Crosstalk between Gut Microbiota and Cancer Immunotherapy: Present Investigations and Future Perspective by Yuhui Tang, Qiaoting Cai, Zhi Tian, Wenkuan Chen, Hailin Tang

“…Gut microbiota is crucial for protecting the homeostasis of immune locally and systemically, and its dysbiosis is essentially correlated to tumorigenesis, cancer progression, and refractoriness to cancer treatments, including the novel immunotherapy. …”
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Genetic Alterations in Presumptive Precursor Lesions of Breast Carcinomas by Michaela Aubele, Martin Werner, Heinz Höfler

“…Cytogenetic and molecular‐genetic analysis of these lesions give evidence for an accumulation of various genetic alterations during breast tumorigenesis. Using immuno‐histochemistry overexpression of the c‐erbB‐2 oncogene was found in ductal carcinoma in situ(DCIS), but not in atypical intraductal hyperplasia (AIDH) and intraductal hyperplasia (IDH). …”
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Tumor-Induced Local and Systemic Impact on Blood Vessel Function by J. Cedervall, A. Dimberg, A-K. Olsson

“…Tumor cells can alter the characteristics of the endothelium by recruitment of leukocytes such as neutrophils and macrophages, which further stimulate inflammation and promote tumorigenesis. Recent findings also suggest that leukocyte-mediated effects on vascular function are not limited to the primary tumor or tissues that represent metastatic sites. …”
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Regulation of Skp2 Expression and Activity and Its Role in Cancer Progression by Chia-Hsin Chan, Szu-Wei Lee, Jing Wang, Hui-Kuan Lin

“…The regulation of cell cycle entry is critical for cell proliferation and tumorigenesis. One of the key players regulating cell cycle progression is the F-box protein Skp2. …”
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Biological functions of 5-methylcytosine RNA-binding proteins and their potential mechanisms in human cancers by Tingting Zhao, Zhe Zhang, Zhuo Chen, Guozheng Xu, Yongxi Wang, Fang Wang

“…It plays an important role in various biological processes, including cell metabolism, growth, apoptosis, and tumorigenesis. By affecting the proliferation, migration, invasion, and drug sensitivity of tumor cells, m5C methylation modification plays a vital part in the initiation and progression of tumors and is closely associated with the poor tumor prognosis. m5C-related proteins are categorized into three functional groups: m5C methyltransferases (m5C writers), m5C demethylases (m5C erasers), and m5C methyl-binding proteins (m5C readers). …”
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Identification of novel pQTL‐SNPs associated with lung adenocarcinoma risk: A multi‐stage study by Yutong Wu, Huiwen Xu, Liping Mao, Rongrong Zhao, Junfeng Chu, Lili Huang, Wendi Zhang, Yiran Liu, Qiong Chen, Xiaobo Tao, Siqi Li, Shenxuan Zhou, Anhui Ning, Zhenyu Li, Tian Tian, Lei Zhang, Jiahua Cui, Guangyu Tian, Minjie Chu

“…After mutation of 3 pQTL‐SNPs (rs7683000, rs73224660, and rs2776937), the expression of corresponding target proteins BST1 and NRP1 decreased, and as potential tumor suppressor proteins, which may promote tumorigenesis and further increasing the risk of developing LUAD (OR >1, p < 0.05); while after mutation the other pQTL‐SNP rs62069916, the corresponding target protein APOH expression was increased, while as a potential tumor suppressor protein, which may inhibit tumorigenesis and further reduced the risk of developing LUAD (OR <1, p < 0.05). …”
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Generation and Characterization of Erythroid Cells from Human Embryonic Stem Cells and Induced Pluripotent Stem Cells: An Overview by Kai-Hsin Chang, Halvard Bonig, Thalia Papayannopoulou

“…In contrast to other ex vivo stem-cell-derived cellular therapeutics, tumorigenesis is not a concern, as RBCs can be irradiated without marked adverse effects on in vivo function. …”
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Imaging Reporters for Proteasome Activity Identify Tumor- and Metastasis-Initiating Cells by Amanda C. Stacer, Hanxiao Wang, Joseph Fenner, Joseph S. Dosch, Anna Salomonnson, Kathryn E. Luker, Gary D. Luker, Alnawaz Rehemtulla, Brian D. Ross

“…Tumor-initiating cells, also designated as cancer stem cells, are proposed to constitute a subpopulation of malignant cells central to tumorigenesis, metastasis, and treatment resistance. …”
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Differentially regulated ADAMTS1, 8, 9, and 18 in pancreas adenocarcinoma by Murat Özgür Kılıç, Büşra Aynekin, Mikdat Bozer, Adem Kara, Hacer Haltaş, Duygu İçen, Kadir Demircan

