Automatic MRI Lymph Node Annotation From CT Labels by Souraja Kundu, Yuji Iwahori, M. K. Bhuyan, Manish Bhatt, Boonserm Kijsirikul, Aili Wang, Akira Ouchi, Yasuhiro Shimizu

“…Moreover, existing cross-modal annotation methods primarily focus on large tumors and require large datasets, making them unsuitable for small lymph nodes with less training data. …”
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CircPRMT5, a Potential Salivary Biomarker, Facilitates the Progression of Head and Neck Squamous Cell Carcinoma via the IGF2BP3-SERPINE1 Pathway by Jiang S, Ou L, Wang Y, Su K, Chen Z, He L, Xu X, Cheng B, Xia J, Fan Z

“…Siqi Jiang,1,2 Linlin Ou,1,2 Yueqi Wang,1,2 Kai Su,1,2 Zhipei Chen,1,2 Lihong He,1,2 Xun Xu,1,2 Bin Cheng,1,2 Juan Xia,1,2 Zhaona Fan1,2 1Hospital of Stomatology, Sun Yat-sen University, Guangzhou, People’s Republic of China; 2Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, People’s Republic of ChinaCorrespondence: Zhaona Fan; Juan Xia, Hospital of Stomatology, Sun Yat-sen University, No. 56 Lingyuanxi Road, Guangzhou, Guangdong, 510055, People’s Republic of China, Tel +86 20 87394123 ; +86 20 83741891, Fax +86 20 83822807, Email fanzhn3@mail.sysu.edu.cn; xiajuan@mail.sysu.edu.cnPurpose: Circular RNAs (circRNAs) are associated with the progression of tumors and hold promise as potential biomarkers for liquid biopsy. …”
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Analyzing Serum Level Changes in Dehydroepiandrosterone Sulfate, Dihydrotestosterone, Progesterone, and Prolactin after Radioactive Iodine Treatment for Papillary Thyroid Carcinoma by Mehrosadat Alavi, Mohammad Atefi, Farzaneh Raeisi

“…Introduction: Effective treatment of papillary thyroid carcinoma (PTC) is total thyroidectomy which is followed by radioactive iodine therapy (RIT) to ablate pathologic thyroid remnants and treat metastatic tumors. However, there are concerns about possible side effects of RIT on different hormones that are important in different aspects including the immune defense system, cardiovascular system, pregnancy, and reproductive health. …”
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Oncolytic virus OH2 extends survival in patients with PD-1 pretreated melanoma: phase Ia/Ib trial results and biomarker insights by Juan Li, Xuan Wang, Li Zhou, Jun Guo, Lu Si, Bixia Tang, Chuanliang Cui, Xiaoting Wei, Xinan Sheng, Siming Li, Zhihong Chi, Lili Mao, Bin Lian, Xieqiao Yan, Yan Kong, Caili Li, Xiangyong Gu, Binlei Liu, Hui Tian, Han Hu

“…Antitumor efficacy was evaluated using the Response Evaluation Criteria in Solid Tumors and immune-RECIST guidelines. NCT04386967 is the clinical trial identifier.Results All 44 patients were enrolled. …”
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High Ki67 expression, HER2 overexpression, and low progesterone receptor levels in high-grade DCIS: significant associations with clinical practice implications by Hossein Schandiz, Hossein Schandiz, Lorant Farkas, Lorant Farkas, Daehoon Park, Yan Liu, Yan Liu, Solveig N. Andersen, Torill Sauer, Jürgen Geisler, Jürgen Geisler

“…This elucidation underscores the translational significance of Ki67 as a prognostic and predictive biomarker in DCIS, with implications for personalized treatment paradigms and patient outcomes.BackgroundThe Ki67 proliferation index is widely used in various tumors, including invasive breast carcinoma (IBC). …”
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Sex and outcomes of patients with microsatellite instability-high and BRAF V600E mutated metastatic colorectal cancer receiving immune checkpoint inhibitors by Michael Hoffmeister, Hermann Brenner, Chiara Cremolini, Sara Lonardi, Filippo Pietrantonio, Julien Taieb, David Tougeron, Robyn L Ward, Marco Vitellaro, Thierry André, Pierre Laurent-Puig, Jitendra Jonnagaddala, Francesca Bergamo, Raghav Sundar, Claire Gallois, Michael J Overman, Jakob Nikolas Kather, Lisa Salvatore, Romain Cohen, Rossana Intini, Priya Jayachandran, Miriam Koopman, Javier Ros, Marwan Fakih, Vincenzo Nasca, Giacomo Mazzoli, Jeanine M L Roodhart, Filippo Ghelardi, Elena Elez, Durgesh Wankhede, Marta Ligero, Joseph Zhao, Koen Zwart, Jeroen Derksen, Nicholas Hawkins, Javier Carmona

