Leveraging Single-Cell Multi-Omics to Decode Tumor Microenvironment Diversity and Therapeutic Resistance by Hussein Sabit, Borros Arneth, Timothy M. Pawlik, Shaimaa Abdel-Ghany, Aysha Ghazy, Rawan M. Abdelazeem, Amany Alqosaibi, Ibtesam S. Al-Dhuayan, Jawaher Almulhim, Noof A. Alrabiah, Ahmed Hashash

“…Future studies will incorporate multi-omics data, spatial relationships in tumor micro-environments, and their translation into personalized cancer therapies. This review emphasizes how single-cell multi-omics can provide insights into the cellular and molecular heterogeneity of the TME, revealing immune evasion mechanisms, metabolic reprogramming, and stromal cell influences. …”
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Engineered ipilimumab variants that bind human and mouse CTLA-4 by Brett Robison, SJ Diong, Anusha Kumar, Thomas M. Moon, Olin Chang, Bryant Chau, Christine Bee, Ishita Barman, Arvind Rajpal, Alan J. Korman, Sean West, Pavel Strop, Peter S. Lee

“…These cross-reactive ipilimumab variants may facilitate improved translatability and future mechanism-of-action studies for anti-CTLA-4 targeting in murine models.…”
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Keratoconus Diagnosis: Validation of a Novel Parameter Set Derived from IOP-Matched Scenario by Dan Lin, Lei Tian, Shu Zhang, Like Wang, Ying Jie, Yongjin Zhou

“…Our study shows that NPS indeed offers comparable performance in keratoconus diagnosis. Translational Relevance. Determining a parameter set after eliminating the influence from IOP is useful in revealing the essential differences between keratoconus and normal corneas and possibly facilitating further progress in keratoconus diagnosis.…”
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A meta-analysis of sex differences in neonatal rodent ultrasonic vocalizations and the implication for the preclinical maternal immune activation model by Alison M. Randell, Stephanie Salia, Lucas F. Fowler, Toe Aung, David A. Puts, Ashlyn Swift-Gallant

“…We discuss how analyzing USV call types and incorporating sex as a biological variable can enhance our understanding of neonatal ultrasonic communication and its translational value in NDD research.…”
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Employing visual thinking skills in the techniques of advertising art by Bydaa Sabih Al-Gharawi

“…It also works on enhancing current education methods to reach excellence in the process of teaching advertisement art techniques, where the research aims to take on skills of visual thinking and adopt them in preparing teaching units that represent weekly lectures for the students of the Department of Printing Design Techniques / First Grade, and develop their abilities in translating visual language carried in advertisements to a written phonic language that requires training on visual thinking skills. …”
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Deep Learning for Traffic Scene Understanding: A Review by Parya Dolatyabi, Jacob Regan, Mahdi Khodayar

“…It examines fundamental techniques such as classification, object detection, and segmentation, and extends to more advanced applications like action recognition, object tracking, path prediction, scene generation and retrieval, anomaly detection, Image-to-Image Translation (I2IT), and person re-identification (Person Re-ID). …”
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Synergistic impact of temperature and pore saturation on corrosion in carbonated reinforced concrete by Li Soon Wan, Mayuko Hirata, Toshinori Oyamoto, Tetsushi Kanda, Kang Hai Tan

“…For concrete with a water-to-cement ratio of 0.65, severe corrosion occurred at substantially lower pore saturation levels at higher temperatures, with even lower thresholds for more porous concrete. To translate these findings into practical tools, multiple linear regression analysis yielded predictive equations relating temperature and pore saturation effects to corrosion rates. …”
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A propaganda document in support of the 19th century Caliphate of Ḥamdallāhi: Nūḥ b. al-Ṭāhir al-Fulānī’s “Letter on the appearance of the twelfth caliph” (Risāla fī ẓuhūr al-khalī... by Mauro Nobili

“…With this article, I edit and translate Nūḥ b. al-Ṭāhir’s Risāla and discuss it in the context of the tension between the Caliphate of Ḥamdallāhi and Sokoto. …”
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Expanding the structural resolution of glycosylation microheterogeneity in therapeutic proteins by salt-free hydrophilic interaction liquid chromatography tandem mass spectrometry by Yutian Gan, Steffen Lippold, John Stobaugh, Christian Schöneich, Feng Yang

“…Glycosylation is a highly complex post-translational modification (PTM) due to its structural heterogeneity, i.e. glycosylation site occupancy, glycan compositions, modifications, and isomers. …”
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Multi-environment and multi-parameter screening of stability and coating efficiency of gold nanoparticle bioconjugates in application media by Junjie Wang, Stefano Giordani, Valentina Marassi, Anna Placci, Barbara Roda, Pierluigi Reschiglian, Andrea Zattoni

“…The developed methodology can fill the vacancy of standard reference quality control (QC) procedures for bioconjugate synthesis and application in (bio)sensors and Nano-pharmaceutics, screening in a short time many combinations, easily scaling up to the semi-preparative scale or translating to different bioconjugates.…”
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DNA-loaded targeted nanoparticles as a safe platform to produce exogenous proteins in tumor B cells by Maria Cristina Grimaldi, Sara Bozzer, Dick J. Sjöström, Dick J. Sjöström, Linnea I. Andersson, Tom Eirik Mollnes, Tom Eirik Mollnes, Per H. Nilsson, Per H. Nilsson, Luca De Maso, Federico Riccardi, Michele Dal Bo, Daniele Sblattero, Paolo Macor

