Molecular Insights in the Anticancer Activity of Natural Tocotrienols: Targeting Mitochondrial Metabolism and Cellular Redox Homeostasis by Raffaella Chiaramonte, Giulia Sauro, Domenica Giannandrea, Patrizia Limonta, Lavinia Casati

“…Cancer cells maintain moderate levels of ROS to promote tumorigenesis, metastasis, and drug resistance; indeed, once the cytotoxicity threshold is exceeded, ROS trigger oxidative damage, ultimately leading to cell death. …”
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Steroid hormone-induced wingless ligands tune female intestinal size in Drosophila by Lisa Zipper, Bernat Corominas-Murtra, Tobias Reiff

“…Together, our findings provide insights into the complex endocrine growth control mechanisms during mating-induced adaptations and might help untangling pleiotropic hormonal effects observed in gastrointestinal tumorigenesis.…”
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Pan-Cancer Analysis of the Cuproptosis-Related Gene DLD by Jiahui Lin, Guowei Wang, Sha Cheng, Yanan Hu, Huan Li, Wanjiang Feng, Xiaoming Liu, Canxia Xu

“…DLD expression is associated with a variety of tumor prognoses and plays an integral role in tumorigenesis, tumor metabolism, and immunity.…”
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Evaluation of C-X-C chemokine receptor type 4 (CXCR4) and Peroxisome proliferator-activated receptor gamma (PPAR-γ) expression in colorectal carcinoma: Relation to the available cl... by Asmaa E. Bedeer, Nehal Abd El-Ghaffar Heabah

“…It is essential to develop drugs against novel targets––involved in CRC tumorigenesis and progression––to improve the management of the disease. …”
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Inhibitory Effect of Aconitine on Colorectal Cancer Malignancy via Inducing Apoptosis and Suppression of Cell Motion by Xuehui Li, Jianglin Hu, Duan Tong, Taotao Yang, Ming Deng

“…Animal experiments were performed to further elucidate aconitine’s effect on CRC tumorigenesis. Results: Aconitine time- and dose-dependently restrained CRC cell viability but was not cytotoxic to normal colorectal mucosa cells. …”
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Research Progress of SGLT2 Inhibitors in Cancer Treatment by Miao X, Zhang J, Huang W, Wang Y, Jin A, Cao J, Zhao Z

“…This article provides a comprehensive review of the role of SGLT2 in tumorigenesis and tumor progression, and explores the underlying mechanisms and potential therapeutic applications of SGLT2 inhibitors as anticancer agents.Keywords: SGLT2 inhibitors, SGLT2, cancer, mechanism…”
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The Beneficial Effects of GLP-1 Receptor Agonists Other than Their Anti-Diabetic and Anti-Obesity Properties by Chenqi Lu, Cong Xu, Jun Yang

“…In recent years, different beneficial effects of GLP-1R agonists were discovered, such as reducing ischemia-reperfusion injury, improving the function of various organs, alleviating substance use disorder, affecting tumorigenesis, regulating bone metabolism, changing gut microbiota composition, and prolonging graft survival. …”
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The Role of the Key Differentially Mutated Gene FGFR3 in the Immune Microenvironment of Bladder Cancer by Jun Jiang, Yan Zhan, Jun Li

“…Therefore, this study is aimed at investigating whether FGFR3 is promising as a biomarker of TME remodeling to explain underlying mechanisms involved in tumorigenesis and metastasis, which may help to make decisions on treatments for bladder cancer.…”
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A Novel Ferroptosis-Related Gene Signature for Prognosis Prediction in Ewing Sarcoma by Runhan Zhao, Zefang Li, Yanran Huang, Chuang Xiong, Chao Zhang, Hao Liang, Jingtao Xu, Xiaoji Luo

“…Ferroptosis, as a form of programmed cell death independent of apoptosis, has been demonstrated that plays a major role in tumorigenesis and cancer treatment. A comprehensive analysis of ferroptosis-related genes (FRGs) may lead to a novel choice for the treatment of Ewing sarcoma (ES). …”
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Study of the association of the known prognostic variables with EGFR expression in head and neck squamous cell carcinomas by Toyaja Jadhav, Ajay Malik, Ahmed Waheed Kashif, Divya Shelly, Prabhashankar S. Mishra, Ajay Kumar Baranwal, Rajesh Sahu

“…EGFR is known to act as a driver of tumorigenesis in various carcinomas. Over expression of EGFR in HNSCC is associated with poor prognosis and resistance to radiotherapy. …”
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Balancing Inflammation: The Link between Th17 and Regulatory T Cells by Maggie L. Diller, Ragini R. Kudchadkar, Keith A. Delman, David H. Lawson, Mandy L. Ford

