Examining factorial validity and internal consistency of Professional Quality of Life (ProQoL-9) among care aides working in Long-term Care (LTC) by Seyedehtanaz Saeidzadeh, Anni Wang, Yinfei Duan, Isaiah Hipel, Peter G. Norton, Carole A. Estabrooks

“…Methods We used surveys collected by the Translating Research in Elder Care (TREC), a pan-Canadian program that collects longitudinal surveys from the healthcare workforce in the LTC. …”
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Predicting the Most Deleterious Missense Nonsynonymous Single-Nucleotide Polymorphisms of Hennekam Syndrome-Causing CCBE1 Gene, In Silico Analysis by Khyber Shinwari, Liu Guojun, Svetlana S. Deryabina, Mikhail A. Bolkov, Irina A. Tuzankina, Valery A. Chereshnev

“…The importance of rs374941368 and rs200149541 in the prediction of post-translation changes was highlighted because it impacts a possible phosphorylation site. …”
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FAecal micRobiota transplantation in primary sclerosinG chOlangitis (FARGO): study protocol for a randomised, multicentre, phase IIa, placebo-controlled trial by Laith Alrubaiy, Rachel Cooney, Tariq Iqbal, Mohammed Nabil Quraishi, Susan Manzoor, Christopher Quince, Palak J Trivedi, Andrew D Beggs, Alexandra Vince, Chris Weston, Benjamin Mullish, Sahida Shabir, Nicola Jackson, Anna Rowe, Victoria Homer, Willem van Schaik, Peter Rimmer, Sarah Al-Shakhshir, Arzoo Patel, Derick Gyimah, Miriam Hares, Elena Efstathiou

“…Key secondary outcomes will be to evaluate the impact of FMT on other liver biochemical parameters, PSC risk scores, circulating and imaging markers of liver fibrosis, health-related quality of life measures, IBD activity and the incidence of PSC-related clinical events. Key translational objectives will be to identify mucosal metagenomic, metatranscriptomic, metabolomic and immunological pathways associated with the administration of FMT.Ethics and dissemination The protocol was approved by the South Central—Hampshire B Research Ethics Committee (REC 23/SC/0147). …”
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High Ki67 expression, HER2 overexpression, and low progesterone receptor levels in high-grade DCIS: significant associations with clinical practice implications by Hossein Schandiz, Hossein Schandiz, Lorant Farkas, Lorant Farkas, Daehoon Park, Yan Liu, Yan Liu, Solveig N. Andersen, Torill Sauer, Jürgen Geisler, Jürgen Geisler

“…This elucidation underscores the translational significance of Ki67 as a prognostic and predictive biomarker in DCIS, with implications for personalized treatment paradigms and patient outcomes.BackgroundThe Ki67 proliferation index is widely used in various tumors, including invasive breast carcinoma (IBC). …”
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Representativeness of the dabigatran, apixaban and rivaroxaban clinical trial populations to real-world atrial fibrillation patients in the United Kingdom: a cross-sectional analys... by Gregory Y H Lip, Sally Lee, Brigitta U Monz, Andreas Clemens, Martina Brueckmann

“…However, assessing representativeness is not a substitute for assessing generalisibility, that is, how well clinical trial results would translate into effectiveness and safety in everyday routine care.…”
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Descemet Endothelial Thickness Comparison Trial 1 (DETECT 1): outcome masked, placebo-controlled trial comparing two types of corneal transplant surgeries and effect of rho kinase... by Thomas M Lietman, Jennifer Rose-Nussbaumer, Bennie H Jeng, Benjamin F Arnold, Winston Chamberlain, Charles C Lin, Jennifer Y Li, William Gensheimer, Jameson Clover, Nicole Varnado, Sarah Abdelrahman

