The Legionella pneumophila effector PieF modulates mRNA stability through association with eukaryotic CCR4−NOT by Harley O'Connor Mount, Malene L. Urbanus, Francesco Zangari, Anne-Claude Gingras, Alexander W. Ensminger

“…With a host range that spans billions of years of evolution (from protists to humans), the interaction between L. pneumophila and its hosts frequently involves conserved eukaryotic pathways (protein translation, ubiquitination, membrane trafficking, autophagy, and the cytoskeleton). …”
Get full text

Influence of spine biomechanics and sagittal balance on the outcome of lumbar discectomy by José Poblete Carrizo, José Poblete Carrizo, Jesús Martínez, Julio González, Alejandra Mosteiro, Ramon Torné, Ramon Torné, Alberto Di Somma, Alberto Di Somma, José Ríos, Joaquim Enseñat, Joaquim Enseñat, Salvador Fuster, Salvador Fuster

“…PurposeSpine biomechanics, particularly sagittal balance and spino-pelvic angulation are determinant factors in the understanding of lumbar degenerative disease. These concepts translated into objective measurements are progressively being integrated into clinical practice. …”
Get full text

Preventing epileptogenesis by interaction between inositol isomers and proteins by Lia Tsverava, Luka Kharkhelauri, Vincenzo Lagani, Giorgi Gamkrelidze, Veriko Bokuchava, Tamar Kiguradze, Merab Kokaia, Revaz Solomonia

“…Inositols can be successfully used in the future for translational research. Plain Language Summary Epilepsy is a common neurological disorder characterized by spontaneous recurrent seizures and a range of associated comorbidities. …”
Get full text

Intracalvariosseous injection: an approach for central nervous system drug delivery through skull bone marrow with a preclinical research in strokeResearch in context by Wenqian Liu, Mo Yang, Nanxing Wang, Xiangrong Liu, Chaoyu Wang, Kaibin Shi, Fu-Dong Shi, Yuesong Pan, Mingjun Zhang, Zhiwei Sun, Yongjun Wang, Yilong Wang

“…The findings provided a foundation for the clinical translation of ICO injection. Funding: This study was supported by The National Natural Science Foundation of China (No. 82425101); Beijing Municipal Science & Technology Commission (No. …”
Get full text

Acceptability and Implementation Challenges of Benzathine Penicillin G Secondary Prophylaxis for Rheumatic Heart Disease in Ethiopia: A Qualitative Study by Eshetie Melese Birru, Kevin T. Batty, Laurens Manning, Stephanie L. Enkel, Brioni R. Moore

“…The interviews were audio recorded, transcribed verbatim, and translated into English for analysis using framework method thematic analysis. …”
Get full text

O-GlcNAcylation attenuates ischemia-reperfusion-induced pulmonary epithelial cell ferroptosis via the Nrf2/G6PDH pathway by Liuqing Yang, Hexiao Tang, Jin Wang, Dawei Xu, Rui Xuan, Songping Xie, Pengfei Xu, Xinyi Li

“…Furthermore, both the chromatin immunoprecipitation (ChIP) assay and the dual-luciferase reporter assay indicated that Nrf2 could bind with translation start site (TSS) of glucose-6-phosphate dehydrogenase (G6PDH) and promote its transcriptional activity. …”
Get full text

Analysis of early effects of human APOE isoforms on Alzheimer’s disease and type III hyperlipoproteinemia pathways using knock-in rat models with humanized APP and APOE by Metin Yesiltepe, Tao Yin, Marc Tambini, Hanmei Bao, Meixia Pan, Cristina d’Abramo, Luca Giliberto, Xianlin Han, Luciano D’Adamio

“…We found that APOE2 hAβ rats had the highest levels of APOE in serum and brain, with no significant transcriptional differences among isoforms, suggesting variations in protein translation or stability. Aβ43 levels were significantly higher in male APOE4 hAβ rats compared to APOE2 hAβ rats. …”
Get full text

Integrating bulk and single-cell RNA sequencing data: unveiling RNA methylation and autophagy-related signatures in chronic obstructive pulmonary disease patients by Shi-Xia Liao, Lan-Ying Zhang, Ling-Mei Shi, Huai-Yu Hu, Yan-Hui Gu, Ting-Hua Wang, Yao Ouyang, Peng-Peng Sun

“…As revealed, we identified 13 RNA methylation-related genes enriched in translation and methylation processes. GSEA and GSVA revealed significant enrichment of these genes in immune and autophagy pathways. …”
Get full text

Use of supervised and unsupervised approaches to make zonal application maps for variable-rate application of crop growth regulators in commercial cotton fields by Maria C. da S. Andrea, Cristiano F. de Oliveira, Fabrícia C. M. Mota, Rafael C. dos Santos, Edilson F. Rodrigues Junior, Lucas M. Bianchi, Rodrigo S. de Oliveira, Caio M. de Gouveia, Victor G. S. Barbosa, Marco A. Bispo E Silva

“…Abstract Background Zonal application maps are designed to represent field variability using key variables that can be translated into tailored management practices. For cotton, zonal maps for crop growth regulator (CGR) applications under variable-rate (VR) strategies are commonly based exclusively on vegetation indices (VIs) variability. …”
Get full text

End-to-End Stroke Imaging Analysis Using Effective Connectivity and Interpretable Artificial Intelligence by Wojciech Ciezobka, Joan Falco-Roget, Cemal Koba, Alessandro Crimi

