Тransplastomic tobacco plants producing the hydrophilic domain of the sheep pox virus coat protein L1R by D. K. Beisenov, G. E. Stanbekova, B. K. Iskakov

“…Subsequent Northern and Western blot analysis showed the gene expression at the transcriptional and translational levels. The recombinant protein yields reached up to 0.9 % of total soluble protein. …”
Get full text

Cost-effectiveness of the Floodlight MS app in Austria. Unlocking the mystery of costs and outcomes of a digital health application for patients with multiple sclerosis by Evelyn Walter, Matthäus Traunfellner, Franz Meyer, Christian Enzinger, Michael Guger, Christian Bsteh, Patrick Altmann, Harald Hegen, Christoph Goger, Veronika Mikl

“…These patients experienced fewer relapses and slower disability progression, translating to a quality-of-life improvement of 4.5 months in perfect health and an incremental-cost-effectiveness-ratio (ICER) of 7,071 €. …”
Get full text

A systematic review of the clinical use of a single-layer bovine collagen-elastin acellular dermal matrix by David M. Hill

“…Manuscripts were excluded if they were primarily animal models, in vitro studies, reviews, expert opinion articles, or lacked sufficient detail. Google Translate was utilized when necessary. Results: Five hundred and thirty-five manuscripts containing potential details of CEM usage were identified. …”
Get full text

Prioritizing Forestation in China Through Incorporating Biogeochemical and Local Biogeophysical Effects by Yu Li, Pengyi Zhang, Huanhuan Wang, Hui Ma, Jie Zhao, Mengyang Xu, Mengyu Wang, Chenhui Guo, Chao Yue

“…Additionally, the BGC effect of forestation can be either reinforced or counteracted by concurrent biogeophysical processes (BGP effect) resulting in local land surface warming or cooling, which can be translated into CO2e (i.e., BGC effect) using a local transient climate response. …”
Get full text

The Multi‐Kinase Inhibitor GZD824 (Olverembatinib) Shows Pre‐Clinical Efficacy in Endometrial Cancer by Dongli Liu, Dylan Glubb, Tracy O'Mara, Caroline E. Ford

“…Whole transcriptome regulation following two doses (0.1 and 1 μM) of GZD824 in Ishikawa and ARK1 cells was investigated via RNA‐seq, and key components of enriched pathways were investigated at the translational level. Key pathways altered included ROR1/Wnt, GCN2‐ATF4, epithelial to mesenchymal transition (EMT) and PI3K‐AKT. …”
Get full text

Liver cancer risk and changes in lifestyle habits after successful hepatitis C virus therapy post-DAA HCV therapy: lifestyle changes and liver cancer risk by Núria Granel, Gemma Iserte, Concepció Bartres, Neus Llarch, Anna Pla, Víctor Sapena, Zoe Mariño, Sabela Lens, Ramón Vilana, Isabel Nuñez, Anna Darnell, Ernest Belmonte, Ángeles García-Criado, Alba Díaz, Marco Sanduzzi-Zamparelli, Carla Fuster, Sergio Muñoz-Martínez, Carmen Ayuso, Jordi Rimola, Alejandro Forner, Alexandre Soler, Ferran Torres, José Ríos, Jordi Bruix, Andrew M. Moon, Xavier Forns, María Reig

“…Conclusions In this prospective cohort, successful HCV therapy was followed by significant changes in lifestyle habits translating into increases in BMI and alcohol consumption. …”
Get full text

New Resinogalea species from Araucaria araucana resin in Chile and reclassification of the genus in the Cryptocaliciomycetidae by Felipe Balocchi, Irene Barnes, Michael J. Wingfield, Rodrigo Ahumada, Cobus M. Visagie

“…Further analyses applying the Genealogical Concordance Phylogenetic Species Recognition (GCPSR) based on ITS, mini chromosome maintenance protein complex (MCM7), RNA polymerase II second largest subunit (RPB2) and translation elongation factor 1-alpha (TEF) gene regions, confirmed that strains represent two new species. …”
Get full text

