Single-cell RNA sequencing reveals tumor heterogeneity in small cell neuroendocrine cervical carcinoma by Xuesong Xiang, Xiang Tao, Keqin Hua, Hua Jiang, Jingxin Ding

“…Overall, these findings provide clues for tumorigenesis, precision treatments and prognostic prediction in SCNECC.…”
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Membrane Bound CRT Fragment Accelerates Tumor Growth of Melanoma B16 Cell In Vivo through Promoting M2 Polarization via TLR4 by Hong-Min Wang, Zhe Zhou, Jie Miao, Bo Zhu, Xiao-Qiu Dai, Qiao Zhong, Fang-Yuan Gong, Xiao-Ming Gao

“…Our data may provide useful clues for better understanding of the potentiating roles of CRT in tumorigenesis.…”
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Remarkable Role of Indoleamine 2,3-Dioxygenase and Tryptophan Metabolites in Infectious Diseases: Potential Role in Macrophage-Mediated Inflammatory Diseases by Yuki Murakami, Masato Hoshi, Yukio Imamura, Yuko Arioka, Yasuko Yamamoto, Kuniaki Saito

“…Originally known for its regulatory function during pregnancy and chronic inflammation in tumorigenesis, the activity of IDO1 seems to modify the inflammatory state of infectious diseases. …”
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Analysis of single nucleotide polymorphism of p16 gene in cytological samples of patients with oral potentially malignant disorders (OPMD) and oral squamous cell carcinoma (OSCC) by Neetu Oommen, Vasanthi V, Ramya Ramadoss, Rajkumar Krishnan

“…Background: pl6 (CDKN2a) play a role in tumorigenesis in some head and neck squamous cell carcinomas. …”
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Investigating the Prognostic and Oncogenic Roles of Membrane-Associated Ring-CH-Type Finger 9 in Colorectal Cancer by Jiayan Zhang, Qinghan Jiao, Zhigang Chen

“…Further research is essential to elucidate precise mechanisms by which MARCHF9 enhances tumorigenesis and to explore its therapeutic potential in CRC management.…”
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Necroptosis could serve as an indicator of therapeutic resistance in viral induced well-differentiated oral squamous cell carcinoma? by Nitya Krishnasamy, Ramya Ramadoss, Suganya Panneer Selvam, Sandhya Sundar, K. Hemashree

“…Concurrently, alterations in pro-inflammatory cytokines and chemokines drive tumorigenesis in viral-induced squamous cell carcinoma, impairing anti-viral immune responses. …”
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Seminal Fluid-Mediated Inflammation in Physiology and Pathology of the Female Reproductive Tract by Anthonio O. Adefuye, Henry A. Adeola, Kurt J. Sales, Arieh A. Katz

“…In sexually active women SF-mediated inflammation has been implicated in physiologic processes such as ovulation, implantation, and parturition while also enhancing tumorigenesis and susceptibility to infection. This review highlights the molecular mechanism by which SF regulates inflammatory pathways in the FMRT and how alterations in these pathways contribute to physiology and pathology of the female reproductive function. …”
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The Transcription Factor Creb is Involved in Sorafenib-Inhibited Renal Cancer Cell Proliferation, Migration and Invasion by Huang Shuaishuai, Cui Pinger, Lin Shuangxia, Yao Xuping, Wang Xue, Ren Yu, Weng Guobin

“…Our previous reports showed that the cyclic-AMP-response element-binding protein (CREB) served as a proto-oncogene in the process of tumorigenesis and mediated the growth and metastatic activity of renal cancer cells. …”
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Transmembrane and Ubiquitin-Like Domain-Containing 1 Promotes Glioma Growth and Indicates Unfavorable Prognosis by Yinggang Liu, Changcheng Cai, Ke Wu, Libo Hu

“…Ubiquitin-related proteins have garnered increasing attention for their roles in tumorigenesis. Transmembrane and ubiquitin-like domain-containing 1 (TMUB1) is a recently discovered protein in the ubiquitin-like domain family, yet its involvement in glioma remains poorly understood. …”
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Exosomes: Key Messengers Mediating the Interaction Between Tumor Cells and CD8+ T Cells in the Tumor Microenvironment by Li Y, Yang Q, Li D, Li W, Men W

