Human induced pluripotent stem cell–derived therapies for regeneration after central nervous system injury by Stephen Vidman, Yee Hang Ethan Ma, Nolan Fullenkamp, Giles W. Plant

“…Lastly, host immune responses to allogeneic grafts must be thoroughly characterized and further developed to reduce the need for immunosuppression. Translation to a clinical setting will involve careful consideration when assessing both physiologic and functional outcomes. …”
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Investigating assumptions in motivational interviewing among general practitioners: a qualitative study by Paul Aujoulat, Amélie Manac’h, Catherine Le Reste, Delphine Le Goff, Jean Yves Le Reste, Marie Barais

“…Focused efforts are needed to translate MI’s potential into routine clinical use.…”
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Formaldehyde and propionic acid do not reduce starch gelatinization within a laboratory setting and may not contribute to reduced pellet quality by K.M. Bowen, L.E. Knarr, E.B. Estanich, S.R. Estep, J.S. Moritz

“…The increase in starch gelatinization with increased heating time may translate to increasing pellet quality.…”
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Bacterial nanocellulose and its oxidized form as functional carriers for pomegranate peel extract: A sustainable approach to bioactive delivery by Vuk Filipovic, Jasmina Nikodinovic-Runic, Katarina Savikin, Jelena Zivkovic, Jelena Mudric, Nemanja Krgovic, Marijana Ponjavic

“…Compared to unmodified BNC, a wider range of bioactive compounds was incorporated on o-BNC due to enhanced binding capacity and porosity, which translated into material stronger antioxidant activity, attributed to presence of additional phenolics like gallic acid and ellagitannins. …”
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A reproducible representation of healthy tibiofemoral kinematics during stair descent using REFRAME – part I: REFRAME foundations and validation by Ariana Ortigas-Vásquez, William R. Taylor, Barbara Postolka, Pascal Schütz, Allan Maas, Matthias Woiczinski, Thomas M. Grupp, Adrian Sauer

“…Here, building on previous work that introduced a frame orientation optimisation method and demonstrated its potential to induce convergence towards a consistent kinematic signal, we present the REference FRame Alignment MEthod (REFRAME) that addresses both rotational and translational kinematics, is validated here for a healthy tibiofemoral joint, and allows flexible selection of optimisation criteria to fittingly address specific research questions. …”
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Information modelling of dynamic impacts on a unique building of a multifunctional complex of parametric architecture by E. K. Agahanov, M. K. Agahanov, E. V. Trufanova

“…The change in design solutions allowed to make the first and second forms of oscillations translational, the third — torsional. The obtained nature of the dynamic response shows the efficiency of the adopted design solutions of the unique building frame. …”
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Genome-wide quantification of polycistronic transcription in Leishmania major by Janne Grünebast, Stephan Lorenzen, Joachim Clos

“…Regulation of gene expression in Leishmania but also in the related Trypanosoma is radically different from all eukaryotic model organisms, dispensing with regulated, gene-specific transcription, and relying instead on highly regulated translation. Our work sheds light on the initiation, elongation, and termination of transcription, maps unidirectional, polycistronic transcription units, provides evidence for transcriptional pausing at or near starting points of RNA synthesis, and quantifies the varying transcription rates of the polycistronic transcription units. …”
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Impact of English proficiency on use of Glasgow Coma Scale in geriatric patients with traumatic brain injury by Veronica Layrisse-Landaeta, Gabriela R Dincheva, Shahenda Khedr, Andrew Geng, Michele Schombs, Kazi Maisha, Steven Y Chao, Chun-Cheng Chen

“…Moreover, GCS remained effective for predicting ICH in LEP individuals, highlighting its value with suitable translation resources.Level of evidence This is a Level III evidence restrospective comparative study.…”
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Neuron-Specific Glycine Metabolism Links Transfer RNA Epitranscriptomic Regulation to Complex Behaviors by Jennifer Blaze, Viviana Dolores Evans, Jessica Abigail Feria Pliego, Petr Unichenko, Behnam Javidfar, Soeren Heissel, Hanan Alwaseem, Zachary Pennington, Denise Cai, Henrik Molina, Christian Henneberger, Schahram Akbarian

“…Methods: To link specific molecular alterations resulting from neuronal Nsun2 ablation to neuropsychiatric phenotypes, we used drug-induced phosphoactivation of stress response translation initiation factors together with disruption of NSUN2-regulated glycine tRNAs and cell type–specific ablation of the glycine cleavage system modeling the excessive upregulation of this amino acid in the Nsun2-deficient brain. …”
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Piloting an external quality assurance program (QAP) for COVID-19 antigen rapid diagnostic tests (Ag-RDTs): findings and lessons learned from Cambodia by Vonthanak Saphonn, John Kaldor, Deborah Williamson, Sothavireak Bory, Philip Cunningham, Jessica Markby, Kennarey Seang, Jacqueline Prestedge, Chan Leakhena Phoeung, Marilyn Ninan, Kanika Heng, Andrew Valley