Left ventromedial prefrontal cortex inhibitory rTMS as an anti-stress intervention in opioid use disorder: Trial design by Tabitha E. Moses, Danielle Lenz, Leslie H. Lundahl, Nicholas A. Mischel, Christine Rabinak, Mark K. Greenwald

“…We hypothesize that stressors will increase executive dysfunction, emotion dysregulation, and drug-seeking, and that left vmPFC inhibitory rTMS will decrease limbic activation, which could translate to reduced craving and drug-seeking. Conclusion: Our findings should offer insights into how neural networks modulate drug-seeking and associated dysfunctions in people with SUDs. …”
Get full text

Development and validation of the Japanese version of the Public Attitudes Toward Epilepsy (PATE‐J) Scale by Junichi Hatakeda, Hiroumi Shimazaki, Izumi Kuramochi, Takayuki Iwayama, Sayaka Kobayashi, Hideyuki Matsuki, Haruo Yoshimasu, Kheng Seang Lim

“…The PATE Scale was translated following standard guidelines and validated by conducting confirmatory factor analysis (CFA) on the complete data set to assess the original two‐factor structure of the PATE Scale. …”
Get full text

Validity and Reliability Assessment of the Arabic Version of the Social and Emotional Competencies Questionnaire in a Moroccan Nursing Student Population by Jamal Ksiksou, Lhoussaine Maskour, Smail Alaoui, Rahma Bouali

“…Methodology consisted of forward and backward translations, linguistic adaptation, and pilot revision. …”
Get full text

Norepinephrine Infusion and the Central Venous Waveform in a Porcine Model of Endotoxemic Hypotension with Resuscitation: A Large Animal Study by Zachary R. Bergman, Roy K. Kiberenge, Richard W. Bianco, Gregory J. Beilman, Colleen M. Brophy, Kyle M. Hocking, Bret D. Alvis, Eric S. Wise

“…This allows contextualization of the novel, venous-derived signal f0 during vasopressor administration, a finding that must be understood prior to clinical translation.…”
Get full text

FORCE platform overcomes barriers of oligonucleotide delivery to muscle and corrects myotonic dystrophy features in preclinical models by Timothy Weeden, Tyler Picariello, Brendan Quinn, Sean Spring, Pei-Yi Shen, Qifeng Qiu, Benjamin F. Vieira, Lydia Schlaefke, Ryan J. Russo, Ya-An Chang, Jin Cui, Monica Yao, Aiyun Wen, Nelson Hsia, Tama Evron, Katy Ovington, Pei-Ni Tsai, Nicholas Yoder, Bo Lan, Reshmii Venkatesan, John Hall, Cody A. Desjardins, Mo Qatanani, Scott Hilderbrand, John Najim, Zhenzhi Tang, Matthew K. Tanner, Romesh Subramanian, Charles A. Thornton, Oxana Ibraghimov-Beskrovnaya, Stefano Zanotti

“…Cynomolgus monkeys were used to determine translatability of DYNE-101 pharmacology to higher species. …”
Get full text

Lived experiences and perspectives of women who had undergone perinatal loss in Nairobi county, Kenya: a qualitative study by Emily Wanja Kaburu, Christopher O Aimakhu, Thomas Matenjwa Kamau, Michael Omondi Owor

“…After the discussions, the audio recordings were transcribed, translated and analysed thematically. Triangulation was then done per thematic area to allow for a deeper understanding of the experiences and perceptions of the study participants.Results The research identified 3 themes and 7 subthemes: (1) ‘Psychosocial challenges of perinatal loss’ with five subthemes;—‘Emotional trauma and grief’, ‘Multiple losses and reproductive pressure’, ‘Broken relationships,’ ‘Violence and abuse’ and ‘Familial stigmatization’. (2) ‘Healthcare experiences.’ (3) ‘Stigma and cultural influences’ with 2 subthemes ‘Societal stigmatisation’, and ‘Cultural perceptions and norms surrounding perinatal loss’.Conclusion Women who have experienced perinatal loss often suffer psychological torture, discrimination, abuse, stigma and trauma. …”
Get full text