“…Dissemination of findings through peer-reviewed publications and national/international meetings will facilitate knowledge translation and guide clinical practice in the field of corneal transplantation.Ethics and dissemination A data and safety monitoring committee (DSMC) has been empaneled by the NEI.All study protocols will be subject to review and approval by WCG IRB as the single IRB of record.This study will comply with the National Institute of Health (NIH) Data Sharing Policy and Policy on the Dissemination of NIH-Funded Clinical Trial Information and the Clinical Trials Registration and Results Information Submission rule. …”
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After neonatal care, what next? A qualitative study of mothers’ post-discharge experiences after premature birth in Kenya by Justinah Maluni, Dorothy Oluoch, Sassy Molyneux, Mwanamvua Boga, Caroline Jones, Florence Murila, Mike English, Sue Ziebland, Lisa Hinton

“…After transcription, the interviews were translated, where applicable, and thematic analysis was undertaken. …”
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Sex and outcomes of patients with microsatellite instability-high and BRAF V600E mutated metastatic colorectal cancer receiving immune checkpoint inhibitors by Michael Hoffmeister, Hermann Brenner, Chiara Cremolini, Sara Lonardi, Filippo Pietrantonio, Julien Taieb, David Tougeron, Robyn L Ward, Marco Vitellaro, Thierry André, Pierre Laurent-Puig, Jitendra Jonnagaddala, Francesca Bergamo, Raghav Sundar, Claire Gallois, Michael J Overman, Jakob Nikolas Kather, Lisa Salvatore, Romain Cohen, Rossana Intini, Priya Jayachandran, Miriam Koopman, Javier Ros, Marwan Fakih, Vincenzo Nasca, Giacomo Mazzoli, Jeanine M L Roodhart, Filippo Ghelardi, Elena Elez, Durgesh Wankhede, Marta Ligero, Joseph Zhao, Koen Zwart, Jeroen Derksen, Nicholas Hawkins, Javier Carmona

“…Finally, we explored two public microarray and RNA-seq datasets from patients with non-metastatic or metastatic MSI-H CRC to gain translational insights on the association between sex, BRAF status and immune contextures/ICI efficacy.Results Although no differences were observed between females and males either overall or in the BRAF wild-type cohort, male sex was associated with inferior progression-free survival (PFS) and overall survival (OS) in the BRAF mutated cohort (in multivariable models, HR for PFS: 1.79, 95% CI: 1.13 to 2.83, p=0.014, and for OS: 2.33, 95% CI: 1.36 to 3.98, p=0.002). …”
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Reinforcing cancer immunotherapy with engineered porous hollow mycobacterium tuberculosis loaded with tumor neoantigens by Jie Jiang, Feng-Ying Huang, Shu-Zhen Dai, Guang-Hong Tan, Ming-Hui Chen, Hengyu Chen, Wu-Ping Zheng, Ri-Hong Wu, Weijing Xie

“…Concurrent administration of the PD-1 antibody with the phMTb-formulated neoantigen vaccine exhibited significant synergistic therapeutic effects.Conclusions The results of our study highlight the potential clinical translation of personalized tumor neoantigen vaccines using the phMTb carrier.…”
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Subcytotoxic transepidermal delivery using low intensity cold atmospheric plasma by Ga Ram Ahn, Hyung-Joon Park, Yu Jin Kim, Min Gyo Song, Hye Sung Han, Woo Geon Lee, Hyuck Ki Hong, Kwang Ho Yoo, Joon Seok, Kyu Back Lee, Beom Joon Kim

“…Under our study conditions, LICAP treatment seems to be a novel approach to facilitate TED with low safety concerns in vitro. Further translational studies are needed for clinical evaluation.…”
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An in-vitro biomechanical comparison of annular ligament repair and reconstructions to restore radial head stability in anterior Monteggia fractures by Kirk Vannitamby, MD, Cole T. Fleet, MESc, Carlos Prada, MD, MSc, FEBHS, James A. Johnson, PhD, Graham J.W. King, MD, MSc, FRCSC

“…For all test states, the anterior translation of the RH relative to the capitellum was quantified as a measure of subluxation. …”
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The impact of architectural modifications on relative resistance to fluid flow in ventricular catheters by Rajesh Kumar Madhavan, Ahmad Faryami, Nathan Tappen, Pranav Gopalakrishnan, Shaheer H. Ajaz, Carolyn A. Harris

