Risk Factors of Hemophagocytic Lymphohistiocytosis in Adults with Fever of Unknown Origin: A Retrospective Study by Tian F, Xie N, Sun W, Zhang W, Zhang W, Chen J, Ruan Q, Song J

“…The incidence of HLH in adults with FUO was 6.4%, with hematological tumors being the primary cause. Multivariate analysis indicated that skin rash and elevated alanine aminotransferase, total bilirubin, triglycerides, lactate dehydrogenase, and ferritin levels were independent risk factors for HLH in adults with FUO.Conclusion: This study revealed the incidence rate, etiology distribution, and risk factors for HLH in adults with FUO. …”
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Deferiprone ameliorates cisplatin induced peripheral neurotoxicity via ferritinophagy adjustment by Hanan Seddiek, Mira Hanna, Amany Elsayed Mohamed Hamoud, Marawan Abd Elbaset, Ahmed M. A. Akabawy, Mohamed Zakaria Kotb, Mohamed Mansour Khalifa

“…Abstract Cisplatin-induced neurotoxicity is one of the limiting factors to its use especially in tumors that demand high drug dosage. One of the Cisplatin pathways is ferritinophagy which may end up in ferroptosis. …”
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Examining the etiology and pregnancy outcomes of 152 critically ill pregnant patients in the Intensive Care Unit by Weiman Liu, Junyou Su, Sumei Wang

“…Results The results showed that the main obstetric factors leading to ICU admission were pregnancy-related hypertensive disease, postpartum hemorrhage, and acute fatty liver of pregnancy; the non-obstetric factors included either pregnancy complicated by heart disease, sepsis, or malignant tumors. The maternal mortality rate was higher in the non-obstetric direct factor group than in the obstetric direct factor group (22.12% vs. 6.25%, p = 0.016). …”
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The Development of Methods of BLOTCHIP^®-MS for Peptidome: Small Samples in Tuberous Sclerosis by Kunio Yui, George Imataka, Kotaro Yuge, Hitomi Sasaki, Tadashi Shiohama, Kyoichi Asada, Hidehisa Tachiki

“…Mutations in the TSC1 and TSC2 genes result in the constitutive hyperactivation of the mammalian target of the rapamycin (mTOR) pathway, contributing to the growth of benign tumors or hamartomas in various organs. TSC2 mutations were associated with a more severe phenotypic spectrum than TSC1 mutations because of the inhibition of the mTOR cascade. …”
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Compilación de un corpus para la enseñanza de la traducción médica by Elizabeth de la Teja Bosch, Ania Mercedes Carballosa González

“…<br /><strong>Resultados:</strong> concentración de encargos de traducción en los temas: tumores malignos, hipertensión, cardiopatías, diabetes mellitus y neumonías. …”
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Mediterranean diet improves liver health but does not protect against azoxymethane-induced colon tumorigenesis compared to Western diet in A/J mice by Weimin Guo, Nicholas Crossland, Jimmy W. Crott

“…Amongst male mice, those fed MED diet presented with significantly more colonic tumors than those on the WRN diet. Conclusion: In this study male mice displayed elevated sensitivity to AOM-induced hepatotoxicity and mortality than females. …”
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Activating CD137 Signaling Promotes Sprouting Angiogenesis via Increased VEGFA Secretion and the VEGFR2/Akt/eNOS Pathway by Bo Li, Yue Zhang, Runting Yin, Wei Zhong, Rui Chen, Jinchuan Yan

“…Combination of antiangiogenesis and immunotherapy may be an effective strategy for treatment of solid tumors. Our previous work reported that activation of CD137 signaling promotes intraplaque angiogenesis. …”
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Simulación de dosis absorbida en terapia molecular mediante método de Monte Carlo utilizando software libre GEANT4: GATE by Waldo José Echevarria Torres, Weiner Manso Nóbrega, Joaquín González González, José Alejandro Fragoso Negrín

“…<p><strong>Fundamento:</strong> aún no existe una forma óptima para determinar la dosis absorbida por los tumores; este desconocimiento es la causa de que la dosis final del tratamiento sea impredecible. …”
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The Identification and Validation of a Robust Immune-Associated Gene Signature in Cutaneous Melanoma by Le-Bin Song, Jiao-Chen Luan, Qi-Jie Zhang, Lin Chen, Hao-Yang Wang, Xue-Chen Cao, Ning-Hong Song, Yan Lu

“…Cutaneous melanoma is defined as one of the most aggressive skin tumors in the world. An increasing body of evidence suggested an indispensable association between immune-associated gene (IAG) signature and melanoma. …”
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Receipt of specialized palliative care and health care utilization at the end of life in hematological cancer patients – the Stockholm experience by Lena von Bahr, Peter Strang, Torbjörn Schultz, Per Fürst