Water use dynamics of almond and pistachio crops in the Mediterranean region amid climate change by Anshika Kandhway, Fabio Scarpare, Mingliang Liu, Roger Nelson, Jennifer C. Adam, Ray G. Anderson, Martha H. Conklin, Mohammad Safeeq

“…These increases in ETc translate to 260 (almonds) and 180 (pistachios) million m3/year of additional water for irrigation in the absence of eCO2 effects. …”
Get full text

Advances in tissue engineering of peripheral nerve and tissue innervation – a systematic review by Jayson Sueters, Rowan van Heiningen, Ralph de Vries, Zeliha Guler, Judith Huirne, Theo Smit

“…In response, tissue-engineered solutions have been developed, yet clinical translations is rare. In this study, a systematic review was performed on tissue-engineered advancements for peripheral nerves and tissues, to aid future developments in bridging the gap toward the clinic by identifying high-potential solutions and unexplored areas. …”
Get full text

From physical activity patterns to cognitive status: development and validation of novel digital biomarkers for cognitive assessment in older adults by Ling-Jie Fan, Feng-Yi Wang, Jun-Han Zhao, Jun-Jie Zhang, Yang-An Li, Jia Tang, Tao Lin, Quan Wei

“…Based on these findings, we developed a proof-of-concept application that demonstrates the feasibility of translating these PA analytics into practical monitoring tools in real-world settings.…”
Get full text

Pancreatic resection with perioperative drug repurposing of propranolol and etodolac: trial protocol of the phase-II randomised placebo controlled PROSPER trial by Phillip Knebel, Thilo Hackert, Markus W Büchler, Ilse Rooman, Markus K Diener, Felix J Hüttner, André L Mihaljevic, Oliver Strobel, Gauthier Bouche, Johannes Hüsing

“…The clinical trial is accompanied by a translational study investigating the mechanisms of action of the combined therapy on a molecular basis.Ethics and dissemination The PROSPER-trial has been approved by the German Federal Institute for Drugs and Medical Devices (reference number 4042875) and the Ethics Committee of the Medical Faculty of the University of Heidelberg (reference number AFmo-385/2018). …”
Get full text

Integrative deep immune profiling of the elderly reveals systems-level signatures of aging, sex, smoking, and clinical traitsResearch in context by Lennart Riemann, Rodrigo Gutierrez, Ivan Odak, Joana Barros-Martins, Lennart M. Roesner, Ximena Leon Lara, Christine Falk, Thomas F. Schulz, Gesine Hansen, Thomas Werfel, Reinhold Förster, Berislav Bošnjak, Felix Jenniches, Norman Klopp, Till Robin Lesker, Martin Stangel

“…Our findings highlight clinically relevant immune signatures that enhance our understanding of aging-related diseases and could guide future research into new treatments, offering translational insights into human health and aging. Funding: Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy—EXC 2155—project number 390874280.…”
Get full text

Characterization and Probiotic Potential of <i>Levilactobacillus brevis</i> DPL5: A Novel Strain Isolated from Human Breast Milk with Antimicrobial Properties Against Biofilm-Formi... by Ivan Iliev, Galina Yahubyan, Elena Apostolova-Kuzova, Mariyana Gozmanova, Daniela Mollova, Iliya Iliev, Lena Ilieva, Mariana Marhova, Velizar Gochev, Vesselin Baev

“…The genome also contains multiple biosynthetic gene clusters such as lanthipeptide class IV, Type III polyketide synthase (T3PKS), and ribosomally synthesized, and post-translationally modified peptides (RiPP-like compounds), all of which are associated with antibacterial properties. …”
Get full text

INTRASPECIFIC VARIABILITY OF THE Sus1 SUCROSE SYNTHASE GENE IN Pisum sativum ACCESSIONS by E. A. Dyachenko, M. A. Slugina

“…All the conservative motifs and active sites were detected in the translated amino acid sequences. It was shown that their sequences were invariable in all the tested accessions. …”
Get full text