“…This transparent analytical framework not only enhances clinical interpretability but also instills confidence in decision-making processes, crucial for translating research findings into clinical practice. …”
Get full text

A novel approach to regulate glucose uptake in an anaplastic thyroid cancer cell line by Shabnam Heydarzadeh, Ali Asghar Moshtaghie, Maryam Daneshpour, Mehdi Hedayati

“…Altogether, these results suggest that the glucose pathway may be an essential target for therapeutic intervention to sensitize tumor cells to the cell death process by inhibition of glucose transporters. Statement of translational relevance: As described in our previously published article, ‘Regulators of glucose uptake in thyroid cancer cell lines’, non-oncogene addiction is one of the recent principles of cancer therapy. …”
Get full text

High-risk human papillomavirus: prevalence, association with clinical and morphological characteristics of invasive cervical cancer by L. S. Mkrtchian, V. I. Kiseleva, B. V. Boyko, L. I. Krikunova, V. A. Petrov, V. R. Gusarova, S. A. Ivanov, A. D. Kaprin, I. A. Zamulaeva

“…The search covered the period from 1990 to 2022 and utilized keywords in Russian and their English translations: cervical cancer, high oncogenic risk HPV, HPV status, HPV genotype, multiple infections, DNA integration, viral load. …”
Get full text

A KSHV RNA-binding protein promotes FOS to inhibit nuclease AEN and transactivate RGS2 for AKT phosphorylation by Vladimir Majerciak, Beatriz Alvarado-Hernandez, Yanping Ma, Shivalee Duduskar, Alexei Lobanov, Maggie Cam, Zhi-Ming Zheng

“…ORF57 protein does not regulate FOS translation but binds to the 13-nt RNA motif near the FOS RNA 5′ end and prolongs FOS mRNA half-life 7.7 times longer than it is in the absence of ORF57. …”
Get full text

The Platelet-Specific Gene Signature in the Immunoglobulin G4-Related Disease Transcriptome by Ali Kemal Oguz, Cagdas Sahap Oygur, Bala Gur Dedeoglu, Irem Dogan Turacli, Sibel Serin Kilicoglu, Ihsan Ergun

“…During the selection of differentially expressed genes (DEGs), the translationally active but significantly low amount of platelet mRNA was specifically considered. …”
Get full text

A User-Centered Design Approach for a Screening App for People With Cognitive Impairment (digiDEM-SCREEN): Development and Usability Study by Michael Zeiler, Nikolas Dietzel, Fabian Haug, Julian Haug, Klaus Kammerer, Rüdiger Pryss, Peter Heuschmann, Elmar Graessel, Peter L Kolominsky-Rabas, Hans-Ulrich Prokosch

“…The app’s usability was evaluated using the System Usability Scale (SUS), and verbal feedback by the end users was obtained using the think-aloud method. ResultsThe translation process during test development took linguistic and cultural aspects into account. …”
Get full text

Evaluation of Performance Metrics Required in Proper Selection of SDN Controller for Integrated Satellite-Terrestrial Networks by Oluwatobi A. Ayofe, Mu'azu J. Musa, Zanna M. Abdullahir, Abdoulie M.S. Tekanyi, Aliyu D. Usman, Ezekiel E. Agbon, Emmanuel A. Otsapa, Agburu O. Adikpe, Matthew Iyobhebhe, Paul Thomas Muge

“…Considering that there are different SDN controllers with their intrinsic characteristics, which translate to different performance characteristics, it is pertinent to determine the SDN controllers that will be most suitable for the specific application area. …”
Get full text

Harnessing Human-Centered Design for Evidence-Based Psychosocial Interventions and Implementation Strategies in Community Settings: Protocol for Redesign to Improve Usability, Enga... by Aaron R Lyon, Sean A Munson, Michael D Pullmann, Brittany Mosser, Tricia Aung, John Fortney, Alex Dopp, Katie P Osterhage, Helen G Haile, Kathryn E Bruzios, Brittany E Blanchard, Ryan Allred, Macey R Fuller, Patrick J Raue, Ian Bennett, Jill Locke, Karen Bearss, Denise Walker, Elizabeth Connors, Eric Bruns, Jenna Van Draanen, Doyanne Darnell, Patricia A Areán

“… BackgroundAlthough substantial progress has been made in establishing evidence-based psychosocial clinical interventions and implementation strategies for mental health, translating research into practice—particularly in more accessible, community settings—has been slow. …”
Get full text

Automated Recipe Generation AI Tool from Food Images using Machine Learning. Approach for Ingredient Extraction and Cooking Instructions by Lwamaza, Eddy, Nuwasiima, Happy

“…Additionally, this chapter discusses the design methodologies and tools utilized to translate conceptual requirements into tangible system specifications. …”
Get full text

Design and application of a multifunctional vented needle (一种多功能排气针的设计与应用) by WANG Li (王俐), LI Xinli (李昕砾), TAN Xiangyan (谭香燕)

Get full text

Effect of wet dressing of Chinese herbs on subcutaneous induration caused by subcutaneous injection of Azacitidine (中药湿敷改善阿扎胞苷皮下注射所致皮下硬结的效果观察)... by ZHAO Jialu (赵佳璐), WANG Huaxin (王华新), LI Ye (李野)

Get full text