“…Exploratory transcriptomic analyses suggest that tumors of males with BRAF mutated MSI-H metastatic CRC are characterized by an enrichment of androgen receptor signature and an immune-depleted microenvironment, with a reduction in memory B cells, activated natural killer cells, and activated myeloid dendritic cells.Conclusions Overall, our findings suggest a complex interplay between sex and BRAF mutational status that may modulate the activity of ICIs in patients with MSI-H mCRC and pave the way to novel tailored strategies.…”
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Anesthesia for pregnant patients with symptomatic neurological disease: 13 years’ experience from a tertiary care center by Stefano Catarci, Bruno Antonio Zanfini, Marco Scorzoni, Salvatore De Martino, Pietro Paolo Giuri, Luciano Frassanito, Gian Luigi Gonnella, Emanuele Capone, Francesco Vitale Di Maio, Giovanni Maddaloni, Antonio Lanzone, Gaetano Draisci

“…The main neurological disorders that affected pregnant women included vascular abnormalities and intracranial bleeding (N = 42, 17.6%), central nervous system tumors (N = 35, 14.6%), epilepsy and episodic and paroxysmal disorders of the central nervous system (N = 34, 14.2%), diseases of the neuromuscular junction and muscles (N = 26, 10.9%), demyelinating central nervous system diseases (N = 24, 10%). …”
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The role of FTO in m6A RNA methylation and immune regulation in Staphylococcus aureus infection-related osteomyelitis by Sijing Liu, Sijing Liu, Sijing Liu, Kai Li, Changhai Long, Mingwu Lao, Biao Ma, Changquan Liu, Haoyuan He, Chunjiang Wang, Wangzhu Chen, Bin Yu

“…Enrichment analyses suggested that these genes were involved in pathways related to the proliferation and oxidation of various immune cells, cellular senescence, and various tumors and immune cells, as well as cell cycle-related functions. …”
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The impact of different gastrointestinal reconstruction techniques on gut microbiota after gastric cancer surgery by Yu Yang, Yu Yang, Hang-Yu Zhou, Guo-Min Zhou, Guo-Min Zhou, Jin Chen, Rui Ming, Dong Zhang, Huai-Wu Jiang, Huai-Wu Jiang

“…IntroductionGastric cancer is one of the common malignant tumors in the digestive tract, characterized by high incidence and mortality rates. …”
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The Benefits of Using a Small Caliber Ureteroscope in Evaluation and Management of Urethral Stricture by Walid Shahrour, Pankaj Joshi, Craig B. Hunter, Vikram S. Batra, Hazem Elmansy, Sandesh Surana, Sanjay Kulkarni

“…Stricture length, tissue quality, presence of other proximal strictures, false passages, and bladder tumors or stones would be assessed visually. If the penile stricture was near obliterative (smaller than 4.5 Fr caliber), a two-staged procedure is elected to be performed. …”
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Transurethral Water Vapor Ablation: Potential for a Novel Prostate Cancer Management Strategy by Warlick CA, Spilseth BD, Dixon CM

“…Warlick et al used this new technology to treat tumors that were visible under magnetic resonance imaging (MRI) and confirmed to be cancerous via biopsy. …”
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Higher levels of oxidative balance score linked to lower risk of gallstones: findings from the 2017–2020 National Health and Nutrition Examination Survey by Ting Xiong, Ting Xiong, Ting Xiong, Zhonghuo Chen, Zhonghuo Chen, Zhonghuo Chen, Jianwei Yi, Jianwei Yi, Jianwei Yi, Taozhi Yu, Taozhi Yu, Taozhi Yu, Kai Wang, Kai Wang, Kai Wang, Kai Wang

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Comprehensive analysis of endoscopic ultrasound (EUS) in mediastinal lesions: patient characteristics, diagnostic outcomes, safety, and efficacy: a multi-country study by Hussein Okasha, Eyad Gadour, Ghias Un Nabi Tayyab, Andrada Seicean, Elbacha Hicham, Emad Emad, Turki Alamri, Nadeem Tehami, Heero Ismael Faraj, Ahmed Alzamzamy, Hiwa Hussein, Mohammed Tag-Adeen, Mohamed Elbasiony, Abed Al-Lehibi, Shereen Saleh, Zaher Houmani, Mohamed Abdelghani, Khaled Ragab, Zahi Ismaili, Othmane Drir, Elsayed Ghoneem, Omar Abdallah, Souad Rebiai, Nonthalee Pausawasdi, Fedoua Rouibaa, Mohamed Borahma, Hassan Atalla, Mahmoud Farouk, Ahmed Altonbary

“…Abstract Background Mediastinal lesions are tumors that develop mainly from structures commonly located in the three compartments of the mediastinum and the paravertebral areas. …”
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