“…Relative resistance impacts fluid outflow efficiency, which may translate to clinical outcomes for hydrocephalus patients. …”
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A Single-Mode 852-nm Faraday Laser by Zhiyang Wang, Zijie Liu, Jianxiang Miao, Hangbo Shi, Xiaomin Qin, Xiaolei Guan, Jia Zhang, Pengyuan Chang, Tiantian Shi, Jingbiao Chen

“…Realizing always atomic translation frequency output, single-mode, high frequency stability, narrow linewidth semiconductor lasers, is one of the ultimate visions of areas related to quantums, such as quantum precision measurement and atomic physics. …”
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5-year migration and inducible displacement of the uncemented LCS and ATTUNE rotating platform knee systems: a secondary report of a randomized controlled RSA trial by Raymond Puijk, Lennard A Koster, Bart G C W Pijls, Jiwanjot Singh, Marjolein Schager, Bart L Kaptein, Peter A Nolte

“…Migration was analyzed using maximum total point motion (MTPM), translations, and rotations, focusing on 5-year migration, continuous migration (> 0.10 mm/year), and inducible displacement. …”
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Is There a Noninvasive Source of MSCs Isolated with GMP Methods with Better Osteogenic Potential? by Carla C. G. Pinheiro, Alessander Leyendecker Junior, Daniela Y. S. Tanikawa, José Ricardo Muniz Ferreira, Reza Jarrahy, Daniela F. Bueno

“…Based on these observations, and the distinct translational advantage of incorporating stem cells from noninvasive tissue sources into tissue engineering protocols, greater study of these specific cell lines in the setting of alveolar cleft repair is indicated.…”
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Assessment of the validity and reliability of the nurses’ professional values scale—revised in Persian version among nursing students by Fahimeh Alsadat Hosseini, Ladan Zarshenas, Kobra Parvan, Maryam Shaygan, Banafsheh Tehranineshat, Brian Thomson

“…Methods This methodological and cross-sectional study aimed to evaluate the validity and reliability of the Persian version of the NPVS-R among nursing students. Following a back-translation process, the Persian version was subjected to face, content, and construct validity assessments. …”
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Identification and validation of glucose metabolism-related gene signature in endometrial cancer by Juan Jiang, Nan Xia, Mei Yang, Ping Qiu, Wei Zhu, Jing Chen, Jiamei Zhu

“…The expression levels of these prognostic genes were quantified at both transcriptional and translational stages using reverse transcription quantitative PCR (RT-qPCR) and immunohistochemistry (IHC) in clinical samples. …”
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“I believe it when there is an expert next to me:” a qualitative analysis on the perceptions and experiences of pregnant women to self-monitor blood pressure in Lombok, Indonesia... by Tigest Tamrat, Yuni Dwi Setiyawati, Maria Barreix, Nya’Jeumpa Madani, Antoine Geissbühler, Anuraj H. Shankar, Ozge Tuncalp

“…Interviews were double transcribed in Bahasa Indonesia and translated to English for thematic analysis using inductive and deductive approaches. …”
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Prevalence of tooth decay in deciduous and permanent teeth in a schoolchildren population: an epidemiological investigation by Silvia Fanelli, Letizia Lugli, Francesca Chiara De Razza, Francesca Gazzani, Saveria Loberto, Elisabetta Cretella Lombardo, Francesco Fabi, Arianna Malara

“…A proper oral hygiene, especially if established at an early age, can translate into benefits in the permanent teeth that can last a lifetime if cared for properly. …”
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A fast monocular 6D pose estimation method for textureless objects based on perceptual hashing and template matching by Jose Moises Araya-Martinez, Jose Moises Araya-Martinez, Vinicius Soares Matthiesen, Vinicius Soares Matthiesen, Simon Bøgh, Jens Lambrecht, Rui Pimentel de Figueiredo

“…For instance, with a rotation step of 10° in the template database, we achieve an average rotation error of 10°, matching the template quantization level, and an average translation error of 14% of the object’s size, with an average processing time of 0.3s per image on a small form-factor NVIDIA AGX Orin device. …”
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