“…Yilin Li,1,* Qiwei Yang,1,* Danni Li,2 Wenya Li,1 Wanfu Men1 1Department of Thoracic Surgery, the First Hospital of China Medical University, Shenyang, 110002, People’s Republic of China; 2Department of Medical Oncology, the First Hospital of China Medical University, Shenyang, 110002, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wanfu Men; Wenya Li, Email 472581624@163.com; saint5288@hotmail.comAbstract: In recent years, with an increasingly profound comprehension of the tumor microenvironment, it has been discovered that the constituent cells within the immune microenvironment, such as macrophages, CD4+T cells, and CD8+T cells, interact with tumor cells in manners conducive to tumorigenesis and progression. Exosomes play a pivotal role as essential mediators for intercellular material exchange and signal transmission in this context. …”
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Lipid metabolic reprogramming and associated ferroptosis in osteosarcoma: From molecular mechanisms to potential targets by Zhiyang Yin, Guanlu Shen, Minjie Fan, Pengfei Zheng

“…Osteosarcoma is a common bone tumor in adolescents, which is characterized by lipid metabolism disorders and plays a key role in tumorigenesis and disease progression. Ferroptosis is an iron-dependent form of programmed cell death associated with lipid peroxidation. …”
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Expression Pattern of a Homeotic Gene, HOXA5, in Normal Breast and in Breast Tumors by Gregory S. Henderson, Paul J. van Diest, Horst Burger, Jose Russo, Venu Raman

“…Furthermore, we found that the survival rate amongst the different low levels of HOXA5 expressing breast tumors was not significant, indicative of an early tumorigenesis process in the absence of innate levels of HOXA5 in normal breast cells.…”
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Exploring the microbiome-gut-testis axis in testicular germ cell tumors by Sona Ciernikova, Aneta Sevcikova, Michal Mego

“…The interplay between the gut and testicular microbiomes is hypothesized to influence tumorigenesis and reproductive health, underscoring the complex role of microbial ecosystems in disease pathology. …”
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A Golgi apparatus‑related subtype and risk signature predicts prognosis and evaluates immunotherapy response in gastric cancer by Ruyue Chen, Zengwu Yao, Lixin Jiang, Jinchen Hu

“…Golgi apparatus, a crucial cellular organelle involved in tumorigenesis, remains underexplored in GC research. …”
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Systematic Characterization of Splicing Dysregulation in Pan Solid Tumor Transcriptome by Jingru Sui, Dan Guo, Xiao Wen, Lei Zhou, Yue Huang, Haoyu Yu, Jinyu Chen, Zhaoqi Liu

“…Whereas spliceosomal mutations are less common in solid tumors, splicing disorders are pervasive and proven to promote tumorigenesis. However, there is a lack of systematic understanding of the overall splicing dysregulation patterns and how widespread different patterns occur within or across solid tumor lineage. …”
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Colibactin-induced damage in bacteria is cell contact independent by Emily Lowry, Amir Mitchell

“…It has been widely studied in mammalian cells due to its potential role in tumorigenesis. However, fundamental questions about its impact in bacteria remain underexplored. …”
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Mechanisms and therapeutic implications of gene expression regulation by circRNA-protein interactions in cancer by Nan Zhang, Xinjia Wang, Yu Li, Yiwei Lu, Chengcheng Sheng, Yumeng Sun, Ningye Ma, Yisheng Jiao

“…Studies have demonstrated that circRNAs can interact with RNA-binding proteins (RBPs), which play crucial roles in tumorigenesis, metastasis, and drug response in cancer by influencing gene expression and altering the processes of tumor initiation and progression. …”
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KLF9-GRK5-HDAC6 axis aggravates osteoarthritis pathogenesis by promoting chondrocyte extracellular matrix degradation and apoptosis by Xiaonan Zhou, Peng Jiang, Huangqi Tan, Yanfang Wang, Lunhao Bai

“…The transcription factor Kruppel-like family factor 9 (KLF9) has been identified as a regulator of tumorigenesis. However, its role in OA is still not fully understood. …”
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Effects of Tp53 Gene Mutations on the Survival of Non-Small Cell Lung Cancer (NSCLC); A Short Review by Zhang C, Yang C, Shi Q

“…Mutations within the TP53 gene represent critical molecular events in NSCLC, contributing to the tumorigenesis in the pulmonary epithelial tissues. TP53 is a widely researched prognostic indicator in NSCLC, and pathological investigations have revealed a weak to mild negative predictive effect for TP53. …”
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The Notch Pathway in Breast Cancer Progression by Emmanuel N. Kontomanolis, Sofia Kalagasidou, Stamatia Pouliliou, Xanthoula Anthoulaki, Nikolaos Georgiou, Valentinos Papamanolis, Zacharias N. Fasoulakis

“…The cross-talk of Notch and estrogens, the effect of Notch in breast cancer stem cells formation, and the dependable Notch overexpression during breast tumorigenesis have been studied enough and undoubtedly linked to breast cancer development. …”
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