Oncogene-tumor suppressor gene feedback interactions and their control by Baltazar D. Aguda, Ricardo C.H. del Rosario, Michael W.Y. Chan

Subjects: Get full text

Changes in Methylation Patterns of Tumor Suppressor Genes during Extended Human Embryonic Stem Cell Cultures by Kyung Min Kang, Jeoung Eun Lee, Ji Eun Park, Hyunjin Kim, Hee Yeon Jang, Minyeon Go, Dong Ryul Lee, Sung Han Shim

“…Here, we investigated whether CpG island (CGI) methylation patterns of 24 tumor suppressor genes could be maintained during extended hESC cultures. …”
Get full text

Transcriptional Regulation of the p53 Tumor Suppressor Gene in S-Phase of the Cell-Cycle and the Cellular Response to DNA Damage by David Reisman, Paula Takahashi, Amanda Polson, Kristy Boggs

Get full text

The Oxidative Stress Response Gene P66SHC and the Tumor Suppressor Gene P53 Induce Mitochondrial Dna Damages by Mirella Trinei, Marco Giorgio, Sara Barozzi, Pier Giuseppe Pelicci

Get full text

The genetic duet of concurrent RASAL1 and PTEN alterations promotes cancer aggressiveness by cooperatively activating the PI3K–AKT pathway by Xiaopei Shen, Jie Tan, Rengyun Liu, Guangwu Zhu, Lisa Rooper, Mingzhao Xing

Subjects: Get full text

Identification of alterations in the nucleotide sequence of the chromatin remodeling gene PBRM1 in clear cell renal cell carcinoma patients by E. A. Klimentova, I. R. Gilyazova, A. A. Izmailov, I. M. Sultanov, M. A. Bermisheva, V. N. Pavlov, E. K. Khusnutdinova

Subjects: Get full text

Regulation and Function of the Peg3 Imprinted Domain by Hongzhi He, Joomyeong Kim

Subjects: Get full text

Molecular Mechanisms of Synergistic Effect of PRIMA‐1met and Oxaliplatin in Colorectal Cancer With Different p53 Status by Xiao‐lan Li, Jianbiao Zhou, Nicole Xin‐Ning Tang, Yi Chai, Meng Zhou, Ai‐di Gao, Zhong‐kai Lu, Han Min

Subjects: Get full text

Tumor-initiating and metastasis-initiating cells of clear-cell renal cell carcinoma by Dinh-Xuan Pham, Tien Hsu

Subjects: Get full text

Differences in phenotypes of normal and malignant cells concerning chromosomal fragility and ganglioside expression by Iskra Sainova, Vera Kolyovska, Desislava Drenska, Dimitar Maslarov, Dimitrina Dimitrova-Dikanarova, Tzvetanka Markova

“…Additionally, the presence and expression of the tumor-suppressor gene HACE-1 in the genome of mouse embryonic stem cells (mESCs) and malignant human cervical carcinoma HeLa cells, both containing an additional copy of this gene, inserted by transfection with appropriate recombinant DNA vectors containing a copy of the tumor-suppressor gene, were tested. …”
Get full text

FHIT Doubts are Clear Now by Anjilna Wali

“…The fragile histidine triad (FHIT) gene is a bonafide tumor-suppressor gene present on the short arm of chromosome 3 and its loss of function has been evaluated in different types of cancers. …”
Get full text

Expression of WW Domain-Containing Oxidoreductase WOX1 in Human Nervous System Tumors by Ming-Fu Chiang, Shur-Tzu Chen, Chen-Peng Lo, Chun-I Sze, Nan-Shan Chang, Yu-Jen Chen

“…Background and ObjectiveS: We aimed to evaluate the expression levels of the tumor suppressor WOX1 in nervous system tumors and its co-expression with p53 and neurofibromatosis type 2/merlin (NF2) tumor suppressor gene products.…”
Get full text

Familial Aggregation of Urinary Tract and Bone Tumors: Searching for a Syndrome by Andreas Frings, Jochen B. Geigl, Bernadette Liegl-Atzwanger, Andreas Leithner

“…To confirm Li-Fraumeni syndrome, we set out to investigate this case by analyzing the tumor suppressor gene p53. However, taking into account all the diagnostic results obtained, Li-Fraumeni syndrome could not be confirmed, but there is still uncertainty regarding a definitive diagnosis.…”
Get full text

Nongenomic Mechanisms of PTEN Regulation by Jimmie E. Fata, Shawon Debnath, Edmund C. Jenkins, Marcia V. Fournier

“…A large amount of data supports the view that PTEN is a bona fide tumor suppressor gene. However, recent evidence suggests that derailment of cellular localization and expression levels of functional nonmutated PTEN is a determining force in inducing abnormal cellular and tissue outcomes. …”
Get full text

胃癌中 MTS1 基因异常甲基化的研究 by 全欣鑫, 周晓东

“…【目的】探讨多肿瘤抑制基因(multiple tumor suppressor gene 1, MTS1)5′端 CpG 岛异常甲基化与原发性胃癌发 病机制之间的关系。…”
Get full text

Annotation of Genes Having Candidate Somatic Mutations in Acute Myeloid Leukemia with Whole-Exome Sequencing Using Concept Lattice Analysis by Kye Hwa Lee, Jae Hyeun Lim, Ju Han Kim

“…In cancer genome studies, the annotation of newly detected oncogene/tumor suppressor gene candidates is a challenging process. …”
Get full text

FBXW7 metabolic reprogramming inhibits the development of colon cancer by down-regulating the activity of arginine/mToR pathways. by Qing Li, Yan Li, Tong Zhou, Yong Zhang, Huiyu Li, Fajia Yuan, Yanghui Bi

“…FBXW7 is a tumor suppressor gene that regulates metabolism and is associated with the onset and progression of colorectal cancer (CRC)), however, the precise mechanism whereby FBXW7 participates in the metabolic reprogramming of CRC remains unclear. …”
Get full text

Genetic Alterations in Presumptive Precursor Lesions of Breast Carcinomas by Michaela Aubele, Martin Werner, Heinz Höfler

“…An expression of mutant p53 tumor suppressor gene as well as expression of cyclin D1 was identified in DCIS. …”
Get full text

Comparison of BRCA1 Gene Expression and CA15-3 Tumor Marker Level in Different Stages of Breast Cancer by Negar Soltani Irdmusa, Haniyeh Bashi Zadeh Fakhar, Masoumeh Heshmati, Mohammad Esmaiel Akbari, Sara Rahimi

“…In this study, we examined the expression of the tumor suppressor gene BRCA1 and the tumor marker CA15-3 in women diagnosed with BC, focusing on different cancer grades. …”
Get full text

MicroRNA-877-5p Inhibits Cell Progression by Targeting FOXM1 in Lung Cancer by Zhiguang Liu, Xinlian Wang, Liqiang Cao, Xiaowei Yin, Qian Zhang, Lan Wang

“…Many researches revealed that microRNAs (miRNAs) function as potential oncogene or tumor suppressor gene. As an antioncogene, miR-877-5p was reduced in many tumors. …”
Get full text