Overview of Platelet Physiology: Its Hemostatic and Nonhemostatic Role in Disease Pathogenesis by Kakali Ghoshal, Maitree Bhattacharyya

“…Platelets activation and dysfunction have been implicated in diabetes, renal diseases, tumorigenesis, Alzheimer’s, and CVD. In conclusion, this paper elucidates that platelets are not that innocent as they keep showing and thus numerous novel platelet biomarkers are upcoming very soon in the field of clinical research which can be important for predicting and diagnosing disease state.…”
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CXCL14 in prostate cancer: complex interactions in the tumor microenvironment and future prospects by Lei Tang, Xin Chen, Jianquan Hou, Xuedong Wei

“…Abstract CXCL14 is a highly conserved chemokine expressed in various cell types, playing crucial roles in both physiological and pathological processes, including immune regulation and tumorigenesis. Recently, the role of CXCL14 in tumors has attracted considerable attention. …”
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A novel necroptosis-related gene signature predicts the prognosis and immunotherapeutic response in breast cancer through immune infiltration by Dezhi Lu, Sifang Qiu, Zhiqiang Zeng

“…Abstract Growing evidence has demonstrated the association between necroptosis and tumorigenesis and immunotherapy. However, the influence of overall necroptosis related genes on prognosis and immune microenvironment of breast cancer is still unclear. …”
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Simultaneous Detection of Different MicroRNA Types Using the ZIP-Code Array System by Sonja U. Weishaupt, Steffen Rupp, Karin Lemuth

“…Their implication in tumorigenesis is based on their dysregulation in many human cancer diseases. …”
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The Impact of the Metabolic Syndrome Severity on the Appearance of Primary and Permanent DNA Damage by Mirta Milić, Luka Kazensky, Martina Matovinović

“…Such changes contribute to an increased risk of tumorigenesis, cancer progression, and mortality. The alkaline comet and micronucleus <i>cytome</i> assay are commonly used assays for DNA damage evaluation. …”
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Revolutionizing precision medicine in oral squamous cell carcinoma: Harnessing 3D in vitro models for translation by Nitesh Buldak, Vishnu Priya Veeraraghavan, Ullas Mony

“…In this review, we discuss the role of the tumor-immune microenvironment (TIME) in tumorigenesis and the 3D in vitro cultures in recreating the tumor microenvironment paving the way for the development of personalized medicine in OSCC.…”
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Glioma Stem Cells: Signaling, Microenvironment, and Therapy by Brandon D. Liebelt, Takashi Shingu, Xin Zhou, Jiangong Ren, Seul A. Shin, Jian Hu

“…Further, GSCs possess unique surface markers, modulate characteristic signaling pathways to promote tumorigenesis, and play key roles in glioma vascular formation. …”
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Drug Delivery System Targeting Cancer-Associated Fibroblast for Improving Immunotherapy by Zhang Z, Wang R, Chen L

“…It has been confirmed that nanomaterials can not only directly target CAFs, but also interact with the tumor microenvironment (TME) and immune cells to affect tumorigenesis. As for the cancer treatment, nanomaterials could enhance the therapeutic effect in many ways. …”
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ASPM Promotes the Progression of Anaplastic Thyroid Carcinomas by Regulating the Wnt/β-Catenin Signaling Pathway by Liang Jiang, Shuai Zhang, Ning An, Guoqing Chai, Changhong Ye

“…Upregulation of ASPM promotes the malignant properties of ATC cells and contributes to tumorigenesis through the Wnt/β-catenin signaling pathway.…”
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FBXW7 Reduces the Cancer Stem Cell-Like Properties of Hepatocellular Carcinoma by Regulating the Ubiquitination and Degradation of ACTL6A by Xing Wang, Ying Li, Yongning Li, Peng Liu, Songbai Liu, Yaozhen Pan

“…Cancer stem cells (CSCs) comprise a subset of tumor cells that can initiate tumorigenesis and promote tumor advance. A previous study showed that the expression of FBXW7 in hepatocellular carcinoma (HCC) clinical samples was lower than that in the adjacent nontumor tissues and was negatively correlated with the invasion and migration of HCC cells. …”
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Oral microbiota: the overlooked catalyst in cancer initiation and progression by Xinlin Wang, Xinlin Wang, Xin He, Xin He, Bin Zhong

“…This paper reviews the role of the oral microbiota in the occurrence and progression of cancer and systematically elucidates the molecular mechanisms by which dysbiosis influences tumorigenesis and tumor progression. This information can provide a theoretical basis for exploring cancer treatment strategies and offer new insights for cancer prevention.…”
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Unravelling single-cell DNA replication timing dynamics using machine learning reveals heterogeneity in cancer progression by Joseph M. Josephides, Chun-Long Chen

