JNK1 Deficient Insulin-Producing Cells Are Protected against Interleukin-1β-Induced Apoptosis Associated with Abrogated Myc Expression by Michala Prause, Christopher Michael Mayer, Caroline Brorsson, Klaus Stensgaard Frederiksen, Nils Billestrup, Joachim Størling, Thomas Mandrup-Poulsen

“…INS-1 cells express JNK1α1, JNK1α2, JNK1β1, JNK1β2, JNK2α1, JNK2α2, JNK3α1, and JNK3α2 mRNA isoform transcripts translating into 46 and 54 kDa isoform JNK proteins. …”
Get full text

Landscape composition and orchard management effects on bat assemblages and bat foraging activity in apple crops by Marcos Miñarro, Daniel García

“…Little is known, however, on how bat assemblages respond to the gradients imposed by anthropogenic landscapes and farming practices and how these environmental effects translate into changes in bat foraging. In this study, we use cider apple crop in northern Spain as a model to address the filtering effects of landscape composition and orchard management on, simultaneously, quantitative and qualitative characteristics of bat local assemblages and their foraging activity. …”
Get full text

Challenges and Barriers Faced by People with TB and Healthcare Workers Providing TB Care and Management – A Qualitative Study by S. Suseendar, Akhil Dhanesh Goel, T. Pritish Baskaran, V. R. Rehana, Pankaj Bhardwaj, Manoj Kumar Gupta, S. Srikanth, Suman Saurabh

“…Interviews were carried out in the Hindi language, audio recorded, and translated to English. Participants were asked about their experiences of challenges and barriers faced during TB care and management. …”
Get full text

Molecular hydrogen reduces dermatitis-induced itch, diabetic itch and cholestatic itch by inhibiting spinal oxidative stress and synaptic plasticity via SIRT1-β-catenin pathway in... by Linlin Zhang, Fangshi Zhao, Yize Li, Zhenhua Song, Lingyue Hu, Yuanjie Li, Rui Zhang, Yonghao Yu, Guolin Wang, Chunyan Wang

“…Taken together, this study uncovers that molecular hydrogen protects against chronic pruritus and spinal pruriceptive sensitization by reducing oxidative damage via up-regulation of SIRT1-dependent β-catenin deacetylation in mice, implying a promising strategy in translational development for itch control.…”
Get full text

PositivMasc: masculinities and violence against women among young people. Identifying discourses and developing strategies for change, a mixed-method study protocol by N Daoud, M Salazar, Claire Edwards, Margaret Scanlon, C Vives-Cases

“…Phase 3 is a knowledge creation and translation phase, based on findings from Phases 1 and 2, where actions and guidelines to promote and support anti-VAW masculinities will be developed.Ethics and dissemination Ethical clearance has been obtained from ethics review boards in each country. …”
Get full text

Understanding the implementation of interventions to improve the management of frailty in primary care: a rapid realist review by David Reeves, Thomas Blakeman, Harm Van Marwijk, Khulud Alharbi, Jung Yin Tsang

“…Key factors that facilitate or inhibit the translation of frailty interventions into practice related to the distribution of resources; patient engagement and professional skill sets to address identified need.Conclusion There remain challenges to achieving successful implementation of frailty interventions in primary care. …”
Get full text

Adipose-Derived Stem Cells in Bone Tissue Engineering: Useful Tools with New Applications by Gabriele Storti, Maria Giovanna Scioli, Bong-Sung Kim, Augusto Orlandi, Valerio Cervelli

“…All these advancements are ultimately intended for a faster translational and clinical application of BTE.…”
Get full text

Mini review of spatially fractionated radiation therapy for cancer management by Shrikant B. Mali

“…A consensus on dose prescription, technical administration, and clinical and translational design parameters for SFRT trials is essential to enable broad participation and successful accrual to rigorously test the SFRT approach. …”
Get full text

Development of quality indicators for hand osteoarthritis care – Results from an European consensus study by Daniel H. Bordvik, Yeliz Prior, Rachael Bamford, Francis Berenbaum, Mathilda Björk, Thalita Blanck, Barbara Slatkowsky Christensen, Krysia Dziedzic, John Edwards, Nazemin Gilanliogullari, Carol Graham, Ida K. Haugen, Margreet Kloppenburg, Hellen Laheij, Marco J.P.F. Ritt, Tanja Stamm, Anne Therese Tveter, Nina Østerås, Ingvild Kjeken

“…The adapted questionnaire was translated from English into Norwegian. Cognitive debriefing interviews with Norwegian and UK hand OA patients were conducted to ensure clarity. …”
Get full text

Sabāhi’s Techniques of Depicting Semantic and Inspirational Functions and Intentions of Verses from Qur’an by Maryam Baghi

“…The research results show that, in addition to conventional methods such as adaptation, quotation, translation, and conceptual usage for emphasis and confirmation, and rhetorical functions; Sabāhi has also dealt with some lesser-known techniques among poets including: A) changing the verse application in a descriptive and discriminative approach, aiming to highlight the subject and theme; B) allusive usage for comparison or statement of preference. …”
Get full text

Validity and reliability of a sport participant psychosocial well-being instrument: a preliminary study by Endang Sepdanius, Nurul Diyana Binti Sanuddin, Mohad Anizu Bin Mohd Nor, M. Adli Bin Mohd Sidi, Bekir Erhan Orhan, Mohd Salleh Aman, Rini Afriani

