Leupaxin promotes hepatic gluconeogenesis and glucose metabolism by coactivation with hepatic nuclear factor 4α by Xiaomin Luo, Fang Liu, Lijun Zhu, Caizhi Liu, Ruhui Shen, Xiaoyin Ding, Yufan Wang, Xiaofang Tang, Yongde Peng, Zhijian Zhang

“…Additionally, we assessed the translational relevance of our findings using human liver tissues from both healthy donors and patients with obesity/type 2 diabetes. …”
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University Interaction with Regional Subjects in the Assessments of the Faculty by M. V. Boguslavsky, N. V. Ladyzhets, O. V. Sannikova, E. V. Neborsky

“…In other words, they do not translate preparedness into action, awaiting action on the part of management.…”
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Adaptation of the disease‐related apathy scale in adults with epilepsy into Turkish: A methodological study by Gülcan Bahcecioglu Turan, Zülfünaz Özer, Seda Başak

“…Methods A total of 172 epilepsy patients receiving care at the Neurology clinic and outpatient clinic of Fırat University Hospital from February to July 2023 were included in this methodological investigation. The E‐RAS was translated into Turkish, and its content and construct validity were thoroughly examined. …”
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A bibliometric analysis of publications in 3D printing in surgery from the web of science database by Bitesh Kumar, Anjan Kumar Dhua, Mohit Garg, Vishesh Jain, Devendra Kumar Yadav, Prabudh Goel, Sachit Anand, Divya Jain

“…Leading countries and institutions are crucial in driving scientific discoveries and translating research into clinical practice.…”
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Trojan-horse silk fibroin nanocarriers loaded with a re-call antigen to redirect immunity against cancer by Luca Mastracci, Patrizio Castagnola, Elia Bari, Francesca Ferrera, Tiziana Altosole, Sara Perteghella, Pierluigi Mauri, Rossana Rossi, Giulia Passignani, Martina Galati, Giuseppina Iliana Astone, Maddalena Mastrogiacomo, Daniela Fenoglio, Dario Di Silvestre, Maria Luisa Torre, Gilberto Filaci

“…This approach could be universally applied for solid cancer treatments if translated into the clinic using re-call antigens of childhood vaccination.…”
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Activating CD137 Signaling Promotes Sprouting Angiogenesis via Increased VEGFA Secretion and the VEGFR2/Akt/eNOS Pathway by Bo Li, Yue Zhang, Runting Yin, Wei Zhong, Rui Chen, Jinchuan Yan

“…We found activation of CD137 signaling for increased VEGFR2 transcription and translation steadily. Moreover, CD137 signaling activated phosphorylated VEGFR2 (Tyr1175) and the downstream Akt/eNOS pathway, whereas neutralizing CD137 signaling weakened the activation of VEGFR2 and the downstream Akt/eNOS pathway. …”
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Modelling the epidemiological and economic impact of digital adherence technologies with differentiated care for tuberculosis treatment in Ethiopia by Richard White, Katherine L Fielding, Salome Charalambous, Nicola Foster, Degu Jerene, Andrew Mganga, Taye Letta, Job van Rest, Amare Worku Tadesse, Rein MGJ Houben, Ahmed Bedru, Kristian van Kalmthout, Christopher Finn McQuaid, Lara Goscé, Jense van der Wal, Martin J Harker, Norma Madden, Tofik Abdurhman, Demekech Gadissa, Tanyaradzwa N Dube, Jason Alacapa, Natasha Deyanova

“…However, our analysis also found large total provider and patient cost savings (US$163 (95% UI US$118; US$211) and US$3 (95%UI: US$1; US$5), respectively, over 2023–2035), translating to a 50.2% (95% UI 35.9%; 65.2%) reduction in total cost of treatment. …”
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Reproductive health literacy scale: a tool to measure the effectiveness of health literacy training by Maha Rauf, Zahra Goliaei, Lana Machta, Jenny Chang, Heike Thiel de Bocanegra

“…After content validity and face validity of the adapted scale, it was translated into Dari, Arabic, and Pashto and was administered to participants of RH literacy training sessions. …”
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Validation of a data-driven motion-compensated PET brain image reconstruction algorithm in clinical patients using four radiotracers by Ole L. Munk, Anders B. Rodell, Patricia B. Danielsen, Josefine R. Madsen, Mie T. Sørensen, Niels Okkels, Jacob Horsager, Katrine B. Andersen, Per Borghammer, Joel Aanerud, Judson Jones, Inki Hong, Sven Zuehlsdorff

“…Results The Hoffman brain phantom study demonstrated the algorithm’s capability to detect and correct for even minimal movements, 1-mm translations and 1⁰ rotations, applied to the phantom. …”
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Frameshift variation in the HMG-CoA reductase gene and unresponsiveness to cholesterol-lowering drugs in type 2 diabetes mellitus patients by Esmat Khaleqsefat, Khder Hussein Rasul, Ramiar Kamal Kheder, Sonia Baban, Jamil Baban

“…This mutation altered the amino acid sequence in the flap domain, replacing isoleucine with a stop codon. As a result, translation was prematurely terminated, leading to the production of truncated proteins.…”
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Standardization and Quality Control of the Herbal Medicine Mist Nibima, Employed to Treat Malaria and COVID-19, Using Physicochemical and Organoleptic Parameters and Quantification... by Emmanuel Kofi Kumatia, Francis Ofosu-Koranteng, Alfred Ampomah Appiah, Kofi Bobi Barimah