“…Conclusions : According to the data obtained from the study, we suggest that these four ADAMTSs may have significant roles in the tumorigenesis and nodal spread of pancreas adenocarcinoma.…”
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Conservative Management of Muscle Invasive Bladder Cancer in Kidney-Pancreas Transplant Patient by Logan D. Glosser, Brandon S. Zakeri, Conner V. Lombardi, Obi O. Ekwenna

“…This report demonstrates a unique case of a patient with kidney-pancreas transplant diagnosed with MIBC treated with TMT that has no evidence of gross tumorigenesis at 3.5 years after diagnosis. Our findings suggest that trimodal therapy should be considered for treatment of MIBC in patients with kidney-pancreatic transplants to preserve the donated allografts.…”
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Mitotic Kinases and p53 Signaling by Geun-Hyoung Ha, Eun-Kyoung Yim Breuer

“…Mitosis is tightly regulated and any errors in this process often lead to aneuploidy, genomic instability, and tumorigenesis. Deregulation of mitotic kinases is significantly associated with improper cell division and aneuploidy. …”
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Transforming Growth Factor-Beta and Matrix Metalloproteinases: Functional Interactions in Tumor Stroma-Infiltrating Myeloid Cells by Jelena Krstic, Juan F. Santibanez

“…Transforming growth factor-beta (TGF-β) is a pleiotropic factor with several different roles in health and disease. In tumorigenesis, it may act as a protumorigenic factor and have a profound impact on the regulation of the immune system response. …”
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Viral mimicry evasion: a new role for oncogenic KRAS mutations by Raymond Chen, Aobo He, Daniel D. De Carvalho

“…These results establish KRAS as a promising target to sensitize immune “cold” tumors to ICI therapy and demonstrate the potential role of oncogenic mutations in viral mimicry evasion during tumorigenesis.…”
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Metabolic Syndrome and Triple-Negative Breast Cancer: A New Paradigm by Andrew A. Davis, Virginia G. Kaklamani

“…The insulin-leptin-adiponectin axis has been implicated mechanistically in breast cancer tumorigenesis. Specifically, increased leptin and decreased adiponectin levels disrupt homeostatic signaling pathways involved in cell proliferation, survival, cell-cycle regulation, and angiogenesis. …”
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Aging, cancer, and autophagy: connections and therapeutic perspectives by Begoña Zapatería, Esperanza Arias, Esperanza Arias

“…The interplay between aging, cancer, and autophagy reveals key insights into tumorigenesis, cellular senescence, and proteostasis dysfunction. …”
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Induced Pluripotent Stem Cells in Cardiovascular Medicine by Toru Egashira, Shinsuke Yuasa, Keiichi Fukuda

“…Human iPS cells are currently generated by transgene introduction principally through viral vectors, which integrate into host genomes, although the associated risk of tumorigenesis is driving research into nonintegration methods. …”
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Endometriosis Gene Expression Heterogeneity and Biosignature: A Phylogenetic Analysis by Mones Abu-Asab, Ming Zhang, Dennis Amini, Nihad Abu-Asab, Hakima Amri

“…In addition, it has identified disruptions within the major regulatory pathways including those involved in cell proliferation, steroidogenesis, angiogenesis, cytoskeletal organization and integrity, and tumorigenesis, as well as cell adhesion and migration. …”
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Evaluation of the role of unconventional prefoldin RPB5 interactor (URI1) in hepatitis B virus infection by Karolína Štaflová, Aleš Zábranský, Iva Pichová

“…HBV infection has been shown to increase the expression of the unconventional prefoldin RPB5 interactor (URI1), a cellular protein that promotes liver tumorigenesis and HCC metastasis. Our study investigated the role of URI1 in HBV infection in vitro. …”
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Tumor cells escape immunosurveillance by hampering LFA-1 by Shishir Upadhyay, Lewis Murugu, Lena Svensson, Lena Svensson

“…In this review, we first detail how leukocytes utilize LFA-1 during immunosurveillance and then explore how tumors counteract this process in the tumor microenvironment (TME) by either altering LFA-1 functions or exploiting it to drive tumorigenesis. Moreover, we discuss therapeutic strategies targeting LFA-1, including inhibitors tested in laboratory studies and animal models, highlighting their potential as anticancer interventions and the need for further research to evaluate their clinical utility.…”
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TRIM21-mediated PRMT1 degradation attenuates colorectal cancer malignant progression by Menghan Cao, Zhiying Shao, Xingyou Qian, Miaolei Chen, Chuyin Deng, Xintian Chen, Tingting Tang, Kaixu Zhang, Sufang Chu, Junnian Zheng, Jin Bai, Zhongwei Li

“…Furthermore, we demonstrate that TRIM21 suppresses the proliferation, tumorigenesis, migration, and metastasis of CRC cells by promoting the ubiquitination-mediated degradation of PRMT1. …”
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