“…The balance between these two cell populations is essential for immune homeostasis and dysregulation of this balance has been implicated in a variety of inflammatory conditions including autoimmunity, allograft rejection, and tumorigenesis. Emerging evidence reports a significant amount of plasticity between the Th17 and regulatory T cell compartments, and the mechanisms by which these cells communicate and influence each other are just beginning to be understood. …”
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PPAR Agonists for the Prevention and Treatment of Lung Cancer by Sowmya P. Lakshmi, Aravind T. Reddy, Asoka Banno, Raju C. Reddy

“…PPARα activation generally inhibits tumorigenesis through its antiangiogenic and anti-inflammatory effects. …”
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Carcinogenic and anticancer activities of microbiota-derived secondary bile acids by Mobina Kouhzad, Friedrich Götz, Tahereh Navidifar, Elahe Taki, Mahsa Ghamari, Roghayeh Mohammadzadeh, Maryam Seyedolmohadesin, Narjess Bostanghadiri

“…The carcinogenic activities of SBAs include DNA damage, promotion of oxidative stress, and modulation of signaling pathways that drive tumorigenesis. Conversely, some SBAs exhibit anticancer properties by inducing apoptosis, inhibiting cell proliferation, and modulating immune responses. …”
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Ligand-Based Pharmacophore Modeling and Virtual Screening of RAD9 Inhibitors by Nirmal K. Prasad, Vishnupriya Kanakaveti, Siddhartha Eadlapalli, Ramakrishna Vadde, Angamba Potshangbam Meetei, Vaibhav Vindal

“…Aberrant RAD9 expression has been linked to breast, lung, thyroid, skin, and prostate tumorigenesis. Overexpression of RAD9 interacts with BCL-2 proteins and blocks the binding sites of BCL-2 family proteins to interact with chemotherapeutic drugs and leads to drug resistance. …”
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Machine Learning-Devised Immune-Related lncRNA Signature Panel Predicts the Prognosis and Immune Landscape in Breast Cancer Novel IRLP Signature in BRCA by Jun-Yu Zhu, An-Qi Lyu, Zhang-Ting Wang, Wai-Yee Chan, Tao Qin, Kai-Kei Miu, He-Rui Yao

“…Long noncoding RNAs (lncRNAs) actively participate in breast cancer (BRCA) tumorigenesis via epigenetic mechanisms. Our study identified immune-related lncRNA (irlncRNA) pairs and compiled them into a set of noncoding gene signatures able to stratify subtypes of BRCA associated with variable degrees of survival and immune cell infiltration. …”
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Macrophages in Tumor Microenvironments and the Progression of Tumors by Ning-Bo Hao, Mu-Han Lü, Ya-Han Fan, Ya-Ling Cao, Zhi-Ren Zhang, Shi-Ming Yang

“…This interaction leads to tumorigenesis, metastasis, and drug resistance. So mediating macrophage to resist tumors is considered to be potential therapy.…”
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Targeting RNA splicing modulation: new perspectives for anticancer strategy? by Xuemei Lv, Xiaoyu Sun, Yang Gao, Xinyue Song, Xiaoyun Hu, Lang Gong, Li Han, Miao He, Minjie Wei

“…In this review, we summarize the splice-altered signatures of cancer cell transcriptomes and the contributions of splicing aberrations to tumorigenesis and progression. Especially, we discuss current and emerging RNA splicing-targeted strategies for cancer therapy, including pharmacological approaches and splice-switching antisense oligonucleotides (ASOs). …”
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Identification of ferroptosis-related signature predicting prognosis and therapeutic responses in pancreatic cancer by Ting Ting Chung, Zanyue Piao, Seung Jin Lee

“…Abstract Ferroptosis plays a role in tumorigenesis by affecting lipid peroxidation and metabolic pathways; however, its prognostic or therapeutic relevance in pancreatic adenocarcinoma (PAAD) remains poorly understood. …”
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lncRNA ZFAS1 Promotes HMGCR mRNA Stabilization via Binding U2AF2 to Modulate Pancreatic Carcinoma Lipometabolism by Luoluo Wang, Yi Ruan, Xiang Wu, Xinhua Zhou

“…Being one of the most lethal malignant tumors worldwide, pancreatic carcinoma (PC) shows strong invasiveness and high mortality. In tumorigenesis and progression, the role played by long-chain noncoding RNAs (lncRNAs) cannot be ignored. …”
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Prognostic and clinicopathological significance of mucin family members expression in gastric cancer: a meta-analysis by Shunda Wang, Yongrun Mu, Jianwei Zhang, Chengfeng Wang

“…Several important mucins exert the function of tumorigenesis or progression in gastric cancer (GC). …”
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