“…Administration of a single oral therapeutic dose (30 mL) of Mist Nibima corresponds to ingestion of 559.2 ± 7.662, 505.5 ± 6.930, 312.6 ± 4.285, 76.8 ± 1.028, and 51.0 ± 0.699 µg of methyl cryptolepinoate, cryptolepine, quindoline, 11-isopropylcryptolepine, and hydroxycryptolepine, respectively. This translates into a corresponding daily dose of 1677.6 ± 22.986, 1516.5 ± 20.790, 937.8 ± 12.855, 230.4 ± 3.084, and 153.0 ± 2.097 µg of methyl cryptolepinoate, cryptolepine, quindoline, 11-isopropylcryptolepine, and hydroxycryptolepine. …”
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Willingness to donate eyes and associated factors among adults in Addis Ababa City, Ethiopia: a mixed-methods approach by Ejigu Gebeye Zeleke, Merkineh Markos Lorato, Wubalem Addis Tefera, Hirut Gebremeskel Mengistu

“…Qualitative data were analysed through thematic content analysis using code software, which included transcription, translation, coding and thematisation, ultimately enriching the quantitative findings.Results and conclusion The study found that 47.2% (95% CI 44.7, 50.0) participants were willing to donate their eyes. …”
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Purification of mesenchymal stromal cell‐derived small extracellular vesicles using ultrafiltration by Rui Lei, Shuai Ren, Hua Ye, Zhanfeng Cui

“…Abstract Mesenchymal stromal cell‐derived small extracellular vesicles (MSC‐sEVs) are pivotal for the curative effects of mesenchymal stromal cells, but their translation into clinical products is hindered by the technical challenges of scaled production and purification. …”
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Comparative assessment of difficulty scales for removal of the third molar of the lower jaw depending on its position by O.O. Gudarian, Zh.M. Nekhanevуch, T.O. Kycherenko, A.V. Shepelya

“…Each of the difficulty scales was presented and translated into Ukrainian for convenient use in the practice of a dental surgeon. …”
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Genotyped cluster investigations versus standard contact tracing: comparative impact on latent tuberculosis infection cascade of care in a low-incidence region by Michael Asare-Baah, Marie Nancy Séraphin, LaTweika A.T. Salmon-Trejo, Lori Johnston, Lina Dominique, David Ashkin, Krishna Vaddiparti, Awewura Kwara, Anthony T. Maurelli, Michael Lauzardo

“…Although genotyped cluster investigations may be superior to contact investigations in generating additional epidemiological links, this may not necessarily translate into reducing infections. Here, we investigated the impact of genotyped cluster investigations compared to standard contact investigations on the LTBI care cascade in a low incidence setting. …”
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Emergency volunteering willingness and participation: a cross-sectional survey of residents in northern China by Hong Sun, Chaojie Liu, Wei Xu, Ye Li, Qunhong Wu, Lijun Gao, Zheng Kang, Yanhua Hao, Ning Ning, Mingli Jiao, Libo Liang, Yu Cui, Mengli Shi, Chao Liang, Xiaowen Zhao, Jie Fei, Qiuyu Wei, Ming Yi

“…Efforts should be made to translate willingness into effective contributions to the emergency response system. …”
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Automatic image generation and stage prediction of breast cancer immunobiological through a proposed IHC-GAN model by Afaf Saad, Noha Ghatwary, Safa M. Gasser, Mohamed S. ElMahallawy

“…Our findings demonstrate promising results in translating H&E images to IHC-equivalent representations, offering a potential solution to reduce the costs associated with traditional HER2 assessment methods. …”
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Assessment of ChatGPT-generated medical Arabic responses for patients with metabolic dysfunction-associated steatotic liver disease. by Saleh A Alqahtani, Reem S AlAhmed, Waleed S AlOmaim, Saad Alghamdi, Waleed Al-Hamoudi, Khalid Ibrahim Bzeizi, Ali Albenmousa, Alessio Aghemo, Nicola Pugliese, Cesare Hassan, Faisal A Abaalkhail

“…<h4>Methods</h4>An English patient questionnaire on MASLD was translated to Arabic. The Arabic questions were then entered into ChatGPT 3.5 on November 12, 2023. …”
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Understanding ICU Nursing Knowledge, Perceived Barriers, and Facilitators of Sepsis Recognition and Management: A Cross-Sectional Study by Katherine A. Kissel, MN, RN, Karla D. Krewulak, PhD, Thérèse G. Poulin, BSc, Ken Kuljit S. Parhar, MD, MSc, Daniel J. Niven, MD, PhD, Vanessa M. Doiron, MScHQ, RN, Kirsten M. Fiest, PhD

“…Nursing workforce changes, knowledge translation gaps, and environmental/organizational barriers may impact sepsis recognition and management within the ICU. …”
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Generation and miRNA Characterization of Equine Induced Pluripotent Stem Cells Derived from Fetal and Adult Multipotent Tissues by Laís Vicari de Figueiredo Pessôa, Pedro Ratto Lisboa Pires, Maite del Collado, Naira Caroline Godoy Pieri, Kaiana Recchia, Aline Fernanda Souza, Felipe Perecin, Juliano Coelho da Silveira, André Furugen Cesar de Andrade, Carlos Eduardo Ambrosio, Fabiana Fernandes Bressan, Flavio Vieira Meirelles

“…We hypothesize that different cell types respond differently to the reprogramming process; thus, the goals of this study were to isolate and characterize equine adult and fetal cells and induce these cells to pluripotency for future regenerative and translational purposes. Methods. Adult equine fibroblasts (eFibros) and mesenchymal cells derived from the bone marrow (eBMmsc), adipose tissue (eADmsc), and umbilical cord tissue (eUCmsc) were isolated, their multipotency was characterized, and the cells were induced in vitro into pluripotency (eiPSCs). eiPSCs were generated through a lentiviral system using the factors OCT4, SOX2, c-MYC, and KLF4. …”
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