“…The targeting mechanism facilitated the interaction of NPs with target cells, thereby enhancing their internalization and subsequent exogenous plasmid DNA (pDNA) translation and protein expression. In the human/zebrafish lymphoma xenograft model, no evidence of toxicity was observed, and targeted NPs demonstrated the capacity to enhance exogenous pDNA expression.ConclusionOur findings provide a rationale for the use of targeted NPs as a DNA delivery system for the local expression of therapeutic proteins.…”
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Validation of a Questionnaire on COVID-19 Knowledge and Attitude for Dental Patients by Mohammad Reza Khami, Mahsa Karimi, Morenike Oluwatoyin Folayan, Ahmad Reza Shamshiri, Prathip Phantumvanit, Armando E Soto-Rojas, Seyed Hossein Bassir, Heikki Murtomaa

“…Materials and Methods: Through a comprehensive literature review, we designed the primary questionnaire in English and then translated it into Persian. The questionnaire consisted of six sections covering background information, knowledge of emergency dental treatments, transmission routes of disease, required preparation, source of information, and attitude. …”
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Young TPI: empowering animal-free science among the next- generation of scientists by Marta G. Valverde, Marta G. Valverde, Fatima Zohra Abarkan, Fatima Zohra Abarkan, Rebecca Van Eijden, Rebecca Van Eijden, Julia M. L. Menon, Julia M. L. Menon, Nikolas Gaio, Nikolas Gaio, Aarti Ramchandran, Aarti Ramchandran, Victoria C. De Leeuw, Victoria C. De Leeuw

“…They not only address important ethical concerns, but also should directly improve research accuracy and reliability through redirecting scientific inquiry toward more reliable and translatable methodologies. Promotion and encouragement for use of animal-free innovations among the next-generation of scientists, alongside knowledge acquisition and training in the increased capabilities of novel technologies, are fundamental for advancing science and the welfare of animals used for scientific purposes. …”
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Theoretical evaluation of the impact of diverse treatment conditions by calculation of the tumor control probability (TCP) of simulated cervical cancer Hyperthermia-Radiotherapy (H... by Sergio Mingo Barba, Adela Ademaj, Dietmar Marder, Oliver Riesterer, Marco Lattuada, Rudolf M. Füchslin, Alke Petri-Fink, Stephan Scheidegger

“…In this context, in-silico biophysical models that translate deviations in the treatment conditions into clinical outcome variations may be used to study the extent of such processes and their influence on combined hyperthermia plus radiotherapy (HT + RT) treatments under varying conditions.Methods An extended linear-quadratic model calibrated for SiHa and HeLa cell lines (cervical cancer) was used to theoretically study the impact of varying HT treatment conditions on radiosensitization and direct HT cell killing effect. …”
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Turkish validity and reliability study of the psychological food involvement scale: PFIS-TR by İrem Nur Şahin, Aslıhan Atar, Özge Yaman, Halime Pulat Demir

“…The PFIS underwent a six-stage translation and cultural adaptation process. Data collection was carried out via Google Forms, with participants completing a general information form, PFIS, and the Addiction-like Eating Behavior Scale (ALEBS). …”
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Kaempferol enhances ER-mitochondria coupling and protects motor neurons from mitochondrial dysfunction and ER stress in C9ORF72-ALS by Federica Pilotto, Paulien Hermine Smeele, Olivier Scheidegger, Rim Diab, Martina Schobesberger, Julieth Andrea Sierra-Delgado, Smita Saxena

“…Importantly, in vivo, chronic kaempferol administration ameliorated pathological motor dysfunction and inhibited motor neuron degeneration, highlighting the translational potential of kaempferol. Lastly, in silico modelling identified a novel kaempferol target and mechanistically the neuroprotective mechanism of kaempferol is through the iP3R-VDAC1 pathway via the modulation of GRP75 expression. …”
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Bidimensional Increment Entropy for Texture Analysis: Theoretical Validation and Application to Colon Cancer Images by Muqaddas Abid, Muhammad Suzuri Hitam, Rozniza Ali, Hamed Azami, Anne Humeau-Heurtier

“…In our proposed method, increments are translated into two-letter words, encoding both the size (magnitude) and direction (sign) of the increments calculated from an image. …”
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The role of the pAbp gene encoding the cytoplasmic poly(A)-binding protein in spermatogenesis of Drosophila melanogaster by E. U. Bolobolova, E. M. Baricheva, N. V. Dorogova

“…Cytoplasmic PABPs participate in the metabolic pathways of the mRNA: translation initiation and termination, cytoplasmic polyadenylation/deadenylation, mRNA stability, mRNA degradation. …”
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Lymphocytic Esophagitis: Navigating an Uncharted Territory by Ahmad Jradi MD, Kaline Maya Khoury MD, Karam Karam MD, Dr. Ihab I. El Hajj MD, Elias Fiani MD

“…This case plays an instrumental role in changing the way physicians translate unexplained chest pain, adding LE to their list of differential diagnosis as prompt detection slows us to start management with PPIs quicker and lessen the burden of symptoms on the patient. …”
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Proteomics and Its Current Application in Biomedical Area: Concise Review by Semira Gobena, Bemrew Admassu, Mebrie Zemene Kinde, Abebe Tesfaye Gessese

“…Keeping abreast of the latest developments in proteomics applications becomes paramount for the development of therapeutics, translational research, and study of diverse diseases. …”
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