RNA binding protein ILF3 increases CEP55 mRNA stability to enhance malignant potential of breast cancer cells and suppress ferroptosis by Sheng Chen, Yangyong Luo, Simin Ruan, Guosen Su, Guoxing Huang

“…CEP55, a key regulator of cell mitosis, plays a significant role in the tumorigenesis of many malignancies. In this study, we elucidated the function of CEP55 in the ferroptosis of breast cancer (BC). …”
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Iron metabolism in a mouse model of hepatocellular carcinoma by Dilay Yilmaz, Umesh Tharehalli, Rossana Paganoni, Paul Knoop, Andreas Gruber, Yuexin Chen, Rui Dong, Frank Leithäuser, Thomas Seufferlein, Kerstin Leopold, André Lechel, Maja Vujić Spasić

“…Additionally, liver tumorigenesis correlated with selective deficits of selenium, zinc and manganese. …”
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ZNF169 promotes thyroid cancer progression via upregulating FBXW10 by Wen Luo, Qiyu Xiao, Ying Fu

“…However, the specific role of ZNF169 in the tumorigenesis of thyroid carcinoma (THCA) remains poorly understood. …”
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Genetics of Endometrial Cancers by Tsuyoshi Okuda, Akihiko Sekizawa, Yuditiya Purwosunu, Masaaki Nagatsuka, Miki Morioka, Masaki Hayashi, Takashi Okai

“…Endometrial cancers exhibit a different mechanism of tumorigenesis and progression depending on histopathological and clinical types. …”
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Targeting protein synthesis pathways in MYC-amplified medulloblastoma by Devendra Kumar, Ranjana Kanchan, Nagendra K. Chaturvedi

“…MYC is known to regulate the transcription of major components of protein synthesis (translation) machinery, leading to promoted rates of protein synthesis and tumorigenesis. MTOR signaling-driven deregulated protein synthesis is widespread in various cancers, including medulloblastoma, which can promote the stabilization of MYC. …”
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HIF-1α Is Associated with Resistance to Hypoxia-Induced Apoptosis in Ameloblastoma by Katherine Julissa Palma Valladares, Karolyny Martins Balbinot, Antonia Taiane Lopes de Moraes, Maria Sueli da Silva Kataoka, Aline Maria Pereira Cruz Ramos, Rommel Thiago Jucá Ramos, Artur Luiz da Costa da Silva, Ricardo Alves Mesquita, David Normando, Sérgio de Melo Alves Júnior, João de Jesus Viana Pinheiro

“…Conclusion. In AMB tumorigenesis, hypoxia is possibly related to antiapoptotic events, which suggests an important role for HIF-1α, GLUT1, Bcl-2, IAP-2, and possibly p53.…”
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Aqp 9 and Brain Tumour Stem Cells by Guri Fossdal, Einar O. Vik-Mo, Cecilie Sandberg, Mercy Varghese, Mari Kaarbø, Emily Telmo, Iver A. Langmoen, Wayne Murrell

“…We, therefore, propose that aquaporin 9 may have a central role in the tumorigenesis of glioblastoma.…”
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Molecular Features and Methylation Status in Early Onset (≤40 Years) Colorectal Cancer: A Population Based, Case-Control Study by Giulia Magnani, Daniela Furlan, Nora Sahnane, Luca Reggiani Bonetti, Federica Domati, Monica Pedroni

“…Hypermethylation of ESR1, GATA5, and WT1 genes suggests possible markers in the earlier diagnosis of colorectal tumorigenesis.…”
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Value of alpha smooth muscle actin (αSMA) and inducible nitric oxide synthase (iNOS) in oral squamous cell carcinoma (OSCC): An immunohistochemical approach to tumor stroma categor... by Heba E.M. Youssef, Basant Hamdy AbouZaid

“…Cancer-associated fibroblasts (CAFs) are the most abundant component of tumor stroma that can direct tumorigenesis. Alpha smooth muscle actin (α-SMA) expression by stromal CAFs is linked to higher aggressive tumor behavior and poor prognosis. …”
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Similarities between Tumour Immune Response and Chronic Wound Microenvironment: Influence of Mesenchymal Stromal/Stem Cells by Kimberly Thando Peta, Melvin Anyasi Ambele, Michael Sean Pepper

“…In the case of the TME, MSCs are reported to promote tumorigenesis by suppressing T, B, and natural killer cells in addition to dendritic cells, cytotoxic T cells, and Th1-associated cytokines, thereby promoting tumour growth. …”
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Hijacking of the nervous system in cancer: mechanism and therapeutic targets by Yu Zhang, Qili Liao, Xuyang Wen, Jiayan Fan, Tifei Yuan, Xuemei Tong, Renbing Jia, Peiwei Chai, Xianqun Fan

