Blood levels of cytokines highlight the role of inflammation in Alzheimer's disease by Lorenzo Campanelli, Pablo Galeano, Federico A. Prestia, Carolina Cuesta, Maria C. Dalmasso, María Flores-López, Cristian Gona, Nicolás Irureta, Claudia Kairiyama, Julieta Lisso, Antonio Jesús López-Gambero, Ines Mintz, Nancy Medel, Karen S. Campuzano, Carolina Muchnik, Gisela V. Novack, Natividad Olivar, Ivana Quiroga, Nerea Requena-Ocaña, Jose Antonio Reyes-Bueno, Pedro Serrano-Castro, Zulma Sevillano, Patricia Solis, Juan Suárez, Ivana Villella, Nancy Wukitsevits, Eduardo M. Castaño, Fernando Taragano, Silvia Kochen, Daniel G. Politis, Luis I. Brusco, Fernando Rodríguez de Fonseca, Laura Morelli

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Prospective evaluation of artificial intelligence (AI) applications for use in cancer pathways following diagnosis: a systematic review by Ajay Aggarwal, Richard Sullivan, Andrew Hope, Peng Yun Ng, Sheba Macheka

“…Most studies failed to establish clinical validity and to translate measured AI efficacy into beneficial clinical outcomes. …”
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Heterothallism and potential hybridization events inferred for twenty-two yellow morel species by Xi-Hui Du, Dongmei Wu, Heng Kang, Hanchen Wang, Nan Xu, Tingting Li, Keliang Chen

“…Phylogenetic analyses of MAT1–1-1, MAT1–2-1, intergenic spacer (IGS), and partial histone acetyltransferase ELP3 (F1) were performed and compared with the species phylogeny framework derived from the ribosomal internal transcribed spacer region (ITS) and translation elongation factor 1-alpha (EF1-a) to evaluate their species delimitation ability and investigate potential hybridization events. …”
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Molecular dynamics simulation based prediction of T-cell epitopes for the production of effector molecules for liver cancer immunotherapy. by Sidra Zafar, Yuhe Bai, Syed Aun Muhammad, Jinlei Guo, Haris Khurram, Saba Zafar, Iraj Muqaddas, Rehan Sadiq Shaikh, Baogang Bai

“…Based on in silico cloning, we found the considerable compatibility of this polyvalent construct with the E. coli expression system and the efficiency of its translation in host. The system-level and machine learning based cross validations showed the possible effect of these T-cell epitopes as potential vaccine candidates for the treatment of liver cancer.…”
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Age and diet affect self-resilience of intestinal microbiome in mice by Chenyi Shao, Shenmin Chen, Huan Yang, Mufan Li, Yinhui Liu, Shu Wen, Jing Xiao, Li Tang

“…Therefore, we must be cautious about translating the microbiome results from mice to humans.…”
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Citizens’ Adoption of an E-Health System During the Pandemic by Faye Lorraine P. Mina, Enrique B. Batara, Eucil P. Hussien, Rabby Q. Lavilles

“…Variables from this theory were operationalized through indicators which were then translated into a self-reported online survey questionnaire distributed through email and Facebook. …”
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Bioactive Coatings on 3D Printed Polycaprolactone Scaffolds for Bone Regeneration: A Novel Murine Femur Defect Model for Examination of the Biomaterial Capacity for Repair by Karen M. Marshall, Jonathan P. Wojciechowski, Vineetha Jayawarna, Abshar Hasan, Cécile Echalier, Sebastien J. P. Callens, Tao Yang, Janos M. Kanczler, Jonathan I. Dawson, Alvaro Mata, Manuel Salmeron‐Sanchez, Molly M. Stevens, Richard O. C. Oreffo

“…In summary, Laponite/BMP‐2 coated PCL‐TMA900 scaffolds offer a biodegradable, osteogenic construct for bone augmentation with potential for development into a large scale polymer scaffold for clinical translation.…”
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A girl with intragenic variants in MARS2 and a chondrodysplasia phenotype by Hiroyuki Iijima, Yuko Tsujioka, Yoshiyuki Tsutsumi, Gen Nishimura, Yasushi Okazaki, Kei Murayama, Mitsuru Kubota, Akira Ohtake

“…Background: The human mitochondrial methionyl-tRNA is crucial for mitochondrial translation, serving as both initiator and elongator in polypeptide chains. …”
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A structural genomics approach to investigate Dystrophin mutations and their impact on the molecular pathways of Duchenne muscular dystrophy by Abdelbaset Mohamed Elasbali, Farah Anjum, Osama A. AlKhamees, Waleed Abu Al-Soud, Mohd Adnan, Anas Shamsi, Md. Imtaiyaz Hassan