“…Background: The treatments of hematological malignancies tend to be intense, and compared with solid tumors, less is known about the health care consumption during end of life (EOL). …”
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Diagnostic performance of artificial intelligence in detection of renal cell carcinoma: a systematic review and meta-analysis by Mahdi Gouravani, Mohammad Shahrabi Farahani, Mohammad Amin Salehi, Shayan Shojaei, Sina Mirakhori, Hamid Harandi, Soheil Mohammadi, Ramy R. Saleh

“…Abstract Objectives The detection of renal cell carcinoma (RCC) tumors in the earlier stages is of great importance for more effective treatment. …”
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Nomogram for prognosis prediction in metastatic pancreatic cancer patients undergoing intra-arterial infusion chemotherapy: incorporating immune-inflammation scores and coagulation... by Yifan Yang, Shaoqi Zong, Yongqiang Hua

“…Abstract Background Pancreatic cancer is one of the most malignant tumors with an inferior prognosis. This study aims to determine the prognostic significance of immune-inflammatory scores and coagulation indices in patients with metastatic pancreatic cancer(MPC) and develop a predictive nomogram. …”
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Direct-Acting Antivirals in Hepatitis C Treatment for Renal Impairment: Liver Safety Concerns and Effectiveness in Peritoneal Dialysis by Hsuan-Yu Hung, Wei-Liang Hung, Ye Gu, Chung-Yu Chen

“…A case–time–control analysis suggested liver instability despite treatment, with comorbid liver tumors (aOR 18.89; 95% CI 5.4–66.12) and hypertension (aOR 4.25; 95% CI 1.49–12.15) linked to higher DILI risk. …”
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Diagnóstico de las necesidades de aprendizaje en imagenología pediátrica del Médico General Integral Básico en Cienfuegos by Bárbara Aleida García Hernández, Bárbara Cabeza Poblet, Alejandro Díaz González

“…Se determinó el nivel de conocimientos sobre: interpretar y/o diagnosticar afecciones respiratorias, diagnóstico radiológico ante un cuadro doloroso abdominal agudo, ventajas diagnósticas del ultrasonido ante una masa tumoral intraabdominal, examen imagenológico a indicar para el diagnóstico de la causa más frecuente de sepsis urinaria, indicación e interpretación del ultrasonido diagnóstico de partes blandas. …”
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Distinct roles of Constitutive Photomorphogenesis Protein 1 homolog (COP1) in human hepatocyte models by Sébastien Soubeyrand, Paulina Lau, Ruth McPherson, Ruth McPherson

“…Prior work in hepatocyte-derived tumors categorized COP1 as an oncogene, but its role in untransformed hepatocytes remains largely unexplored. …”
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Automated skin melanoma diagnostics based on mathematical model of artificial convolutional neural network by D. A. Gavrilov, E. I. Zakirov, E. V. Gameeva, V. Yu. Semenov, O. Yu. Aleksandrova

“…In the proposed project, we will focusour a en on on the diagnosis of human skin diseases.At the moment, melanoma is one of the most dangerous types of malignant tumors of the skin with a lot of deaths due to rapid metastasis, which is difficult to treat. …”
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Coexistent Non–Small Cell Carcinoma and Small Cell Carcinoma in a Patient Presenting with Hyponatremia by Mitchell D. Ross, Sreeja Biswas Roy, Pradnya D. Patil, Jasmine L. Huang, Nitika Thawani, Ralph Drosten, Tanmay S. Panchabhai

“…In patients with multiple lung nodules, a diagnosis of synchronous multiple primary lung cancers (MPLCs) is crucial, as inadvertent upstaging of patients with MPLC (to T3 and/or T4 tumors) can lead to erroneous staging, inaccurate prognosis, and improper treatment. …”
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The utilization of the multimodal immunotherapy for the opsoclonus–myoclonus syndrome can reduce relapses and permanent neurological sequelae by Fang He, Miriam Kessi, Ciliu Zhang, Jing Peng, Fei Yin, Lifen Yang

“…Besides, surgical resections were done for the cases with tumors. The disease course was monophasic for five cases and five cases achieved remission. …”
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Lebanese Cannabis sativa L. extract protects from cisplatin-induced nephrotoxicity in mice by inhibiting podocytes apoptosis by Alia Khalil, Sahar Al Toufaily, Wassim Shebaby, Marissa El Hage, Dima Mroue, Wissam Faour, Mohamad Mroueh

“…Abstract Background Cisplatin is an anti-cancer drug used to treat a plethora of solid tumors. However, it is associated with dose dependent nephrotoxicity limiting its use as anticancer agent. …”
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Necesidades de aprendizaje del especialista en Medicina General Integral para el diagnóstico precoz del cáncer de mama by Lidia Torres Ajá, Miriam Iglesias León, Carlos Zerquera Álvarez

“…<strong>Fundamento: </strong>el cáncer mamario es la primera causa de muerte por tumores malignos en el sexo femenino. La evolución y sobrevida de estas pacientes depende, en gran medida, de la realización de un diagnóstico precoz, el cual está condicionado por los conocimientos que tengan los profesionales de la atención primaria acerca de esta enfermedad. …”
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