“…The preimplementation training including the Khmer-translated documentation was conducted virtually for Tier 1 laboratories and in-person for Tier 2 laboratories. …”
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Tools to improve discharge equity: Protocol for the pilot TIDE trial by Kirsten Austad, Cecilia Thai, Alegna Zavatti, Nhi Nguyen, Diana Bautista-Hurtado, Patrick Kenney, Noelia Lugo, Joo H. Lee, Howard Lanney, Ziming Xuan, Erika G. Cordova-Ramos, Mari-Lynn Drainoni, Brian Jack

“…The TIDE intervention includes a translated medication calendar, pictographs, and an audio recording of the discharge instructions in the patient's preferred language. …”
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Temperature- and ontogeny-dependent metabolism in invasive early juvenile round goby (Neogobius melanostomus) by Hunter A. Herron, Sina Zarini, William Andrew Thompson, Andy J. Turko, Sigal Balshine

“…We also found that the bioenergetics models previously developed for adults do not effectively translate to juveniles; the current models underestimated observed RMR values by ~20–60% depending on temperature. …”
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A Hybrid Contextual Embedding and Hierarchical Attention for Improving the Performance of Word Sense Disambiguation by Robbel Habtamu Yigzaw, Beakal Gizachew Assefa, Elefelious Getachew Belay

“…It plays a crucial role in natural language applications such as machine translation, question-answering, chatbots, information retrieval, sentiment analysis, and overall language comprehension. …”
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Integrated Business and Engineering Educational Experience for Medical Students in the Development of Pediatric Medical Devices by Jennifer J. Li, Jonathan Lee, Mayilone Sathialingam, Nhi Ha, Tamara Galoyan, Ethan Faye, Michael Kim, Tara Shelby, Rishabh Shah, Yelim Lee, Melissa Bent, Juan C. Espinoza

“…METHODS An internship program was developed by the Keck Translational Biotechnology Association and the West Coast Consortium for Technology & Innovation in Pediatrics (CTIP), a Food and Drug Administration-funded pediatric medical device accelerator. …”
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Dutch Validation of the Self-Evaluation of Negative Symptoms Scale (SNS) by Tim van Brouwershaven, Anika Poppe, Gerdina Hendrika Maria Pijnenborg, André Aleman, Nynke Boonstra, Shiral Gangadin, Sonia Dollfus, Wim Veling, Stynke Castelein, Jan Alexander de Vos, Edith Liemburg, PHAMOUS-researchers, Lisette van der Meer

“…Here, we aim to evaluate the psychometric properties of the Dutch translation of the SNS and the relationship between the SNS and functional outcomes. …”
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Implementing Machine Learning for Supply-Demand Shifts and Price Impacts in Farmer Market for Tool and Equipment Sharing by Manik Rakhra, Amitabh Bhargava, Deepshikha Bhargava, Ramandeep Singh, Astha Bhanot, Abdul Wahab Rahmani

“…The third category is particularly prevalent in underdeveloped nations such as India, owing to a lack of competence, a lack of effective translation, and most crucially, a lack of financial resources. …”
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Preclinical optimization of a GPC2-targeting CAR T-cell therapy for neuroblastoma by Nan Li, Haiying Qin, Rosa Nguyen, Mitchell Ho, Ming Sun, Eytan Ruppin, Michael C Kelly, Yingying Cao, Reona Okada, Jeyshka M Reyes-González, Hannah G Stack, Charlie Seibert, Carol J Thiele

“…We developed a new chimeric antigen receptor (CAR) targeting glypican-2 (GPC2) and conducted iterative preclinical engineering of the CAR structure to maximize its anti-tumor efficacy before clinical translation.Methods We evaluated different GPC2-CAR constructs by measuring the CAR activity in vitro. …”
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Policy analysis of the Global Financing Facility in Uganda by Phillip Wanduru, Doris Kwesiga, Mary Kinney, Asha George, Peter Waiswa

“…Conclusion The learnings from this study provide insights into the translation of globally conceived health initiatives at country level, highlighting enablers and challenges. …”
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An Open‐Label Phase II Trial of Pembrolizumab, an Immune Checkpoint Inhibitor Alone or in Combination With Oral Azacitidine as Second‐Line Therapy for Advanced Head and Neck Squamo... by Vinod K. Ramani, Srimonta Gayen, Radheshyam Naik

“…Conclusion The findings of this trial will have translational implications, in terms of immune reprogramming induced by epigenetic therapy among a subset of advanced H & N cancer patients in a clinical setting.…”
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Semantic and Syntactic Dimensional Analysis of Rural Wooden Mosque Architecture in Borçka by Birgül Çakıroğlu, Reyhan Akat, Evren Osman Çakıroğlu, Taner Taşdemir

“…These analyses provide practical strategies for translating abstract religious principles into tangible design elements, enhancing their applicability in both educational and professional contexts. …”
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