“…Additionally, aggregation propensity, frustration analysis, and post-translational modification sites were analyzed for functional disruptions.ResultsOf the 184 substitutions analyzed, 50 were identified as deleterious, with 41 predicted to be pathogenic. …”
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Phosphate-sensing mechanisms and functions of phosphate as a first messenger by Yuichi Takashi

“…Furthermore, the post-translational modification of FGF23 protein via a gene product of GALNT3 is the main regulatory mechanism of enhanced FGF23 production due to high dietary phosphate. …”
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Community Consultations to Support Scoping Review Knowledge Dissemination by Sarah L. Canham, Rachel Weldrick, Elizabeth Siantz, Jeffrey N. Rose, Danielle Maude Littman, Morgan Cruz Erisman, Kyle Rehn, Shannon Jones, Sumiko Anderson, Anne McNamara, Emma Greenwood

“…Study findings contribute to the literature on how to engage with community around collaborative problem-solving and the importance of incorporating diverse perspectives, fostering empathy and inclusivity, and translating ideas into actionable steps.…”
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Microneedle technology for enhanced topical treatment of skin infections by Tingting Peng, Yangyan Chen, Xuanyu Luan, Wanshan Hu, Wentao Wu, Bing Guo, Chao Lu, Chuanbin Wu, Xin Pan

“…The limitations of antimicrobial MNs toward clinical translation are offered regarding large-scale production, quality control, and policy guidance. …”
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Update on Low-Molecular Weight Hyaluronic Acid in Dermatology: A Scoping Review by Stephanie Waggett, Elliott Lyles, Todd Schlesinger

“…Conclusion: Exploration and understanding of the properties and benefits of LMW-HA are key to translating its usage in the clinical setting. Basic scientists and dermatologists have achieved substantial progress over the past two decades, and several applications of LMW-HA in dermatology were identified. …”
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Tree shrew as a new animal model for musculoskeletal disorders and aging by Xiaocui Wei, Honghao Li, Jingyang Qiu, Jianlin Jiao, Xiongtian Guo, Gaosheng Yin, Ping Yang, Yi Han, Qiongzhi Zhao, Hao Zeng, Zhi Rao, Xuefei Gao, Kai Li, Pinglin Lai, Sheng Zhang, Chengliang Yang, Di Lu, Xiaochun Bai

“…However, successful therapeutic development and translation have been hampered by the lack of clinically-relevant animal models. …”
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Uncertainty impact of isotherm models on liquid-phase adsorption thermodynamics: A bayesian inference perspective by Thiago Reschützegger, Nina Paula Gonçalves Salau

“…., R² ≈ 0.99), this flexibility in the Sips model does not consistently translate into reliable thermodynamic interpretations. …”
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Social network sites (SNS) an archetype of techno-social stress: A systematic review by January F. Naga, Ryan A. Ebardo

“…Only English-language articles were considered to avoid translation complexities. Studies were categorized and coded using the Stressor-Strain-Outcome (SSO) model to examine demographic variations in stressor impacts and coping mechanisms. …”
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Two different mechanisms support selective attention at different phases of training. by Sirawaj Itthipuripat, Kexin Cha, Anna Byers, John T Serences

“…Moreover, these data facilitate the translation of results across different species and across experimental procedures that employ different behavioral training regimes.…”
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The influence of hepatocyte growth factor on the proliferation and differentiation of stem cells by Rafał Bieś, Agnieszka Mikosińska, Jakub Parys, Mateusz Litwin, Patrycja Kałuziak, Marta Jajczak, Maciej Mossakowski, Aleksandra Witek, Martyna Kaźmierczak, Stanisław Jesionek

“…Despite its potential as a therapeutic target, the complexity of HGF/c-Met signaling and the associated challenges, such as off-target effects and limited understanding of its role in different disease contexts, pose significant obstacles to clinical translation. Objectives: This review aims to examine the role of the HGF/c-Met pathway in tissue regeneration and cancer, with a focus on its therapeutic potential. …”
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University as a City and University as a State: Methodological Tools of William Clark by V. K. Pichugina, Z. A. Lurie

“…Despite the fact that the translation of William Clark’s book into Russian was carried out in 2017, the methodology proposed is undeservedly little known to the researchers of higher education and, in general, has not received fundamental review in the scientific tradition. …”
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From botany to bedside: a review of the health benefits of Lycium barbarum as a functional food by Alois Berisha, Elena-Alexandra Alexa, Robbie Kelleher, Tao Zhang

“…Despite promising findings, gaps in the evidence base, including the need for larger, long-term, and rigorously controlled trials, remain significant barriers to clinical translation. By integrating traditional medicinal knowledge with modern scientific insights, this review underscores L. barbarum’s potential as a functional food and therapeutic agent. …”
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