An epigenetic memory at the CYP1A gene in cancer-resistant, pollution-adapted killifish by Samantha Carrothers, Rafael Trevisan, Nishad Jayasundara, Nicole Pelletier, Emma Weeks, Joel N. Meyer, Richard Di Giulio, Caren Weinhouse

“…We detected a bivalent domain in the CYP1A promoter enhancer comprising both activating and repressive histone post-translational modifications. Activating modifications, relative to repressive ones, showed greater increases in response to PAH in sensitive embryos, relative to tolerant, consistent with greater gene activation. …”
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Comparative Study of Ectopic Lymphoid Aggregates in Sheep and Murine Models of Bleomycin-Induced Pulmonary Fibrosis by Udari Eshani Perera, Louise Organ, Simon G. Royce, Chrishan S. Samuel, Habtamu B. Derseh, Sasika N. V. Dewage, Emmanuel Koumoundouros, Andrew Stent, Kenneth J. Snibson

“…This study evaluated the histopathological and inflammatory components of bleomycin-induced pulmonary fibrosis in mouse and sheep models, in terms of their ability to translate to the human IPF. Merino sheep (n = 8) were bronchoscopically administered with two bleomycin infusions, two weeks apart, into a caudal lung segment, with a saline (control) administered into a caudal segment in the opposite lung. …”
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Continuum of Care - Building bridges between different phases of the patient's pathway by Michael Adolph, Marek Lichota

“…While guidelines on nutritional care exist, translating these guidelines into individualized nutritional plans is essential for providing optimal patient care. …”
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Human Fat-Derived Mesenchymal Stem Cells Xenogenically Implanted in a Rat Model Show Enhanced New Bone Formation in Maxillary Alveolar Tooth Defects by Andrew Wofford, Austin Bow, Steven Newby, Seth Brooks, Rachel Rodriguez, Tom Masi, Stacy Stephenson, Jack Gotcher, David E. Anderson, Josh Campbell, Madhu Dhar

“…Gelfoam®, a commonly used clinical biomaterial, can serve as a scaffold to deliver and maintain MSCs to the defect site. Translating this strategy to preclinical animal models provides hope for bone tissue engineering.…”
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Impulsive-Compulsive Behaviours in Belgian-Flemish Parkinson’s Disease Patients: A Questionnaire-Based Study by Emke Maréchal, Benjamin Denoiseux, Ellen Thys, Patrick Cras, David Crosiers

“…To develop and perform partial validation of a Belgian-Flemish version of the Questionnaire for Impulsive-Compulsive Disorders in Parkinson’s Disease (QUIP) as a screening instrument for ICB in PD patients. Methods. Using a translation-backtranslation method, we developed a Belgian-Flemish version of the QUIP, which was subsequently completed by 88 PD patients. …”
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Therapeutic potential of mesenchymal stem cell-derived extracellular vesicles in ischemic stroke: A meta-analysis of preclinical studies by Xiaoming Zhang, Yibing Guo, Kun Fang, Xiangqian Huang, Duo Lan, Mengqi Wang, Lina Jia, Xunming Ji, Ran Meng, Da Zhou

“…These findings pave the way for further research and potential clinical translation.…”
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Towards the praxis of a sustainable knowledge‑based economy by Agnieszka Klimska

“…Implementation of the preferred directions of development, requires not so much efficient, but proper management, i.e. one which would translate itself onto the plane of decision-making and, subsequently, that of application. …”
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The Future of Law Firms (and Lawyers) in the Age of Artificial Intelligence by Anthony E. Davis

“…Part I briefly describes some of the ways AI is already in use in ordinary life - from facial recognition, through medical diagnosis to translation services. Part II describes how AI is transforming what it means to provide legal services in six primary areas: litigation review; expertise automation; legal research; contract analytics; contract and litigation document generation; and predictive analytics. …”
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A novel protein encoded by porcine circANKRD17 activates the PPAR pathway to regulate intramuscular fat metabolism by Xiao He, Fang Xie, Ying Nie, Xuefeng Wang, Junyi Luo, Ting Chen, Qianyun Xi, Yongliang Zhang, Jiajie Sun

“…In addition, we discovered that circANKRD17 has an open reading frame and can be translated into a novel 571-amino-acid protein that promotes lipid metabolism. …”
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The decline of walleye populations: an ecological tipping point? by Greg G. Sass

“…Walleye/ogaa (Sander vitreus (Mitchill)) (hereafter, walleye; ogaa = Ojibwe translation) populations have historically supported important multi-use, harvest-oriented fisheries. …”
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Exploring the role and mechanisms of MAGEA4 in tumorigenesis, regulation, and immunotherapy by Weijian Zhu, Qiang Yi, Zheng Chen, Jiaqi Wang, Kui Zhong, Xinting Ouyang, Kuan Yang, Bowei Jiang, Jianing Zhong, Jinghua Zhong

