Kurimori, Adriana R. B. Matutino, Alberto Codima, Veridiana P. Camargo, Olavo Feher, Rodrigo R. Munhoz

“…Giant cell tumor of bone (GCT) is a rare, locally aggressive neoplasm characterized by the presence of giant cells with osteoclast activity. …”
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Pretreatment level of circulating tumor cells is associated with lymph node metastasis in papillary thyroid carcinoma patients with ≤ 55 years old by Ming Yu, Jiaqin Deng, Yihua Gu, Yeqian Lai, Yuedong Wang

Subjects: “…Circulating tumor cells…”
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3D synergistic tumor-liver analysis further improves the efficacy prediction in hepatocellular carcinoma: a multi-center study by Yurong Jiang, Jiawei Zhang, Zhaochen Liu, Jinxiong Zhang, Xiangrong Yu, Danyan Lin, Dandan Dong, Mingyue Cai, Chongyang Duan, Shuyi Liu, Wenhui Wang, Yuan Chen, Qiyang Li, Weiguo Xu, Meiyan Huang, Sirui Fu

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Tumor Protective Activity of CD4+ but Not of CD8+ T Cells in DNA-Vaccinated Mice Challenged with bcr-abl-Transformed Cells by Martina Petráčková, Vincent Lučanský, Vladimír Vonka

“…All nonimmunized animals developed tumors. All animals untreated with the antibodies as well as those in which CD8+ T cells had been depleted, were fully protected against the challenge. …”
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