“…Our methodology brings critical insights into chromosomal aberrations and highlights the ubiquitous aneuploidy process during tumorigenesis. The copy number and scRT profiles obtained by analysing >119,000 high-quality human single cells from different cell lines, patient tumours and patient-derived xenograft samples leads to a multi-sample heterogeneity-resolved scRT atlas. …”
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PYR-41 and Thalidomide Impair Dendritic Cell Cross-Presentation by Inhibiting Myddosome Formation and Attenuating the Endosomal Recruitments of p97 and Sec61 via NF-κB Inactivation... by Xiang You, Dan Dan Xu, Di Zhang, Jie Chen, Feng Guang Gao

“…PYR-41 and thalidomide have therapeutic effects on inflammation-associated diseases with side effects such as tumorigenesis. Cross-presentation allows dendritic cells (DC) to present endogenous antigen and induce protective immunity against microbe infection and tumors. …”
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VEGF Promotes Proliferation of Human Glioblastoma Multiforme Stem-Like Cells through VEGF Receptor 2 by Chengshi Xu, Xing Wu, Jianhong Zhu

“…GBM is a lethal cancer, characterized by florid vascularization and aberrantly elevated vascular endothelial growth factor (VEGF). VEGF promotes tumorigenesis and angiogenesis of human GBM stem-like cells (GBSCs). …”
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Aging and tumors: a dynamic interaction by Yudi Zhang, Siqiang Zhu, Zhaodong Liu, Yonghao Hu, Yongjian Zhang, Liang Shang, Leping Li

“…This article initially examines the role of cellular senescence in tumorigenesis, emphasizing the correlation between telomere length—a marker of cellular senescence—and tumor risk. …”
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Targeting lipid metabolism of macrophages: A new strategy for tumor therapy by Nan Shao, Hui Qiu, Jing Liu, Daimin Xiao, Juanjuan Zhao, Chao Chen, Jiajia Wan, Mengmeng Guo, Guiyou Liang, Xu Zhao, Lin Xu

“…Tumor-associated macrophage (TAM) has emerged as a crucial regulator in tumorigenesis and promising target for tumor treatment.Aim of review: A thorough understanding of TAM lipid metabolism and its value in tumorigenesis may provide new ideas for TAM-based anti-tumor therapy.Key scientific concepts of review: TAMs can be divided into two main types, M1-like TAMs and M2-like TAMs, which play anti-tumor and pro-tumor functions in tumor occurrence and development, respectively. …”
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PreS1 deletions in genotype C HBV leads to severe hepatic inflammation and hepatocarcinogenesis via the IRE1-JNK axis by Yu-Min Choi, Junghwa Jang, Dong Hyun Kim, Ziyun Kim, Eunseo Kim, Won Hyeok Choe, Bum-Joon Kim

“…Methods: The effects of HBV replicative capacity, ER stress signaling, inflammation, cell death, and tumorigenesis resulting from PreS1 deletions were investigated through in vitro and in vivo experiments. …”
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Anticancer Role of PPARγ Agonists in Hematological Malignancies Found in the Vasculature, Marrow, and Eyes by P. J. Simpson-Haidaris, S. J. Pollock, S. Ramon, N. Guo, C. F. Woeller, S. E. Feldon, R. P. Phipps

“…It is well accepted that inflammation and tumorigenesis are linked. Because peroxisome proliferator-activated receptor (PPAR)-γ agonists are potent mediators of anti-inflammatory responses, it was a logical extension to examine the role of PPARγ agonists in the treatment and prevention of cancer. …”
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Tumor-Derived CXCL1 Promotes Lung Cancer Growth via Recruitment of Tumor-Associated Neutrophils by Ming Yuan, Ha Zhu, Junfang Xu, Yuanyuan Zheng, Xuetao Cao, Qiuyan Liu

“…Although their contribution to tumorigenesis and progression is still controversial, accumulating evidence recently has demonstrated that tumor-associated neutrophils (TANs) play a key role in multiple aspects of cancer biology. …”
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The role of circadian rhythm regulator PERs in oxidative stress, immunity, and cancer development by Baimei Zhao, Eugenie Nepovimova, Qinghua Wu

“…At the heart of this interaction lies the PERIOD proteins (PERs), pivotal to the circadian clock, influencing the timing of physiological and behavioral processes and impacting oxidative stress, immune functionality, and tumorigenesis. PER1 orchestrates the cooperation of the enzyme GPX1, modulating mitochondrial dynamics in sync with daily rhythms and oxidative stress, thus regulating the mechanisms managing energy substrates. …”
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