“…This article comprehensively reviews the structure and function of MAGEA4, as well as recent research progress in solid tumors, providing a theoretical foundation for the clinical translation of MAGEA4 and its application in immunotherapy.…”
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The Efficiency of Direct Maturation: the Comparison of Two hiPSC Differentiation Approaches into Motor Neurons by Catherine Schaefers, Simone Rothmiller, Horst Thiermann, Theo Rein, Annette Schmidt

“…However, these often apply viral vectors, feeder cells, or antibiotics to generate hiPSC and MNs, limiting their translational potential. In this study, a virus-, feeder-, and antibiotic-free method was used for reprogramming hiPSC, which were maintained in culture medium produced under clinical good manufacturing practice. …”
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Re-Calibrating Network by Refining Initial Features Through Generative Gradient Regularization by Naim Reza, Ho Yub Jung

“…Notably, this refinement in features translates to improved generalization and the proposed method also eliminates the necessity of total retraining of the target network. …”
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Ceramic Hollow Fibre Constructs for Continuous Perfusion and Cell Harvest from 3D Hematopoietic Organoids by Mark C. Allenby, Asma Tahlawi, José C. F. Morais, Kang Li, Nicki Panoskaltsis, Athanasios Mantalaris

“…Herein, we propose HFs to improve 3D cell culture nutrient and metabolite diffusion, increase culture volume and cell density, and continuously harvest products for translational cell therapy biomanufacturing protocols.…”
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The impacts on population health by China's regional health data centers and the potential mechanism of influence by Jiaoli Cai, Yue Li, Peter C Coyte

“…Background China recently established a series of pilot regional health data centers with a mandate to acquire, consolidate, analyze, and translate data into evidence for health policy decision-making. …”
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Injectable Hierarchical Bioactive Hydrogels with Fibroblast Growth Factor 21/Edaravone/Caffeic Acid Asynchronous Delivery for Treating Parkinson's Disease by Junpeng Xu, Peng Dai, Chen Zhang, Na Dong, Caiyan Li, Chonghui Tang, Zhihao Jin, Shih‐Ho Lin, Luyang Ye, Tianmiao Sun, Yukai Jin, Fenzan Wu, Lihua Luo, Ping Wu, Shengcun Li, Xiaokun Li, Shan‐hui Hsu, Dawei Jiang, Zhouguang Wang

“…The combination of clinical drugs targeting different symptoms with smart hydrogels to achieve asynchronous releases is highly translational and challenging. Here, a hierarchical bioactive hydrogel (OACDP) is designed with asynchronous release based on PD pathology. …”
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Embellishments from a Linguistic View: a Semiotic Analysis by Fatemeh Bahrami

“…The present paper aims at investigating some embellishments in Persian poems according to Saussure dealing with the following questions: 1- What aspects of Saussure’s viewpoint are adequate for explaining “pun”, “ambiguity”, “congeries” & “alliteration”?   2- Why does translation bleach aesthetical aspect of poems? To answer the first question, investigating the data reveals that aesthetic aspect of aforementioned embellishments follows from the interaction of neighboring signs in the chain, which simultaneously causes interfaces between syntagmatic and associative axes to represent various activated relations between present and absent signs, according to their similarities in signifiers, signified or both parts of the signs. …”
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Glutamine missense suppressor transfer RNAs inhibit polyglutamine aggregation by Rasangi Tennakoon, Teija M.I. Bily, Farah Hasan, Sunidhi Syal, Aaron Voigt, Tugce B. Balci, Kyle S. Hoffman, Patrick O’Donoghue

“…HD-causative polyQ alleles lead to protein aggregation, which is a prerequisite for disease. Translation fidelity modifies protein aggregation, and several studies suggest that mutating one or two glutamine (Gln) residues in polyQ reduces aggregation. …”
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Arrêt sur image et premier plan absolu dans les poèmes homériques de Michael Longley by Melanie White

“…Using diverse processes between translation and creation, Michael Longley proposes a variation on epic simultaneity by superposing different planes of reality, most remarkably thanks to the use of clauses linked by “as”, which end up being blurred into a single perspective. …”
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Establishment and characterization of ovarian clear cell carcinoma patient-derived xenografts by Joseph J. Caumanns, Shang Li, Gert J. Meersma, Evelien W. Duiker, Ate G. J. van der Zee, G. Bea A. Wisman, Steven de Jong

“…In conclusion, the high phenotypic and molecular similarity allows the established PDXs to serve as potential preclinical models for future translational research of OCCC.…”
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