“…On the contrary, the nervous system potentially has a suppressive effect on tumorigenesis, further underscoring a dual-edged role of neurons in cancer progression. …”
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Extracellular Vesicle-Loaded Oncogenic lncRNA NEAT1 from Adipose-Derived Mesenchymal Stem Cells Confers Gemcitabine Resistance in Pancreatic Cancer via miR-491-5p/Snail/SOCS3 Axis by Rongxiang Wu, Zhan Su, Le Zhao, Ruifeng Pei, Yiren Ding, Deqiang Li, Shuo Zhu, Lu Xu, Wei Zhao, Wuyuan Zhou

“…PCa cells were cocultured with EVs extracted from ADSCs, followed by assessment of malignant phenotypes, tumorigenesis, and gemcitabine resistance of PCa cells using gain- or loss-of-function experiments. …”
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Revealing Genomic Profile That Underlies Tropism of Myeloma Cells Using Whole Exome Sequencing by Youngil Koh, Daeyoon Kim, Woo-June Jung, Kwang-Sung Ahn, Sung-Soo Yoon

“…Pathway analysis using KEGG database showed that mutated genes specific of SNU_MM1393_BM were related to differentiation, while those of SNU_MM1393_SC were related to tumorigenesis. Conclusion. We found out genetic changes that underlie tropism of myeloma cells using WES. …”
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DDX3 participates in miRNA biogenesis and RNA interference through translational control of PACT and interaction with AGO2 by Ming‐Chih Lai, Yen‐Ling Yu, Chiao‐Nung Chen, Jau‐Song Yu, Hsin‐Yuan Hung, Shih‐Peng Chan

“…Emerging evidence suggests that DDX3 plays a vital role in tumorigenesis and cancer progression, however, its underlying mechanism is still not fully understood. …”
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Sophocarpine inhibits the proliferation and induces apoptosis of glioblastoma cells through regulating the miR-21/PTEN/PI3K/AKT axis by Feng Si, Qian Wang, Fei Chen, Xiangdong Lu

“…Abstract Sophocarpine (SC) has been reported to suppress tumorigenesis. But the effect of SC on glioblastoma (GBM) is unknown. …”
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Pan-cancer analysis shows that TNFSF4 is a potential prognostic and immunotherapeutic biomarker for multiple cancer types including liver cancer by Zhaoda Deng, Lincheng Li, Zihe Meng, Guineng Zeng, Rui Cao, Rong Liu

“…Therefore, comprehensive bioinformatics analysis of pan-cancer was performed to determine the mechanisms through which TNFSF4 regulates tumorigenesis. Methods RNA-seq data for 33 cancers were analyzed from UCSC XENA database. …”
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Multiple Components of the VHL Tumor Suppressor Complex Are Frequently Affected by DNA Copy Number Loss in Pheochromocytoma by David A. Rowbotham, Katey S. S. Enfield, Victor D. Martinez, Kelsie L. Thu, Emily A. Vucic, Greg L. Stewart, Kevin L. Bennewith, Wan L. Lam

“…Our results indicate that VHL elongin BC protein complex components other than VHL could be important for PCC tumorigenesis and merit further investigation.…”
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High expression of nucleotide-binding oligomerization domain protein 1 correlates with poor prognosis and immune cell infiltration in Glioblastoma Multiforme patients by Hongyang Zhao, Beiwu Lan, Zenghui Zhao, Peining Zhu, Chong Wang, Yufei Gao

“…Abstract Nucleotide-binding oligomerization domain protein 1 (NOD1) is one of the innate immune receptors that has been associated with tumorigenesis and abnormally expressed in various cancers. …”
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Role of silent mutations in KRAS-mutant tumors by Jun Lu, Chao Zhou, Feng Pan, Hongyu Liu, Haohua Jiang, Hua Zhong, Baohui Han, Xiangxiang Pan

“…Silent mutations within the RAS gene have garnered increasing attention for their potential roles in tumorigenesis and therapeutic strategies. Kirsten-RAS (KRAS) mutations, predominantly oncogenic, are pivotal drivers in various cancers. …”
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DUOX2 Expression Is Increased in Barrett Esophagus and Cancerous Tissues of Stomach and Colon by Ran Qi, Yunfeng Zhou, Xiaozhen Li, Hong Guo, Lei Gao, Lijuan Wu, Yufeng Wang, Qiang Gao

“…DUOX2 in Barrett esophagus, gastric cancer, and CRC may be involved in the tumorigenesis of these tissues.…”
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