“…Method: This study has four phases: preparation, translation, field trials, and validation methods. Seven experts evaluated the study based on content, clarity, and feasibility. …”
Get full text

Recognition and cleavage of human tRNA methyltransferase TRMT1 by the SARS-CoV-2 main protease by Angel D'Oliviera, Xuhang Dai, Saba Mottaghinia, Sophie Olson, Evan P Geissler, Lucie Etienne, Yingkai Zhang, Jeffrey S Mugridge

“…Together, these data provide new insights into substrate recognition by SARS-CoV-2 Mpro that could help guide future antiviral therapeutic development and show how proteolysis of TRMT1 during SARS-CoV-2 infection impairs both TRMT1 tRNA binding and tRNA modification activity to disrupt host translation and potentially impact COVID-19 pathogenesis or phenotypes.…”
Get full text

Harnessing marine bacteria for next-gen antibiotics: potent inhibition of S. aureus and Riemerella anatipestifer through in vitro, omics, and chemoinformatics approach with enhance... by Syed Shams ul Hassan, Huizi Jin

“…A transcriptome analysis of active compound 4 showed its antibacterial effect on R. anatipestifer by inhibiting 30S and 50S ribosomal subunits, resistance mechanisms, and gliding motility proteins IX secretion system (T9SS) and interfering with protein translations process, secretion system, defense and resistance mechanisms, ultimately resulting in effective inhibition of normal bacterial growth and its motility. …”
Get full text

In situ natural radioactivity and radiological hazard assessments of granite gneiss outcrops in parts of the Southwestern Basement Complex of Nigeria by Adedibu Sunny Akingboye, Omowumi Ademila

“…However, increase in estimated mean of AGDE and ELCR; 525.620 and 1.273 above the world permissible standards of 300 and respectively does not translate to significant radiological threats. Therefore, control measure by constant monitoring of the radioactivity levels of the area and rocks should be practiced.…”
Get full text

MetaRange.jl: A Dynamic and Metabolic Species Range Model for Plant Species by Jana Blechschmidt, Juliano Sarmento Cabral

“…A promising research direction is to expand demographically explicit metapopulation models by integrating metabolic constraints. We translated and expanded a previously developed R metapopulation model to Julia language and published it as a Julia module. …”
Get full text

High hemolytic activity in Staphylococcus aureus t1081/ST45 due to increased hla protein production and potential RNAIII-independent regulation by Yu-Tzu Lin, Ngoc-Niem Bui, Yu-Syuan Cheng, Cheng-Wen Lin, Chun-Li Lee, Tai-Fen Lee, Po-Ren Hsueh

“…Moreover, the higher translation levels may be independent of the known regulator RNAIII, indicating a potential RNAIII-independent mechanism for Hla regulation.…”
Get full text

The responsiveness of surgical research to Māori in Aotearoa, New Zealand—a scoping reviewResearch in context by Jamie-Lee Rahiri, Noah Appleby, Makayla Kahi, Annaliese Wheeler, Jason Tuhoe, Shanthi Ameratunga, Rachelle Love, Wiremu MacFater, Matire Harwood

“…Funding: This study was supported by a Health Research Council of New Zealand Health Delivery Research Activation Grant (21/860) and Māori Health Knowledge Translation Grant (25/234). The funders had no role in the study design, conception, data collection, analysis, interpretation, or report writing. …”
Get full text

Proteomic insights into dual-species biofilm formation of E. coli and E. faecalis on urinary catheters by Kidon Sung, Miseon Park, Ohgew Kweon, Angel Paredes, Alena Savenka, Saeed A Khan

“…E. coli exhibited a more proactive response, emphasizing motility, transcription, and protein synthesis for biofilm establishment; whereas E. faecalis displayed a more reserved strategy, potentially downregulating metabolic activity, transcription, and translation in response to cohabitation with E. coli. …”
Get full text

Validation of the Italian version of the intuitive exercise scale: a four-factor structure in the general population by Paolo Mancin, Marta Ghisi, Tatiana Moro, Silvia Cerea

“…The present study aimed to validate an Italian translation of the IEXS, exploring its factorial structure, invariance, internal consistency, and convergent validity. …”
Get full text

The fibronectin-targeting PEG-FUD imaging probe shows enhanced uptake during fibrogenesis in experimental lung fibrosis by Thomas J. Harr, Nikesh Gupta, Babita Rahar, Kristen Stott, Yadira Medina-Guevara, Metti K. Gari, Angie T. Oler, Ivy Sohee McDermott, Hye Jin Lee, Morteza Rasoulianboroujeni, Ashley M. Weichmann, Amir Forati, Kelsey Holbert, Trevor S. Langel, Kade W. Coulter, Brian M. Burkel, Bianca R. Tomasini-Johansson, Suzanne M. Ponik, Jonathan W. Engle, Reinier Hernandez, Glen S. Kwon, Nathan Sandbo, Ksenija Bernau

“…These data suggest that PEG-FUD targets fibronectin associated with active fibrogenesis in this model, making it a promising candidate for a clinically translatable molecular imaging probe to non-invasively determine pulmonary fibrosis disease activity, enabling accelerated therapeutic decision-making.…”
Get full text